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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Antimicrobial Agents

Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance

Jochem B. Buila Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands;b Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, NetherlandsCorrespondence[email protected]
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Jason D. Oliverc F2G Ltd, Manchester, UKView further author information
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Derek Lawc F2G Ltd, Manchester, UKView further author information
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Tim Baltussena Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, NetherlandsView further author information
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Jan Zolla Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands;b Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, NetherlandsView further author information
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Margriet W. J. Hokkena Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, NetherlandsView further author information
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Marlou Tehupeiory-Kooremana Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands;b Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, NetherlandsView further author information
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Willem J. G. Melchersa Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands;b Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, NetherlandsView further author information
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Mike Birchc F2G Ltd, Manchester, UKView further author information
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Paul E. Verweija Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands;b Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, NetherlandsView further author information
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Pages 703-714 | Received 30 Nov 2021, Accepted 23 Jan 2022, Published online: 01 Mar 2022

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Chin Fen Neoh, Wirawan Jeong, David CM Kong & Monica A Slavin. (2023) The antifungal pipeline for invasive fungal diseases: what does the future hold?. Expert Review of Anti-infective Therapy 21:6, pages 577-594.
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Articles from other publishers (20)

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Emily Puumala, David Sychantha, Elizabeth Lach, Shawn Reeves, Sunna Nabeela, Meea Fogal, AkshatKumar Nigam, Jarrod W. Johnson, Alán Aspuru-Guzik, Rebecca S. Shapiro, Priya Uppuluri, Subha Kalyaanamoorthy, Jakob Magolan, Luke Whitesell, Nicole Robbins, Gerard D. Wright & Leah E. Cowen. (2024) Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chemical Biology 31:4, pages 760-775.e17.
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Lisa Kriegl, Matthias Egger, Johannes Boyer, Martin Hoenigl & Robert Krause. (2024) New treatment options for critically important WHO fungal priority pathogens. Clinical Microbiology and Infection.
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Norman van Rhijn, Isabelle S. R. Storer, Mike Birch, Jason D. Oliver, Michael J. Bottery & Michael J. Bromley. (2023) Aspergillus fumigatus strains that evolve resistance to the agrochemical fungicide ipflufenoquin in vitro are also resistant to olorofim. Nature Microbiology 9:1, pages 29-34.
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Corinne Pinder, Ressa Lebedinec, Tim P. Levine, Mike Birch & Jason D. Oliver. (2023) Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species. PLOS ONE 18:8, pages e0289441.
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Victor Michel, Nizar Mahlaoui, Marie Elisabeth Bougnoux, Dea Garcia-Hermoso, Fanny Lanternier & Romain Lévy. (2023) Prolonged Remission of Azole-Resistant Lung Aspergillosis with Olorofim, in an Adolescent with X-Linked Chronic Granulomatous Disease. Journal of Clinical Immunology 43:6, pages 1170-1172.
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Iacopo Franconi, Cosmeri Rizzato, Noemi Poma, Arianna Tavanti & Antonella Lupetti. (2023) Candida parapsilosis Sensu Stricto Antifungal Resistance Mechanisms and Associated Epidemiology. Journal of Fungi 9:8, pages 798.
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Hideo Ishii. (2023) New chemical fungicides in relation to risk for resistance development. Tropical Plant Pathology 49:1, pages 18-35.
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Amanda Bombassaro, Bram Spruijtenburg, Fernanda Medeiros, Bruna Jacomel Favoreto de Souza Lima, Luana Beatriz Ballardin, Marconi Rodrigues de Farias, Vania Aparecida Vicente, Flavio de Queiroz‐Telles, Jacques F. Meis & Theun de Groot. (2023) Genotyping and antifungal susceptibility testing of Sporothrix brasiliensis isolates from Southern Brazil . Mycoses 66:7, pages 585-593.
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Cléa Melenotte, Vishukumar Aimanianda, Monica Slavin, José María Aguado, Darius Armstrong‐James, Yee‐Chun Chen, Shahid Husain, Christian Van Delden, Faouzi Saliba, Agnès Lefort, Francoise Botterel & Olivier Lortholary. (2023) Invasive aspergillosis in liver transplant recipients. Transplant Infectious Disease 25:3.
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Paloma Osset-Trénor, Amparo Pascual-Ahuir & Markus Proft. (2023) Fungal Drug Response and Antimicrobial Resistance. Journal of Fungi 9:5, pages 565.
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Ricardo Cruz & William M. Wuest. (2023) Beyond ergosterol: Strategies for combatting antifungal resistance in Aspergillus fumigatus and Candida auris. Tetrahedron 133, pages 133268.
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Norman van Rhijn, Sam Hemmings, Isabelle S. R. Storer, Clara Valero, Hajer Bin Shuraym, Gustavo H. Goldman, Fabio Gsaller, Jorge Amich & Michael J. Bromley. (2022) Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus. mBio 13:6.
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Pilar Escribano, Ana Gómez, Elena Reigadas, Patricia Muñoz & Jesús Guinea. (2022) EUCAST-Obtained Olorofim MICs against Aspergillus and Scedosporium Species and Lomentospora prolificans Showed High Agreements between Visual Inspection and Spectrophotometric Readings. Antimicrobial Agents and Chemotherapy 66:9.
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Neil A. R. Gow, Carolyn Johnson, Judith Berman, Alix T. Coste, Christina A. Cuomo, David S. Perlin, Tihana Bicanic, Thomas S. Harrison, Nathan Wiederhold, Mike Bromley, Tom Chiller & Keegan Edgar. (2022) The importance of antimicrobial resistance in medical mycology. Nature Communications 13:1.
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Pilar Escribano, Ana Gómez, Elena Reigadas, Patricia Muñoz & Jesús Guinea. (2022) In vitro activity of olorofim against Aspergillus fumigatus sensu lato clinical isolates: activity is retained against isolates showing resistance to azoles and/or amphotericin B. Clinical Microbiology and Infection 28:9, pages 1291.e7-1291.e10.
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Nathan P. Wiederhold. (2022) Pharmacodynamics, Mechanisms of Action and Resistance, and Spectrum of Activity of New Antifungal Agents. Journal of Fungi 8:8, pages 857.
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