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Research Paper

Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling

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Pages 2984-2999 | Received 29 Mar 2021, Accepted 10 Jun 2021, Published online: 24 Jun 2021

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Zheng Tian, Xinan Zhang & Mingli Sun. (2021) Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis. Frontiers in Pharmacology 12.
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