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Human Vaccines & Immunotherapeutics Volume 13, 2017 - Issue 7
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Research Papers

F199E substitution reduced toxicity of Clostridium perfringens epsilon toxin by depriving the receptor binding capability

Jingjing KangLife Science Institute of Hebei Normal University, Shijiazhuang, Hebei Province, PR China
,
Jie GaoLife Science Institute of Hebei Normal University, Shijiazhuang, Hebei Province, PR China
,
Wenwu YaoState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR China
,
Lin KangState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR China
,
Shan GaoState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR China
,
Hao YangState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR China
,
Bin JiState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR China
,
Ping LiState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR China
,
Jing LiuState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR China
,
Jiahao YaoState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR China
,
Wenwen XinState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR ChinaCorrespondence[email protected]
,
Baohua ZhaoLife Science Institute of Hebei Normal University, Shijiazhuang, Hebei Province, PR ChinaCorrespondence[email protected]
&
Jinglin WangState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, PR ChinaCorrespondence[email protected]
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Pages 1598-1608 | Received 12 Dec 2016, Accepted 02 Mar 2017, Published online: 17 Apr 2017

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Jie Gao, Wenwen Xin, Jing Huang, Bin Ji, Shan Gao, Liang Chen, Lin Kang, Hao Yang, Xin Shen, Baohua Zhao & Jinglin Wang. (2018) Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors. Virulence 9:1, pages 1601-1614.
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Articles from other publishers (8)

Bin Ji, Jianxiang Huang, Kexuan Zou, Meijun Liu, Yufeng Pei, Jing Huang, Yong Wang, Jinglin Wang, Ruhong Zhou, Wenwen Xin & Jie Song. (2023) Direct Visualization of the Dynamic Process of Epsilon Toxin on Hemolysis. Small Methods 7:7.
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Jing Huang, Baohua Zhao, Tingting Liu, Lin Kang, Jiaxin Li, Zishuo Guo, Ming Chen, Shan Gao, Jing Wang, Yanwei Li, Jinglin Wang & Wenwen Xin. (2023) Statins as Potential Preventative Treatment of ETX and Multiple Pore-Forming Toxin-Induced Diseases. International Journal of Molecular Sciences 24:6, pages 5414.
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Zhijun Geng, Lin Kang, Jing Huang, Shan Gao, Jing Wang, Yuan Yuan, Yanwei Li, Jinglin Wang & Wenwen Xin. (2021) Epsilon toxin from Clostridium perfringens induces toxic effects on skin tissues and HaCaT and human epidermal keratinocytes. Toxicon 198, pages 102-110.
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Mahdieh Mahboobi, Hamid Sedighian, Ehsan Malekara, Saeed Khalili, Mohammad Reza Rahbar, Kobra Ahmadi Zanoos, Raheleh Halabian & Abolfazl Jahangiri. (2020) Harnessing an Integrative In Silico Approach to Engage Highly Immunogenic Peptides in an Antigen Design Against Epsilon Toxin (ETX) of Clostridium perfringens. International Journal of Peptide Research and Therapeutics 27:2, pages 1019-1026.
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Zhigang Jiang, Jitao Chang, Fang Wang, Yinglin Qi, Yixin Li, Debin Yu & Li Yu. (2020) Etx-Y71A as a non-toxic mutant of Clostridium perfringens epsilon toxin induces protective immunity in mice and sheep. Vaccine 38:42, pages 6553-6561.
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Jennifer R. Linden, Claudia Flores, Eric F. Schmidt, Francisco A. Uzal, Adam O. Michel, Marissa Valenzuela, Sebastian Dobrow & Timothy Vartanian. (2019) Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. PLOS Pathogens 15:11, pages e1008014.
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Helen Morcrette, Monika Bokori-Brown, Stephanie Ong, Leo Bennett, Brendan W. Wren, Nick Lewis & Richard W. Titball. (2019) Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein. npj Vaccines 4:1.
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Jennifer Linden, Kiel Telesford, Samantha Shetty, Paige Winokour, Sylvia Haigh, Ellen Cahir-McFarland, Giovanna Antognetti, Abhishek Datta, Tao Wang, Werner Meier & Timothy Vartanian. (2018) A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization. Antibodies 7:4, pages 37.
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