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Human Vaccines & Immunotherapeutics Volume 15, 2019 - Issue 9
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Research Paper

Immunogenicity and safety of an investigational tetravalent recombinant subunit vaccine for dengue: results of a Phase I randomized clinical trial in flavivirus-naïve adults

Susan B. Manoffa Merck & Co., Inc, Kenilworth, NJ, USAView further author information
,
Michele Saussera Merck & Co., Inc, Kenilworth, NJ, USAView further author information
,
Amy Falk Russella Merck & Co., Inc, Kenilworth, NJ, USAView further author information
,
Jason Martina Merck & Co., Inc, Kenilworth, NJ, USAView further author information
,
David Radleya Merck & Co., Inc, Kenilworth, NJ, USAView further author information
,
Donna Hyatta Merck & Co., Inc, Kenilworth, NJ, USAView further author information
,
Christine C. Robertsa Merck & Co., Inc, Kenilworth, NJ, USAView further author information
,
Jason Lickliterb Nucleus Network LTD, Melbourne, AustraliaView further author information
,
Janakan Krishnarajahc Linear Clinical Research LTD, Perth, AustraliaView further author information
,
Andrew Betta Merck & Co., Inc, Kenilworth, NJ, USAView further author information
,
Sheri Dubeya Merck & Co., Inc, Kenilworth, NJ, USAORCID Iconhttps://orcid.org/0000-0002-0712-9865View further author information
ORCID Icon,
Tyler Finna Merck & Co., Inc, Kenilworth, NJ, USAView further author information
&
Beth-Ann Collera Merck & Co., Inc, Kenilworth, NJ, USACorrespondence[email protected]
View further author information
 show all
Pages 2195-2204 | Received 26 Apr 2018, Accepted 27 Oct 2018, Published online: 03 Jun 2019

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Sidhant Jain, Neha Vimal, Nilza Angmo, Madhumita Sengupta & Suraj Thangaraj. (2023) Dengue Vaccination: Towards a New Dawn of Curbing Dengue Infection. Immunological Investigations 52:8, pages 1096-1149.
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Adam T Waickman, Krista Newell, Timothy P Endy & Stephen J Thomas. (2023) Biologics for dengue prevention: up-to-date. Expert Opinion on Biological Therapy 23:1, pages 73-87.
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Chung-Hao Huang, Yu-Te Tsai, Seng-Fan Wang, Wen-Hung Wang & Yen-Hsu Chen. (2021) Dengue vaccine: an update. Expert Review of Anti-infective Therapy 19:12, pages 1495-1502.
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Fakhriedzwan Idris, Donald Heng Rong Ting & Sylvie Alonso. (2021) An update on dengue vaccine development, challenges, and future perspectives. Expert Opinion on Drug Discovery 16:1, pages 47-58.
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Laura Lazo. (2020) Dengue virus 4: the ‘black sheep’ of the family?. Expert Review of Vaccines 19:9, pages 807-815.
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Laura Lazo, Iris Valdes, Gerardo Guillén, Lisset Hermida & Lázaro Gil. (2019) Aiming at the heart: the capsid protein of dengue virus as a vaccine candidate. Expert Review of Vaccines 18:2, pages 161-173.
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Almonther Abdullah Hershan. (2023) Dengue Virus: Molecular Biology and Recent Developments in Control Strategies, Prevention, Management, and Therapeutics. Journal of Pharmacology and Pharmacotherapeutics 14:2, pages 107-124.
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Monica Palanichamy Kala, Ashley L. St. John & Abhay P. S. Rathore. (2023) Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines. Current Treatment Options in Infectious Diseases 15:2, pages 27-52.
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Jesús M. Torres-Flores, Arturo Reyes-Sandoval & Ma Isabel Salazar. (2022) Dengue Vaccines: An Update. BioDrugs 36:3, pages 325-336.
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Albert To, Chih-Yun Lai, Teri Ann S. Wong, Madhuri Namekar, Michael M. Lieberman & Axel T. Lehrer. (2022) Adjuvants Differentially Modulate the Immunogenicity of Lassa Virus Glycoprotein Subunits in Mice. Frontiers in Tropical Diseases 3.
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Mohd Ishtiaq Anasir & Chit Laa Poh. (2022) Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics. Medical Microbiology and Immunology 211:1, pages 1-18.
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Harun Norshidah, Ramachandran Vignesh & Ngit Shin Lai. (2021) Updates on Dengue Vaccine and Antiviral: Where Are We Heading?. Molecules 26:22, pages 6768.
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Pierre Magal, Ousmane Seydi, Glenn Webb & Yixiang Wu. (2021) A Model of Vaccination for Dengue in the Philippines 2016–2018. Frontiers in Applied Mathematics and Statistics 7.
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Connor A. P. Scott, Alberto A. Amarilla, Summa Bibby, Natalee D. Newton, Roy A. Hall, Jody Hobson-Peters, David A. Muller, Keith J. Chappell, Paul R. Young, Naphak Modhiran & Daniel Watterson. (2021) Implications of Dengue Virus Maturation on Vaccine Induced Humoral Immunity in Mice. Viruses 13:9, pages 1843.
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Ada Maria Barcelos Alves, Simone Morais Costa & Paolla Beatriz Almeida Pinto. (2021) Dengue Virus and Vaccines: How Can DNA Immunization Contribute to This Challenge?. Frontiers in Medical Technology 3.
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Ali Ahmed & Gul Majid Khan. 2021. Human Viruses: Diseases, Treatments and Vaccines. Human Viruses: Diseases, Treatments and Vaccines 71 80 .
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Sergio C. Araujo, Lennon R. Pereira, Rubens P. S. Alves, Robert Andreata-Santos, Alex I. Kanno, Luis Carlos S. Ferreira & Viviane M. Gonçalves. (2020) Anti-Flavivirus Vaccines: Review of the Present Situation and Perspectives of Subunit Vaccines Produced in Escherichia coli. Vaccines 8:3, pages 492.
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Anna P. DurbinKristen K. PierceBeth D. KirkpatrickPalmtama GrierBeulah P. SabundayoHelen HeMichele SausserAmy Falk RussellJason MartinDonna HyattMelissa CookJeffrey R. SachsAndrew Wen-Tseng LeeLiman WangBeth-Ann CollerStephen S. Whitehead. (2020) Immunogenicity and Safety of a Tetravalent Recombinant Subunit Dengue Vaccine in Adults Previously Vaccinated with a Live Attenuated Tetravalent Dengue Vaccine: Results of a Phase-I Randomized Clinical Trial. The American Journal of Tropical Medicine and Hygiene 103:2, pages 855-863.
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Milind M. Gore. (2020) Vaccines Against Dengue and West Nile Viruses in India: The Need of the Hour. Viral Immunology 33:6, pages 423-433.
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Abdullah M. Izmirly, Sana O. Alturki, Sawsan O. Alturki, Jennifer Connors & Elias K. Haddad. (2020) Challenges in Dengue Vaccines Development: Pre-existing Infections and Cross-Reactivity. Frontiers in Immunology 11.
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Jin Sun, Senyan Du, Zhihang Zheng, Gong Cheng & Xia Jin. (2020) Defeat Dengue and Zika Viruses With a One-Two Punch of Vaccine and Vector Blockade. Frontiers in Microbiology 11.
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Kaihao Feng, Xiaoyan Zheng, Ran Wang, Na Gao, Dongying Fan, Ziyang Sheng, Hongning Zhou, Hui Chen & Jing An. (2020) Long-Term Protection Elicited by a DNA Vaccine Candidate Expressing the prM-E Antigen of Dengue Virus Serotype 3 in Mice. Frontiers in Cellular and Infection Microbiology 10.
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