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Human Vaccines & Immunotherapeutics Volume 11, 2015 - Issue 9
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Research Paper

A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters

Yuan-Kai WangDepartment of Infectious Diseases and Global Health; Tufts University Cummings School of Veterinary Medicine; North Grafton, MAUSA;School of Agriculture and Biology; Shanghai Jiao Tong University; Shanghai Key Laboratory of Veterinary Biotechnology; Key Laboratory of Urban Agriculture (South) Ministry of Agriculture; Shanghai, PR China
,
Ya-Xian YanSchool of Agriculture and Biology; Shanghai Jiao Tong University; Shanghai Key Laboratory of Veterinary Biotechnology; Key Laboratory of Urban Agriculture (South) Ministry of Agriculture; Shanghai, PR China
,
Hyeun Bum KimDepartment of Infectious Diseases and Global Health; Tufts University Cummings School of Veterinary Medicine; North Grafton, MAUSA;Department of Animal Resource and Science; Dankook University; Cheonan, Choongnam, South Korea
,
Xianghong JuDepartment of Infectious Diseases and Global Health; Tufts University Cummings School of Veterinary Medicine; North Grafton, MAUSA
,
Song ZhaoDepartment of Infectious Diseases and Global Health; Tufts University Cummings School of Veterinary Medicine; North Grafton, MAUSA
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Keshan ZhangDepartment of Infectious Diseases and Global Health; Tufts University Cummings School of Veterinary Medicine; North Grafton, MAUSA
,
Saul TziporiDepartment of Infectious Diseases and Global Health; Tufts University Cummings School of Veterinary Medicine; North Grafton, MAUSA
&
Xingmin SunDepartment of Infectious Diseases and Global Health; Tufts University Cummings School of Veterinary Medicine; North Grafton, MAUSA;Clinical and Translational Science Institute; Tufts University; Boston, MAUSACorrespondence[email protected]
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Pages 2215-2222 | Received 31 Oct 2014, Accepted 14 May 2015, Published online: 08 Aug 2015

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Vo Van Giau, Hyon Lee, Seong Soo A An & John Hulme. (2019) Recent advances in the treatment of C. difficile using biotherapeutic agents. Infection and Drug Resistance 12, pages 1597-1615.
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Articles from other publishers (8)

Shaohui Wang, Xianghong Ju, Joshua Heuler, Keshan Zhang, Zhibian Duan, Hiran Malinda Lamabadu Warnakulasuriya Patabendige, Song Zhao & Xingmin Sun. (2023) Recombinant Fusion Protein Vaccine Containing Clostridioides difficile FliC and FliD Protects Mice against C. difficile Infection. Infection and Immunity 91:4.
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Shaohui Wang, Duolong Zhu & Xingmin Sun. (2022) Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection. Microbiology Spectrum 10:3.
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Jaime Hughes, Carl Aston, Michelle L. Kelly & Ruth Griffin. (2022) Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile. Pharmaceutics 14:5, pages 1086.
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Yuanguo Wang, Shaohui Wang, Laurent Bouillaut, Chunhui Li, Zhibian Duan, Keshan Zhang, Xianghong Ju, Saul Tzipori, Abraham L. Sonenshein & Xingmin Sun. (2018) Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters. Infection and Immunity 86:11.
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Shaohui Wang, Yuanguo Wang, Ying Cai, Ciaran P. Kelly & Xingmin Sun. (2018) Novel Chimeric Protein Vaccines Against Clostridium difficile Infection. Frontiers in Immunology 9.
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Dongbo Xu, Linna Han, Chunhui Li, Qi Cao, Duolong Zhu, Nolan H. Barrett, Dedra Harmody, Jing Chen, Haining Zhu, Peter J. McCarthy, Xingmin Sun & Guojun Wang. (2018) Bioprospecting Deep-Sea Actinobacteria for Novel Anti-infective Natural Products. Frontiers in Microbiology 9.
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Duolong Zhu, Joseph A. Sorg & Xingmin Sun. (2018) Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection. Frontiers in Cellular and Infection Microbiology 8.
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Yi-Wen Liu, Yu-Hung Chen, Jenn-Wei Chen, Pei-Jane Tsai & I-Hsiu Huang. (2017) Immunization with Recombinant TcdB-Encapsulated Nanocomplex Induces Protection against Clostridium difficile Challenge in a Mouse Model. Frontiers in Microbiology 8.
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