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Emerging Microbes & Infections Volume 10, 2021 - Issue 1
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Antimicrobial Agents

Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin

Xi Jina Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-2981-8581View further author information
ORCID Icon,
Qiong Chend Department of Clinical Laboratory, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-8013-5770View further author information
ORCID Icon,
Fang Shena Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;e Department of Clinical Laboratory, The second Hospital of Shaoxing, Shaoxing, People’s Republic of ChinaView further author information
,
Yan Jianga Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaView further author information
,
Xueqing Wua Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaView further author information
,
Xiaoting Huaa Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-8215-916XView further author information
ORCID Icon,
Ying Fuf Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1177-0871View further author information
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Yunsong Yua Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2903-918XView further author information
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Pages 1129-1136 | Received 02 Feb 2021, Accepted 26 May 2021, Published online: 13 Jun 2021

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Cong Zhou, Hui Zhang, Maosuo Xu, Yajuan Liu, Baoyu Yuan, Yong Lin & Fang Shen. (2023) Within-Host Resistance and Virulence Evolution of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST11 Under Antibiotic Pressure. Infection and Drug Resistance 16, pages 7255-7270.
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Junjun Chen, Huan Zhang & Xuelian Liao. (2023) Hypervirulent Klebsiella pneumoniae. Infection and Drug Resistance 16, pages 5243-5249.
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Yan Jia, Ya Liu, Yilin Huang, Jie Wang, Hanyue Wang, Shu Tan, Yuxin Shi, Qingxia Wang & Jie Peng. (2023) Clinical Characteristics, Drug Resistance, and Risk Factors for Death of Klebsiella pneumoniae Infection in Patients with Acute Pancreatitis: A Single-Center Retrospective Study from China. Infection and Drug Resistance 16, pages 5039-5053.
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Fang Rong, Ziyi Liu, Pengbin Yang, Feng Wu, Yu Sun, Xuewei Sun & Jun Zhou. (2023) Epidemiological and Molecular Characteristics of blaNDM-1 and blaKPC-2 Co-Occurrence Carbapenem-Resistant Klebsiella pneumoniae. Infection and Drug Resistance 16, pages 2247-2258.
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Ruishan Liu, Hao Xu, Junhui Zhao, Xinjun Hu, Lingjiao Wu, Jie Qiao, Haoyu Ge, Xiaobing Guo, Jianjun Gou & Beiwen Zheng. (2023) Emergence of mcr-8.2-harboring hypervirulent ST412 Klebsiella pneumoniae strain from pediatric sepsis: A comparative genomic survey. Virulence 14:1.
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Gabriele Arcari & Alessandra Carattoli. (2023) Global spread and evolutionary convergence of multidrug-resistant and hypervirulent Klebsiella pneumoniae high-risk clones. Pathogens and Global Health 117:4, pages 328-341.
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Min Zhou, Richu Liang, Quan Liao, Pingfu Deng, Wentao Fan & Chenzhuo Li. (2022) Lumbar Cistern Drainage and Gentamicin Intrathecal Injection in the Treatment of Carbapenem-Resistant Klebsiella Pneumoniae Intracranial Infection After Intracerebral Hemorrhage craniotomy: A Case Report. Infection and Drug Resistance 15, pages 6975-6983.
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Xiucai Zhang, Chao Fang, Junfeng Zhang, Wang Hua, Rong He & Mingming Zhou. (2022) Carbapenemase- and Colistin Resistant Escherichia coli Strains from Children in China: High Genetic Diversity and First Report of blaNDM-5, blaCTX-M-65, blaOXA-10, blaTEM-1, and mcr-1.1 Genes Co-Occurrence in E. coli ST156. Infection and Drug Resistance 15, pages 5315-5320.
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Xu Huang, Mingxiao Han, Fei Jin, Zhichen Zhu & Haifang Zhang. (2022) Analysis of a Refractory Case of Pediatric Meningitis Caused by Klebsiella pneumoniae Co-Resistant to Carbapenems and Polymyxins. Infection and Drug Resistance 15, pages 5309-5313.
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Hua Zou, Yan Shen, Chunli Li & Qiuhong Li. (2022) Two Phenotypes of Klebsiella pneumoniae ST147 Outbreak from Neonatal Sepsis with a Slight Increase in Virulence. Infection and Drug Resistance 15, pages 1-12.
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Chao Liu, Pengcheng Du, Ping Yang, Jiajia Zheng, Juan Yi, Ming Lu & Ning Shen. (2023) Emergence and Inter- and Intrahost Evolution of Pandrug-Resistant Klebsiella pneumoniae Coharboring tmexCD1-toprJ1, bla NDM-1 , and bla KPC-2 . Microbiology Spectrum 11:2.
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Suyeon Park, Hyunkeun Kim & Kwan Soo Ko. (2023) Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35. Journal of Biomedical Science 30:1.
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Shuangshuang Li, Xudong Feng, Min Li & Zhen Shen. (2023) In vivo adaptive antimicrobial resistance in Klebsiella pneumoniae during antibiotic therapy. Frontiers in Microbiology 14.
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Lei Zha, Xue Zhang, Yusheng Cheng, Qiancheng Xu, Lingxi Liu, Simin Chen, Zhiwei Lu, Jun Guo & Boris Tefsen. (2023) Intravenous Polymyxin B as Adjunctive Therapy to High-Dose Tigecycline for the Treatment of Nosocomial Pneumonia Due to Carbapenem-Resistant Acinetobacter baumannii and Klebsiella pneumoniae: A Propensity Score-Matched Cohort Study. Antibiotics 12:2, pages 273.
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Jenna M. Kuhn & Yuanpu Peter Di. (2023) Determination of Mutational Timing of Colistin-Resistance Genes through Klebsiella pneumoniae Evolution. Pharmaceutics 15:1, pages 270.
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Qiang Wang, Mengyuan Chen, Qian Ou, Lina Zheng, Xuejing Chen, Guofeng Mao, Jiaqi Fang, Dazhi Jin & Xiaofang Tang. (2022) Carbapenem-resistant hypermucoviscous Klebsiella pneumoniae clinical isolates from a tertiary hospital in China: Antimicrobial susceptibility, resistance phenotype, epidemiological characteristics, microbial virulence, and risk factors. Frontiers in Cellular and Infection Microbiology 12.
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Jinzhu Huang, Miao Yi, Yaling Yuan, Peiwen Xia, Bingxue Yang, Jiajia Liao, Zijun Dang, Shengli Luo & Yun Xia. (2022) Emergence of a Fatal ST11-KL64 Tigecycline-Resistant Hypervirulent Klebsiella pneumoniae Clone Cocarrying bla NDM and bla KPC in Plasmids . Microbiology Spectrum 10:6.
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Reham Omar Yahya. (2022) Problems Associated with Co-Infection by Multidrug-Resistant Klebsiella pneumoniae in COVID-19 Patients: A Review. Healthcare 10:12, pages 2412.
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Shigang Yao, Dawei Wei, Na Tang, Yuqin Song, Chao Wang, Jie Feng & Gang Zhang. (2022) Efficient Suppression of Natural Plasmid-Borne Gene Expression in Carbapenem-Resistant Klebsiella pneumoniae Using a Compact CRISPR Interference System. Antimicrobial Agents and Chemotherapy 66:11.
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Congjuan Xu, Xiaoya Wei, Yongxin Jin, Fang Bai, Zhihui Cheng, Shuiping Chen, Xiaolei Pan & Weihui Wu. (2022) Development of Resistance to Eravacycline by Klebsiella pneumoniae and Collateral Sensitivity-Guided Design of Combination Therapies. Microbiology Spectrum 10:5.
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Xuemei Jiang, Lina ZhaoZhen ShenJunying Zhu. (2022) Emergence of a Hypermucoviscous Klebsiella pneumoniae Strain Coproducing K. pneumoniae Carbapenemase-2 and New Delhi Metallo-β-Lactamase-5 Carbapenemases in Shanghai, China . Microbial Drug Resistance 28:10, pages 980-987.
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Siyi Liu, Yinhuan Ding, Yifei Xu, Zhaoyinqian Li, Zhangrui Zeng & Jinbo Liu. (2022) An outbreak of extensively drug-resistant and hypervirulent Klebsiella pneumoniae in an intensive care unit of a teaching hospital in Southwest China. Frontiers in Cellular and Infection Microbiology 12.
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Wenzhong Peng, Yanhao Wu, Rongli Lu, Yunpeng Zheng, Jie Chen & Pinhua Pan. (2022) Successful treatment of acute respiratory distress syndrome caused by hypervirulent Klebsiella pneumoniae with extracorporeal membrane oxygenation and continuous renal replacement therapy: A case report and literature review. Frontiers in Medicine 9.
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Gilberto G. Gaspar, Gustavo Tamasco, Nathália Abichabki, Ana Flavia T. Scaranello, Maria Auxiliadora-Martins, Renata Pocente, Leonardo N. Andrade, María-Eugenia Guazzaroni, Rafael Silva-Rocha & Valdes R. Bollela. (2022) Nosocomial Outbreak of Extensively Drug-Resistant (Polymyxin B and Carbapenem) Klebsiella pneumoniae in a Collapsed University Hospital Due to COVID-19 Pandemic. Antibiotics 11:6, pages 814.
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Chenlu Xiao, Yan Zhu, Zhitao Yang, Dake Shi, Yuxing Ni, Li Hua & Jian Li. (2022) Prevalence and Molecular Characteristics of Polymyxin-Resistant Pseudomonas aeruginosa in a Chinese Tertiary Teaching Hospital. Antibiotics 11:6, pages 799.
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Lilan Sun, Lang Sun, Xue Li, Xinxin Hu, Xiukun Wang, Tongying Nie, Youwen Zhang & Xuefu You. (2022) A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae. Frontiers in Cellular and Infection Microbiology 11.
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Yawei Zhang, Xiaojuan Wang, Shifu Wang, Shijun Sun, Henan Li, Hongbin Chen, Qi Wang & Hui Wang. (2021) Emergence of Colistin Resistance in Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Under the Pressure of Tigecycline. Frontiers in Microbiology 12.
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Yawei Zhang, Xiaojuan Wang, Qi Wang, Hongbin Chen, Henan Li, Shuyi Wang, Ruobing Wang & Hui Wang. (2021) Emergence of Tigecycline Nonsusceptible and IMP-4 Carbapenemase-Producing K2-ST65 Hypervirulent Klebsiella pneumoniae in China. Microbiology Spectrum 9:2.
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Yingying Kong, Qingyang Sun, Hangfei Chen, Mohamed S. Draz, Xinyou Xie, Jun Zhang & Zhi Ruan. (2021) Transmission Dynamics of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Strains Carrying Capsular Loci KL64 and rmpA/rmpA2 Genes. Frontiers in Microbiology 12.
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