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OncoImmunology Volume 10, 2021 - Issue 1
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Research Article

Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma

Michael G. Whitea Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Robert Szczepaniak Sloanea Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Russell G. Witta Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Alexandre Reubenb Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0003-4510-0382View further author information
ORCID Icon,
Pierre Olivier Gaudreaua Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
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Miles C. Andrewsa Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;c Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia;d School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, AustraliaView further author information
,
Ningping Fenge Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Sarah Johnsona Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Caleb A. Classf Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Christopher Bristowe Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Khalida Wanig Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Courtney Hudgensh Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0001-8312-7485View further author information
ORCID Icon,
Luigi Nezii Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Teresa Manzoi Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Mariana Pettaccia De Macedoh Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Jianhua Hug Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Richard Davisb Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Hong Jianga Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Peter Prietoa Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Elizabeth Burtona Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
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Patrick Hwuj Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Hussein Tawbij Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
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Jeffrey Gershenwalda Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0003-4519-5369View further author information
ORCID Icon,
Alexander J. Lazarh Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-6395-4499View further author information
ORCID Icon,
Michael T. Tetzlaffh Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Willem Overwijkj Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;k Oncology Research, Nektar Therapeutics, San Francisco, CA, USAView further author information
,
Scott E Woodmanj Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Zachary A. Coopera Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;l Translational Sciences Oncology, MedImmune, Gaithersburg, MD, USAView further author information
,
Joseph R. Marszaleke Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
,
Michael A. Daviesj Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-0977-0912View further author information
ORCID Icon,
Timothy P. Heffernane Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION), University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
&
Jennifer A. Wargoa Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;i Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence[email protected] [email protected]
View further author information
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Article: 1992880 | Received 22 Jun 2021, Accepted 08 Oct 2021, Published online: 06 Nov 2021

Citations (6)

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François Ghiringhelli. (2022) MAPK signaling regulates the efficacy of chemoimmunotherapy. Molecular & Cellular Oncology 9:1.
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Articles from other publishers (5)

M. Rakaee, S. Andersen, K. Giannikou, E.-E. Paulsen, T.K. Kilvaer, L.-T.R. Busund, T. Berg, E. Richardsen, A.P. Lombardi, E. Adib, M.I. Pedersen, M. Tafavvoghi, S.G.F. Wahl, R.H. Petersen, A.L. Bondgaard, C.W. Yde, C. Baudet, P. Licht, M. Lund-Iversen, B.H. Grønberg, L. Fjellbirkeland, Å. Helland, M. Pøhl, D.J. Kwiatkowski & T. Donnem. (2023) Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial. Annals of Oncology 34:7, pages 578-588.
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Maximilian Haist, Henner Stege, Michael Kuske, Julia Bauer, Annika Klumpp, Stephan Grabbe & Matthias Bros. (2023) Combination of immune-checkpoint inhibitors and targeted therapies for melanoma therapy: The more, the better?. Cancer and Metastasis Reviews 42:2, pages 481-505.
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Kerstin Thol, Piotr Pawlik & Nicholas McGranahan. (2022) Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution. Genome Medicine 14:1.
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Xiaoting Wang, Xiaojie Li, Yuan Xia, Danyang Wang, Xiaohan Li, Ling Liu, Qiusheng Zheng, Defang Li & Qingling Jiang. (2022) Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells. Journal of Natural Products 85:5, pages 1351-1362.
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Russell G. Witt, Derek J. Erstad & Jennifer A. Wargo. (2022) Neoadjuvant therapy for melanoma: rationale for neoadjuvant therapy and pivotal clinical trials. Therapeutic Advances in Medical Oncology 14, pages 175883592210830.
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