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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 49, 2021 - Issue 1
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Research Article

Inhibiting the PI3K/AKT/mTOR signalling pathway with copper oxide nanoparticles from Houttuynia cordata plant: attenuating the proliferation of cervical cancer cells

Hongmin Chena Department of Gynaecology, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou City, ChinaCorrespondence[email protected]
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Xiaojie Fenga Department of Gynaecology, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou City, China
,
Ling Gaoa Department of Gynaecology, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou City, China
,
Suresh Mickymarayb Department of Biology, College of Science, Al-Zulfi, Majmaah University, Majmaah, Saudi Arabia
,
Anand Paramasivamc Department of Basic Medical Sciences, College of Dentistry, Al-Zulfi, Majmaah University, Majmaah, Saudi Arabia
,
Faiz Abdulaziz Alfaizb Department of Biology, College of Science, Al-Zulfi, Majmaah University, Majmaah, Saudi Arabia
,
Hussain A. Almasmoumd Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
,
Mazen M. Ghaithd Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
,
Riyad A. Almaimanie Department of Biochemistry, College of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0001-7944-2597
ORCID Icon &
Ibrahim Abdel Aziz Ibrahimf Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
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Pages 240-249 | Received 31 Jul 2020, Accepted 04 Feb 2021, Published online: 10 Mar 2021

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Guobin Zhang, Hong Wan, Rony Mia, Qinglin Huang, Huihong Liu & Sakil Mahmud. (2022) Fabrication and stabilization of nanosilver using Houttugniae for antibacterial and catalytic application. International Journal of Environmental Analytical Chemistry 0:0, pages 1-21.
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Shahnaz Majeed, Nur Iwana Naqibah Binti Shamsunazatul, Mohammed Danish, Mohamad Nasir Mohamad Ibrahim, Ravindran Muthukumarasamy & Mohammed Tahir Ansari. (2023) Mitochondrial Membrane Depolarization, Oxidative Stress Induced Cell Death in Human Pancreatic Adenocarcinoma Cells (PANC-1) Treated with Biologically Engineered Gallic Acid Coated Copper Oxide Nanoparticles. Journal of Cluster Science 34:5, pages 2665-2680.
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Marwa M. Abu-Serie & Eisayeda Zeinab A. Abdelfattah. (2023) A comparative study of smart nanoformulations of diethyldithiocarbamate with Cu4O3 nanoparticles or zinc oxide nanoparticles for efficient eradication of metastatic breast cancer. Scientific Reports 13:1.
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Yinzhen Fan, Zhenli Cheng, Lejiao Mao, Ge Xu, Na Li, Mengling Zhang, Ping Weng, Lijun Zheng, Xiaomei Dong, Siyao Hu, Bin Wang, Xia Qin, Xuejun Jiang, Chengzhi Chen, Jun Zhang & Zhen Zou. (2022) PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles. Journal of Nanobiotechnology 20:1.
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Chunmei Hu, Wenjia Zhu, Ying Lu, Yanfang Ren, Jinyu Gu, Yaping Song & Junyu He. (2022) Alpinia officinarum mediated copper oxide nanoparticles: synthesis and its antifungal activity against Colletotrichum gloeosporioides. Environmental Science and Pollution Research 30:11, pages 28818-28829.
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Chang-Jun Liu, Xiao-Dan Fan, Jian-Guo Jiang, Qiu-Xiong Chen & Wei Zhu. (2022) Potential anticancer activities of securinine and its molecular targets. Phytomedicine 106, pages 154417.
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Khushabu Gulia, Abija James, Sadanand Pandey, Kamal Dev, Deepak Kumar & Anuradha Sourirajan. (2022) Bio-Inspired Smart Nanoparticles in Enhanced Cancer Theranostics and Targeted Drug Delivery. Journal of Functional Biomaterials 13:4, pages 207.
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C. Laldinsangi. (2022) The therapeutic potential of Houttuynia cordata: A current review. Heliyon 8:8, pages e10386.
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Ngoan Thi Thao Nguyen, Luan Minh Nguyen, Thuy Thi Thanh Nguyen, Rock Keey Liew, Duyen Thi Cam Nguyen & Thuan Van Tran. (2022) Recent advances on botanical biosynthesis of nanoparticles for catalytic, water treatment and agricultural applications: A review. Science of The Total Environment 827, pages 154160.
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Lili Xie, Yuqiang Li & Weiwei Cheng. (2022) Green fabrication of copper oxide nanoparticles by Tragopogon collinus leaf extract: Characterization and exploring their selective anticancer effects against human leukemia cell line. Journal of Drug Delivery Science and Technology 72, pages 103342.
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Sumera Zaib, Urooj Y. Virk, Javed I. Wattoo, Hamid S. Shah, Nasser S. Awwad, Hala A. Ibrahium & Imtiaz Khan. (2022) Antiproliferative and Proapoptotic Effect of Daucus carota in Cervical Cancer Cells: An In Vitro Approach . ChemistrySelect 7:12.
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Yaxing Zhou, Hai Zhang, Zhiyi Cheng & Honggang Wang. (2022) Regulation of the PI3K/AKT/mTOR signaling pathway with synthesized bismuth oxide nanoparticles from Ginger (Zingiber officinale) extract: Mitigating the proliferation of colorectal cancer cells. Arabian Journal of Chemistry 15:2, pages 103607.
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SevgiIrtegun Kandemir & Polat Ipek. (2022) Antiproliferative effect of Potentilla fulgens on glioblastoma cancer cells through downregulation of Akt/mTOR signaling pathway. Journal of Cancer Research and Therapeutics 0:0, pages 0.
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Kumar Ganesan, Yan Wang, Fei Gao, Qingqing Liu, Chen Zhang, Peng Li, Jinming Zhang & Jianping Chen. (2021) Targeting Engineered Nanoparticles for Breast Cancer Therapy. Pharmaceutics 13:11, pages 1829.
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Xin Chen, Pengli Xu, Huijun Zhang, Xiaosan Su, Lihua Guo, Xuhong Zhou, Junliang Wang, Peng Huang, Qingzhi Zhang & Ruifen Sun. (2021) EGFR and ERK activation resists flavonoid quercetin‑induced anticancer activities in human cervical cancer cells in vitro . Oncology Letters 22:5.
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Abdul-Rehman Phull, Akhtar Ali, Kyu Ree Dhong, Muhammad Zia, Prasad G. Mahajan & Hye-Jin Park. (2021) Synthesis, characterization, anticancer activity assessment and apoptosis signaling of fucoidan mediated copper oxide nanoparticles. Arabian Journal of Chemistry 14:8, pages 103250.
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Suresh Mickymaray, Faiz Abdulaziz Alfaiz, Anand Paramasivam, Vishnu Priya Veeraraghavan, Nanthini Devi Periadurai, Krishna Mohan Surapaneni & Guangfeng Niu. (2021) Rhaponticin suppresses osteosarcoma through the inhibition of PI3K-Akt-mTOR pathway. Saudi Journal of Biological Sciences 28:7, pages 3641-3649.
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Youzhi Sun, Qianjun Chen#Pei Liu, Yi Zhao, Yanhua He, Xiao Zheng, Wei Mao, Lei Jia, Kumar Ganesan, Feizhi Mo & Jianping Chen. (2021) Impact of Traditional Chinese Medicine Constitution on Breast Cancer Incidence: A Case-Control and Cross-Sectional Study. Pharmacophore 12:2, pages 46-56.
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