Advanced search
Publication Cover
Emerging Microbes & Infections Volume 11, 2022 - Issue 1
Submit an article Journal homepage
5,736
Views
52
CrossRef citations to date
0
Altmetric
Influenza infections

Novel H5N6 reassortants bearing the clade 2.3.4.4b HA gene of H5N8 virus have been detected in poultry and caused multiple human infections in China

Wenli Gua State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Jianzhong Shia State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Pengfei Cuia State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Cheng Yana State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Yaping Zhanga State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Congcong Wanga State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Yuancheng Zhanga State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Xin Xinga State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Xianying Zenga State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Liling Liua State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Guobin Tiana State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaView further author information
,
Yasuo Suzukic Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, JapanView further author information
,
Chengjun Lia State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of China;b Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, People’s Republic of ChinaView further author information
,
Guohua Denga State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Hualan Chena State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of China;b Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
 show all
Pages 1174-1185 | Received 09 Feb 2022, Accepted 03 Apr 2022, Published online: 25 Apr 2022

Citations (52)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (11)

Yingying Du, Jun Xia, Zhengxiang Wang, Jie Xu, Yanhong Ji, Yinghong Jin, Ling Pu & Shuai Xu. (2024) Evolution of H6N6 viruses in China between 2014 and 2019 involves multiple reassortment events. Emerging Microbes & Infections 13:1.
Read now
Bao Tuan Duong, Seon Ju Yeo & Hyun Park. (2024) Identification of specific neutralizing antibodies for highly pathogenic avian influenza H5 2.3.4.4b clades to facilitate vaccine design and therapeutics. Emerging Microbes & Infections 13:1.
Read now
Yubo Zhao, Pucheng Chen, Yuzhen Hu, Jing Liu, Yongping Jiang, Xianying Zeng, Guohua Deng, Jianzhong Shi, Yanbing Li, Guobin Tian, Jinxiong Liu & Hualan Chen. (2024) Recombinant duck enteritis virus bearing the hemagglutinin genes of H5 and H7 influenza viruses is an ideal multivalent live vaccine in ducks. Emerging Microbes & Infections 13:1.
Read now
Xin Xing, Jianzhong Shi, Pengfei Cui, Cheng Yan, Yaping Zhang, Yuancheng Zhang, Congcong Wang, Yuan Chen, Xianying Zeng, Guobin Tian, Liling Liu, Yuntao Guan, Chengjun Li, Yasuo Suzuki, Guohua Deng & Hualan Chen. (2024) Evolution and biological characterization of H5N1 influenza viruses bearing the clade 2.3.2.1 hemagglutinin gene. Emerging Microbes & Infections 13:1.
Read now
Jung-Hoon Kwon, Kateri Bertran, Dong-Hun Lee, Miria Ferreira Criado, Lindsay Killmaster, Mary J. Pantin-Jackwood & David E. Swayne. (2023) Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens. Emerging Microbes & Infections 12:1.
Read now
Yanwen Wang, Mengjing Wang, Hong Zhang, Conghui Zhao, Yaping Zhang, Jinyan Shen, Xiaohong Sun, Hongke Xu, Yujiao Xie, Xinxin Gao, Pengfei Cui, Dong Chu, Yubao Li, Wenqiang Liu, Peng Peng, Guohua Deng, Jing Guo & Xuyong Li. (2023) Prevalence, evolution, replication and transmission of H3N8 avian influenza viruses isolated from migratory birds in eastern China from 2017 to 2021. Emerging Microbes & Infections 12:1.
Read now
Jianzhong Shi, Xianying Zeng, Pengfei Cui, Cheng Yan & Hualan Chen. (2023) Alarming situation of emerging H5 and H7 avian influenza and effective control strategies. Emerging Microbes & Infections 12:1.
Read now
Wanchen Zhao, Xin Liu, Xinyu Zhang, Zhiwei Qiu, Jun Jiao, Yang Li, Ruyi Gao, Xiaoquan Wang, Jiao Hu, Xiaowen Liu, Shunlin Hu, Xinan Jiao, Daxin Peng, Min Gu & Xiufan Liu. (2023) Virulence and transmission characteristics of clade 2.3.4.4b H5N6 subtype avian influenza viruses possessing different internal gene constellations. Virulence 14:1.
Read now
Wenjun Shi, Zhibo Shan, Li Jiang, Guangwen Wang, Xuyuan Wang, Yu Chang, Yuzhen Hu, Bo Wang, Qibing Li, Yihan Wang, Guohua Deng, Jianzhong Shi, Yongping Jiang, Xianying Zeng, Guobin Tian, Hualan Chen & Chengjun Li. (2023) ABTB1 facilitates the replication of influenza A virus by counteracting TRIM4-mediated degradation of viral NP protein. Emerging Microbes & Infections 12:2.
Read now
Libing Zhang, Kaituo Liu, Qin Su, Xiao Chen, Xiaoquan Wang, Qingfeng Li, Wenlei Wang, Xuhua Mao, Jinmei Xu, Xin Zhou, Qin Xu, Le Zhou, Xiufan Liu & Pinghu Zhang. (2022) Clinical features of the first critical case of acute encephalitis caused by the avian influenza A (H5N6) virus. Emerging Microbes & Infections 11:1, pages 2437-2446.
Read now
Pengfei Cui, Jianzhong Shi, Congcong Wang, Yuancheng Zhang, Xin Xing, Huihui Kong, Cheng Yan, Xianying Zeng, Liling Liu, Guobin Tian, Chengjun Li, Guohua Deng & Hualan Chen. (2022) Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China. Emerging Microbes & Infections 11:1, pages 1693-1704.
Read now

Articles from other publishers (41)

Yujie HouGuohua DengPengfei CuiXianying ZengBin LiDongxue WangXinwen HeCheng YanYaping ZhangJiongjie LiJinming MaYanbing LiXiurong WangGuobin TianHuihui KongLijie TangYasuo SuzukiJianzhong Shi & Hualan Chen. (2024) Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination. Emerging Microbes & Infections.
Crossref
Siru Lin, Junhong Chen, Ke Li, Yang Liu, Siyuan Fu, Shumin Xie, Aimin Zha, Aiguo Xin, Xinyu Han, Yuting Shi, Lingyu Xu, Ming Liao & Weixin Jia. (2024) Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses, China, 2021–2022. Virologica Sinica.
Crossref
Ji-Yun Kim, Sol Jeong, Da-Won Kim, Dong-Wook Lee, Dong-Hun Lee, Daehun Kim & Jung-Hoon Kwon. (2024) Genomic epidemiology of highly pathogenic avian influenza A (H5N1) virus in wild birds in South Korea during 2021–2022: Changes in viral epidemic patterns. Virus Evolution 10:1.
Crossref
Alice Fusaro, José L. Gonzales, Thijs Kuiken, Gražina Mirinavičiūtė, Éric Niqueux, Karl Ståhl, Christoph Staubach, Olov Svartström, Calogero Terregino, Katriina Willgert, Francesca Baldinelli, Roxane Delacourt, Alexandros Georganas & Lisa Kohnle. (2024) Avian influenza overview December 2023–March 2024. EFSA Journal 22:3.
Crossref
Xianying Zeng, Jianzhong Shi & Hualan Chen. (2024) Control of highly pathogenic avian influenza through vaccination1. Journal of Integrative Agriculture.
Crossref
Yuzhen Hu, Li Jiang, Guangwen Wang, Yangming Song, Zhibo Shan, Xuyuan Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Hualan Chen & Chengjun Li. (2023) M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes. Science China Life Sciences 67:3, pages 579-595.
Crossref
Siqi Tang, Bing Han, Chaofan Su, Hailing Li, Shiyuchen Zhao, Haoyu Leng, Yali Feng & Ying Zhang. (2024) Wild Bird-Origin H6N2 Influenza Virus Acquires Enhanced Pathogenicity after Single Passage in Mice. Viruses 16:3, pages 357.
Crossref
Ima Fauziah, Herjuno Ari Nugroho, Nova Dilla Yanthi, Rida Tiffarent & Sugiyono Saputra. (2024) Potential zoonotic spillover at the human–animal interface: A mini-review. Veterinary World, pages 289-302.
Crossref
Nadezhda B. Rudometova, Anastasia A. Fando, Lyubov A. Kisakova, Denis N. Kisakov, Mariya B. Borgoyakova, Victoria R. Litvinova, Vladimir A. Yakovlev, Elena V. Tigeeva, Danil I. Vahitov, Sergey V. Sharabrin, Dmitriy N. Shcherbakov, Veronika I. Evseenko, Ksenia I. Ivanova, Andrei S. Gudymo, Tatiana N. Ilyicheva, Vasiliy Yu. Marchenko, Alexander A. Ilyichev, Andrey P. Rudometov & Larisa I. Karpenko. (2024) Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus. Vaccines 12:2, pages 143.
Crossref
Zhannan Wang, Yingkai He, Wenfeng Wang, Yawen Tian, Chongbo Ge, Futing Jia, Tongyu Zhang, Gerui Zhang, Mingyue Wang, Jinshuo Gong, Haibin Huang, Jianzhong Wang, Chunwei Shi, Wentao Yang, Xin Cao, Yan Zeng, Nan Wang, Aidong Qian, Yanlong Jiang, Guilian Yang & Chunfeng Wang. (2023) A novel “prime and pull” strategy mediated by the combination of two dendritic cell-targeting designs induced protective lung tissue-resident memory T cells against H1N1 influenza virus challenge. Journal of Nanobiotechnology 21:1.
Crossref
Cornelia Adlhoch, Alice Fusaro, José L. Gonzales, Thijs Kuiken, Gražina Mirinavičiūtė, Éric Niqueux, Karl Ståhl, Christoph Staubach, Calogero Terregino, Katriina Willgert, Francesca Baldinelli, Kateryna Chuzhakina, Roxane Delacourt, Alexandros Georganas, Milen Georgiev & Lisa Kohnle. (2023) Avian influenza overview September–December 2023. EFSA Journal 21:12.
Crossref
Zhanfei Yan, You Li, Shujian Huang & Feng Wen. (2023) Global distribution, receptor binding, and cross-species transmission of H6 influenza viruses: risks and implications for humans. Journal of Virology 97:11.
Crossref
Xu Zhou, Siwen Wang, Yue Ma, Yanbing Li, Guohua Deng, Jianzhong Shi & Xiurong Wang. (2023) Rapid detection of avian influenza virus based on CRISPR-Cas12a. Virology Journal 20:1.
Crossref
Lisa Bauer, Feline F.W. Benavides, Edwin J.B. Veldhuis Kroeze, Emmie de Wit & Debby van Riel. (2023) The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans. Trends in Neurosciences 46:11, pages 953-970.
Crossref
Pengfei Cui, Jianzhong Shi, Cheng Yan, Congcong Wang, Yuancheng Zhang, Yaping Zhang, Xin Xing, Yuan Chen, Jie Zhang, Liling Liu, Xianying Zeng, Guobin Tian, Chengjun Li, Yasuo Suzuki, Guohua Deng & Hualan Chen. (2023) Analysis of avian influenza A (H3N8) viruses in poultry and their zoonotic potential, China, September 2021 to May 2022. Eurosurveillance 28:41.
Crossref
Cornelia Adlhoch, Alice Fusaro, José L Gonzales, Thijs Kuiken, Gražina Mirinavičiūtė, Éric Niqueux, Christoph Staubach, Calogero Terregino, Francesca Baldinelli, Alessia Rusinà & Lisa Kohnle. (2023) Avian influenza overview June–September 2023. EFSA Journal 21:10.
Crossref
Ana Marandino, Gonzalo Tomás, Yanina Panzera, Carmen Leizagoyen, Ramiro Pérez, Lucía Bassetti, Raúl Negro, Sirley Rodríguez & Ruben Pérez. (2023) Spreading of the High-Pathogenicity Avian Influenza (H5N1) Virus of Clade 2.3.4.4b into Uruguay. Viruses 15:9, pages 1906.
Crossref
Hai Xu, Shanyuan Zhu, Roshini Govinden & Hafizah Y. Chenia. (2023) Multiple Vaccines and Strategies for Pandemic Preparedness of Avian Influenza Virus. Viruses 15:8, pages 1694.
Crossref
Jiqing Li, Guohua Deng, Jianzhong Shi, Yaping Zhang, Xianying Zeng, Guobin Tian, Yongping Jiang, Liling Liu, Huihui Kong & Hualan Chen. (2023) Genetic and Biological Characterization of H3N2 Avian Influenza Viruses Isolated from Poultry Farms in China between 2019 and 2021. Transboundary and Emerging Diseases 2023, pages 1-13.
Crossref
Liuke Sun, Huihui Kong, Mengmeng Yu, Zhenyu Zhang, Haili Zhang, Lei Na, Yuxing QuYuan Zhang, Hualan Chen & Xiaojun Wang. (2023) The SUMO-interacting motif in NS2 promotes adaptation of avian influenza virus to mammals. Science Advances 9:28.
Crossref
Jingman Tian, Xiaoli Bai, Minghui Li, Xianying Zeng, Jia Xu, Peng Li, Miao Wang, Xingdong Song, Zhiguo Zhao, Guobin Tian, Liling Liu, Yuntao Guan, Yanbing Li & Hualan Chen. (2023) Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021. Emerging Infectious Diseases 29:7.
Crossref
Cornelia Adlhoch, Alice Fusaro, José L Gonzales, Thijs Kuiken, Angeliki Melidou, Gražina Mirinavičiūtė, Éric Niqueux, Karl Ståhl, Christoph Staubach, Calogero Terregino, Francesca Baldinelli, Alessandro Broglia & Lisa Kohnle. (2023) Avian influenza overview April – June 2023. EFSA Journal 21:7.
Crossref
Sheng Chen, Shuqun Shen, Yutao Teng, Ruoying Li, Xinheng Zhang, Jiajia Liu, Zhiqiang Wu, Zhuanqiang Yan, Feng Chen & Qingmei Xie. (2023) A Novel Triple Reassortment H3N8 Avian Influenza Virus: Characteristics, Pathogenicity, and Transmissibility. Transboundary and Emerging Diseases 2023, pages 1-14.
Crossref
Pan Huang, Lujia Sun, Jinhao Li, Qingyi Wu, Nima Rezaei, Shibo Jiang & Chungen Pan. (2023) Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and universal influenza vaccines. Cell Discovery 9:1.
Crossref
Zhuoliang He, Xia Wang, Yu Lin, Siyu Feng, Xinyu Huang, Luxiang Zhao, Junsheng Zhang, Yangbao Ding, Weiqiang Li, Runyu Yuan & Peirong Jiao. (2023) Genetic characteristics of waterfowl-origin H5N6 highly pathogenic avian influenza viruses and their pathogenesis in ducks and chickens. Frontiers in Microbiology 14.
Crossref
Cornelia Adlhoch, Alice Fusaro, José L Gonzales, Thijs Kuiken, Grazina Mirinaviciute, Éric Niqueux, Karl Stahl, Christoph Staubach, Calogero Terregino, Alessandro Broglia, Lisa Kohnle & Francesca Baldinelli. (2023) Avian influenza overview March – April 2023. EFSA Journal 21:6.
Crossref
Shicheng Zhang, Jianhao Yang, Defang Zhou, Tianxing Yan, Gen Li, Xiaojing Hao, Qi Yang, Xiangyu Cheng, Hengyang Shi, Qing Liu, Yubao Li & Ziqiang Cheng. (2023) Development of a DAS–ELISA for Gyrovirus Homsa1 Prevalence Survey in Chickens and Wild Birds in China. Veterinary Sciences 10:5, pages 312.
Crossref
Li Jiang, Hualan Chen & Chengjun Li. (2023) Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins. Cell Insight 2:2, pages 100079.
Crossref
Ruikun Du, Qinghua Cui, Zinuo Chen, Xiujuan Zhao, Xiaojing Lin & Lijun Rong. (2023) Revisiting influenza A virus life cycle from a perspective of genome balance. Virologica Sinica 38:1, pages 1-8.
Crossref
Fei Meng, Yan Chen, Zuchen Song, Qiu Zhong, Yijie Zhang, Chuanling Qiao, Cheng Yan, Huihui Kong, Liling Liu, Chengjun Li, Huanliang Yang & Hualan Chen. (2022) Continued evolution of the Eurasian avian-like H1N1 swine influenza viruses in China. Science China Life Sciences 66:2, pages 269-282.
Crossref
Ahmed Kandeil, Ahmed Kayed, Yassmin Moatasim, Basma Emad Aboulhoda, Ahmed Nageh El Taweel, Omnia Kutkat, Mohamed El Sayes, Mokhtar Gomaa, Rabeh El-Shesheny, Richard Webby, Ghazi Kayali & Mohamed A. Ali. (2023) Molecular identification and virological characteristics of highly pathogenic avian influenza A/H5N5 virus in wild birds in Egypt. Microbial Pathogenesis 174, pages 105928.
Crossref
Yanwen Wang, Hong Zhang, Mengjing Wang, Jing Guo, Conghui Zhao, Pengfei Cui, Guohua Deng, Dong Chu, Jinyan Shen, Xiaohong Sun, Xinxin Gao, Yubao Li, Wenqiang Liu, Peng Peng & Xuyong Li. (2022) Genetic Analysis of a Novel H16N3 Virus Isolated from a Migratory Gull in China in 2021 and Animal Studies of Infection. Microbiology Spectrum 10:6.
Crossref
Pirom Noisumdaeng, Juthamas Phadungsombat, Sasrinakarn Weerated, Witthawat Wiriyarat & Pilaipan Puthavathana. (2022) Genetic evolution of hemagglutinin and neuraminidase genes of H5N1 highly pathogenic avian influenza viruses in Thailand. PeerJ 10, pages e14419.
Crossref
Yong-Myung Kang, Hyun-Kyu Cho, Sung-Jun An, Hyun-Jun Kim, Youn-Jeong Lee & Hyun-Mi Kang. (2022) Updating the National Antigen Bank in Korea: Protective Efficacy of Synthetic Vaccine Candidates against H5Nx Highly Pathogenic Avian Influenza Viruses Belonging to Clades 2.3.2.1 and 2.3.4.4. Vaccines 10:11, pages 1860.
Crossref
Xinyu Miao, Mingcan Feng, Ouwen Zhu, Fan Yang, Yinyan Yin, Yuncong Yin, Sujuan Chen, Tao Qin, Daxin Peng & Xiufan Liu. (2022) H5N8 Subtype avian influenza virus isolated from migratory birds emerging in Eastern China possessed a high pathogenicity in mammals. Transboundary and Emerging Diseases 69:6, pages 3325-3338.
Crossref
Conghui Zhao, Jing Guo, Xianying Zeng, Jianzhong Shi, Guohua Deng, Yaping Zhang, Yanwen Wang, Qi Ma, Xinxin Gao, Pengfei Cui, Liling Liu, Xuyong Li & Hualan Chen. (2022) Novel H7N7 avian influenza viruses detected in migratory wild birds in eastern China between 2018 and 2020. Microbes and Infection 24:8, pages 105013.
Crossref
Xianliang Ke, Zhongzi Yao, Yangyu Tang, Mengting Yang, Yong Li, Guoxiang Yang, Jing Chen, Guang Chen, Wei Feng, Hesong Zheng & Quanjiao Chen. (2022) Highly Pathogenic Avian Influenza A (H5N1) Virus in Swans, Central China, 2021. Microbiology Spectrum 10:5.
Crossref
Hanlin Liu, Changrong Wu, Zifeng Pang, Rui Zhao, Ming Liao & Hailiang Sun. (2022) Phylogenetic and Phylogeographic Analysis of the Highly Pathogenic H5N6 Avian Influenza Virus in China. Viruses 14:8, pages 1752.
Crossref
Junhong Chen, Lingyu Xu, Tengfei Liu, Shumin Xie, Ke Li, Xiao Li, Mengmeng Zhang, Yifan Wu, Xinkai Wang, Jinfeng Wang, Keyi Shi, Beibei Niu, Ming Liao & Weixin Jia. (2022) Novel Reassortant Avian Influenza A(H5N6) Virus, China, 2021. Emerging Infectious Diseases 28:8, pages 1703-1707.
Crossref
Xian-ying ZENG, Xin-wen HE, Fei MENG, Qi MA, Yan WANG, Hong-mei BAO, Yan-jing LIU, Guo-hua DENG, Jian-zhong SHI, Yan-bing LI, Guo-bin TIAN & Hua-lan CHEN. (2022) Protective efficacy of an H5/H7 trivalent inactivated vaccine (H5-Re13, H5-Re14, and H7-Re4 strains) in chickens, ducks, and geese against newly detected H5N1, H5N6, H5N8, and H7N9 viruses. Journal of Integrative Agriculture 21:7, pages 2086-2094.
Crossref
Lin Ding, Jie Li, Xue Li & Bingqian Qu. (2022) Evolutionary and Mutational Characterization of the First H5N8 Subtype Influenza A Virus in Humans. Pathogens 11:6, pages 666.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.