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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Coronaviruses

Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro

Binli Maoa Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
,
Vu Thuy Khanh Le-Trillingb Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyView further author information
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Kai Wanga Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-0137-1247View further author information
ORCID Icon,
Denise Mennerichb Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyView further author information
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Jie Hua Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
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Zhenyu Zhaoa Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
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Jiaxin Zhenga Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
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Yingying Denga Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
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Benjamin Katschinskib Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyView further author information
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Shilei Xuc Department of General Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
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Guiji Zhanga Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
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Xuefei Caia Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
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Yuan Hua Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-0038-1574View further author information
ORCID Icon,
Jianwei Wangd Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
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Mengji Lub Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyView further author information
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Ailong Huanga Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
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Ni Tanga Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Mirko Trillingb Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyCorrespondence[email protected]
View further author information
&
Yong Lina Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence[email protected]
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Pages 483-497 | Received 06 Aug 2021, Accepted 05 Jan 2022, Published online: 10 Feb 2022

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Changqing Yu, Guosheng Wang, Qiang Liu, Jingbo Zhai, Mengzhou Xue, Qiang Li, Yuanhua Xian & Chunfu Zheng. (2023) Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage. Emerging Microbes & Infections 12:1.
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Laith Ashour. (2023) Roles of the ACE/Ang II/AT1R pathway, cytokine release, and alteration of tight junctions in COVID-19 pathogenesis. Tissue Barriers 11:2.
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German A. Islan, Boris Rodenak-Kladniew, Nehuen Noacco, Nelson Duran & Guillermo R. Castro. (2022) Prodigiosin: a promising biomolecule with many potential biomedical applications. Bioengineered 13:6, pages 14227-14258.
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