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Human Vaccines & Immunotherapeutics Volume 18, 2022 - Issue 1

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Immunotherapy – Research Paper

IL-6/IFN-γ double knockdown CAR-T cells reduce the release of multiple cytokines from PBMCs in vitro

Huihui Zhanga R&D Department, Qilu Cell Therapy Technology Co., Ltd, Jinan, Shandong, ChinaView further author information

Xiaofei Lvb Institute of Immunotherapy, Yinfeng Life Science Research Institute, Jinan, Shandong, ChinaView further author information

Qunfang Konga R&D Department, Qilu Cell Therapy Technology Co., Ltd, Jinan, Shandong, ChinaView further author information

Yi Tana R&D Department, Qilu Cell Therapy Technology Co., Ltd, Jinan, Shandong, China;b Institute of Immunotherapy, Yinfeng Life Science Research Institute, Jinan, Shandong, ChinaCorrespondence[email protected]

https://orcid.org/0000-0001-7310-9355 View further author information

Pages 1-14 | Received 13 May 2021, Accepted 05 Dec 2021, Published online: 20 Jan 2022

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https://doi.org/10.1080/21645515.2021.2016005
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Na An, Yuming Pan, Linlin Yang, Qiongli Zhang, Sisi Deng, Qiaoxia Zhang & Xin Du. (2023) Anti-Acute Myeloid Leukemia Activity of CD38-CAR-T Cells with PI3Kδ Downregulation. Molecular Pharmaceutics.
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Yaping Chen, Melanie Mach, Ali-Reza Shokouhi, Hao Zhe Yoh, David C. Bishop, Takahide Murayama, Koukou Suu, Yasuhiro Morikawa, Simon C. Barry, Kenneth Micklethwaite, Roey Elnathan & Nicolas H. Voelcker. (2023) Efficient non-viral CAR-T cell generation via silicon-nanotube-mediated transfection. Materials Today 63, pages 8-17.
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Xinping Cao, Xin Jin, Xiaomei Zhang, Paudel Utsav, Yi Zhang, Ruiting Guo, Wenyi Lu & Mingfeng Zhao. (2023) Small-Molecule Compounds Boost CAR-T Cell Therapy in Hematological Malignancies. Current Treatment Options in Oncology 24:3, pages 184-211.
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Simona Laurino, Mariarita Brancaccio, Tiziana Angrisano, Giovanni Calice, Sabino Russi, Pellegrino Mazzone, Giuseppina Di Paola, Michele Aieta, Vitina Grieco, Gabriella Bianchino, Geppino Falco & Tiziana Notarangelo. (2023) Role of IL-6/STAT3 Axis in Resistance to Cisplatin in Gastric Cancers. Biomedicines 11:3, pages 694.
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Philipp Schaible, Wolfgang Bethge, Claudia Lengerke & Reka Agnes Haraszti. (2023) RNA Therapeutics for Improving CAR T-cell Safety and Efficacy. Cancer Research 83:3, pages 354-362.
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Caio Raony Farina Silveira, Amanda Cristina Corveloni, Sâmia Rigotto Caruso, Nathália Araújo Macêdo, Natália Moscheta Brussolo, Felipe Haddad, Taisa Risque Fernandes, Pamela Viani de Andrade, Maristela Delgado Orellana & Renato Luiz Guerino-Cunha. (2022) Cytokines as an important player in the context of CAR-T cell therapy for cancer: Their role in tumor immunomodulation, manufacture, and clinical implications. Frontiers in Immunology 13.
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