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OncoImmunology Volume 10, 2021 - Issue 1
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Original Research

Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers

Angela Tataa Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University Alpert Medical School, Providence, Rhode Island, USAORCID Iconhttps://orcid.org/0000-0001-9534-4663View further author information
ORCID Icon,
Garvin Dodarda Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University Alpert Medical School, Providence, Rhode Island, USAORCID Iconhttps://orcid.org/0000-0003-3464-6443View further author information
ORCID Icon,
Céline Fugèrea Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University Alpert Medical School, Providence, Rhode Island, USAView further author information
,
Corinne Legetb Innate Pharma Research Labs., Marseille, FranceView further author information
,
Mélody Orsb Innate Pharma Research Labs., Marseille, FranceView further author information
,
Benjamin Rossib Innate Pharma Research Labs., Marseille, FranceView further author information
,
Eric Vivierb Innate Pharma Research Labs., Marseille, France;c Centre d’Immunologie De Marseille-Luminy, Aix Marseille Université, Marseille, France;d Service d’Immunologie, Hôpital De La Timone, Assistance Publique-Hôpitaux De Marseille, Marseille, FranceORCID Iconhttps://orcid.org/0000-0001-7022-8287View further author information
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Laurent Brossaya Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University Alpert Medical School, Providence, Rhode Island, USA;e Lead ContactCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7497-8488View further author information
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Article: 1933808 | Received 22 Mar 2021, Accepted 18 May 2021, Published online: 15 Jun 2021

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Surojit Karmakar, Pradipta Pal & Girdhari Lal. (2021) Key Activating and Inhibitory Ligands Involved in the Mobilization of Natural Killer Cells for Cancer Immunotherapies. ImmunoTargets and Therapy 10, pages 387-407.
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Articles from other publishers (18)

Wenjian Bi, Zhiyu Xu, Feng Liu, Zhi Xie, Hao Liu, Xiaotian Zhu, Wenge Zhong, Peipei Zhang & Xing Tang. (2024) Genome-wide analyses reveal the contribution of somatic variants to the immune landscape of multiple cancer types. PLOS Genetics 20:1, pages e1011134.
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Tatjana Sauerer, Giuliano Filippini Velázquez & Christoph Schmid. (2023) Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy. Molecular Cancer 22:1.
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Haiping Jia, Huiying Wan & Dingding Zhang. (2023) Innate lymphoid cells: a new key player in atopic dermatitis. Frontiers in Immunology 14.
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Antonio Astorga-Gamaza, David Perea, Nerea Sanchez-Gaona, Marta Calvet-Mirabent, Ana Gallego-Cortés, Judith Grau-Expósito, Ildefonso Sanchez-Cerrillo, Joan Rey, Josep Castellví, Adrian Curran, Joaquin Burgos, Jordi Navarro, Paula Suanzes, Vicenç Falcó, Meritxell Genescà, Enrique Martín-Gayo & Maria J. Buzon. (2023) KLRG1 expression on natural killer cells is associated with HIV persistence, and its targeting promotes the reduction of the viral reservoir. Cell Reports Medicine 4:10, pages 101202.
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Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Somnath Tagore, Aleksandar Obradovic, Collin Jugler, Meri Rogava, Johannes C Melms, Patrick McCann, Catherine Spina, Charles G Drake, Matthew C Dallos & Benjamin Izar. (2023) KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response. Journal for ImmunoTherapy of Cancer 11:9, pages e006782.
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Wei Song, Gang Wang, Cheng Wang, Lulu Liu, Liming Zhang, Ruoyu Zhang, Haixi Zhang & Keqian Shi. (2023) Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing. Frontiers in Immunology 14.
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Zhenzhen Hui, Yulin Ren, Dong Zhang, Yulong Chen, Wenwen Yu, Jie Cao, Liang Liu, Tao Wang, Shanshan Xiao, Liuqing Zheng, Yue Pu, Feng Wei, Jian You & Xiubao Ren. (2023) PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127+ and KLRG1+ CD8 T cells. npj Precision Oncology 7:1.
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Le Tong, Carlos Jiménez-Cortegana, Apple H.M. Tay, Stina Wickström, Lorenzo Galluzzi & Andreas Lundqvist. (2022) NK cells and solid tumors: therapeutic potential and persisting obstacles. Molecular Cancer 21:1.
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Hengjun Qian, Danning Dong, Peiwen Fan, Yaning Feng, Yanchun Peng, Xuan Yao & Ruozheng Wang. (2022) Expression of KLRG1 on subpopulations of lymphocytes in the peripheral blood of patients with locally advanced nasopharyngeal carcinoma and prognostic analysis. Precision Radiation Oncology 6:3, pages 199-208.
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Atsushi Ito, Yuichi Akama, Naoko Satoh-Takayama, Kanako Saito, Takuma Kato, Eiji Kawamoto, Arong Gaowa, Eun Jeong Park, Motoshi Takao & Motomu Shimaoka. (2022) Possible Metastatic Stage-Dependent ILC2 Activation Induces Differential Functions of MDSCs through IL-13/IL-13Rα1 Signaling during the Progression of Breast Cancer Lung Metastasis. Cancers 14:13, pages 3267.
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Pengfei Li, Xiangshun Ren, Yuanyuan Zheng, Jinming Sun & Gang Ye. (2022) Tumor promoting effect of circ_002172 associates with induced immune escape in breast cancer via the miR-296-5p/CXCL12 axis. International Immunopharmacology 106, pages 108530.
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Samantha M. Borys, Arup K. Bag, Laurent Brossay & Dennis O. Adeegbe. (2022) The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells. Frontiers in Immunology 13.
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Alessandro Poggi & Maria Raffaella Zocchi. (2022) Natural killer cells and immune-checkpoint inhibitor therapy: Current knowledge and new challenges. Molecular Therapy - Oncolytics 24, pages 26-42.
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Ran Xu, Tong Lu, JiaYing Zhao, Jun Wang, Bo Peng & LinYou Zhang. (2022) Identification of Tumor Antigens and Immune Subtypes in Lung Adenocarcinoma for mRNA Vaccine Development. Frontiers in Cell and Developmental Biology 10.
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Ondřej Vaněk, Barbora Kalousková, Celeste Abreu, Shiva Nejadebrahim & Ondřej Skořepa. 2022. Immunotherapeutics. Immunotherapeutics 91 133 .
Hendrik Possemiers, Thao-Thy Pham, Marion Coens, Emilie Pollenus, Sofie Knoops, Sam Noppen, Leen Vandermosten, Sigrid D’haese, Luna Dillemans, Fran Prenen, Dominique Schols, Blandine Franke-Fayard & Philippe E. Van den Steen. (2021) Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome. PLOS Pathogens 17:11, pages e1010114.
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Nicolas Jacquelot, Maryam Ghaedi, Kathrin Warner, Douglas C. Chung, Sarah Q. Crome & Pamela S. Ohashi. (2021) Immune Checkpoints and Innate Lymphoid Cells—New Avenues for Cancer Immunotherapy. Cancers 13:23, pages 5967.
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