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OncoImmunology Volume 10, 2021 - Issue 1
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Research Article

Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway

Jeong Hun Kima Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, Korea;c Graduate School of Department of Biomedical Science, Cha University, Seongnam, KoreaView further author information
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Won Suk Leea Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, KoreaView further author information
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Hye Jin Leea Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, Korea;c Graduate School of Department of Biomedical Science, Cha University, Seongnam, KoreaView further author information
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Hannah Yanga Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, KoreaView further author information
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Seung Joon Leea Laboratory of Translational Immuno-Oncology, Seongnam, Korea;c Graduate School of Department of Biomedical Science, Cha University, Seongnam, KoreaView further author information
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So Jung Konga Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, KoreaView further author information
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Soyeon Jed Medical Science Study Centre, Syntekabio Inc, Seoul, South KoreaView further author information
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Hyun-Jin Yangd Medical Science Study Centre, Syntekabio Inc, Seoul, South KoreaView further author information
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Jongsun Junge Insilico Clinical Trial Research Center, Syntekabio Inc, Daejeon, South KoreaView further author information
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Jaekyung Cheona Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, Korea;c Graduate School of Department of Biomedical Science, Cha University, Seongnam, KoreaView further author information
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Beodeul Kanga Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, Korea;c Graduate School of Department of Biomedical Science, Cha University, Seongnam, KoreaView further author information
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Hong Jae Chona Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, Korea;c Graduate School of Department of Biomedical Science, Cha University, Seongnam, KoreaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6979-5812View further author information
ORCID Icon &
Chan Kima Laboratory of Translational Immuno-Oncology, Seongnam, Korea;b Medical Oncology, Department of Internal Medicine,CHA Bundang Medical Center, Cha University, Seongnam, Korea;c Graduate School of Department of Biomedical Science, Cha University, Seongnam, KoreaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9780-6155View further author information
ORCID Icon show all
Article: 2005280 | Received 08 Jul 2021, Accepted 08 Nov 2021, Published online: 26 Nov 2021

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Quanjun Yang, Juan Hao, Mengyi Chi, Yaxian Wang, Bo Xin, Jinglu Huang, Jin Lu, Jie Li, Xipeng Sun, Chunyan Li, Yan Huo, Jianping Zhang, Yonglong Han & Cheng Guo. (2022) Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism. OncoImmunology 11:1.
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Xiao Dong, Shu Xia, Shubo Du, Mao-Hua Zhu, Xing Lai, Shao Q. Yao, Hong-Zhuan Chen & Chao Fang. (2023) Tumor Metabolism-Rewriting Nanomedicines for Cancer Immunotherapy. ACS Central Science 9:10, pages 1864-1893.
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Trevor W. Stone & Richard O. Williams. (2023) Modulation of T cells by tryptophan metabolites in the kynurenine pathway. Trends in Pharmacological Sciences 44:7, pages 442-456.
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Yun Beom Sang, Hannah Yang, Won Suk Lee, Seung Joon Lee, Seul-Gi Kim, Jaekyung Cheon, Beodeul Kang, Chang Woo Kim, Hong Jae Chon & Chan Kim. (2022) High Serum Levels of IL-6 Predict Poor Responses in Patients Treated with Pembrolizumab plus Axitinib for Advanced Renal Cell Carcinoma. Cancers 14:23, pages 5985.
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Won Suk Lee, Dong Sung Kim, Jeong Hun Kim, Yoonki Heo, Hannah Yang, Eun-Jin Go, Jin Hyoung Kim, Seung Joon Lee, Byung Cheol Ahn, Jung Sun Yum, Hong Jae Chon & Chan Kim. (2022) Intratumoral immunotherapy using a TLR2/3 agonist, L-pampo, induces robust antitumor immune responses and enhances immune checkpoint blockade. Journal for ImmunoTherapy of Cancer 10:6, pages e004799.
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