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Bioengineered Volume 12, 2021 - Issue 1
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Research paper

miR-7/EGFR/MEGF9 axis regulates cartilage degradation in osteoarthritis via PI3K/AKT/mTOR signaling pathway

Lifeng Jianga Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
,
Xindie Zhoub Department of Orthopedics, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, ChinaView further author information
,
Kai Xua Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
,
Pengfei Hua Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
,
Jiapeng Baoa Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
,
Jin Lic Department of Orthopedics Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, ChinaView further author information
,
Junfeng Zhud Department of Orthopedics Surgery, Suichang Branch of the Second Affiliated Hospital, Zhejiang University School of Medicine (Suichang County People’s Hospital in Zhejiang Province), Suichang, LiShui, ChinaCorrespondence[email protected]
View further author information
&
Lidong Wua Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaCorrespondence[email protected]
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Pages 8622-8634 | Received 15 Jul 2021, Accepted 29 Sep 2021, Published online: 18 Oct 2021

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Qiuliang Liu, Kai Pian, Zhen Tian, Haitao Duan, Qi Wang, Hui Zhang, Longyan Shi & Dongjian Song. (2022) Calcium-binding protein 39 overexpression promotes macrophages from ‘M1’ into ‘M2’ phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis. Bioengineered 13:4, pages 9855-9871.
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Yuanmei Che, Jianglong He, Xiaopeng Li, Daxian Wu, Yi Zhang & Guicai Yuan. (2022) Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis. Bioengineered 13:3, pages 6839-6855.
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Yuan Li, Linru Zhao & Wufang Qi. (2022) Uric acid, as a double-edged sword, affects the activity of epidermal growth factor (EGF) on human umbilical vein endothelial cells by regulating aging process. Bioengineered 13:2, pages 3877-3895.
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Shouliang Xiong, Yong Zhao & Tiantong Xu. (2021) DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis. Bioengineered 12:2, pages 11138-11155.
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Qingqing Xia, Quan Wang, Feng Lin & Junjuan Wang. (2021) miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis. Bioengineered 12:2, pages 11225-11238.
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