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Emerging Microbes & Infections Volume 10, 2021 - Issue 1
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Research Article

A single-amino-acid mutation at position 225 in hemagglutinin attenuates H5N6 influenza virus in mice

Xingtian Konga College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, People’s Republic of China;b State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
,
Lizheng Guanb State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
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Jianzhong Shib State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
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Huihui Kongb State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
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Yaping Zhangb State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
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Xianying Zengb State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
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Guobin Tianb State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
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Liling Liub State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
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Chengjun Lib State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaView further author information
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Yoshihiro Kawaokac Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, JapanView further author information
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Guohua Dengb State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaCorrespondence[email protected]
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&
Hualan Chena College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, People’s Republic of China;b State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaCorrespondence[email protected]
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Pages 2052-2061 | Received 20 Aug 2021, Accepted 20 Oct 2021, Published online: 07 Nov 2021

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Pengfei Cui, Jianzhong Shi, Congcong Wang, Yuancheng Zhang, Xin Xing, Huihui Kong, Cheng Yan, Xianying Zeng, Liling Liu, Guobin Tian, Chengjun Li, Guohua Deng & Hualan Chen. (2022) Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China. Emerging Microbes & Infections 11:1, pages 1693-1704.
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Wenli Gu, Jianzhong Shi, Pengfei Cui, Cheng Yan, Yaping Zhang, Congcong Wang, Yuancheng Zhang, Xin Xing, Xianying Zeng, Liling Liu, Guobin Tian, Yasuo Suzuki, Chengjun Li, Guohua Deng & Hualan Chen. (2022) Novel H5N6 reassortants bearing the clade 2.3.4.4b HA gene of H5N8 virus have been detected in poultry and caused multiple human infections in China. Emerging Microbes & Infections 11:1, pages 1174-1185.
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Kaituo Liu, Yaqian Guo, Huafen Zheng, Zhuxing Ji, Miao Cai, Ruyi Gao, Pinghu Zhang, Xiaowen Liu, Xiulong Xu, Xiaoquan Wang & Xiufan Liu. (2023) Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K. Virologica Sinica 38:1, pages 47-55.
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Conghui Zhao, Jing Guo, Xianying Zeng, Jianzhong Shi, Guohua Deng, Yaping Zhang, Yanwen Wang, Qi Ma, Xinxin Gao, Pengfei Cui, Liling Liu, Xuyong Li & Hualan Chen. (2022) Novel H7N7 avian influenza viruses detected in migratory wild birds in eastern China between 2018 and 2020. Microbes and Infection 24:8, pages 105013.
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Hongyu Chen, Hongqi Liu & Xiaozhong Peng. (2022) Reverse genetics in virology: A double edged sword. Biosafety and Health 4:5, pages 303-313.
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Wentao Shen, Qian Wang, Zhengxiang Wang, Minxuan Liu, Yingying Du, Lvfeng Yuan, Lu Han, Krzysztof Smietanka, Hualan Chen, Shuai Xu & Qiyun Zhu. (2022) Specific Monoclonal Antibodies Targeting Unique HA Epitopes Block H7N9 Influenza A Viral Replication. Journal of Virology 96:18.
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Honglei Sun, Guojing Deng, Haoran Sun, Jingwei Song, Wei Zhang, Han Li, Xiaohui Wei, Fangtao Li, Xin Zhang, Jiyu Liu, Juan Pu, Yipeng Sun, Qi Tong, Yuhai Bi, Yufeng Xie, Jianxun Qi, Kin-Chow Chang, George Fu Gao & Jinhua Liu. (2022) N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals. PNAS Nexus 1:3.
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