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Emerging Microbes & Infections Volume 10, 2021 - Issue 1
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Coronaviruses

Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants

Danwei YuNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Yuanmei ZhuNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4515-6864View further author information
ORCID Icon,
Tao JiaoNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Tong WuNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Xia XiaoNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Bo QinNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Huihui ChongNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Xiaobo LeiNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Lili RenNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Sheng CuiNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence[email protected]
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Jianwei WangNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1116-4559View further author information
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Yuxian HeNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1227-1240 | Received 27 Apr 2021, Accepted 26 May 2021, Published online: 18 Jun 2021

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Yuanmei Zhu, Xiaojing Dong, Nian Liu, Tong Wu, Huihui Chong, Xiaobo Lei, Lili Ren, Jianwei Wang & Yuxian He. (2022) SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including Omicron. Emerging Microbes & Infections 11:1, pages 1819-1827.
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Gino Castillo, Juan Carlos Mora-Díaz, Mary Breuer, Pallavi Singh, Rahul K Nelli & Luis G Giménez-Lirola. (2023) Molecular mechanisms of human coronavirus NL63 infection and replication. Virus Research 327, pages 199078.
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Yue Hu, Yuanmei Zhu, Yanying Yu, Nian Liu, Xiaohui Ju, Qiang Ding & Yuxian He. (2023) Design and characterization of novel SARS-CoV-2 fusion inhibitors with N-terminally extended HR2 peptides. Antiviral Research 212, pages 105571.
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Kohei Tsuji, Kofi Baffour-Awuah Owusu, Yutaro Miura, Takahiro Ishii, Kouki Shinohara, Takuya Kobayakawa, Akino Emi, Takashi Nakano, Youichi Suzuki & Hirokazu Tamamura. (2023) Dimerized fusion inhibitor peptides targeting the HR1–HR2 interaction of SARS-CoV-2. RSC Advances 13:13, pages 8779-8793.
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Yuanmei Zhu, Min Li, Nian Liu, Tong Wu, Xuelian Han, Guangyu Zhao & Yuxian He. (2023) Development of highly effective LCB1-based lipopeptides targeting the spike receptor-binding motif of SARS-CoV-2. Antiviral Research 211, pages 105541.
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Titus A. Olukitibi, Zhujun Ao, Bryce Warner, Rodrigo Unat, Darwyn Kobasa & Xiaojian Yao. (2023) Significance of Conserved Regions in Coronavirus Spike Protein for Developing a Novel Vaccine against SARS-CoV-2 Infection. Vaccines 11:3, pages 545.
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Yuanmei Zhu, Yue Hu, Nian Liu, Huihui Chong & Yuxian He. (2022) Potent inhibition of diverse Omicron sublineages by SARS-CoV-2 fusion-inhibitory lipopeptides. Antiviral Research 208, pages 105445.
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Tong Wu, Yuanmei Zhu, Nian Liu, Yue Hu, Huihui Chong & Yuxian He. (2022) Resistance profile and mechanism of severe acute respiratory syndrome coronavirus-2 variants to LCB1 inhibitor targeting the spike receptor-binding motif. Frontiers in Microbiology 13.
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Navid Tamjid, Sedigheh Eskandari, Zeinab Karimi, Navid Nezafat & Manica Negahdaripour. (2022) Vaccinomics strategy to design an epitope peptide vaccine against Helicobacter pylori. Process Biochemistry 121, pages 380-395.
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F. Sacchetta, D. Graf, H. Laqua, M. A. Ambroise, J. Kussmann, A. Dreuw & C. Ochsenfeld. (2022) An effective sub-quadratic scaling atomic-orbital reformulation of the scaled opposite-spin RI-CC2 ground-state model using Cholesky-decomposed densities and an attenuated Coulomb metric. The Journal of Chemical Physics 157:10.
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