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Clinical Trials

Safety and tolerability of Triumeq in amyotrophic lateral sclerosis: the Lighthouse trial

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Pages 595-604 | Received 09 Apr 2019, Accepted 08 Jun 2019, Published online: 08 Jul 2019

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Crossref
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Crossref
Mamede de Carvalho. (2020) Needling the future in ALS. Clinical Neurophysiology 131:8, pages 1973-1974.
Crossref
Adriano Chiò, Letizia Mazzini & Gabriele Mora. (2020) Disease-modifying therapies in amyotrophic lateral sclerosis. Neuropharmacology 167, pages 107986.
Crossref
G.Y. Wang, S.L. Rayner, R. Chung, B.Y. Shi & X.J. Liang. (2020) Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis. Materials Today Bio 6, pages 100055.
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Antonina Dolei, Gabriele Ibba, Claudia Piu & Caterina Serra. (2019) Expression of HERV Genes as Possible Biomarker and Target in Neurodegenerative Diseases. International Journal of Molecular Sciences 20:15, pages 3706.
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