18,636
Views
53
CrossRef citations to date
0
Altmetric
Mini Review

Role of antibody-dependent enhancement (ADE) in the virulence of SARS-CoV-2 and its mitigation strategies for the development of vaccines and immunotherapies to counter COVID-19

ORCID Icon, , &
Pages 3055-3060 | Received 05 May 2020, Accepted 11 Jul 2020, Published online: 26 Aug 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Neema Negi, Shesh Prakash Maurya, Ravinder Singh & Bimal Kumar Das. (2022) An update on host immunity correlates and prospects of re-infection in COVID-19. International Reviews of Immunology 41:4, pages 367-392.
Read now
Marco Tuccori, Sara Ferraro, Irma Convertino, Emiliano Cappello, Giulia Valdiserra, Corrado Blandizzi, Fabrizio Maggi & Daniele Focosi. (2020) Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline. mAbs 12:1.
Read now

Articles from other publishers (51)

Sheng Feng, Zechang Fan, Keyue Zhou, Shanshan Ma, Mingzheng Liang, He Zhang, Yubiao Xie, Zhuo Ha, Ningyi Jin & Huijun Lu. (2023) Subunit vaccine raised against the SARS‐CoV‐2 spike of Delta and Omicron variants. Journal of Medical Virology 95:10.
Crossref
Sarah B. Dubbs, Cheyenne Falat & Lauren Rosenblatt. (2023) Immune-based Therapies—What the Emergency Physician Needs to Know. Immunology and Allergy Clinics of North America 43:3, pages 569-582.
Crossref
Marina M. Ziganshina, Nadezhda V. Shilova, Eugenia O. Khalturina, Natalya V. Dolgushina, Sergey V. Borisevich, Ekaterina L. Yarotskaya, Nicolai V. Bovin & Gennady T. Sukhikh. (2023) Antibody-Dependent Enhancement with a Focus on SARS-CoV-2 and Anti-Glycan Antibodies. Viruses 15:7, pages 1584.
Crossref
Jyoti Sawant, Ajit Patil & Swarali Kurle. (2023) A Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections. Vaccines 11:7, pages 1240.
Crossref
Li Yang, Jiaxiu He, Zhi Song, Wen Zhen, Ru Chen, Cheng Zhang, Heng Yang & Ding Liu. (2023) Experiences from COVID ‐19 vaccination in patients with epilepsy . Epilepsia Open 8:2, pages 307-312.
Crossref
Francesco La Torre, Andrea Taddio, Chiara Conti & Marco Cattalini. (2023) Multi-Inflammatory Syndrome in Children (MIS-C) in 2023: Is It Time to Forget about It?. Children 10:6, pages 980.
Crossref
İrem Ceren Erbaş, Yıldız Ekemen Keleş, Emine Hafize Erdeniz, Ayşe Tekin Yılmaz, Edanur Yeşil, Özlem Çakıcı, Mehtap Akça, Nursel Kara Ulu, Fatih Dinç, Dilek Yılmaz Çiftdoğan, Selim Öncel, Necdet Kuyucu, Anıl Tapısız & Nurşen Belet. (2023) Evaluation of possible COVID-19 reinfection in children: A multicenter clinical study. Archives de Pédiatrie 30:3, pages 187-191.
Crossref
Sinei Ramos Soares, Maria Karoliny da Silva Torres, Sandra Souza Lima, Kevin Matheus Lima de Sarges, Erika Ferreira dos Santos, Mioni Thieli Figueiredo Magalhães de Brito, Andréa Luciana Soares da Silva, Mauro de Meira Leite, Flávia Póvoa da Costa, Marcos Henrique Damasceno Cantanhede, Rosilene da Silva, Adriana de Oliveira Lameira Veríssimo, Izaura Maria Vieira Cayres Vallinoto, Rosimar Neris Martins Feitosa, Juarez Antônio Simões Quaresma, Tânia do Socorro Souza Chaves, Giselle Maria Rachid Viana, Luiz Fábio Magno Falcão, Eduardo José Melo dos Santos, Antonio Carlos Rosário Vallinoto & Andréa Nazaré Monteiro Rangel da Silva. (2023) Antibody Response to the SARS-CoV-2 Spike and Nucleocapsid Proteins in Patients with Different COVID-19 Clinical Profiles. Viruses 15:4, pages 898.
Crossref
Shinian Li & Yaping Chen. (2023) Epitopes screening and vaccine molecular design of SADS-CoV based on immunoinformatics. Frontiers in Veterinary Science 9.
Crossref
Hamid Nasrollahi, Atefe Ghamar Talepoor, Zahra Saleh, Mahsa Eshkevar Vakili, Paria Heydarinezhad, Narges Karami, Maryam Noroozi, Seppo Meri & Kurosh Kalantar. (2023) Immune responses in mildly versus critically ill COVID-19 patients. Frontiers in Immunology 14.
Crossref
Martina Grando, Massimiliano Balbi & Marco Zeppieri. (2022) COVID-19-induced liver injury in adult patients: A brief overview. World Journal of Virology 11:6, pages 443-452.
Crossref
Shahab Falahi, Maryam Maleki & Azra Kenarkoohi. (2022) An Updated Review on Complicated Mechanisms of COVID-19 Pathogenesis and Therapy: Direct Viral Damage, Renin-angiotensin System Dysregulation, Immune System Derangements, and Endothelial Dysfunction. Infectious Disorders - Drug Targets 22:7.
Crossref
Yalong Yang & Fenghua Xu. (2022) Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2. Frontiers in Immunology 13.
Crossref
Olga V. Krusko, Evgenia A. Novikova, Pyotr K. Potapov & Alla G. Petrova. (2022) Genetic pattern of the COVID-19 course and reinfection. Bulletin of the Russian Military Medical Academy 24:3, pages 593-604.
Crossref
Lin Gan, Yan Chen, Jinlin Tan, Xuezhi Wang & Dingmei Zhang. (2022) Does potential antibody-dependent enhancement occur during SARS-CoV-2 infection after natural infection or vaccination? A meta-analysis. BMC Infectious Diseases 22:1.
Crossref
Xiaoke Yang, Xin Zhang, Xiaotian Zhao, Mengqi Yuan, Kehui Zhang, Jingwen Dai, Xiangyu Guan, Hua-Ji Qiu & Yongfeng Li. (2022) Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections. Viruses 14:8, pages 1739.
Crossref
Xiao-Yan Huang, Li-Juan Yang, Xiang Hu, Xing-Xing Zhang, Xiao Gu, Lin-Jia Du, Zhi-Ying He & Xue-Jiang Gu. (2022) Elevated levels of fructosamine are independently associated with SARS-CoV-2 reinfection: A 12-mo follow-up study. World Journal of Diabetes 13:7, pages 543-552.
Crossref
Christian M. Tegeler, Tatjana Bilich, Yacine Maringer, Helmut R. Salih, Juliane S. Walz, Annika Nelde & Jonas S. Heitmann. (2022) Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort. International Journal of Infectious Diseases 120, pages 187-195.
Crossref
Jie Wang & Wenbin Dong. (2022) COVID-19: the possibility, ways, mechanisms, and interruptions of mother-to-child transmission. Archives of Gynecology and Obstetrics 307:6, pages 1687-1696.
Crossref
Omer Sager, Ferrat Dincoglan, Selcuk Demiral & Murat Beyzadeoglu. (2022) Potential Utility of Radiopharmaceuticals in the Battle Against SARSCov- 2 and COVID-19 Pandemic. Current Radiopharmaceuticals 15:2, pages 93-95.
Crossref
Tejas kant, Upma Narain & Arun Kant. (2022) ACUTE TELOGEN EFFLUVIUM: A SEQUELA OF COVID-19 INFECTION. GLOBAL JOURNAL FOR RESEARCH ANALYSIS, pages 114-115.
Crossref
Sema Koç Yıldırım, Ece Erbağcı & Neslihan Demirel Öğüt. (2022) Evaluation of patients with telogen effluvium during the pandemic: May the monocytes be responsible for post COVID‐19 telogen effluvium?. Journal of Cosmetic Dermatology 21:5, pages 1809-1815.
Crossref
Viola Denninger, Catherine K. Xu, Georg Meisl, Alexey S. Morgunov, Sebastian Fiedler, Alison Ilsley, Marc Emmenegger, Anisa Y. Malik, Monika A. Piziorska, Matthias M. Schneider, Sean R. A. Devenish, Vasilis Kosmoliaptsis, Adriano Aguzzi, Heike Fiegler & Tuomas P. J. Knowles. (2022) Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2. ACS Infectious Diseases 8:4, pages 790-799.
Crossref
Sarah B. Dubbs, Cheyenne Falat & Lauren Rosenblatt. (2022) Immune-based Therapies—What the Emergency Physician Needs to Know. Emergency Medicine Clinics of North America 40:1, pages 135-148.
Crossref
Wael Bahnan, Sebastian Wrighton, Martin Sundwall, Anna Bläckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thomas Hellmark, Vidar Wendel-Hansen, Robert PA. Wallin, Johan Malmstöm, Lars Malmström, Mats Ohlin, Magnus Rasmussen & Pontus Nordenfelt. (2022) Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2. Frontiers in Immunology 12.
Crossref
Massimo Pizzato, Chiara Baraldi, Giulia Boscato Sopetto, Davide Finozzi, Carmelo Gentile, Michele Domenico Gentile, Roberta Marconi, Dalila Paladino, Alberto Raoss, Ilary Riedmiller, Hamza Ur Rehman, Annalisa Santini, Valerio Succetti & Lorenzo Volpini. (2022) SARS-CoV-2 and the Host Cell: A Tale of Interactions. Frontiers in Virology 1.
Crossref
ArunC Inamadar. (2022) Covid induced telogen effluvium (CITE): An insight. Indian Dermatology Online Journal 13:4, pages 445.
Crossref
Victor Araujo Correa, Amanda Izeli Portilho, Emanuelle Baldo Gaspar & Elizabeth De Gaspari. 2022. Frontiers of COVID-19. Frontiers of COVID-19 19 29 .
Johnny Chun-Chau Sung, Ying Liu, Kam-Chau Wu, Man-Chung Choi, Chloe Ho-Yi Ma, Jayman Lin, Emily Isabel Cheng He, David Yiu-Ming Leung, Eric Tung-Po Sze, Yusuf Khwaja Hamied, Dominic Man-Kit Lam & Keith Wai-Yeung Kwong. (2021) Expression of SARS-CoV-2 Spike Protein Receptor Binding Domain on Recombinant B. subtilis on Spore Surface: A Potential COVID-19 Oral Vaccine Candidate. Vaccines 10:1, pages 2.
Crossref
Monica Neagu, Carolina Constantin & Mihaela Surcel. (2021) Testing Antigens, Antibodies, and Immune Cells in COVID-19 as a Public Health Topic—Experience and Outlines. International Journal of Environmental Research and Public Health 18:24, pages 13173.
Crossref
Grigore Mihaescu, Mariana Carmen Chifiriuc, Corneliu Ovidiu Vrancianu, Marian Constantin, Roxana Filip, Mihaela Roxana Popescu, Liliana Burlibasa, Anca Cecilia Nicoara, Alexandra Bolocan, Ciprian Iliescu & Gratiela Gradisteanu Pircalabioru. (2021) Antiviral Immunity in SARS-CoV-2 Infection: From Protective to Deleterious Responses. Microorganisms 9:12, pages 2578.
Crossref
Angela Quirino, Nadia Marascio, Giorgio Settimo Barreca, Luigia Gallo, Aida Giancotti, Angelo Giuseppe Lamberti, Cinzia Peronace, Enrico Maria Trecarichi, Paolo Fusco, Maria Mazzitelli, Francesca Divenuto, Grazia Pavia, Angela Suraci, Giovanni Matera & Maria Carla Liberto. (2021) SARS-CoV-2: Some Aspects of Molecular Evolution, Cellular Pathogenesis, and Immune System Mechanism Elusion. Applied Sciences 11:24, pages 11605.
Crossref
Lorenzo Lo Muzio, Mariateresa Ambosino, Eleonora Lo Muzio & Mir Faeq Ali Quadri. (2021) SARS-CoV-2 Reinfection Is a New Challenge for the Effectiveness of Global Vaccination Campaign: A Systematic Review of Cases Reported in Literature. International Journal of Environmental Research and Public Health 18:20, pages 11001.
Crossref
Neil Formica, Raburn Mallory, Gary Albert, Michelle Robinson, Joyce S. Plested, Iksung Cho, Andreana Robertson, Filip Dubovsky & Gregory M. Glenn. (2021) Different dose regimens of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373) in younger and older adults: A phase 2 randomized placebo-controlled trial. PLOS Medicine 18:10, pages e1003769.
Crossref
Pankaj Garg. (2021) The New Variants of Corona-Virus Mutations: An Understanding to Their Infectivity, Immunological Tolerance and Vaccine Efficacy. Nano LIFE 11:03, pages 2130010.
Crossref
Robert S. Shapiro. (2021) COVID‐19 vaccines and nanomedicine. International Journal of Dermatology 60:9, pages 1047-1052.
Crossref
Ki-Back Chu, Hae-Ji Kang, Keon-Woong Yoon, Hae-Ahm Lee, Eun-Kyung Moon, Beom-Ku Han & Fu-Shi Quan. (2021) Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 Domains. Vaccines 9:8, pages 920.
Crossref
Zhangkai Jason Cheng, Mingshan Xue, Peiyan Zheng, Jiali Lyu, Zhiqing Zhan, Haisheng Hu, Yong Zhang, Xiaohua Douglas Zhang & Baoqing Sun. (2021) Factors Affecting the Antibody Immunogenicity of Vaccines against SARS-CoV-2: A Focused Review. Vaccines 9:8, pages 869.
Crossref
Jingzhou Wang, Christopher Kaperak, Toshiro Sato & Atsushi Sakuraba. (2023) Covid-19 Reinfection: A Rapid Systematic Review of Case Reports and Case Series. Journal of Investigative Medicine 69:6, pages 1253-1255.
Crossref
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin & Qing Xie. (2021) Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections. Frontiers of Medicine 15:4, pages 644-648.
Crossref
Daniele Focosi, Fabrizio Maggi, Massimo Franchini, Adriano Aguzzi, Maria Lanza, Alessandro Mazzoni & Francesco Menichetti. (2021) Patient-blood management for COVID19 convalescent plasma therapy: relevance of affinity and donor–recipient differences in concentration of neutralizing antibodies. Clinical Microbiology and Infection 27:7, pages 987-992.
Crossref
Daniele Focosi, Angelo Genoni, Ersilia Lucenteforte, Silvia Tillati, Antonio Tamborini, Pietro Giorgio Spezia, Lorenzo Azzi, Andreina Baj & Fabrizio Maggi. (2021) Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin. Life 11:4, pages 298.
Crossref
Natalia Ruetalo, Ramona Businger, Karina Althaus, Simon Fink, Felix Ruoff, Michaela Pogoda, Angelika Iftner, Tina Ganzenmüller, Klaus Hamprecht, Bertram Flehmig, Tamam Bakchoul, Markus F. Templin & Michael Schindler. (2021) Antibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 Patients. mSphere 6:1.
Crossref
Luis Ángel Ortiz López, Luis Alberto Morales León, David Fernando Palazuelos Ramírez, José Francisco Lam Rascón & Luis Alberto Castillo Díaz. (2021) Papel de los tejidos orales durante la infección por SARS-CoV-2.. Revista de la Asociación Dental Mexicana 78:3, pages 167-175.
Crossref
Gabriela Athziri Sánchez-Zuno, Mónica Guadalupe Matuz-Flores, Guillermo González-Estevez, Ferdinando Nicoletti, Francisco Javier Turrubiates-Hernández, Katia Mangano & José Francisco Muñoz-Valle. (2021) A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies. International Journal of Immunopathology and Pharmacology 35, pages 205873842110501.
Crossref
Alfredo Rossi, Francesca Magri, Alvise Sernicola, Simone Michelini, Gemma Caro, Marta Muscianese, Marco Di Fraia, Camilla Chello, Maria Caterina Fortuna & Teresa Grieco. (2021) Telogen Effluvium after SARS-CoV-2 Infection: A Series of Cases and Possible Pathogenetic Mechanisms. Skin Appendage Disorders 7:5, pages 377-381.
Crossref
Yixin Liu, Xinsheng Zhou, Xuan Liu & Xiaotao Jiang. (2021) The immunology and immunotherapy for COVID-19. Expert Reviews in Molecular Medicine 23.
Crossref
Arezoo Hosseini, Vida Hashemi, Navid Shomali, Faezeh Asghari, Tohid Gharibi, Morteza Akbari, Saber Gholizadeh & Abbas Jafari. (2020) Innate and adaptive immune responses against coronavirus. Biomedicine & Pharmacotherapy 132, pages 110859.
Crossref
Abdur Rauf, Tareq Abu-Izneid, Ahmed Olatunde, Anees Ahmed Khalil, Fahad A. Alhumaydhi, Tabussam Tufail, Mohammad Ali Shariati, Maksim Rebezov, Zainab M. Almarhoon, Yahia N. Mabkhot, Abdulrhman Alsayari & Kannan R. R. Rengasamy. (2020) COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies. International Journal of Environmental Research and Public Health 17:21, pages 8155.
Crossref
Taylon Felipe Silva, Fernanda Tomiotto-Pellissier, Raquel Arruda Sanfelice, Manoela Daiele Gonçalves, Bruna Taciane da Silva Bortoleti, Mariana Barbosa Detoni, Ana Carolina Jacob Rodrigues, Amanda Cristina Machado Carloto, Virgínia Márcia Concato, Elaine da Silva Siqueira, Idessania Nazareth Costa, Wander Rogério Pavanelli, Ivete Conchon-Costa & Milena Menegazzo Miranda-Sapla. (2020) A 21st Century Evil: Immunopathology and New Therapies of COVID-19. Frontiers in Immunology 11.
Crossref
Liangwei Duan, Qianqian Zheng, Hongxia Zhang, Yuna Niu, Yunwei Lou & Hui Wang. (2020) The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens. Frontiers in Immunology 11.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.