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Bioengineered Volume 12, 2021 - Issue 1
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Research Paper

The anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and oxidative stress in vivo and vitro

The protective mechanism of rhein in preventing obesity

Li Jia Department of Pediatrics, Guang’anmen Hospital, Chinese Academy of Traditional Chinese Medicine, BeiJing, ChinaView further author information
&
Huan Gub Department of Cardiology of Integrated Traditional Chinese and Western Medicine China-Japan Friendship Hospital, BeiJing, ChinaCorrespondence[email protected]
View further author information
Pages 5797-5813 | Received 16 Jul 2021, Accepted 12 Aug 2021, Published online: 13 Sep 2021

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Cong Liu, Qian Cao, Yueqin Chen, Xi Chen, Yujie Zhu, Zhonghua Zhang & Wei Wei. (2023) Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway. Journal of Receptors and Signal Transduction 43:2, pages 62-71.
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Articles from other publishers (12)

Shuyan Li, Bingqing Li, Tao Liu, Jialun Du, Lei Zhang, Ziwen Wu, Tian Tian & Lei Wang. (2024) Effect of the Combined Treatment of Taoren Chengqi Decoction with Laser Photocoagulation on Diabetic Retinopathy. Journal of Biobased Materials and Bioenergy 18:4, pages 650-655.
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Xin‐Yuan Zhao, Ji‐Qiu Wang, G. Gregory Neely, Yan‐Chuan Shi & Qiao‐Ping Wang. (2023) Natural compounds as obesity pharmacotherapies. Phytotherapy Research 38:2, pages 797-838.
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Yuanyuan Ren, Zi Li, Jiaoyu Li, Rui Liang, Zhen Wang, Yiduo Bai, Yafang Yang, Qian Tang, Yaolei Fu, Xiaobo Zhang, Yu Zhang, Yi Yu & Yuyan Xiong. (2023) m 6 A mRNA methylation: Biological features, mechanisms, and therapeutic potentials in type 2 diabetes mellitus . Obesity Reviews 24:12.
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Wanru Xia, Shuqian Li, LinZehao Li, Shibo Zhang, Xiaolei Wang, Wenyu Ding, Lina Ding, Xiandang Zhang & Zhibin Wang. (2023) Role of anthraquinones in combating insulin resistance. Frontiers in Pharmacology 14.
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Changsheng Yan, Yuan Ma, He Li, Jitao Cui, Xiaoyu Guo, Gang Wang & Liang Ji. (2023) Endoplasmic reticulum stress promotes caspase-1-dependent acinar cell pyroptosis through the PERK pathway to aggravate acute pancreatitis. International Immunopharmacology 120, pages 110293.
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Xiang Li, Chuan Xiao, Jia Yuan, Xianjun Chen, Qing Li & Feng Shen. (2023) Rhein-attenuates LPS-induced acute lung injury via targeting NFATc1/Trem2 axis. Inflammation Research 72:6, pages 1237-1255.
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Xi Huang, Lifang Zhu & Yin Gong. (2023) Rhein induces bone regeneration via alleviating inflammation in murine periodontitis model. Oral Diseases.
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Tingting Deng, Jinxin Du, Ying Yin, Baorui Cao, Zhiying Wang, Zhongwen Zhang, Meina Yang & Jinxiang Han. (2023) Rhein for treating diabetes mellitus: A pharmacological and mechanistic overview. Frontiers in Pharmacology 13.
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Amir Ajoolabady, Cynthia Lebeaupin, Ne N. Wu, Randal J. Kaufman & Jun Ren. (2022) ER stress and inflammation crosstalk in obesity. Medicinal Research Reviews 43:1, pages 5-30.
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Chuanshan Yao & Feng Wang. (2022) Inhibition of hypoxia‐induced HIF‐1α‐mediated autophagy enhances the in vitro antitumor activity of rhein in pancreatic cancer cells. Journal of Applied Toxicology 42:12, pages 1937-1947.
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Ting Qiu, Jia-Xue Shi, Chao Cheng, Hong Jiang, Hai-Nan Ruan, Jun Li & Chan-Min Liu. (2022) Avicularin Attenuates Lead-Induced Impairment of Hepatic Glucose Metabolism by Inhibiting the ER Stress-Mediated Inflammatory Pathway. Nutrients 14:22, pages 4806.
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Qiming Xiao, Xixi Yu, Xinwei Yu, Shundi Liu, Jianping Jiang, Yu Cheng, Hao Lin, Yuzhen Wang, Xiaoshan Zhang, Xiaoxia Ye & Zheng Xiang. (2022) An integrated network pharmacology and cell metabolomics approach to reveal the role of rhein, a novel PPARα agonist, against renal fibrosis by activating the PPARα–CPT1A axis. Phytomedicine 102, pages 154147.
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