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Coronaviruses

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

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Pages 178-195 | Received 04 Nov 2020, Accepted 24 Dec 2020, Published online: 29 Jan 2021

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Yang Wu, Mingwei Li, Jin Tian, Haoxin Yan, Yudi Pan, Hongyan Shi, Da Shi, Jianfei Chen, Longjun Guo & Li Feng. (2023) Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3. PLOS Pathogens 19:10, pages e1011702.
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Lili Huang, Youli Tao, Xiping Wu, Jianzhang Wu, Mengya Shen & Zhiwei Zheng. (2023) The role of NLRP12 in inflammatory diseases. European Journal of Pharmacology 956, pages 175995.
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Danaya Pakotiprapha, Sakonwan Kuhaudomlarp, Ruchanok Tinikul & Sittinan Chanarat. (2023) Bridging the Gap: Can COVID-19 Research Help Combat African Swine Fever?. Viruses 15:9, pages 1925.
Crossref
Dianqi Zhang, Likai Ji, Xu Chen, Yumin He, Yijie Sun, Li Ji, Tiancheng Zhang, Quan Shen, Xiaochun Wang, Yan Wang, Shixing Yang, Wen Zhang & Chenglin Zhou. (2023) SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation. iScience 26:9, pages 107705.
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Yingjie Xiang, Chunxiao Mou, Kaichuang Shi, Xiang Chen, Xia Meng, Wenbin Bao & Zhenhai Chen. (2023) SADS‐CoV nsp1 inhibits the IFN‐β production by preventing TBK1 phosphorylation and inducing CBP degradation. Journal of Medical Virology 95:9.
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Jia Wang, Meifang Zhang, Yanli Ding, Yuxi Lin, Yan Xue, Xiaohong Wang & Xin Wang. (2023) Coronaviral Main Protease Induces LPCAT3 Cleavage and Endoplasmic Reticulum (ER) Stress. Viruses 15:8, pages 1696.
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Nitin K. Saksena, Srinivas Bonam Reddy, Monica Miranda-Saksena, Thyago H.S. Cardoso, Edson M.A. Silva, Juliana C. Fereira & Wael M. Rabeh. (2023) SARS-CoV-2 variants, its recombinants and epigenomic exploitation of host defenses. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, pages 166836.
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Annette von Delft, Matthew D. Hall, Ann D. Kwong, Lisa A. Purcell, Kumar Singh Saikatendu, Uli Schmitz, John A. Tallarico & Alpha A. Lee. (2023) Accelerating antiviral drug discovery: lessons from COVID-19. Nature Reviews Drug Discovery 22:7, pages 585-603.
Crossref
Haojie He, Wenzhe Wang, Liang Li, Xin Zhang, Hongyan Shi, Jianfei Chen, Da Shi, Mei Xue & Li Feng. (2023) Activation of the NLRP1 Inflammasome and Its Role in Transmissible Gastroenteritis Coronavirus Infection. Journal of Virology 97:6.
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Brian V. Tsu, Rimjhim Agarwal, Nandan S. Gokhale, Jessie Kulsuptrakul, Andrew P. Ryan, Elizabeth J. Fay, Lennice K. Castro, Christopher Beierschmitt, Christina Yap, Elizabeth A. Turcotte, Sofia E. Delgado-Rodriguez, Russell E. Vance, Jennifer L. Hyde, Ram Savan, Patrick S. Mitchell & Matthew D. Daugherty. (2023) Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. PLOS Biology 21:6, pages e3002144.
Crossref
Kai Zhao, Yini Li, Mengzhun Guo, Lijia Ma & Bobo Dang. (2023) Identification of SARS-CoV-2 PLpro and 3CLpro human proteome substrates using substrate phage display coupled with protein network analysis. Journal of Biological Chemistry 299:6, pages 104831.
Crossref
Zhaoxuan Low, Rafidah Lani, Vunjia Tiong, Chitlaa Poh, Sazaly AbuBakar & Pouya Hassandarvish. (2023) COVID-19 Therapeutic Potential of Natural Products. International Journal of Molecular Sciences 24:11, pages 9589.
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Alessandra Sacchi, Flavia Giannessi, Andrea Sabatini, Zulema Antonia Percario & Elisabetta Affabris. (2023) SARS-CoV-2 Evasion of the Interferon System: Can We Restore Its Effectiveness?. International Journal of Molecular Sciences 24:11, pages 9353.
Crossref
Suresh V. Kuchipudi, Cedric Tan, Lucy van Dorp, Maureen Lichtveld, Bradley Pickering, Jeff Bowman, Samira Mubareka & Francois Balloux. (2023) Coordinated surveillance is essential to monitor and mitigate the evolutionary impacts of SARS-CoV-2 spillover and circulation in animal hosts. Nature Ecology & Evolution 7:7, pages 956-959.
Crossref
Hai-xin Huang, Chen-chen Zhao, Xiao-xiao Lei, Xin-yu Zhang, Yu-ying Li, Tian Lan, Bao-peng Zhao, Jing-yi Lu, Wen-chao Sun, Hui-jun Lu & Ning-yi Jin. (2023) Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A. Frontiers in Immunology 14.
Crossref
Joseph K. Sampson Duncan, Danyang Xu, Maria Licursi, Michael A. Joyce, Holly A. Saffran, Kaiwen Liu, Jin Gohda, D. Lorne Tyrrell, Yasushi Kawaguchi & Kensuke Hirasawa. (2023) Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection. Frontiers in Immunology 14.
Crossref
Melinda Metzler, Rebecca George Tharyan, Kevin Klann, Katharina Grikscheit, Denisa Bojkova, Jindrich Cinatl, Georg Tascher, Sandra Ciesek & Christian Münch. (2023) SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells. Molecular & Cellular Proteomics 22:5, pages 100537.
Crossref
Yunfan Shi, Liting Dong, Zhuang Ju, Qiufu Li, Yanru Cui, Yiran Liu, Jiaoyu He & Xianping Ding. (2023) Exploring potential SARS-CoV-2 Mpro non-covalent inhibitors through docking, pharmacophore profile matching, molecular dynamic simulation, and MM-GBSA. Journal of Molecular Modeling 29:5.
Crossref
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Crossref
Pawel M. Wydorski, Jerzy Osipiuk, Benjamin T. Lanham, Christine Tesar, Michael Endres, Elizabeth Engle, Robert Jedrzejczak, Vishruth Mullapudi, Karolina Michalska, Krzysztof Fidelis, David Fushman, Andrzej Joachimiak & Lukasz A. Joachimiak. (2023) Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin. Nature Communications 14:1.
Crossref
Chia-Ming Su, Yijun Du, Raymond R. R. Rowland, Qiuhong Wang & Dongwan Yoo. (2023) Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses. Frontiers in Immunology 14.
Crossref
Shu Y. Luo, Eman W. Moussa, Joaquin Lopez-Orozco, Alberto Felix-Lopez, Ray Ishida, Nawell Fayad, Erik Gomez-Cardona, Henry Wang, Joyce A. Wilson, Anil Kumar, Tom C. Hobman & Olivier Julien. (2023) Identification of Human Host Substrates of the SARS-CoV-2 M pro and PL pro Using Subtiligase N-Terminomics . ACS Infectious Diseases 9:4, pages 749-761.
Crossref
Yi-Yang Pan, Liu-Can Wang, Feng Yang & Min Yu. (2023) Interferon-lambda: New functions on intestinal symptoms in COVID-19. World Journal of Gastroenterology 29:13, pages 1942-1954.
Crossref
Shahrzad Ahmadi, Mahsa Bazargan, Reza Elahi & Abdolreza Esmaeilzadeh. (2023) Immune evasion of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); molecular approaches. Molecular Immunology 156, pages 10-19.
Crossref
Kexin Jia, Yijie Li, Tiegang Liu, Xiaohong Gu & Xiaojiaoyang Li. (2023) New insights for infection mechanism and potential targets of COVID-19: Three Chinese patent medicines and three Chinese medicine formulas as promising therapeutic approaches. Chinese Herbal Medicines 15:2, pages 157-168.
Crossref
Jian Deng, Sheng‐Nan Zheng, Yang Xiao, Mei‐Ling Nan, Jing Zhang, Lulu Han, Yi Zheng, Yanying Yu, Qiang Ding, Chengjiang Gao & Pei‐Hui Wang. (2023) SARS‐CoV‐2 NSP8 suppresses type I and III IFN responses by modulating the RIG‐I/MDA5, TRIF, and STING signaling pathways. Journal of Medical Virology 95:4.
Crossref
Liu Song, Dianbing Wang, Ghulam Abbas, Min Li, Mengmeng Cui, Jufang Wang, Zhanglin Lin & Xian-En Zhang. (2023) The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genes. Journal of Biological Chemistry 299:3, pages 102990.
Crossref
Yaqin Li, Yance Zhu, Yue Wang, Yi Feng, Dongliang Li, Shuai Li, Panpan Qin, Xia Yang, Lu Chen, Jun Zhao, Chao Zhang & Yongtao Li. (2023) Characterization of RNA G-quadruplexes in porcine epidemic diarrhea virus genome and the antiviral activity of G-quadruplex ligands. International Journal of Biological Macromolecules 231, pages 123282.
Crossref
Jian Deng, Yi Zheng, Sheng‐Nan Zheng, Mei‐Ling Nan, Lulu Han, Jing Zhang, Yunyun Jin, Ji‐An Pan, Chengjiang Gao & Pei‐Hui Wang. (2023) SARS‐CoV‐2 NSP7 inhibits type I and III IFN production by targeting the RIG‐I/MDA5, TRIF, and STING signaling pathways. Journal of Medical Virology 95:3.
Crossref
Shi Yu, Huina Hu, Qiangyun Ai, Rong Bai, Kaixiong Ma, Minmin Zhou & Shaobo Wang. (2023) SARS-CoV-2 Spike-Mediated Entry and Its Regulation by Host Innate Immunity. Viruses 15:3, pages 639.
Crossref
Alexander A. Mironov, Maksim A. Savin & Galina V. Beznoussenko. (2023) COVID-19 Biogenesis and Intracellular Transport. International Journal of Molecular Sciences 24:5, pages 4523.
Crossref
Ignacio A. Gallardo, Daniel A. Todd, Stella T. Lima, Jonathan R. Chekan, Norman H. Chiu & Ethan Will Taylor. (2023) SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles. Antioxidants 12:3, pages 559.
Crossref
Katarina Z. Doctor, Elizabeth Gilmour, Marilyn Recarte, Trinity R. Beatty, Intisar Shifa, Michaela Stangel, Jacob Schwisow, Dagmar H. Leary & Patricia M. Legler. (2023) Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses. Viruses 15:2, pages 542.
Crossref
Elizabeth M. Diessner, Gemma R. Takahashi, Thomas J. Cross, Rachel W. Martin & Carter T. Butts. (2023) Mutation Effects on Structure and Dynamics: Adaptive Evolution of the SARS-CoV-2 Main Protease. Biochemistry 62:3, pages 747-758.
Crossref
Noémi Miltner, Gergő Kalló, Éva Csősz, Márió Miczi, Tibor Nagy, Mohamed Mahdi, János András Mótyán & József Tőzsér. (2023) Identification of SARS-CoV-2 Main Protease (Mpro) Cleavage Sites Using Two-Dimensional Electrophoresis and In Silico Cleavage Site Prediction. International Journal of Molecular Sciences 24:4, pages 3236.
Crossref
Yiwu Chen, Yuanzhu Zhang, Xi Wang, Jian Zhou, Lerong Ma, Jianing Li, Lin Yang, Hongsheng Ouyang, Hongming Yuan & Daxin Pang. (2023) Transmissible Gastroenteritis Virus: An Update Review and Perspective. Viruses 15:2, pages 359.
Crossref
Haoran Sun, Jasper Fuk-Woo Chan & Shuofeng Yuan. (2023) Cellular Sensors and Viral Countermeasures: A Molecular Arms Race between Host and SARS-CoV-2. Viruses 15:2, pages 352.
Crossref
Judith M. Minkoff & Benjamin tenOever. (2023) Innate immune evasion strategies of SARS-CoV-2. Nature Reviews Microbiology.
Crossref
Christopher Rainville, David E. Sterner & Kumar Suresh. 2023. Deubiquitinases. Deubiquitinases 269 282 .
Yan Li, Jiaxin Yang, Siyu Shen, Wei Wang, Nian Liu, Haoran Guo & Wei Wei. (2022) SARS‐CoV‐2‐encoded inhibitors of human LINE‐1 retrotransposition. Journal of Medical Virology 95:1.
Crossref
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Crossref
Yabin Zhang, Shiyan Liu, Qingjia Xu, Huihui Li & Kefeng Lu. (2022) Cleavage of the selective autophagy receptor SQSTM1/p62 by the SARS-CoV-2 main protease NSP5 prevents the autophagic degradation of viral membrane proteins. Molecular Biomedicine 3:1.
Crossref
Izabela Ciaston, Ewelina Dobosz, Jan Potempa & Joanna Koziel. (2022) The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseases. Molecular Aspects of Medicine 88, pages 101143.
Crossref
José Ednésio da Cruz Freire, José Edvar Monteiro Júnior, Daniel Pascoalino Pinheiro, Grayce Ellen da Cruz Paiva Lima, Camila Lopes do Amaral, Victor Rezende Veras, Mayara Ponte Madeira, Erika Bastos Lima Freire, Renan Galvão Ozório, Virgínia Oliveira Fernandes, Ana Paula Dias Rangel Montenegro, Raquel Carvalho Montenegro, Jeová Keny Baima Colares & Renan Magalhães Montenegro Júnior. (2022) Evaluation of the anti-diabetic drug sitagliptin as a novel attenuate to SARS-CoV-2 evidence-based in silico: molecular docking and molecular dynamics. 3 Biotech 12:12.
Crossref
Qazi Mohammad Sajid Jamal. (2022) Antiviral Potential of Plants against COVID-19 during Outbreaks—An Update. International Journal of Molecular Sciences 23:21, pages 13564.
Crossref
Young-Su Yi. (2022) Potential benefits of ginseng against COVID-19 by targeting inflammasomes. Journal of Ginseng Research 46:6, pages 722-730.
Crossref
Haruaki Nobori, Keita Fukao, Takayuki Kuroda, Naomi Anan, Ryoichi Tashima, Masaaki Nakashima, Sayuri Noda, Minako Tajiri, Mikinori Torii, Shinsuke Toba, Kentaro Uemura, Takao Sanaki, Takao Shishido, Yuki Tachibana & Teruhisa Kato. (2022) Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse model. Journal of Antimicrobial Chemotherapy 77:11, pages 2984-2991.
Crossref
Cameron Lee Shetler, Juliana C. Ferreira, Thyago H. S. Cardoso, Edson M.A. Silva, Nitin K. Saksena & Wael M. Rabeh. (2022) Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2. Biochemical Journal 479:20, pages 2175-2193.
Crossref
Wenchun Fan, Matthew B. McDougal & John W. Schoggins. (2022) Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity. Journal of Virology 96:19.
Crossref
Yaru Wu, Zhenling Ma, Yanyan Zhang, Min Zhang, Xixi Shi, Menghao Zhang, Wenwen Zhang & Wei Liu. (2022) The role of cyclophilins in viral infection and the immune response. Journal of Infection 85:4, pages 365-373.
Crossref
Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang & Zhe Han. (2022) SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis. Communications Biology 5:1.
Crossref
Hao Zhou, Michelle Møhlenberg, Jigarji C. Thakor, Hardeep Singh Tuli, Pengfei Wang, Yehuda G. Assaraf, Kuldeep Dhama & Shibo Jiang. (2022) Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron Variant. Clinical Microbiology Reviews 35:3.
Crossref
Meng Li, Xinguo Liu, Shaolong Zhang, Shanshan Liang, Qinggang Zhang & Jianzhong Chen. (2022) Deciphering the binding mechanism of inhibitors of the SARS-CoV-2 main protease through multiple replica accelerated molecular dynamics simulations and free energy landscapes. Physical Chemistry Chemical Physics 24:36, pages 22129-22143.
Crossref
Alessia Catalano, Domenico Iacopetta, Jessica Ceramella, Azzurra Chiara De Maio, Giovanna Basile, Federica Giuzio, Maria Grazia Bonomo, Stefano Aquaro, Thomas J. Walsh, Maria Stefania Sinicropi, Carmela Saturnino, Athina Geronikaki & Giovanni Salzano. (2022) Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?. Foods 11:18, pages 2884.
Crossref
Theopilus Watuguly, Yohanes Bare, Dewi Ratih Tirt & Indranila Kustarini. (2022) In silico Study Phytosterol Cymbopogon citratus and Curcuma longa as Inhibitor Agent 3C-Like Protease SARS-CoV-2. Pakistan Journal of Biological Sciences 25:9, pages 867-874.
Crossref
James W. Saville, Alison M. Berezuk, Shanti S. Srivastava & Sriram Subramaniam. (2022) Three-Dimensional Visualization of Viral Structure, Entry, and Replication Underlying the Spread of SARS-CoV-2. Chemical Reviews 122:17, pages 14066-14084.
Crossref
Mikhail A. Hameedi, Erica T. Prates, Michael R. Garvin, Irimpan I. Mathews, B. Kirtley Amos, Omar Demerdash, Mark Bechthold, Mamta Iyer, Simin Rahighi, Daniel W. Kneller, Andrey Kovalevsky, Stephan Irle, Van-Quan Vuong, Julie C. Mitchell, Audrey Labbe, Stephanie Galanie, Soichi Wakatsuki & Daniel Jacobson. (2022) Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro. Nature Communications 13:1.
Crossref
Subodh Kumar Samrat, Jimin Xu, Xuping Xie, Eleonora Gianti, Haiying Chen, Jing Zou, Jason G. Pattis, Khaled Elokely, Hyun Lee, Zhong Li, Michael L. Klein, Pei-Yong Shi, Jia Zhou & Hongmin Li. (2022) Allosteric inhibitors of the main protease of SARS-CoV-2. Antiviral Research 205, pages 105381.
Crossref
Jia Yi, Jiameng Miao, Qingwei Zuo, Felix Owusu, Qiutong Dong, Peizhe Lin, Qilong Wang, Rui Gao, Xianbin Kong & Long Yang. (2022) COVID-19 pandemic: A multidisciplinary perspective on the pathogenesis of a novel coronavirus from infection, immunity and pathological responses. Frontiers in Immunology 13.
Crossref
Kriti Khare & Rajesh Pandey. (2022) Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is key. Frontiers in Immunology 13.
Crossref
Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y. A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H. M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents & Christian Betzel. (2022) Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease. Communications Biology 5:1.
Crossref
Carolina Chiale, Trever T. Greene & Elina I. Zuniga. (2022) Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*. Immunological Reviews 309:1, pages 12-24.
Crossref
Esther Moga, Elionor Lynton-Pons & Pere Domingo. (2022) The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection. Frontiers in Immunology 13.
Crossref
Mariem Znaidia, Caroline Demeret, Sylvie van der Werf & Anastassia V. Komarova. (2022) Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options. Viruses 14:6, pages 1247.
Crossref
Huiting Chen, Zhaozhong Zhu, Ye Qiu, Xingyi Ge, Heping Zheng & Yousong Peng. (2022) Prediction of coronavirus 3C-like protease cleavage sites using machine-learning algorithms. Virologica Sinica 37:3, pages 437-444.
Crossref
Lucas Prescott. (2022) SARS-CoV-2 3CLpro whole human proteome cleavage prediction and enrichment/depletion analysis. Computational Biology and Chemistry 98, pages 107671.
Crossref
Hakan Alici, Hakan Tahtaci & Kadir Demir. (2022) Design and various in silico studies of the novel curcumin derivatives as potential candidates against COVID-19 -associated main enzymes. Computational Biology and Chemistry 98, pages 107657.
Crossref
Chunye Zhang & Ming Yang. (2022) Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small Molecules. International Journal of Molecular Sciences 23:11, pages 6083.
Crossref
Nicola Gambacorta, Leonardo Caputo, Laura Quintieri, Linda Monaci, Fulvio Ciriaco & Orazio Nicolotti. (2022) Rational Discovery of Antiviral Whey Protein-Derived Small Peptides Targeting the SARS-CoV-2 Main Protease. Biomedicines 10:5, pages 1067.
Crossref
Lennart Brewitz, Jos J. A. G. Kamps, Petra Lukacik, Claire Strain‐Damerell, Yilin Zhao, Anthony Tumber, Tika R. Malla, Allen M. Orville, Martin A. Walsh & Christopher J. Schofield. (2022) Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease. ChemMedChem 17:9.
Crossref
Saba R. Aliyari, Natalie Quanquin, Olivier Pernet, Shilei Zhang, Lulan Wang & Genhong Cheng. (2022) The Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2. Pathogens 11:5, pages 538.
Crossref
Shilei Zhang, Lulan Wang & Genhong Cheng. (2022) The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies. Molecular Therapy 30:5, pages 1869-1884.
Crossref
Chue Vin Chin & Mohsan Saeed. (2022) Surgical Strikes on Host Defenses: Role of the Viral Protease Activity in Innate Immune Antagonism. Pathogens 11:5, pages 522.
Crossref
Benjamin M. Scott, Vincent Lacasse, Ditte G. Blom, Peter D. Tonner & Nikolaj S. Blom. (2022) Predicted coronavirus Nsp5 protease cleavage sites in the human proteome. BMC Genomic Data 23:1.
Crossref
Sameer-ul-Salam Mattoo, Seong-Jun Kim, Dae-Gyun Ahn & Jinjong Myoung. (2022) Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a Coin. Viruses 14:3, pages 530.
Crossref
Wenxiang Xue, Chan Ding, Kun Qian & Ying Liao. (2022) The Interplay Between Coronavirus and Type I IFN Response. Frontiers in Microbiology 12.
Crossref
Soo-Jin Oh & Ok Sarah Shin. (2022) SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways. Journal of Microbiology 60:3, pages 290-299.
Crossref
Fushan Shi, Qian Lv, Tingjun Wang, Jidong Xu, Wei Xu, Yuhua Shi, Xinyu Fu, Tianming Yang, Yang Yang, Lenan Zhuang, Weihuan Fang, Jinyan Gu & Xiaoliang Li. (2022) Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 Fragment. mBio 13:1.
Crossref
Evgenii Gusev, Alexey Sarapultsev, Liliya Solomatina & Valeriy Chereshnev. (2022) SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19. International Journal of Molecular Sciences 23:3, pages 1716.
Crossref
Chao Sui, Tongyang Xiao, Shengyuan Zhang, Hongxiang Zeng, Yi Zheng, Bingyu Liu, Gang Xu, Chengjiang Gao & Zheng Zhang. (2022) SARS-CoV-2 NSP13 Inhibits Type I IFN Production by Degradation of TBK1 via p62-Dependent Selective Autophagy. The Journal of Immunology 208:3, pages 753-761.
Crossref
Yi Zheng, Jian Deng, Lulu Han, Meng-Wei Zhuang, Yanwen Xu, Jing Zhang, Mei-Ling Nan, Yang Xiao, Peng Zhan, Xinyong Liu, Chengjiang Gao & Pei-Hui Wang. (2022) SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules. Signal Transduction and Targeted Therapy 7:1.
Crossref
Hong Guo-Parke, Dermot Linden, Sinéad Weldon, Joseph C. Kidney & Clifford C. Taggart. (2022) Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium. Medicina 58:1, pages 121.
Crossref
Raul S. Freitas, Tyler F. Crum & Kislay Parvatiyar. (2022) SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3. Frontiers in Cellular and Infection Microbiology 11.
Crossref
Valeria Lodde, Matteo Floris, Rachel Munk, Jennifer L. Martindale, Davide Piredda, Catello Mario Panu Napodano, Francesco Cucca, Sergio Uzzau, Kotb Abdelmohsen, Myriam Gorospe, Ji Heon Noh & M. Laura Idda. (2022) Systematic identification of NF90 target RNAs by iCLIP analysis. Scientific Reports 12:1.
Crossref
Omkar Indari, Shweta Jakhmola, Dharmendra Kashyap, Budhadev Baral, Tarun Prakash Verma, Khushboo Jain & Hem Chandra Jha. 2022. Frontiers of COVID-19. Frontiers of COVID-19 67 111 .
Nongluk Sriwilaijaroen & Yasuo Suzuki. 2022. Glycovirology. Glycovirology 243 271 .
Sijing Long, Li Yang, Wei Dang, Shuyu Xin, Mingjuan Jiang, Wentao Zhang, Jing Li, Yiwei Wang, Senmiao Zhang & Jianhong Lu. (2021) Cellular Deubiquitylating Enzyme: A Regulatory Factor of Antiviral Innate Immunity. Frontiers in Microbiology 12.
Crossref
Xingyu Li, Zhuo Dong, Yan Liu, Weifeng Song, Jieying Pu, Guanmin Jiang, Yongjian Wu, Lei Liu & Xi Huang. (2021) A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response. Frontiers in Immunology 12.
Crossref
Qi Zhang, Zhiqiang Chen, Chenxiao Huang, Jiuyuan Sun, Minfei Xue, Tingting Feng, Wen Pan, Kezhen Wang & Jianfeng Dai. (2021) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon Response. Frontiers in Cellular and Infection Microbiology 11.
Crossref
Chinmay Saha, Sayantan Laha, Raghunath Chatterjee & Nitai P. Bhattacharyya. (2021) Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico Analysis. Non-Coding RNA 7:4, pages 74.
Crossref
Ahmed A. Al-Karmalawy, Raya Soltane, Ayman Abo Elmaaty, Mohamed A. Tantawy, Samar A. Antar, Galal Yahya, Amani Chrouda, Rami Adel Pashameah, Muhamad Mustafa, Mobarak Abu Mraheil & Ahmed Mostafa. (2021) Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview. Vaccines 9:11, pages 1317.
Crossref
Weiling Li, Jialu Qiao, Qiang You, Shan Zong, Qian Peng, Yuchen Liu, Song Hu, Wei Liu, Shufen Li, Xiji Shu & Binlian Sun. (2021) SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS. Frontiers in Immunology 12.
Crossref
Kiramage Chathuranga, Asela Weerawardhana, Niranjan Dodantenna & Jong-Soo Lee. (2021) Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing. Experimental & Molecular Medicine 53:11, pages 1647-1668.
Crossref
Jin-Yan Li, Zhi-Jian Zhou, Qiong Wang, Qing-Nan He, Ming-Yi Zhao, Ye Qiu & Xing-Yi Ge. (2021) Innate Immunity Evasion Strategies of Highly Pathogenic Coronaviruses: SARS-CoV, MERS-CoV, and SARS-CoV-2. Frontiers in Microbiology 12.
Crossref
Yongzhen Liu, Chao Qin, Youliang Rao, Chau Ngo, Joshua J. Feng, Jun Zhao, Shu Zhang, Ting-Yu Wang, Jessica Carriere, Ali Can Savas, Mehrnaz Zarinfar, Stephanie Rice, Hanging Yang, Weiming Yuan, Julio A. Camarero, Jianhua Yu, Xiaojiang S. Chen, Chao Zhang & Pinghui Feng. (2021) SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response. mBio 12:5.
Crossref
Isabel Pablos, Yoan Machado, Hugo C. Ramos de Jesus, Yasir Mohamud, Reinhild Kappelhoff, Cecilia Lindskog, Marli Vlok, Peter A. Bell, Georgina S. Butler, Peter M. Grin, Quynh T. Cao, Jenny P. Nguyen, Nestor Solis, Srinivas Abbina, Wioletta Rut, John C. Vederas, Laszlo Szekely, Attila Szakos, Marcin Drag, Jayachandran N. Kizhakkedathu, Karen Mossman, Jeremy A. Hirota, Eric Jan, Honglin Luo, Arinjay Banerjee & Christopher M. Overall. (2021) Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome. Cell Reports 37:4, pages 109892.
Crossref
Cheng‐Lung Ku, I‐Ting Chen & Ming‐Zong Lai. (2021) Infection‐induced inflammation from specific inborn errors of immunity to COVID‐19. The FEBS Journal 288:17, pages 5021-5041.
Crossref
Mansi Srivastava, Dwight Hall, Okiemute Beatrice Omoru, Hunter Mathias Gill, Sarah Smith & Sarath Chandra Janga. (2021) Mutational Landscape and Interaction of SARS-CoV-2 with Host Cellular Components. Microorganisms 9:9, pages 1794.
Crossref
Keng-Chang Tsai, Yu-Ching Lee & Tien-Sheng Tseng. (2021) Comprehensive Deep Mutational Scanning Reveals the Immune-Escaping Hotspots of SARS-CoV-2 Receptor-Binding Domain Targeting Neutralizing Antibodies. Frontiers in Microbiology 12.
Crossref
Masaud Shah & Hyun Goo Woo. (2021) Molecular Perspectives of SARS-CoV-2: Pathology, Immune Evasion, and Therapeutic Interventions. Molecules and Cells 44:6, pages 408-421.
Crossref
Nathanael D. Reynolds, Nathalie M. Aceves, Jinny L. Liu, Jaimee R. Compton, Dagmar H. Leary, Brendan T. Freitas, Scott D. Pegan, Katarina Z. Doctor, Fred Y. Wu, Xin Hu & Patricia M. Legler. (2021) The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease. ACS Infectious Diseases 7:6, pages 1483-1502.
Crossref
Thomas Kehrer, Adolfo García-Sastre & Lisa Miorin. (2021) Control of Innate Immune Activation by Severe Acute Respiratory Syndrome Coronavirus 2 and Other Coronaviruses. Journal of Interferon & Cytokine Research 41:6, pages 205-219.
Crossref
Mengjia Wu, Yi Zhang, Mark Grosser, Steven Tipper, Deon Venter, Hua Lin & Jie Lu. (2021) Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics. Frontiers in Research Metrics and Analytics 6.
Crossref
Ruibang Luo, Agnès Delaunay‐Moisan, Kenneth Timmis & Antoine Danchin. (2021) SARS‐CoV ‐2 biology and variants: anticipation of viral evolution and what needs to be done . Environmental Microbiology 23:5, pages 2339-2363.
Crossref
Yajuan Rui, Jiaming Su, Si Shen, Ying Hu, Dingbo Huang, Wenwen Zheng, Meng Lou, Yifei Shi, Meng Wang, Shiqi Chen, Na Zhao, Qi Dong, Yong Cai, Rongzhen Xu, Shu Zheng & Xiao-Fang Yu. (2021) Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins. Signal Transduction and Targeted Therapy 6:1.
Crossref
Yuan-Qin Min, Mengzhuo Huang, Xiulian Sun, Fei Deng, Hualin Wang & Yun-Jia Ning. (2021) Immune evasion of SARS-CoV-2 from interferon antiviral system. Computational and Structural Biotechnology Journal 19, pages 4217-4225.
Crossref
Alessandra C. Setaro & Marta M. Gaglia. (2021) All hands on deck: SARS-CoV-2 proteins that block early anti-viral interferon responses. Current Research in Virological Science 2, pages 100015.
Crossref
Duo Xu, Mahamaya Biswal, Arrmund Neal & Rong Hai. (2021) Devil's tools: SARS-CoV-2 antagonists against innate immunity. Current Research in Virological Science 2, pages 100013.
Crossref