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Human Vaccines & Immunotherapeutics Volume 18, 2022 - Issue 6
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Immunotherapeutics – Research Article

Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development

Dustin Hicksa Department of Pharmacology, University of Minnesota, Minneapolis, MN, USAORCID Iconhttps://orcid.org/0000-0002-6934-4050View further author information
ORCID Icon,
Carly Baehra Department of Pharmacology, University of Minnesota, Minneapolis, MN, USAORCID Iconhttps://orcid.org/0000-0002-3395-6776View further author information
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Pedro Silva-Ortiza Department of Pharmacology, University of Minnesota, Minneapolis, MN, USAORCID Iconhttps://orcid.org/0000-0001-6135-9111View further author information
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Aaron Khaimraja Department of Pharmacology, University of Minnesota, Minneapolis, MN, USAORCID Iconhttps://orcid.org/0000-0002-2588-0900View further author information
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Diego Luengasa Department of Pharmacology, University of Minnesota, Minneapolis, MN, USAORCID Iconhttps://orcid.org/0000-0002-4550-841XView further author information
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Fatima A. Hamida Department of Pharmacology, University of Minnesota, Minneapolis, MN, USAORCID Iconhttps://orcid.org/0000-0003-3496-2104View further author information
ORCID Icon &
Marco Pravetonia Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA;b Center for Immunology, University of Minnesota, Minneapolis, MN, USA;c School of Medicine, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1036-0184View further author information
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Article: 2122507 | Received 27 Jun 2022, Accepted 04 Sep 2022, Published online: 04 Oct 2022

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Read on this site (1)

Suky Martinez, Hannah Harris, Thomas Chao, Rachel Luba, Marco Pravetoni, Sandra D Comer & Jermaine D Jones. (2023) The potential role of opioid vaccines and monoclonal antibodies in the opioid overdose crisis. Expert Opinion on Investigational Drugs 32:3, pages 181-185.
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Articles from other publishers (4)

Mingliang Lin, Lisa M. Eubanks, Nishant M. Karadkhelkar, Steven Blake & Kim D. Janda. (2023) Catalytic Antibody Blunts Carfentanil-Induced Respiratory Depression. ACS Pharmacology & Translational Science 6:5, pages 802-811.
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Karam Chamoun, Lucie Chevillard, Aline Hajj, Jacques Callebert & Bruno Mégarbane. (2023) Mechanisms of Neurorespiratory Toxicity Induced by Fentanyl Analogs—Lessons from Animal Studies. Pharmaceuticals 16:3, pages 382.
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Gianna Triller, Evi P. Vlachou, Hamidreza Hashemi, Monique van Straaten, Johan P. Zeelen, Yosip Kelemen, Carly Baehr, Cheryl L. Marker, Sandra Ruf, Anna Svirina, Monica Chandra, Katharina Urban, Anastasia Gkeka, Sebastian Kruse, Andreas Baumann, Aubry K. Miller, Marc Bartel, Marco Pravetoni, C. Erec Stebbins, F. Nina Papavasiliou & Joseph P. Verdi. (2023) A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl. Cell Reports 42:2, pages 112049.
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Justas V. Rodarte, Carly Baehr, Dustin Hicks, Tyler L. Liban, Connor Weidle, Peter B. Rupert, Rajwana Jahan, Abigail Wall, Andrew T. McGuire, Roland K. Strong, Scott Runyon, Marco Pravetoni & Marie Pancera. (2023) Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding. Structure 31:1, pages 20-32.e5.
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