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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 46, 2018 - Issue 7
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Original Articles

Development of a novel nano-sized anti-VEGFA nanobody with enhanced physicochemical and pharmacokinetic properties

Farnaz KhodabakhshDepartment of Nanobiotechnology, Advanced Technology Group, Pasteur Institute of Iran, Tehran, Iran; ;Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;
,
Dariush NorouzianDepartment of Nanobiotechnology, Advanced Technology Group, Pasteur Institute of Iran, Tehran, Iran;
,
Behrouz VaziriBiotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran; Correspondence[email protected]
,
Reza Ahangari CohanDepartment of Nanobiotechnology, Advanced Technology Group, Pasteur Institute of Iran, Tehran, Iran; Correspondence[email protected]
,
Soroush SardariDrug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;
,
Fereidoun MahboudiBiotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;
,
Mahdi BehdaniVenom & Biotherapeutics Molecules Laboratory, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;
,
Kamran MansouriMedical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;
&
Ardavan MehdizadehDepartment of Civil Engineering, Sharif University of Technology, Tehran, Iran
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Pages 1402-1414 | Received 01 Jul 2017, Accepted 16 Aug 2017, Published online: 25 Aug 2017

Citations (16)

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Read on this site (2)

Farnaz Khodabakhsh, Morteza Salimian, Mohammad Hossein Hedayati, Reza Ahangari Cohan & Dariush Norouzian. (2021) Challenges and advancements in the pharmacokinetic enhancement of therapeutic proteins. Preparative Biochemistry & Biotechnology 51:6, pages 519-529.
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Farnaz Khodabakhsh, Mahdi Behdani, Abbas Rami & Fatemeh Kazemi-Lomedasht. (2018) Single-Domain Antibodies or Nanobodies: A Class of Next-Generation Antibodies. International Reviews of Immunology 37:6, pages 316-322.
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Articles from other publishers (14)

Farnaz Khodabakhsh, Davoud Nouri Inanlou, Vahid Asgary, Razieh Bigdeli, Samane Sadat Mirmoosa, Ramin Farhoudi & Reza Ahangari Cohan. (2023) Cerium Nanoparticles Can Enhance Humoral and Cellular Immune Responses of Multi-epitope Vaccine Candidates. BioNanoScience.
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Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt & Mathieu Vinken. (2023) Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury. Journal of Nanobiotechnology 21:1.
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Yue Ji, Dingkang Liu, Haichao Zhu, Lichen Bao, Ruilong Chang, Xiangdong Gao & Jun Yin. (2023) Unstructured polypeptides as a versatile drug delivery technology. Acta Biomaterialia 164, pages 74-93.
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Zahra Naderiyan, Nazli Sotoudeh, Alireza Shoari, Hajarossadat Ghaderi, Mahdi Habibi-Anbouhi, Reza Moazzami, Reza Ahangari Cohan & Mahdi Behdani. (2022) In Vitro and In Vivo Studies of a Heminecrolysin Toxin–VEGF Fusion Protein as a Novel Therapeutic for Solid Tumor Targeting. Molecular Biotechnology 65:5, pages 766-773.
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Antonio G. Goncalves, Emily J. Hartzell, Millicent O. Sullivan & Wilfred Chen. (2022) Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine. Advanced Drug Delivery Reviews 191, pages 114570.
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Alireza Shoari, Mehdi Tahmasebi, Farnaz Khodabakhsh, Reza Ahangari Cohan, Akbar Oghalaie & Mahdi Behdani. (2022) Angiogenic biomolecules specific nanobodies application in cancer imaging and therapy; review and updates. International Immunopharmacology 105, pages 108585.
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Farnaz Khodabakhsh, Parnaz Merikhian, Mohammad Reza Eisavand & Leila Farahmand. (2021) Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling. Cancer Cell International 21:1.
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Aurélie Rondon, Sohaib Mahri, Francisco Morales‐Yanez, Mireille Dumoulin & Rita Vanbever. (2021) Protein Engineering Strategies for Improved Pharmacokinetics. Advanced Functional Materials 31:44, pages 2101633.
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Nuthan V. BathulaHemashree BommadevaraJerrard M. Hayes. (2021) Nanobodies: The Future of Antibody-Based Immune Therapeutics. Cancer Biotherapy and Radiopharmaceuticals 36:2, pages 109-122.
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Raf Van Campenhout, Serge Muyldermans, Mathieu Vinken, Nick Devoogdt & Timo W.M. De Groof. (2021) Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor. Biomolecules 11:1, pages 63.
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Somayeh Mazaheri, Yeganeh Talebkhan, Fereidoun Mahboudi, Leila Nematollahi, Reza Ahangari Cohan, Esmat Mirabzadeh Ardakani, Elham Bayat, Masoumeh Sabzalinejad, Soroush Sardari & Fatemeh Torkashvand. (2020) Improvement of Certolizumab Fab′ properties by PASylation technology. Scientific Reports 10:1.
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Farnaz Khodabakhsh, Morteza Salimian, Ardavan Mehdizadeh, Mohammad Sadeq Khosravy, Alireza Vafabakhsh, Elmira Karami & Reza Ahangari Cohan. (2020) New Proline, Alanine, Serine Repeat Sequence for Pharmacokinetic Enhancement of Anti-VEGF Single-Domain Antibody. Journal of Pharmacology and Experimental Therapeutics 375:1, pages 69-75.
Crossref
Emily Y. Yang & Khalid Shah. (2020) Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics. Frontiers in Oncology 10.
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Safieh Aghaabdollahian, Reza Ahangari Cohan, Dariush Norouzian, Fatemeh Davami, Mohammad Reza Asadi Karam, Fatemeh Torkashvand, Golnaz Vaseghi, Reza Moazzami & Sakineh Latif Dizaji. (2019) Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology. Scientific Reports 9:1.
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