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Emerging Microbes & Infections Volume 9, 2020 - Issue 1
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Letter

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

Ya-Nan Zhanga Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of China;e University of Chinese Academy of Sciences, Beijing, People’s Republic of ChinaView further author information
,
Qiu-Yan Zhangb The Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou, People’s Republic of China;c The Joint Center of Translational Precision Medicine, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of ChinaView further author information
,
Xiao-Dan Lia Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of China;d School of Medicine, Hunan Normal University, Changsha, People’s Republic of ChinaView further author information
,
Jin Xionga Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of ChinaView further author information
,
Shu-Qi Xiaoa Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of ChinaView further author information
,
Zhen Wangf Drug Discovery Center for Infectious Disease, Nankai University, Tianjin, People’s Republic of ChinaView further author information
,
Zhe-Rui Zhanga Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of China;e University of Chinese Academy of Sciences, Beijing, People’s Republic of ChinaView further author information
,
Cheng-Lin Denga Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of ChinaView further author information
,
Xing-Lou Yanga Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of ChinaView further author information
,
Hong-Ping Weia Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of ChinaView further author information
,
Zhi-Ming Yuana Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-3234-9616View further author information
ORCID Icon,
Han-Qing Yea Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Bo Zhanga Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of China;b The Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou, People’s Republic of China;c The Joint Center of Translational Precision Medicine, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China;f Drug Discovery Center for Infectious Disease, Nankai University, Tianjin, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8895-3679View further author information
ORCID Icon show all
Pages 1170-1173 | Received 18 Mar 2020, Published online: 02 Jun 2020

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Antonella Di Sotto, Mehdi Valipour, Aala Azari, Silvia Di Giacomo & Hamid Irannejad. (2023) Benzoindolizidine Alkaloids Tylophorine and Lycorine and Their Analogues with Antiviral, Anti-Inflammatory, and Anticancer Properties: Promises and Challenges. Biomedicines 11:10, pages 2619.
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Doha H. Abou Baker, Emad M. Hassan & Souad El Gengaihi. (2023) An overview on medicinal plants used for combating coronavirus: Current potentials and challenges. Journal of Agriculture and Food Research 13, pages 100632.
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Yu-Jia Shi, Jia-Qi Li, Hong-Qing Zhang, Cheng-Lin Deng, Qin-Xuan Zhu, Bo Zhang & Xiao-Dan Li. (2023) A high throughput antiviral screening platform for alphaviruses based on Semliki Forest virus expressing eGFP reporter gene. Virologica Sinica 38:4, pages 585-594.
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Huishuang Lu, Jiaxiu Ma, Yalan Li, Jin Zhang, Yaxin An, Wei Du & Xuefei Cai. (2023) Bioinformatic and systems biology approach revealing the shared genes and molecular mechanisms between COVID-19 and non-alcoholic hepatitis. Frontiers in Molecular Biosciences 10.
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Zhaoxuan Low, Rafidah Lani, Vunjia Tiong, Chitlaa Poh, Sazaly AbuBakar & Pouya Hassandarvish. (2023) COVID-19 Therapeutic Potential of Natural Products. International Journal of Molecular Sciences 24:11, pages 9589.
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Hyeon-Min Cha, Uk-Il Kim, Soo Bin Ahn, Myoung Kyu Lee, Haemi Lee, Hyungtae Bang, Yejin Jang, Seong Soon Kim, Myung Ae Bae, Kyungjin Kim & Meehyein Kim. (2023) Evaluation of Antiviral Activity of Gemcitabine Derivatives against Influenza Virus and Severe Acute Respiratory Syndrome Coronavirus 2. ACS Infectious Diseases 9:4, pages 1033-1045.
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Ngoc-Thao-Hien Le, Steven De Jonghe, Kristien Erven, Tom Vermeyen, Aliou M. Baldé, Wouter A. Herrebout, Johan Neyts, Christophe Pannecouque, Luc Pieters & Emmy Tuenter. (2023) Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis. Molecules 28:7, pages 3222.
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Surjeet Verma, Motebang D.V. Nakin, Zesipho Makhosayafana & Namrita Lall. (2023) The Role of Aquatic Plants in Natural Products and Drug Discovery. Letters in Drug Design & Discovery 20:4, pages 386-407.
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Shahkaar Aziz, Muhammad Waqas, Tapan Kumar Mohanta, Sobia Ahsan Halim, Aqib Iqbal, Amjad Ali, Asaad Khalid, Ashraf N. Abdalla, Ajmal Khan & Ahmed Al-Harrasi. (2023) Identifying non-nucleoside inhibitors of RNA-dependent RNA-polymerase of SARS-CoV-2 through per-residue energy decomposition-based pharmacophore modeling, molecular docking, and molecular dynamics simulation. Journal of Infection and Public Health 16:4, pages 501-519.
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Xiaoqi Deng, Yu Luo, Tianjun Guan & Xiaodan Guo. (2023) Identification of the Genetic Influence of SARS-CoV-2 Infections on IgA Nephropathy Based on Bioinformatics Method. Kidney and Blood Pressure Research 48:1, pages 367-384.
Crossref
Jerald J. Nair & Johannes van Staden. (2023) Antiviral alkaloid principles of the plant family Amaryllidaceae. Phytomedicine 108, pages 154480.
Crossref
Dhwani Upadhyay, Arti Gaur, Maru Minaxi, Vijay Upadhye & Prasad Andhare. 2023. Recent Frontiers of Phytochemicals. Recent Frontiers of Phytochemicals 511 533 .
Janaína B. Seibert, Tatiane R. Amparo, Tamires C. Almeida, Gustavo H.B. de Souza & Orlando D.H. dos Santos. 2023. 187 240 .
Barış KURT. (2022) Investigation of The Potential Inhibitor Effects Of Lycorine On Sars-Cov-2 Main Protease (Mpro) Using Molecular Dynamics Simulations and MMPBSA. International Journal of Life Sciences and Biotechnology 5:3, pages 424-435.
Crossref
Sibei Lei, Xiaohua Chen, Jieping Wu, Xingmei Duan & Ke Men. (2022) Small molecules in the treatment of COVID-19. Signal Transduction and Targeted Therapy 7:1.
Crossref
Faezeh Almasi, Wen Dang, Fatemeh Mohammadipanah & Ning Li. (2022) Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms. Archives of Pharmacal Research 45:12, pages 909-937.
Crossref
Banlambhabok Khongthaw, Kanika Dulta, Pankaj Kumar Chauhan, Vinod Kumar & Joshua O. Ighalo. (2022) Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19). Inflammopharmacology 30:6, pages 1955-1976.
Crossref
Katarina Bijelić, Maja Hitl & Nebojša Kladar. (2022) Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence. Antibiotics 11:11, pages 1614.
Crossref
M. Sadegh Saberian, Kathleen P. Moriarty, Andrea D. Olmstead, Christian Hallgrimson, Francois Jean, Ivan R. Nabi, Maxwell W. Libbrecht & Ghassan Hamarneh. (2022) DEEMD: Drug Efficacy Estimation Against SARS-CoV-2 Based on Cell Morphology With Deep Multiple Instance Learning. IEEE Transactions on Medical Imaging 41:11, pages 3128-3145.
Crossref
Xiaoying Xu, Yuheng Chen, Xinyu Lu, Wanlin Zhang, Wenxiu Fang, Luping Yuan & Xiaoyan Wang. (2022) An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges. Biochemical Pharmacology 205, pages 115279.
Crossref
Purvi Trivedi, Amna Abbas, Christian Lehmann & H. P. Vasantha Rupasinghe. (2022) Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies. Journal of Xenobiotics 12:4, pages 289-306.
Crossref
Guobo Xie, Haojie Xu, Jianming Li, Guosheng Gu, Yuping Sun, Zhiyi Lin, Yinting Zhu, Weiming Wang, Youfu Wang & Jiang Shao. (2022) DRPADC: A novel drug repositioning algorithm predicting adaptive drugs for COVID-19. Computers & Chemical Engineering 166, pages 107947.
Crossref
Yangzhen Chen, Yecheng You, Shuqi Wang, Lin Jiang, Lili Tian, Shaozhou Zhu, Xiaoping An, Lihua Song, Yigang Tong & Huahao Fan. (2022) Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus. International Journal of Molecular Sciences 23:19, pages 11250.
Crossref
Mohsen Mohammadi, Yousef Yahyapour, Sina Nasrollahian, Mohammad Hossein Tayefeh-Arbab, Mostafa Javanian, Mohammad Rajabi Fadardi, Seyedeh Nasim Mousavi Kani, Parisa Honarvar Bakeshloo, Roshanak Saghebi, Mehdi Rajabnia, Mehrdad Halaji & Abazar Pournajaf. (2022) A Review on Herbal Secondary Metabolites Against COVID-19 Focusing on the Genetic Variants of SARS-CoV-2. Jundishapur Journal of Natural Pharmaceutical Products 17:4.
Crossref
Nitin Sharma, Giriraj T. Kulkarni, Anant Narayan Bhatt, Saurabh Satija, Lubhan Singh, Anjana Sharma, Kamal Dua, Ritu Karwasra, Asim Ali Khan, Nadeem Ahmad & Khalid Raza. (2022) Therapeutic Options for the SARS-CoV-2 Virus: Is There a Key in Herbal Medicine?. Natural Product Communications 17:9, pages 1934578X2211263.
Crossref
Haoxiang Xiao, Xuezeng Xu, Luyang Du, Xiyang Li, Huadong Zhao, Zheng Wang, Lin Zhao, Zhi Yang, Shaofei Zhang, Yang Yang & Changyu Wang. (2022) Lycorine and organ protection: Review of its potential effects and molecular mechanisms. Phytomedicine 104, pages 154266.
Crossref
Tommi Välikangas, Sini Junttila, Kalle T. Rytkönen, Anu Kukkonen-Macchi, Tomi Suomi & Laura L. Elo. (2022) COVID-19-specific transcriptomic signature detectable in blood across multiple cohorts. Frontiers in Genetics 13.
Crossref
Sina Cafer Demir, Arzu Birinci Yildirim, Arzu Ucar Turker & Ismail Eker. (2022) Seasonal variation in alkaloid content, phenolic constituent and biological activities of some Leucojum aestivum L. populations in Turkey. South African Journal of Botany 147, pages 713-723.
Crossref
Ahmed Al-Harrasi, Tapan Behl, Tanuj Upadhyay, Sridevi Chigurupati, Shvetank Bhatt, Aayush Sehgal, Saurabh Bhatia, Sukhbir Singh, Neelam Sharma, Shantini Vijayabalan, Vasanth Raj Palanimuthu, Suprava Das, Rajwinder Kaur, Lotfi Aleya & Simona Bungau. (2022) Targeting natural products against SARS-CoV-2. Environmental Science and Pollution Research 29:28, pages 42404-42432.
Crossref
Pakorn Sagulkoo, Apichat Suratanee & Kitiporn Plaimas. (2022) Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing. Biomolecules 12:5, pages 690.
Crossref
Xiaoming Bai, Hongmin Sun, Shuo Wu, Yuhuan Li, Lifei Wang & Bin Hong. (2022) Identifying Small-Molecule Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Establishing a Fluorometric Assay. Frontiers in Immunology 13.
Crossref
Ana C. Puhl, Thomas R. Lane, Fabio Urbina & Sean Ekins. (2022) The Need for Speed and Efficiency: A Brief Review of Small Molecule Antivirals for COVID-19. Frontiers in Drug Discovery 2.
Crossref
Hooman Aghamirza Moghim Aliabadi, Reza Eivazzadeh‐Keihan, Arezoo Beig Parikhani, Sara Fattahi Mehraban, Ali Maleki, Sepideh Fereshteh, Masoume Bazaz, Ashkan Zolriasatein, Bahareh Bozorgnia, Saman Rahmati, Fatemeh Saberi, Zeinab Yousefi Najafabadi, Shadi Damough, Sara Mohseni, Hamid Salehzadeh, Vahid Khakyzadeh, Hamid Madanchi, Gholam Ali Kardar, Payam Zarrintaj, Mohammad Reza Saeb & Masoud Mozafari. (2022) COVID‐19: A systematic review and update on prevention, diagnosis, and treatment. MedComm 3:1.
Crossref
Anoop Narayanan, Manju Narwal, Sydney A. Majowicz, Carmine Varricchio, Shay A. Toner, Carlo Ballatore, Andrea Brancale, Katsuhiko S. Murakami & Joyce Jose. (2022) Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay. Communications Biology 5:1.
Crossref
Shen Tan, Martin G. Banwell, Wen‐Cai Ye, Ping Lan & Lorenzo V. White. (2022) The Inhibition of RNA Viruses by Amaryllidaceae Alkaloids: Opportunities for the Development of Broad‐Spectrum Anti‐Coronavirus Drugs . Chemistry – An Asian Journal 17:4.
Crossref
Peng-xuan Ren, Wei-juan Shang, Wan-chao Yin, Huan Ge, Lin Wang, Xiang-lei Zhang, Bing-qian Li, Hong-lin Li, Ye-chun Xu, Eric H. Xu, Hua-liang Jiang, Li-li Zhu, Lei-ke Zhang & Fang Bai. (2021) A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors. Acta Pharmacologica Sinica 43:2, pages 483-493.
Crossref
Zheng Yao Low, Ashley Jia Wen Yip & Sunil Kumar Lal. (2022) Repositioning anticancer drugs as novel COVID-19 antivirals: targeting structural and functional similarities between viral proteins and cancer. Expert Reviews in Molecular Medicine 24.
Crossref
Denisse de Loera. 2022. Biomedical Innovations to Combat COVID-19. Biomedical Innovations to Combat COVID-19 339 385 .
Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology 343 374 .
Amin Osman Elzupir. (2021) Molecular Docking and Dynamics Investigations for Identifying Potential Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2: Repurposing of Approved Pyrimidonic Pharmaceuticals for COVID-19 Treatment. Molecules 26:24, pages 7458.
Crossref
Rajeev K. Singla, Xuefei He, Hitesh Chopra, Christos Tsagkaris, Li Shen, Mohammad Amjad Kamal & Bairong Shen. (2021) Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources. Frontiers in Pharmacology 12.
Crossref
Na Li, Zhen Wang, Rui Wang, Zhe-Rui Zhang, Ya-Nan Zhang, Cheng-Lin Deng, Bo Zhang, Lu-Qing Shang & Han-Qing Ye. (2021) In Vitro Inhibition of Alphaviruses by Lycorine. Virologica Sinica 36:6, pages 1465-1474.
Crossref
Luca Di Gianfrancesco. (2021) The (Still Unknown) Hypothetical Protective Role of COVID-19 Therapy in Bladder Cancer. Journal of Clinical Medicine 10:23, pages 5473.
Crossref
Khoshnur Jannat, Alok K. Paul, Tohmina A. Bondhon, Anamul Hasan, Muhammad Nawaz, Rownak Jahan, Tooba Mahboob, Veeranoot Nissapatorn, Polrat Wilairatana, Maria de Lourdes Pereira & Mohammed Rahmatullah. (2021) Nanotechnology Applications of Flavonoids for Viral Diseases. Pharmaceutics 13:11, pages 1895.
Crossref
Chawon Yun, Hyun Jae Lee & Choong Jae Lee. (2021) Small Molecule Drug Candidates for Managing the Clinical Symptoms of COVID-19: a Narrative Review. Biomolecules & Therapeutics 29:6, pages 571-581.
Crossref
Ali Kishk, Maria Pires Pacheco & Thomas Sauter. (2021) DCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling. iScience 24:11, pages 103331.
Crossref
Erica Españo, Jiyeon Kim, Kiho Lee & Jeong-Ki Kim. (2021) Phytochemicals for the treatment of COVID-19. Journal of Microbiology 59:11, pages 959-977.
Crossref
Howaida I. Abd-Alla, Dalila Souguir & Mohamed O. Radwan. (2021) Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives. Archives of Pharmacal Research 44:11, pages 903-986.
Crossref
Xuan Lv, Miao Zhang, Shengzhu Yu, Chong Zhang, Tian Fang, Dan Liu, Beiping Jia, Meng Zhu, Bei Wang, Qing Wang, Yingqi Zhu & Guijun Wang. (2021) Antiviral and virucidal activities of lycorine on duck tembusu virus in vitro by blocking viral internalization and entry. Poultry Science 100:10, pages 101404.
Crossref
Zineb Jalal, Meryem Bakour & Badiaa Lyoussi. (2021) Medicinal Plants and Zinc: Impact on COVID-19 Pandemic. The Scientific World Journal 2021, pages 1-9.
Crossref
Wei Chen, Zhihao Wang, Yawen Wang & Yiping Li. (2021) Natural Bioactive Molecules as Potential Agents Against SARS-CoV-2. Frontiers in Pharmacology 12.
Crossref
Seydou Ka, Natacha Merindol, Aïssatou Aïcha Sow, Amita Singh, Karima Landelouci, Mélodie B. Plourde, Geneviève Pépin, Marco Masi, Roberta Di Lecce, Antonio Evidente, Matar Seck, Lionel Berthoux, Laurent Chatel-Chaix & Isabel Desgagné-Penix. (2021) Amaryllidaceae Alkaloid Cherylline Inhibits the Replication of Dengue and Zika Viruses. Antimicrobial Agents and Chemotherapy 65:9.
Crossref
Muhammed Tural Ates, Arzu Birinci Yildirim & Arzu Ucar Turker. (2021) Enhancement of alkaloid content (galanthamine and lycorine) and antioxidant activities (enzymatic and non-enzymatic) unders salt stress in summer snowflake (Leucojum aestivum L.). South African Journal of Botany 140, pages 182-188.
Crossref
Luisa D. Burgers & Robert Fürst. (2021) Natural products as drugs and tools for influencing core processes of eukaryotic mRNA translation. Pharmacological Research 170, pages 105535.
Crossref
Young-Hee Jin, Jung Sun Min, Sangeun Jeon, Jihye Lee, Seungtaek Kim, Tamina Park, Daeui Park, Min Seong Jang, Chul Min Park, Jong Hwan Song, Hyoung Rae Kim & Sunoh Kwon. (2021) Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections. Phytomedicine 86, pages 153440.
Crossref
Ruikun Du, Laura Cooper, Zinuo Chen, Hyun Lee, Lijun Rong & Qinghua Cui. (2021) Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro. Antiviral Research 190, pages 105075.
Crossref
Sajad Fakhri, Zeinab Nouri, Seyed Zachariah Moradi, Esra Küpeli Akkol, Sana Piri, Eduardo Sobarzo-Sánchez, Mohammad Hosein Farzaei & Javier Echeverría. (2021) Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic Candidates. Molecules 26:10, pages 2917.
Crossref
Alshaimaa M. Hamoda, Bahgat Fayed, Naglaa S. Ashmawy, Abdel-Nasser A. El-Shorbagi, Rania Hamdy & Sameh S. M. Soliman. (2021) Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold. Frontiers in Pharmacology 12.
Crossref
Mohammad Bagher Majnooni, Sajad Fakhri, Gholamreza Bahrami, Maryam Naseri, Mohammad Hosein Farzaei & Javier Echeverría. (2021) Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-21.
Crossref
Jimin Xu, Yu Xue, Richard Zhou, Pei‐Yong Shi, Hongmin Li & Jia Zhou. (2020) Drug repurposing approach to combating coronavirus: Potential drugs and drug targets. Medicinal Research Reviews 41:3, pages 1375-1426.
Crossref
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Crossref
Dana Atrahimovich, Raviv Harris, Ron Eitan, Menashe Cohen & Soliman Khatib. (2021) Galantamine Quantity and Alkaloid Profile in the Bulbs of Narcissus tazetta and daffodil cultivars (Amaryllidaceae) Grown in Israel. Metabolites 11:3, pages 185.
Crossref
Anirban Mandal, Ajeet Kumar Jha & Banasri Hazra. (2021) Plant Products as Inhibitors of Coronavirus 3CL Protease. Frontiers in Pharmacology 12.
Crossref
Nicola Borbone, Gennaro Piccialli, Giovanni Nicola Roviello & Giorgia Oliviero. (2021) Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses. Molecules 26:4, pages 986.
Crossref
Yejin Jang, Jin Soo Shin, Myoung Kyu Lee, Eunhye Jung, Timothy An, Uk-Il Kim, Kyungjin Kim & Meehyein Kim. (2021) Comparison of Antiviral Activity of Gemcitabine with 2′-Fluoro-2′-Deoxycytidine and Combination Therapy with Remdesivir against SARS-CoV-2. International Journal of Molecular Sciences 22:4, pages 1581.
Crossref
Zihua Zheng, Elisabetta Groaz, Robert Snoeck, Steven De Jonghe, Piet Herdewijn & Graciela Andrei. (2020) Influence of 4′-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2. ACS Medicinal Chemistry Letters 12:1, pages 88-92.
Crossref
Pedro N. Batalha, Luana S.M. Forezi, Carolina G.S. Lima, Fernanda P. Pauli, Fernanda C.S. Boechat, Maria Cecília B.V. de Souza, Anna C. Cunha, Vitor F. Ferreira & Fernando de C. da Silva. (2021) Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches. Bioorganic Chemistry 106, pages 104488.
Crossref
Koichi Watashi. (2021) Identifying and repurposing antiviral drugs against severe acute respiratory syndrome coronavirus 2 with in silico and in vitro approaches. Biochemical and Biophysical Research Communications 538, pages 137-144.
Crossref
Tianguang Huang, Lin Sun, Dongwei Kang, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan & Luis Menéndez-Arias. 2021. Antiviral Drug Discovery and Development. Antiviral Drug Discovery and Development 219 260 .
Burtram C. Fielding, Carlos da Silva Maia Bezerra Filho, Nasser S. M. Ismail & Damião Pergentino de Sousa. (2020) Alkaloids: Therapeutic Potential against Human Coronaviruses. Molecules 25:23, pages 5496.
Crossref
Mohammad Bagher Majnooni, Sajad Fakhri, Yalda Shokoohinia, Narges Kiyani, Katrina Stage, Pantea Mohammadi, Mohammad Mehdi Gravandi, Mohammad Hosein Farzaei & Javier Echeverría. (2020) Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury. Frontiers in Pharmacology 11.
Crossref
Aleksandr Ianevski, Rouan Yao, Mona Høysæter Fenstad, Svetlana Biza, Eva Zusinaite, Tuuli Reisberg, Hilde Lysvand, Kirsti Løseth, Veslemøy Malm Landsem, Janne Fossum Malmring, Valentyn Oksenych, Sten Even Erlandsen, Per Arne Aas, Lars Hagen, Caroline H. Pettersen, Tanel Tenson, Jan Egil Afset, Svein Arne Nordbø, Magnar Bjørås & Denis E. Kainov. (2020) Potential Antiviral Options against SARS-CoV-2 Infection. Viruses 12:6, pages 642.
Crossref
Arwa Bohra, Shubham Atal, Abhishek Anand, Sagar Goyal, Rajnish Joshi & Anurag Kanase. (2022) Transcriptomic Analysis of the Peripheral Immune Cell of SARS-CoV-2 Infected Patients for Bridging the Genotype-Phenotype Gap and Drug Prediction: A Precision Medicine Approach. SSRN Electronic Journal.
Crossref

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