Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection

Daniel Delittoa Department of Surgery, Stanford University School of Medicine, Stanford, USA;b Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USACorrespondence[email protected]
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Daniel J. Zabranskyc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Fangluo Chenc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Elizabeth D. Thompsonc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USA;f Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Jacquelyn W. Zimmermanc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Todd D. Armstrongc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

James M. Leathermanc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Reecha Surib Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA;c The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Tamara Y. Lopez-Vidalc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Amanda L. Huffc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Melissa R. Lymanc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Samantha R. Guinnc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Marina Barettic The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Luciane T. Kagoharac The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Won Jin Hoc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Nilofer S. Azadc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

William R. Burnsb Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA;c The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Jin Heb Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA;c The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Christopher L. Wolfgangg Department of Surgery, New York University Grossman School of Medicine, New York, USAView further author information

Richard A. Burkhartb Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA;c The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Lei Zhengb Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA;c The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Mark Yarchoanc The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Neeha Zaidic The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USAView further author information

Elizabeth M. Jaffeec The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA;d The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, USA;e The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, USA;f Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA

https://orcid.org/0000-0003-3841-6549 View further author information

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Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection

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Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection

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