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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 21, 2020 - Issue 1-2
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Clinical

HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation

Alessandro Arosio1 School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza, Italy, View further author information
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Riccardo Cristofani2 Dip. di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy, ORCID Iconhttps://orcid.org/0000-0003-2719-846XView further author information
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Orietta Pansarasa3 Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy, View further author information
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Valeria Crippa2 Dip. di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy, ;3 Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy, ORCID Iconhttps://orcid.org/0000-0002-3058-5711View further author information
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Chiara Riva1 School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza, Italy, View further author information
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Riccardo Sirtori1 School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza, Italy, View further author information
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Virginia Rodriguez-Menendez1 School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza, Italy, View further author information
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Nilo Riva4 Neuropathology Unit and Dept. of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milano, Italy, View further author information
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Francesca Gerardi5 NEuroMuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milano, Italy, and View further author information
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Christian Lunetta5 NEuroMuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milano, Italy, and View further author information
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Cristina Cereda3 Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy, View further author information
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Angelo Poletti2 Dip. di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy, ORCID Iconhttps://orcid.org/0000-0002-8883-0468View further author information
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Carlo Ferrarese1 School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza, Italy, ;6 Department of Neurology, San Gerardo Hospital, Monza, ItalyORCID Iconhttps://orcid.org/0000-0002-7499-6600View further author information
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Lucio Tremolizzo1 School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza, Italy, ;6 Department of Neurology, San Gerardo Hospital, Monza, ItalyView further author information
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Gessica Sala1 School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza, Italy, Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3573-7523View further author information
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Pages 51-62 | Received 02 Jul 2019, Accepted 16 Sep 2019, Published online: 30 Oct 2019

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Emma Renman, Rifat Ekici, Mia Sundström & Kristina Lejon. (2022) HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse. Autoimmunity 55:8, pages 520-528.
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Articles from other publishers (20)

Afshin Babazadeh, Stephanie L. Rayner, Albert Lee & Roger S. Chung. (2023) TDP-43 as a therapeutic target in neurodegenerative diseases: Focusing on motor neuron disease and frontotemporal dementia. Ageing Research Reviews 92, pages 102085.
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Yi Liu, Lan Tan & Meng-Shan Tan. (2023) Chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapy. Molecular and Cellular Biochemistry 478:10, pages 2173-2190.
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Akiko Idera, Lisa M. Sharkey, Yuki Kurauchi, Keiichi Kadoyama, Henry L. Paulson, Hiroshi Katsuki & Takahiro Seki. (2023) Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways. Journal of Pharmacological Sciences 152:3, pages 182-192.
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Dalinda Isabel Sánchez-Vidaña, Jingjing Li, Samuel Abokyi, Jackie Ngai-Man Chan, Shirley Pui-Ching Ngai & Benson Wui-Man Lau. (2023) In vitro methods in autophagy research: Applications in neurodegenerative diseases and mood disorders. Frontiers in Molecular Neuroscience 16.
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Jaime Carrasco, Rosa Antón, Alejandro Valbuena, David Pantoja-Uceda, Mayur Mukhi, Rubén Hervás, Douglas V. Laurents, María Gasset & Javier Oroz. (2023) Metamorphism in TDP-43 prion-like domain determines chaperone recognition. Nature Communications 14:1.
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Ankur Rakesh Dubey, Som Mohanlal Patwa, Sumit Kinger, Yuvraj Anandrao Jagtap, Prashant Kumar, Sarika Singh, Rohan Dhiman, Hem Chandra Jha & Amit Mishra. (2022) Improper Proteostasis: Can It Serve as Biomarkers for Neurodegenerative Diseases?. Molecular Neurobiology 59:6, pages 3382-3401.
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Benjamin S. Rutledge, Wing-Yiu Choy & Martin L. Duennwald. (2022) Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease. Journal of Biological Chemistry 298:5, pages 101905.
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Haruo Kanno, Kyoichi Handa, Taishi Murakami, Toshimi Aizawa & Hiroshi Ozawa. (2022) Chaperone-Mediated Autophagy in Neurodegenerative Diseases and Acute Neurological Insults in the Central Nervous System. Cells 11:7, pages 1205.
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Sean S. Keating, Rebecca San Gil, Molly E.V. Swanson, Emma L. Scotter & Adam K. Walker. (2022) TDP-43 pathology: From noxious assembly to therapeutic removal. Progress in Neurobiology 211, pages 102229.
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Angeleen Fleming, Mathieu Bourdenx, Motoki Fujimaki, Cansu Karabiyik, Gregory J. Krause, Ana Lopez, Adrián Martín-Segura, Claudia Puri, Aurora Scrivo, John Skidmore, Sung Min Son, Eleanna Stamatakou, Lidia Wrobel, Ye Zhu, Ana Maria Cuervo & David C. Rubinsztein. (2022) The different autophagy degradation pathways and neurodegeneration. Neuron 110:6, pages 935-966.
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Vidhya Bharathi, Akarsh Bajpai, Irene T. Parappuram & Basant K. Patel. (2022) Elevated constitutive expression of Hsp40 chaperone Sis1 reduces TDP-43 aggregation-induced oxidative stress in Ire1 pathway dependent-manner in yeast TDP-43 proteinopathy model of amyotrophic lateral sclerosis. Biochemical and Biophysical Research Communications 595, pages 28-34.
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Amelina Albornoz, Alvaro Sequeida, Christian Rodríguez & Mauricio Budini. 2022. Autophagy in Health and Disease. Autophagy in Health and Disease 399 412 .
Raquel Gómez-Sintes & Esperanza Arias. (2021) Chaperone-mediated autophagy and disease: Implications for cancer and neurodegeneration. Molecular Aspects of Medicine 82, pages 101025.
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Noeli Soares Melo Silva, Luiz Fernando de Camargo Rodrigues, Paulo Roberto Dores-Silva, Carlos Alberto Montanari, Carlos Henrique Inácio Ramos, Leandro Ramos Souza Barbosa & Júlio César Borges. (2021) Structural, thermodynamic and functional studies of human 71 kDa heat shock cognate protein (HSPA8/hHsc70). Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1869:12, pages 140719.
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Zhaozhong Liao, Bin Wang, Wenjing Liu, Qian Xu, Lin Hou, Jinlian Song, Qingming Guo & Ning Li. (2021) Dysfunction of chaperone-mediated autophagy in human diseases. Molecular and Cellular Biochemistry 476:3, pages 1439-1454.
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Elisa Conti, Gessica Sala, Susanna Diamanti, Marco Casati, Christian Lunetta, Francesca Gerardi, Claudia Tarlarini, Lorena Mosca, Nilo Riva, Yuri Falzone, Massimo Filippi, Ildebrando Appollonio, Carlo Ferrarese & Lucio Tremolizzo. (2021) Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis. Scientific Reports 11:1.
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Eva Maria Johanna de Boer, Viyanti K Orie, Timothy Williams, Mark R Baker, Hugo M De Oliveira, Tuomo Polvikoski, Matthew Silsby, Parvathi Menon, Mehdi van den Bos, Glenda M Halliday, Leonard H van den Berg, Ludo Van Den Bosch, Philip van Damme, Matthew C Kiernan, Michael A van Es & Steve Vucic. (2021) TDP-43 proteinopathies: a new wave of neurodegenerative diseases. Journal of Neurology, Neurosurgery & Psychiatry 92:1, pages 86-95.
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Riccardo Cristofani, Valeria Crippa, Maria Elena Cicardi, Barbara Tedesco, Veronica Ferrari, Marta Chierichetti, Elena Casarotto, Margherita Piccolella, Elio Messi, Mariarita Galbiati, Paola Rusmini & Angelo Poletti. (2020) A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases. Frontiers in Aging Neuroscience 12.
Crossref
Yuan Chao Xue, Chen Seng Ng, Pinhao Xiang, Huitao Liu, Kevin Zhang, Yasir Mohamud & Honglin Luo. (2020) Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis. Frontiers in Molecular Neuroscience 13.
Crossref
Emiliano Vicencio, Sebastián Beltrán, Luis Labrador, Patricio Manque, Melissa Nassif & Ute Woehlbier. (2020) Implications of Selective Autophagy Dysfunction for ALS Pathology. Cells 9:2, pages 381.
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