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Research Paper

Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis

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Pages 2676-2687 | Received 19 Apr 2021, Accepted 31 May 2021, Published online: 11 Jun 2021

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GuoQing Chen, Lu Chen, Yan Huang, XiongShan Zhu & YuanLan Yu. (2022) Increased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells. Bioengineered 13:2, pages 3620-3633.
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Dehui Chen, Linquan Zhou, Gang Chen, Taotao Lin, Jiemin Lin, Xin Zhao, Wenwen Li, Shengyu Guo, Rongcan Wu, Zhenyu Wang & Wenge Liu. (2024) FUNDC1-induced mitophagy protects spinal cord neurons against ischemic injury. Cell Death Discovery 10:1.
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Xizhe Bai, Zhe Zhang, Xi Li, Yangjun Yang & Shuzhe Ding. (2023) FUNDC1: An Emerging Mitochondrial and MAMs Protein for Mitochondrial Quality Control in Heart Diseases. International Journal of Molecular Sciences 24:11, pages 9151.
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Yang Bai, Jinjing Wu, Zhenyu Yang, Xu’an Wang, Dongni Zhang & Jun Ma. (2022) Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications. Cell Biology and Toxicology 39:1, pages 33-51.
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Haiyang Yu, Qinhao Chen, Ziming Wang, Xiaojun Qian & Yueyin Pan. (2022) Pan-cancer and single-cell analysis reveals FAM83D expression as a cancer prognostic biomarker. Frontiers in Genetics 13.
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Heng-Jing Hu, Xiu-Heng Wang, Tian-Qing Zhang, Yao Liu, Zheng-Rong Chen, Zhi-Zhu Zhang, Hong Huang, Hui-Fang Tang & Zhi-Sheng Jiang. (2022) PLK1 promotes cholesterol efflux and alleviates atherosclerosis by up-regulating ABCA1 and ABCG1 expression via the AMPK/PPARγ/LXRα pathway. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1867:12, pages 159221.
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Amir Ajoolabady, Mario Chiong, Sergio Lavandero, Daniel J. Klionsky & Jun Ren. (2022) Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment. Trends in Molecular Medicine 28:10, pages 836-849.
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Xi Sun, Yanna Han, Chaorun Dong, Huan Qu, Yahan Yu, Jiaming Ju, Yunlong Bai & Baofeng Yang. (2022) Daming capsule protects against myocardial infarction by promoting mitophagy via the SIRT1/AMPK signaling pathway. Biomedicine & Pharmacotherapy 151, pages 113162.
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Mahshid Deldar Abad Paskeh, Ava Asadi, Sepideh Mirzaei, Mehrdad Hashemi, Maliheh Entezari, Rasoul Raesi, Kiavash Hushmandi, Ali Zarrabi, Yavuz Nuri Ertas, Amir Reza Aref, Saeed Samarghandian, Russel J. Reiter & Jun Ren. (2022) Targeting AMPK signaling in ischemic/reperfusion injury: From molecular mechanism to pharmacological interventions. Cellular Signalling 94, pages 110323.
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Yu Liu, Guojun Chu, Wenzhi Shen, Yuefan Zhang, Wei Xu & Yongsheng Yu. (2022) XMU-MP-1 protects heart from ischemia/reperfusion injury in mice through modulating Mst1/AMPK pathway. European Journal of Pharmacology 919, pages 174801.
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Guoyong Li, Junli Li, Ruochen Shao, Jiahao Zhao & Mao Chen. (2021) FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases. Frontiers in Cell and Developmental Biology 9.
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Dingyi Lv, Minghao Luo, Zhe Cheng, Ruiyu Wang, Xiyang Yang, Yongzheng Guo, Longxiang Huang, Xiang Li, Bi Huang, Jian Shen, Suxin Luo & Jianghong Yan. (2021) Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis. Oxidative Medicine and Cellular Longevity 2021, pages 1-22.
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Wylly Ramsés García-Niño, Cecilia Zazueta, Mabel Buelna-Chontal & Alejandro Silva-Palacios. (2021) Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury. Life 11:11, pages 1123.
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