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Bioengineered Volume 12, 2021 - Issue 2
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Research Paper

Empagliflozin protects diabetic pancreatic tissue from damage by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway in pancreatic β cells: in vitro and in vivo studies

Pan Liua School of Clinical Medicine, Chengdu Medical College, Chengdu, China;b Department of Endocrinology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, ChinaView further author information
,
Zhengdong Zhanga School of Clinical Medicine, Chengdu Medical College, Chengdu, China;c Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, ChinaORCID Iconhttps://orcid.org/0000-0002-5869-6472View further author information
ORCID Icon,
Jinwu Wangd School of Biosciences and Technology, Chengdu Medical College, Chengdu, ChinaView further author information
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Xiao Zhanga School of Clinical Medicine, Chengdu Medical College, Chengdu, China;b Department of Endocrinology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, ChinaView further author information
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Xiaoping Yue School of Public Health, Chengdu Medical College, Chengdu, ChinaView further author information
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Yao Lia School of Clinical Medicine, Chengdu Medical College, Chengdu, China;b Department of Endocrinology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, ChinaCorrespondence[email protected]
View further author information
Pages 9356-9366 | Received 20 Aug 2021, Accepted 28 Oct 2021, Published online: 25 Nov 2021

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Limei Lin & Yin Zhang. (2023) Chemical Constituents and Antidiabetic Activity of Dichloromethane Extract from Ficus carica Leaves. Diabetes, Metabolic Syndrome and Obesity 16, pages 979-991.
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Articles from other publishers (9)

Nadezda ApostolovaTeresa VezzaJordi MuntaneMilagros RochaVíctor M. Víctor. (2023) Mitochondrial Dysfunction and Mitophagy in Type 2 Diabetes: Pathophysiology and Therapeutic Targets. Antioxidants & Redox Signaling 39:4-6, pages 278-320.
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Pan Liu, Zhengdong Zhang, Yichen Cai, Yunjiao Yang, Jun Yuan & Qiu Chen. (2023) Inhibition of the pyroptosis-associated inflammasome pathway: The important potential mechanism of ginsenosides in ameliorating diabetes and its complications. European Journal of Medicinal Chemistry 253, pages 115336.
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Shuofei Yang, Yu Feng, Liang Chen, Zheyu Wang, Jiaquan Chen, Qihong Ni, Xiangjiang Guo, Lan Zhang & Guanhua Xue. (2023) Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway. Translational Research 254, pages 115-127.
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Ece Guler, Ayse Nur Hazar-Yavuz, Esra Tatar, Mohammad Morid Haidari, Gul Sinemcan Ozcan, Gokhan Duruksu, Manuel Pedro F Graça, Deepak M Kalaskar, Oguzhan Gunduz & Muhammet Emin Cam. (2023) Oral empagliflozin-loaded tri-layer core-sheath fibers fabricated using tri-axial electrospinning: Enhanced in vitro and in vivo antidiabetic performance. International Journal of Pharmaceutics 635, pages 122716.
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George Anderson. (2023) Type I Diabetes Pathoetiology and Pathophysiology: Roles of the Gut Microbiome, Pancreatic Cellular Interactions, and the ‘Bystander’ Activation of Memory CD8+ T Cells. International Journal of Molecular Sciences 24:4, pages 3300.
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Jun Zhou, Shan Yan, Xu Guo, Yanguo Gao, Shiqi Chen, Xiaohan Li, Yonghong Zhang, Qibin Wang, Tao Zheng & Li Chen. (2023) Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions. International Immunopharmacology 114, pages 109543.
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Jia-yao Yuan, Yu Fu, Zhi-hai Feng, Feng Sang, Ming-yi Shao & Lei-lei Li. (2022) Potential Mechanisms and Effects of Chinese Medicines in Treatment of Diabetic Atherosclerosis by Modulating NLRP3 Inflammasome: A Narrative Review. Chinese Journal of Integrative Medicine 28:8, pages 753-761.
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Sandra Feijóo-Bandín, Alana Aragón-Herrera, Manuel Otero-Santiago, Laura Anido-Varela, Sandra Moraña-Fernández, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, Oreste Gualillo, José Ramón González-Juanatey & Francisca Lago. (2022) Role of Sodium-Glucose Co-Transporter 2 Inhibitors in the Regulation of Inflammatory Processes in Animal Models. International Journal of Molecular Sciences 23:10, pages 5634.
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Yiqian Xing, Yuchi He, Yuan Zhang, Heting Wang, Sihan Peng, Chunguang Xie, Jian Kang, Ya Liu & Xiyu Zhang. (2022) Emodin Alleviates High-Glucose-Induced Pancreatic β-Cell Pyroptosis by Inhibiting NLRP3/GSDMD Signaling. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-10.
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