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Mini Review

Exploring the possible use of saponin adjuvants in COVID-19 vaccine

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Pages 2944-2953 | Received 16 Jul 2020, Accepted 02 Oct 2020, Published online: 09 Dec 2020

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Read on this site (3)

Rahul Singh, Rinku Sharma, Rajat Varshney, Gorakh Mal, Mayukh Ghosh & Birbal Singh. (2023) Evaluation of immunological adjuvant activities of saponin rich fraction from the fruits of Asparagus adscendens Roxb. with less adverse reactions. Drug and Chemical Toxicology 46:3, pages 557-565.
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Kuldeep Dhama, Manish Dhawan, Ruchi Tiwari, Talha Bin Emran, Saikat Mitra, Ali A. Rabaan, Saad Alhumaid, Zainab Al Alawi & Abbas Al Mutair. (2022) COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges. Human Vaccines & Immunotherapeutics 18:5.
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Gaurav Joshi, Pobitra Borah, Shweta Thakur, Praveen Sharma, Mayank & Ramarao Poduri. (2021) Exploring the COVID-19 vaccine candidates against SARS-CoV-2 and its variants: where do we stand and where do we go?. Human Vaccines & Immunotherapeutics 17:12, pages 4714-4740.
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Articles from other publishers (16)

Marcelo M. Jesus, Daniela P. Lage, Danniele L. Vale, Camila S. Freitas, Breno L. Pimenta, Gabriel J.L. Moreira, Fernanda F. Ramos, Isabela A.G. Pereira, Raquel S. Bandeira, Fernanda Ludolf, Grasiele S.V. Tavares, Alexsandro S. Galdino, Mariana C. Duarte, Daniel Menezes-Souza, Miguel A. Chávez-Fumagalli, Antônio L. Teixeira, Denise U. Gonçalves, Bruno M. Roatt, Myron Christodoulides, Vívian T. Martins & Eduardo A.F. Coelho. (2023) Immunization with recombinant LiHyp1 protein plus adjuvant is protective against tegumentary leishmaniasis. Parasitology Research 122:12, pages 2917-2931.
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Arivukarasu Palanisamy, Rinku Sharma, Prithvi Pal Singh, Upendra Sharma, Rajendra Damu Patil, Gorakh Mal & Birbal Singh. (2023) Shatavarin-IV saponin adjuvant elicits IgG and IgG2b responses against Staphylococcus aureus bacterin in a murine model. Heliyon 9:4, pages e15339.
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Daniela P. Lage, Amanda S. Machado, Camila S. Freitas, Danniele L. Vale, Flávia P. Linhares, Jamille M.O. Cardoso, João A. Oliveira-da-Silva, Fernanda F. Ramos, Isabela A.G. Pereira, Fernanda Ludolf, Grasiele S.V. Tavares, Raquel S. Bandeira, Jamil S. Oliveira, Daniel Menezes-Souza, Mariana C. Duarte, Alexsandro S. Galdino, Myron Christodoulides, Miguel A. Chávez-Fumagalli, Bruno M. Roatt, Vívian T. Martins & Eduardo A.F. Coelho. (2023) Recombinant endonuclease III protein from Leishmania infantum associated with Th1-type adjuvants is immunogenic and induces protection against visceral leishmaniasis. Molecular Immunology 155, pages 79-90.
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Mohammad Bagher Majnooni, Sajad Fakhri, Syed Mustafa Ghanadian, Gholamreza Bahrami, Kamran Mansouri, Amin Iranpanah, Mohammad Hosein Farzaei & Mahdi Mojarrab. (2023) Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways. Metabolites 13:3, pages 323.
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Daniel Mieres-Castro & Freddy Mora-Poblete. (2023) Saponins: Research Progress and Their Potential Role in the Post-COVID-19 Pandemic Era. Pharmaceutics 15:2, pages 348.
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Faith Ndung'u, Steven Nyanjom, Samuel Omari, Eunice Wainaina, Robinson Mugasiali & James Kimotho. (2023) Preliminary assessment of adjuvant activities of Glycine Max (L.) Merr saponin extract in BALB/c mice immunized with hepatitis B virus vaccine. F1000Research 12, pages 1145.
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Catarina Faria-Silva, Miriam de Sousa, Manuela Colla Carvalheiro, Pedro Simões & Sandra Simões. (2022) Alpha-tomatine and the two sides of the same coin: An anti-nutritional glycoalkaloid with potential in human health. Food Chemistry 391, pages 133261.
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Xiaojin Chen, Xudong Fan & Fanzhu Li. (2022) Development and Evaluation of a Novel Diammonium Glycyrrhizinate Phytosome for Nasal Vaccination. Pharmaceutics 14:10, pages 2000.
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Amir Ghaemi, Parisa Roshani Asl, Hedieh Zargaran, Delaram Ahmadi, Asim Ali Hashimi, Elahe Abdolalipour, Sahar Bathaeian & Seyed Mohammad Miri. (2022) Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity. Frontiers in Immunology 13.
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Da Wang, Luping Sha, Chen Xu, Ying Huang, Chengcheng Tang, Tingting Xu, Xianzhe Li, Donghua Di, Jie Liu & Li Yang. (2022) Natural saponin and cholesterol assembled nanostructures as the promising delivery method for saponin. Colloids and Surfaces B: Biointerfaces 214, pages 112448.
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Ram Siripuram, Zinka Bartolek, Ketki Patil, Saj S. Gill & S. Balakrishna Pai. (2022) Disruption of Colorectal Cancer Network by Polyphyllins Reveals Pivotal Entities with Implications for Chemoimmunotherapy. Biomedicines 10:3, pages 583.
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Sudha Porte, Veenu Joshi, Kamal Shah & NagendraSingh Chauhan. (2022) Plants' steroidal saponins - A review on its pharmacology properties and analytical techniques. World Journal of Traditional Chinese Medicine 8:3, pages 350.
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Yve V. S. Magedans & Michael A. Phillips. 2022. Plant Secondary Metabolism Engineering. Plant Secondary Metabolism Engineering 119 128 .
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang & Baik Lin Seong. (2021) Epigallocatechin-3-Gallate as a Novel Vaccine Adjuvant. Frontiers in Immunology 12.
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Axel Schmidt, Heribert Helgers, Florian Lukas Vetter, Alex Juckers & Jochen Strube. (2021) Digital Twin of mRNA-Based SARS-COVID-19 Vaccine Manufacturing towards Autonomous Operation for Improvements in Speed, Scale, Robustness, Flexibility and Real-Time Release Testing. Processes 9:5, pages 748.
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Pallavi Sharma, Arti Tyagi, Pravin Bhansali, Shubhra Pareek, Vineeta Singh, Ashal Ilyas, Rajeev Mishra & Nitesh Kumar Poddar. (2021) Saponins: Extraction, bio-medicinal properties and way forward to anti-viral representatives. Food and Chemical Toxicology 150, pages 112075.
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