New insights into the metabolic and nutritional determinants of severe combined immunodeficiency

Martha S FieldDivision of Nutritional Sciences; Cornell University; Ithaca, NYUSA

Elena KamyninaDivision of Nutritional Sciences; Cornell University; Ithaca, NYUSA

David WatkinsDepartment of Human Genetics, McGill University; Department of Medical Genetics; McGill University Health Center; Montreal, Quebec, Canada

David S RosenblattDepartment of Human Genetics, McGill University; Department of Medical Genetics; McGill University Health Center; Montreal, Quebec, Canada

Patrick J StoverDivision of Nutritional Sciences; Cornell University; Ithaca, NYUSA;Graduate Field of Biochemistry; Molecular and Cell Biology; Cornell University; Ithaca, NYUSACorrespondence[email protected]

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Ayaka Sugiura, Gabriela Andrejeva, Kelsey Voss, Darren R. Heintzman, Xincheng Xu, Matthew Z. Madden, Xiang Ye, Katherine L. Beier, Nowrin U. Chowdhury, Melissa M. Wolf, Arissa C. Young, Dalton L. Greenwood, Allison E. Sewell, Shailesh K. Shahi, Samantha N. Freedman, Alanna M. Cameron, Patrik Foerch, Tim Bourne, Juan C. Garcia-Canaveras, John Karijolich, Dawn C. Newcomb, Ashutosh K. Mangalam, Joshua D. Rabinowitz & Jeffrey C. Rathmell. (2022) MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity 55:1, pages 65-81.e9.
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Manas R. Purohit, Lakkakula Saikrishna, Henu Verma, L.V.K.S. Bhaskar & Syed A. Hussain. (2021) Association Between MTHFD1 1958G > A Variant and non-Syndromic Cleft lip and Palate: An Updated Meta-Analysis . The Cleft Palate-Craniofacial Journal, pages 105566562110464.
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David Watkins & David S. Rosenblatt. (2020) Immunodeficiency and inborn disorders of vitamin B12 and folate metabolism. Current Opinion in Clinical Nutrition & Metabolic Care 23:4, pages 241-246.
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Hua Yu, Han Wang, Hai-Rong Xu, Yu-Chan Zhang, Xue-Bo Yu, Meng-Chao Wu, Guang-Zhi Jin & Wen-Ming Cong. (2019) Overexpression of MTHFD1 in hepatocellular carcinoma predicts poorer survival and recurrence. Future Oncology 15:15, pages 1771-1780.
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Martha S. FieldElena KamyninaJames Chon & Patrick J. Stover. (2018) Nuclear Folate Metabolism. Annual Review of Nutrition 38:1, pages 219-243.
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Elena KamyninaErica R. LachenauerAislyn C. DiRisioRebecca P. LiebenthalMartha S. FieldPatrick J. Stover. (2017) Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis. Proceedings of the National Academy of Sciences 114:12.
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David Watkins & David S. Rosenblatt. (2016) Lessons in biology from patients with inherited disorders of vitamin B12 and folate metabolism. Biochimie 126, pages 3-5.
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New insights into the metabolic and nutritional determinants of severe combined immunodeficiency

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New insights into the metabolic and nutritional determinants of severe combined immunodeficiency

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