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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 17, 2016 - Issue 7-8
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Research Article

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis

Benjamin GaastraMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
Aleksey ShatunovMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
Sara PulitUniversity Medical Centre Utrecht, Utrecht, The Netherlands,
,
Ashley R. JonesMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
William SprovieroMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
Alexandra GillettDepartment of Statistical Genetics, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
Zhongbo ChenMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
Janine KirbySheffield Institute for Translational Neuroscience, Sheffield, UK,
,
Isabella FoghMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
John F. PowellMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
P. Nigel LeighBrighton and Sussex Medical School, Brighton, UK, and
,
Karen E. MorrisonFaculty of Medicine, University of Southampton, Southampton, UK
,
Pamela J. ShawSheffield Institute for Translational Neuroscience, Sheffield, UK,
,
Christopher E. ShawMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
,
Leonard H. van den BergUniversity Medical Centre Utrecht, Utrecht, The Netherlands,
,
Jan H. VeldinkUniversity Medical Centre Utrecht, Utrecht, The Netherlands,
,
Cathryn M. LewisDepartment of Statistical Genetics, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK,
&
Ammar Al-ChalabiMaurice Wohl Clinical Neuroscience Institute, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK, Correspondence[email protected]
 show all
Pages 593-599 | Received 29 Apr 2016, Accepted 13 Jun 2016, Published online: 01 Sep 2016

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Shyuan T. Ngo, Restuadi Restuadi, Allan F. McCrae, Ruben P. Van Eijk, Fleur Garton, Robert D. Henderson, Naomi R. Wray, Pamela A. McCombe & Frederik J. Steyn. (2020) Progression and survival of patients with motor neuron disease relative to their fecal microbiota. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:7-8, pages 549-562.
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Pamela A. McCombe, Fleur C Garton, Matthew Katz, Naomi R Wray & Robert D Henderson. (2020) What do we know about the variability in survival of patients with amyotrophic lateral sclerosis?. Expert Review of Neurotherapeutics 20:9, pages 921-941.
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Articles from other publishers (15)

Lu Yang, Yanfei Cheng, Yicheng Zhu, Liying Cui & Xiaoguang Li. (2023) The Serotonergic System and Amyotrophic Lateral Sclerosis: A Review of Current Evidence. Cellular and Molecular Neurobiology 43:6, pages 2387-2414.
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Puja R. Mehta, Anna-Leigh Brown, Michael E. Ward & Pietro Fratta. (2023) The era of cryptic exons: implications for ALS-FTD. Molecular Neurodegeneration 18:1.
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Farid Rajabli, Briseida E. Feliciano-Astacio, Holly N. Cukier, Liyong Wang, Anthony J. Griswold, Kara L. Hamilton-Nelson, Larry D. Adams, Vanessa C. Rodriguez, Pedro R. Mena, Sergio Tejada, Katrina Celis, Patrice L. Whitehead, Derek J. Van Booven, Natalia K. Hofmann, Parker L. Bussies, Michael Prough, Angel Chinea, Nereida I. Feliciano, Badri N. Vardarajan, Christiane Reitz, Joseph H. Lee, Martin J. Prince, Ivonne Z. Jimenez, Richard P. Mayeux, Heriberto Acosta, Clifton L. Dalgard, Jonathan L. Haines, Jeffery M. Vance, Michael L. Cuccaro, Gary W. Beecham & Margaret A. Pericak-Vance. (2021) Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus. Neurobiology of Aging 104, pages 115.e1-115.e7.
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Jessica R. Morrice, Christopher A. Shaw & Cheryl Y. Gregory‐Evans. 2021. Spectrums of Amyotrophic Lateral Sclerosis. Spectrums of Amyotrophic Lateral Sclerosis 35 56 .
Aleksey Shatunov & Ammar Al-Chalabi. (2021) The genetic architecture of ALS. Neurobiology of Disease 147, pages 105156.
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Giovanna Morello, Salvatore Salomone, Velia D’Agata, Francesca Luisa Conforti & Sebastiano Cavallaro. (2020) From Multi-Omics Approaches to Precision Medicine in Amyotrophic Lateral Sclerosis. Frontiers in Neuroscience 14.
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Sara L. Dominguez, Timothy Earr, Michelle Dourado, Hai Ngu, William J. Meilandt & Jesse E. Hanson. (2020) Inducible EphA4 knockout causes motor deficits in young mice and is not protective in the SOD1G93A mouse model of ALS. Scientific Reports 10:1.
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Raul Juntas-Morales, Nicolas Pageot, Abdelkarim Bendarraz, Sébastien Alphandéry, Frédéric Sedel, Stéphanie Seigle & William Camu. (2020) High-dose pharmaceutical grade biotin (MD1003) in amyotrophic lateral sclerosis: A pilot study. EClinicalMedicine 19, pages 100254.
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Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J. P. Alix, Iain D. Wilkinson, Tom M. Jenkins & Pamela J. Shaw. (2019) Biomarkers in Motor Neuron Disease: A State of the Art Review. Frontiers in Neurology 10.
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Stéphanie Philtjens, Sara Van Mossevelde, Julie van der Zee, Eline Wauters, Lubina Dillen, Mathieu Vandenbulcke, Rik Vandenberghe, Adrian Ivanoiu, Anne Sieben, Christiana Willems, Luisa Benussi, Roberta Ghidoni, Giuliano Binetti, Barbara Borroni, Alessandro Padovani, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Alexandre de Mendonça, Gabriel Miltenberger-Miltényi, Isabel Hernández, Merce Boada, Agustín Ruiz, Benedetta Nacmias, Sandro Sorbi, Maria Rosário Almeida, Isabel Santana, Jordi Clarimón, Alberto Lleó, Giovanni B. Frisoni, Raquel Sanchez-Valle, Albert Lladó, Estrella Gómez-Tortosa, Ellen Gelpi, Marleen Van den Broeck, Karin Peeters, Patrick Cras, Peter P. De Deyn, Sebastiaan Engelborghs, Marc Cruts & Christine Van Broeckhoven. (2018) Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia. Neurobiology of Aging 66, pages 181.e3-181.e10.
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Ruben P.A. van EijkAshley R. JonesWilliam SprovieroAleksey ShatunovPamela J. ShawP. Nigel LeighCarolyn A. YoungChristopher E. ShawGabriele MoraJessica MandrioliGiuseppe BorgheroPaolo VolantiFrank P. DiekstraWouter van RheenenEsther VerstraeteMarinus J.C. EijkemansJan H. VeldinkAdriano ChioAmmar Al-ChalabiLeonard H. van den BergMichael A. van EsC Allen, C Counsell, A Farrin, A Al-Chalabi, B Dickie, J Kelly, P N Leigh, C L Murphy, C Payan, G Reynolds, P Shaw, I N Steen, M Thornhill, J Waters, J Zajicek, P N Leigh, A Al-Chalabi, P J Shaw, C A Young, M Thornhill, I N Steen, C L Murphy, K E Morrison, S Dhariwal, R Hornabrook, L Savage, D J Burn, T K Khoo, J Kelly, C L Murphy, A Al-Chalabi, A Dougherty, P N Leigh, L Wijesekera, M Thornhill, C M Ellis, R Ali, K O'Hanlon, J Panicker, L Pate, P Ray, L Wyatt, C A Young, L Copeland, J Ealing, H Hamdalla, I Leroi, C Murphy, F O'Keeffe, E Oughton, L Partington, P Paterson, D Rog, A Sathish, D Sexton, J Smith, H Vanek, S Dodds, T L Williams, I N Steen, J Clarke, C Eziefula, R Howard, R Orrell, K Sidle, R Sylvester, W Barrett, C Merritt, K Talbot, M R Turner, C Whatley, C Williams, J Williams, C Cosby, C O Hanemann, I Imam, C Phillips, L Timings, S E Crawford, C Hewamadduma, R Hibberd, H Hollinger, C McDermott, G Mills, M Rafiq, P J Shaw, A Taylor, E Waines, T Walsh, R Addison-Jones, J Birt, M Hare, T Majid, R. Tortelli, E. D'Errico, I. Bartolomei, E. Barbarossa, B. Depau, E. Costantino, E. D'Amico, A. Uncini, C. Manzoli, R. Quatrale, E. Sette, E. Montanari, M. Merello, D. Zarcone, M. Mascolo, M. Vignolo, S. Messina, C. Morelli, K. Marinou, L. Papetti, C. Lunetta, K. Gorni, D. De Cicco, C. Pipia, P. Sola, E. Georgoulopoulou, A. Sagnelli, G. Tedeschi, G. Oggioni, N. Nasuelli, C. D'Ascenzo, V. Cima, M. Aiello, R. Rizzi, E. Rinaldi, M. Luigetti, A. Conte, A. Torzini, G. Greco, R. Mutani, G. Fuda & M.A. Tommasi. (2017) Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials. Neurology 89:18, pages 1915-1922.
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Orla Hardiman, Ammar Al-Chalabi, Adriano Chio, Emma M. Corr, Giancarlo Logroscino, Wim Robberecht, Pamela J. Shaw, Zachary Simmons & Leonard H. van den Berg. (2017) Amyotrophic lateral sclerosis. Nature Reviews Disease Primers 3:1.
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Sarah Martin, Ahmad Al Khleifat & Ammar Al-Chalabi. (2017) What causes amyotrophic lateral sclerosis?. F1000Research 6, pages 371.
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