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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Coronaviruses

Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trial

Álvaro Sánchez Barruecoa ENT and Cervicofacial Surgery Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain;b ENT and Cervicofacial Surgery Department, Villalba General University Hospital, Collado Villalba, SpainORCID Iconhttps://orcid.org/0000-0002-7919-5765View further author information
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María Victoria Mateos-Morenoc Department of Dental Clinical Specialties, School of Dentistry, Madrid Complutense University, Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-8237-4596View further author information
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Yolanda Martínez-Beneytod Department of Dermatology, Stomatology and Radiology, University of Murcia, Murcia, Spain;e Murcian Institute of Biosanitary Research (IMIB), Murcia, SpainORCID Iconhttps://orcid.org/0000-0002-1523-9415View further author information
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Elisa García-Vázquezf Infectious Diseases Unit, Virgen de la Arrixaca University Clinical Hospital, IMIB, Murcia, SpainView further author information
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Alfonso Campos Gonzáleza ENT and Cervicofacial Surgery Department, Fundación Jiménez Díaz University Hospital, Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-7742-7497View further author information
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Javier Zapardiel Ferrerog Microbiology Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain;h Villalba General University Hospital, Collado Villalba, SpainView further author information
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Abel Bogoya Castañoa ENT and Cervicofacial Surgery Department, Fundación Jiménez Díaz University Hospital, Madrid, SpainView further author information
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Ignacio Alcalá Ruedab ENT and Cervicofacial Surgery Department, Villalba General University Hospital, Collado Villalba, SpainORCID Iconhttps://orcid.org/0000-0003-3309-187XView further author information
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José Miguel Villacampa Aubáa ENT and Cervicofacial Surgery Department, Fundación Jiménez Díaz University Hospital, Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-1321-007XView further author information
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Carlos Cenjor Española ENT and Cervicofacial Surgery Department, Fundación Jiménez Díaz University Hospital, Madrid, SpainView further author information
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Laura Moreno-Parradoi Microbiology Service, Murcian Institute of Biosanitary Research, Virgen de la Arrixaca University Clinical Hospital, Murcia, SpainView further author information
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Verónica Ausina-Márquezj Department of Dentistry, European University of Valencia, Valencia, SpainView further author information
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Sandra García-Estebank Genomics & Health Department, FISABIO-Public Health Foundation, Valencia, SpainView further author information
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Alejandro Artachok Genomics & Health Department, FISABIO-Public Health Foundation, Valencia, SpainView further author information
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F. Xavier López-Labradork Genomics & Health Department, FISABIO-Public Health Foundation, Valencia, Spain;l Department of Microbiology and Ecology, Medical School, University of Valencia, Valencia, Spain;m CIBER in Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-9403-8258View further author information
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Alex Mirak Genomics & Health Department, FISABIO-Public Health Foundation, Valencia, Spain;m CIBER in Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9127-3877View further author information
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María D. Ferrerk Genomics & Health Department, FISABIO-Public Health Foundation, Valencia, SpainORCID Iconhttps://orcid.org/0000-0002-4521-1632View further author information
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Pages 1833-1842 | Received 05 Apr 2022, Accepted 30 Jun 2022, Published online: 27 Jul 2022

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Alvaro Sánchez Barrueco, María Victoria Mateos-Moreno, José Miguel Villacampa Aubá, Alfonso Campos González, Abel Bogoya Castaño, Raúl Rubio Yanguas, Asier Blanco Goñi, Javier Zapardiel Ferrero, Carlos Cenjor Español, Verónica Ausina Márquez, Sandra García-Esteban, Alejandro Artacho, F. Xavier López Labrador, Alex Mira & María D. Ferrer. (2023) In vivo effect of mouthwashes on viable viral load of SARS-CoV-2 in saliva: a pilot study. Journal of Oral Microbiology 15:1.
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Daisuke Onozuka, Satoko Takatera, Hiroo Matsuo, Hisao Yoshida, Shigeto Hamaguchi, Shungo Yamamoto, Ryuichi Minoda Sada, Koichiro Suzuki, Keiji Konishi & Satoshi Kutsuna. (2024) Oral mouthwashes for asymptomatic to mildly symptomatic adults with COVID-19 and salivary viral load: a randomized, placebo-controlled, open-label clinical trial. BMC Oral Health 24:1.
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Sasha R. Weller, John E. Burnell, Brandon M. Aho, Bright Obeng, Emily L. Ledue, Juyoung K. Shim, Samuel T. Hess & Julie A. Gosse. (2024) Antimicrobial cetylpyridinium chloride causes functional inhibition of mitochondria as potently as canonical mitotoxicants, nanostructural disruption of mitochondria, and mitochondrial Ca2+ efflux in living rodent and primary human cells. Food and Chemical Toxicology 186, pages 114547.
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Giulia Brunello, Viktoria Wolf, Robert Kerberger, Michael Bernhard, Nadine Lübke, Jürgen Becker, Beryl Schwarz‐Herzke, Jörg Timm & Kathrin Becker. (2023) Eligibility and efficacy of a CPC‐ and CHX ‐based antiviral mouthwash for the elimination of SARS‐CoV ‐2 from the saliva: A randomized, double‐blind, controlled clinical trial . Journal of Clinical Periodontology 51:2, pages 158-166.
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Leticia M. Bezinelli, Luciana Corrêa, Stephany Beyerstedt, Marcella L. Franco, Érika B. Rangel, Carlos Guillermo Benítez, Nelson Hamerschlak, João R.R. Pinho, Debora Heller & Fernanda P. Eduardo. (2023) Reduction of SARS-CoV-2 viral load in saliva after rinsing with mouthwashes containing cetylpyridinium chloride: a randomized clinical study. PeerJ 11, pages e15080.
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Luca Sbricoli, Lucia Schiavon, Giulia Brunello, Paola Brun, Kathrin Becker & Stefano Sivolella. (2023) Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis. Japanese Dental Science Review 59, pages 334-356.
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Zoë Brookes, Leanne Teoh, Fabian Cieplik & Purnima Kumar. (2023) Mouthwash Effects on the Oral Microbiome: Are They Good, Bad, or Balanced?. International Dental Journal 73, pages S74-S81.
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Mingrui Zhang, Nan Meng, Hong Duo, Yuanbo Yang, Qing Dong & Jianqi Gu. (2023) Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis. BMC Infectious Diseases 23:1.
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Bright Obeng, Christian M. Potts, Bailey E. West, John E. Burnell, Patrick J. Fleming, Juyoung K. Shim, Marissa S. Kinney, Emily L. Ledue, Suraj Sangroula, Alan Y. Baez Vazquez & Julie A. Gosse. (2023) Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilization. Food and Chemical Toxicology 179, pages 113980.
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Miriam Ting, Alex Dahlkemper, Jeremy J. Schwartz, Manzel Woodfork & Jon B. Suzuki. (2023) Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review. Biomedicines 11:6, pages 1694.
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E.L. Bonn, A. Rohrhofer, F.X. Audebert, H. Lang, D.L. Auer, K.J. Scholz, P. Schuster, J.J. Wenzel, K.-A. Hiller, W. Buchalla, J.M. Gottsauner, V. Vielsmeier, B. Schmidt & F. Cieplik. (2023) Efficacy of a Mouthwash Containing CHX and CPC in SARS-CoV-2–Positive Patients: A Randomized Controlled Clinical Trial. Journal of Dental Research 102:6, pages 608-615.
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Filippo D'Amico, Matteo Moro, Marco Saracino, Marilena Marmiere, Maria Bernadette Cilona, Graham Lloyd‐Jones & Alberto Zangrillo. (2023) Efficacy of Cetylpyridinium Chloride mouthwash against SARS‐CoV‐2: A systematic review of randomized controlled trials. Molecular Oral Microbiology 38:3, pages 171-180.
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David Herrera, Mariano Sanz, Lior Shapira, Carlos Brotons, Iain Chapple, Thomas Frese, Filippo Graziani, F. D. Richard Hobbs, Olivier Huck, Eva Hummers, Søren Jepsen, Oleg Kravtchenko, Phoebus Madianos, Ana Molina, Mehmet Ungan, Josep Vilaseca, Adam Windak & Shlomo Vinker. (2023) Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology ( EFP ) and the European arm of the World Organization of Family Doctors ( WONCA Europe) . Journal of Clinical Periodontology 50:6, pages 819-841.
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Fridus Van der Weijden. (2023) Aerosol in the oral health-care setting: a misty topic. Clinical Oral Investigations 27:S1, pages 23-32.
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Johanna Weber, Eva L. Bonn, David L. Auer, Christian Kirschneck, Wolfgang Buchalla, Konstantin J. Scholz & Fabian Cieplik. (2023) Preprocedural mouthwashes for infection control in dentistry—an update. Clinical Oral Investigations 27:S1, pages 33-44.
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Tom Jefferson, Liz Dooley, Eliana Ferroni, Lubna A Al-Ansary, Mieke L van Driel, Ghada A Bawazeer, Mark A Jones, Tammy C Hoffmann, Justin Clark, Elaine M Beller, Paul P Glasziou & John M Conly. (2023) Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database of Systematic Reviews 2023:4.
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Claudio Mendes PANNUTI, Isabella Neme Ribeiro dos REIS, Nathalia Vilela SOUZA, Maria Luisa Silveira SOUTO, Carlos Guillermo Benítez SILVA, Leticia Mello BEZINELLI, Clarisse Martins MACHADO, Giuseppe Alexandre ROMITO & Cristina Cunha VILLAR. (2023) Efficacy of mouthrinses in reducing oral SARS-COV-2 load: a review. Brazilian Oral Research 37.
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Pardis Ziaeefar, Narjes Bostanghadiri, Parsa Yousefzadeh, Julian Gabbay, Amir Hashem Shahidi Bonjar, Mitra Ghazizadeh Ahsaie, Rosella Centis, Mohammad Sabeti, Giovanni Sotgiu, Giovanni Battista Migliori & Mohammad Javad Nasiri. (2022) The efficacy of mouthwashes in reducing SARS-CoV-2 viral loads in human saliva: A systematic review. New Microbes and New Infections 49-50, pages 101064.
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