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Review

Herbal Immunomodulators in Aquaculture

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Keep up to date with the latest research on this topic with citation updates for this article.

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Shabana Shameem M.Karthika Mayavan & Ramasubramanian Venkatachalam. (2023) Influence of quercetin loaded mesoporous silica nanoparticles (QMSNs) on immunity and diseases resistance in Nile tilapia (Oreochromis niloticus). Journal of Applied Aquaculture 35:3, pages 585-604.
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Mohsen Abdel-Tawwab, Talal Abo Selema, Mahmoud Abotaleb, Riad Khalil, Ashraf Soliman, Nader Sabry, Ali Gouda, Nashwa Abdel-Razek, Elsayed Eldessouki, Suzan El-Werwary, Hend El-Saftawy, Adel H. Saad, Ibrahim H. Ibrahim & Sherien Shady. (2023) Dietary effects of Sanacore® GM on productive performance, immune-antioxidative status, cytokines, and resistance of European sea bass to Vibrio alginolyticus infection. Journal of Applied Aquaculture 0:0, pages 1-21.
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Ehsan Ahmadifar, Morteza Yousefi, Msoumeh Karimi, Raha Fadaei Raieni, Maryam Dadar, Sevdan Yilmaz, Mahmoud A. O. Dawood & Hany M. R. Abdel-Latif. (2021) Benefits of Dietary Polyphenols and Polyphenol-Rich Additives to Aquatic Animal Health: An Overview. Reviews in Fisheries Science & Aquaculture 29:4, pages 478-511.
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Articles from other publishers (98)

Yan Zhou, Lei Liu, Chenguang Song, Yang Hu & Jiong Chen. (2024) The potent potential of Gentiana Macrophylla pall aqueous extract in protecting largemouth bass against Micropterus Salmoides Rhabdovirus: A promising application of herbal crude extract in the fight against MSRV. Aquaculture 578, pages 740069.
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Wendy Wee, Noor Khalidah Abdul Hamid, Khairiyah Mat, Raja Ili Airina Raja Khalif, Nor Dini Rusli, Mohammad Mijanur Rahman, Muhammad Anamul Kabir & Lee Seong Wei. (2024) The effects of mixed prebiotics in aquaculture: A review. Aquaculture and Fisheries 9:1, pages 28-34.
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Jesús Roldan-Juarez, Rubén Pinares, Carlos E. Smith, Cielo A. Llerena, Virgilio Machaca & Dante M. Pizarro. (2023) Microencapsulated essential oils influence the growth and foregut histomorphometry of Nile tilapia (Oreochromis niloticus) fingerlings. Veterinary and Animal Science 22, pages 100316.
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Ebtehal E. Hussein, Mahmoud M. Habiba, Ahmed M. Ashry, Ahmed M. Al-Zayat, Islam I. Teiba, Akram Ismael Shehata, Shimaa A. Shahin, Ibrahim Talat El-Ratel, Kumbukani Mzengereza, Mavuto Tembo & Mohammed F. El Basuini. (2023) Effects of dietary supplementation with organic acids mixture on growth, feed efficiency, hematobiochemical parameters, immunity, and intestinal microbiota of Gilthead seabream (Sparus aurata) juveniles. Aquaculture Reports 33, pages 101846.
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Jinbiao Jiao, Jiayun Yao, Feng Lin, Xuemei Yuan, Lei Huang, Jing Chen, Xianqi Peng, Haiqi Zhang & Shengqi Su. (2023) The Infection Properties of Trionyx sinensis Hemorrhagic Syndrome Virus and the Antiviral Effect of Curcumin In Vivo. Animals 13:23, pages 3665.
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Qi Wang, Jinqiang Huang, Yongjuan Li, Shenji Wu, Lu Zhao, Yucai Pan, Yujun Kang & Zhe Liu. (2023) Chinese herbal medicines mixture improved antioxidant enzymes, immunity and disease resistance to infectious hematopoietic necrosis virus infection in rainbow trout (Oncorhynchus mykiss). Aquaculture International.
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Yan Zhou, Tian-Xiu Qiu, Huan Wang, Ling Hu, Lei Liu & Jiong Chen. (2023) Application of rhein as an immunostimulant controls spring viremia of carp virus infection. Fish & Shellfish Immunology 142, pages 109128.
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Mingxiang Lu, Renzhi Liu, Zhifei Chen, Chen Su & Luqing Pan. (2023) Effects of dietary dihydromyricetin on growth performance, antioxidant capacity, immune response and intestinal microbiota of shrimp (Litopenaeus vannamei). Fish & Shellfish Immunology 142, pages 109086.
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Zahra Yazdani, Mehdi Shamsaie Mehrgan, Jina Khayatzadeh, Seyed Pezhman Hosseini Shekarabi & Masoud Homayouni Tabrizi. (2023) Dietary green-synthesized curcumin-mediated zinc oxide nanoparticles promote growth performance, haemato-biochemical profile, antioxidant status, immunity, and carcass quality in Nile tilapia (Oreochromis niloticus). Aquaculture Reports 32, pages 101717.
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Thi Cam Tu Phan, Thi Kim Lien Nguyen, Thi Phuong Thao Truong, Thi Tuyet Ngan Pham, Truong Giang Huynh & Xuan Diep Doan. (2023) Effects of noni fruit extract on the growth performance, digestive enzymes, and stress tolerance of juvenile whiteleg shrimp (Litopenaeus vannamei). The Egyptian Journal of Aquatic Research.
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Ibrahim Adeshina, Bilal Ahamad Paray, Eijaz Ahmed Bhat, Aishat D. Ibrahim & Lateef O. Tiamiyu. (2023) Stimulatory effect of dietary alpha‐lipoic acid on growth performance, antioxidant capacity, liver enzymes, immunity and protection of African catfish, Clarias gariepinus (B.), Edwardsiella tarda infection . Journal of Animal Physiology and Animal Nutrition.
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Ghasem Rashidian, Mahyar Zare, Hamidreza Tabibi, Vlastimil Stejskal & Caterina Faggio. (2023) The synergistic effects of four medicinal plant seeds and chelated minerals on the growth, immunity, and antioxidant capacity of rainbow trout (Oncorhynchus mykiss). Fish & Shellfish Immunology 139, pages 108930.
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Saeed Hajirezaee, Ahmad Rafieepour & Mohammad Hossein Khanjani. (2023) Ameliorating effects of gingko, Ginkgo biloba extract on waterborne toxicity of Titanium dioxide nanoparticles (TiO2) in the Rainbow trout, Oncorhynchus mykiss: Growth, histology, oxidative stress, immunity, antioxidant defense and liver function. Aquaculture Reports 31, pages 101635.
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To Dinh Phuc, Nguyen Thuy Huong, Pham Thi Thu Dan, Bui Thi Hong Linh & Truong Van Mui. (2023) Effect from Combinations of Yucca schidigera extract with Bacillus Strains on the Growth of White Leg Shrimp (Penaeus vannamei), Density of Vibrio sp., and on the Ammonia and Nitrite Content of Culture Water. Journal of Pure and Applied Microbiology.
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Saeed Hajirezaee & Mohammad Hossein Khanjani. (2023) Rosmarinic acid alone or in combination with Lactobacillus rhamnosus ameliorated resistance to ammonia stress in the rainbow trout, Oncorhynchus mykiss : growth, immunity, antioxidant defense and liver functions . Annals of Animal Science 23:3, pages 819-831.
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Saefudin, Ratu Safitri & Tri Handayani. (2023) A review article effect of immersion Curcuma xanthorriza Roxb. extract for the survival of goldfish seed (Cyprinus carpio L.) after being infected with Aeromonas hydrophila. IOP Conference Series: Earth and Environmental Science 1211:1, pages 012021.
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Hamed Ghafarifarsani, Maryam Aftabgard, Seyed Hossein Hoseinifar, Mahdieh Raeeszadeh & Hien Van Doan. (2023) Comparative effects of savory (Satureja hortensis), dill (Anethum graveolens), and mooseer (Allium hirtifolium) essential oils on growth, digestive, and immunoantioxidant parameters and resistance to Aeromonas hydrophila in juvenile common carp (Cyprinus carpio). Aquaculture 572, pages 739541.
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Hiam Elabd, Heba H. Mahboub, Shimaa M. R. Salem, Abdelwahab M. Abdelwahab, Khairiah Mubarak Alwutayd, Mohamed Shaalan, Sameh H. Ismail, Abdelfattah M. Abdelfattah, A. Khalid, Abdallah Tageldein Mansour, Heba S. Hamed & Hadeer Youssuf. (2023) Nano-Curcumin/Chitosan Modulates Growth, Biochemical, Immune, and Antioxidative Profiles, and the Expression of Related Genes in Nile tilapia, Oreochromis niloticus. Fishes 8:7, pages 333.
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Guanglu Liu, Lili Zhu, Yi Wu, Chunjie Wang, Yunsheng Wang, Qiushuo Zheng, Mengyao Tian, Haitong Wang & Ya-Hong Chen. (2023) Herbal active small molecule as an immunomodulator for potential application on resistance of common carp against SVCV infection. Fish & Shellfish Immunology 137, pages 108782.
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Morteza Yousefi, Hossein Adineh, Maryam Ghadamkheir, Seyed Amir Mahdi Hashemianfar & Sevdan Yilmaz. (2023) Effects of dietary Pennyroyal essential oil on growth performance, digestive enzymes’ activity, and stress responses of common carp, Cyprinus carpio. Aquaculture Reports 30, pages 101574.
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Morteza Yousefi, Seyyed Morteza Hoseini, Evgeny Vladimirovich Kulikov, Nikolay Valerievich Babichev, Marina Vladimirovna Bolshakova, Marina Ivanovna Shopinskaya, Roman Vasilievich Rogov & Andrey Nikolaevich Zharov. (2023) Effects of dietary pomegranate peel supplementation on growth performance and biochemical responses of common carp, Cyprinus carpio, to chronic crowding stress. Aquaculture Reports 30, pages 101532.
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Afaf D. Abdelmagid, Alshaimaa M. Said, Eman A. Abd El-Gawad, Sara A. Shalaby & Mahmoud A. O. Dawood. (2022) Glyphosate-induced liver and kidney dysfunction, oxidative stress, immunosuppression in Nile tilapia, but ginger showed a protection role. Veterinary Research Communications 47:2, pages 445-455.
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Daniel Leonardo Cala Delgado, Linda Lucia Castillo Caceres, Sebastián Alexander Cely Gómez & Aníbal Domínguez Odio. (2023) Effect of dietary garlic (Allium sativum) on the zootechnical performance and health indicators of aquatic animals: A mini-review. Veterinary World, pages 965-976.
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Sevdan Yilmaz, Ekrem Şanver Çelik, Sebahattin Ergün, Ehsan Ahmadifar & Hany M.R. Abdel-Latif. (2023) Effects of dietary walnut (Juglans regia) leaves extract on immunity, gene expression responses, and disease resistance in Oreochromis niloticus. Fish & Shellfish Immunology 135, pages 108656.
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Gamal A. Gabr, Yousif Saleh Ibrahim, Sarmad Ghazi Al-Shawi, Munther Abosaooda, Jitendra Gupta, Khulood H. Oudaha, Khudargan Mavlonov, Abduladheem Turki Jalil, Karkaz M. Thalij, Yasser Fakri Mustafa, Mohammad Khodadadi & Mahnaz Dadras. (2023) Single or combined consumption of resveratrol and the probiotic, Lactobacillus acidophilus attenuate the effects of crowding stress on growth, immune characteristics, and antioxidant defense in the common carp, (Cyprinus carpio). Aquaculture Reports 29, pages 101471.
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Mehmet Arif Zoral. (2022) Medicinal plants: are they safe enough for fish health?. Aquaculture International 31:2, pages 1077-1096.
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Sofia Vardali, Christina Papadouli, George Rigos, Ioannis Nengas, Panagiota Panagiotaki & Eleni Golomazou. (2023) Recent Advances in Mycotoxin Determination in Fish Feed Ingredients. Molecules 28:6, pages 2519.
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César Estay-Moyano, José M. Mazón-Suastegui, Edgar Zapata-Vívenes, César Lodeiros & Jesus Simal-Gandara. (2023) Evaluation of Moringa oleifera and corn starch as feed for seed production of the pearl oyster Pteria sterna (Gould,1851). Aquaculture 567, pages 739259.
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Zahra Sourani, Sadegh Shirian, Shafigh Shafiei, Nadia Mosayebi & Amin Nematollahi. (2023) Modulation of Immune-Related Gene Expressions in Zebrafish (Danio rerio) by Dietary Purslane (Portulaca oleracea) Extract. Marine Biotechnology 25:1, pages 214-221.
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Sib Sankar Giri, Sang Guen Kim, Kang Jeong Woo, Won Joon Jung, Sung Bin Lee, Young Min Lee, Su Jin Jo, Mae Hyun Hwang, JaeHong Park, Ji Hyung Kim, Sukumaran V & Se Chang Park. (2023) Effects of Bougainvillea glabra leaf on growth, skin mucosal immune responses, and disease resistance in common carp Cyprinus carpio. Fish & Shellfish Immunology 132, pages 108514.
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Paula Senff, Björn Baßmann, Frederik Kaiser, Harvey Harbach, Christophe Robin & Pascal Fontaine. (2022) Root‐released organic compounds in aquaponics and their potential effects on system performance. Reviews in Aquaculture.
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Mohsen Abdel‐Tawwab, Talal A. M. Abo Selema, Ashraf M. Soliman, Sherien H. H. Shady & Riad H. Khalil. (2022) Effects of a commercial feed additive (Sanacore® GM ) on water quality, productive performance and blood profile of gilthead seabream ( Sparus aurata ) . Aquaculture Research 53:17, pages 6310-6323.
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Noer Kasanah, Maria Ulfah & David C. Rowley. (2022) Natural products as antivibrio agents: insight into the chemistry and biological activity. RSC Advances 12:53, pages 34531-34547.
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Abdallah S. Salah, Sahar H. El-Nagar, Ahmed Elsheshtawy, Ibtesam Al-Dhuayan, Alamira Marzouk Fouad, Mashael M. Alnamshan, Hossam I. Kadira, Nouf K. Alaqeel, Set A. El-Shobokshy, Mustafa Shukry & Hanan H. Abd-Elhafeez. (2022) Exploring the multimodal role of Cnicus benedictus extract in the modulation of growth, hematobiochemical, histopathological, antioxidative performance, and immune-related gene expression of Oreochromis niloticus challenged with Aeromonas hydrophila. Frontiers in Marine Science 9.
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Seerengaraj Vijayaram, Yun-Zhang Sun, Antonio Zuorro, Hamed Ghafarifarsani, Hien Van Doan & Seyed Hossein Hoseinifar. (2022) Bioactive immunostimulants as health-promoting feed additives in aquaculture: A review. Fish & Shellfish Immunology 130, pages 294-308.
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Morteza Yousefi, Seyyed Morteza Hoseini, Behrooz Abtahi, Yury Anatolyevich Vatnikov, Evgeny Vladimirovich Kulikov & Natalya Yurievna Rodionova. (2022) Effects of dietary methanolic extract of hyssop, Hyssopus officinalis, on growth performance, hepatic antioxidant, humoral and intestinal immunity, and intestinal bacteria of rainbow trout, Oncorhynchus mykiss. Frontiers in Marine Science 9.
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Hiam Elabd, Hadeer Youssuf, Heba H. Mahboub, Shimaa M.R. Salem, Walaa A. Husseiny, A. Khalid, Heba S. El-Desouky & Caterina Faggio. (2022) Growth, hemato-biochemical, immune-antioxidant response, and gene expression in Nile tilapia (Oreochromis niloticus) received nano iron oxide-incorporated diets. Fish & Shellfish Immunology 128, pages 574-581.
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Ehsan Ahmadifar, Sedigheh Mohammadzadeh, Naser Kalhor, Morteza Yousefi, Mohsen Shahriari Moghadam, Watcharapong Naraballobh, Mehdi Ahmadifar, Seyed Hossein Hoseinifar & Hien Van Doan. (2022) Cornelian cherry (Cornus mas L.) fruit extract improves growth performance, disease resistance, and serum immune-and antioxidant-related gene expression of common carp (Cyprinus carpio). Aquaculture 558, pages 738372.
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Moisés Villanueva, Guillermo Espinosa-Reyes, Rogelio Flores-Ramirez, Angel Natanael Rojas-Velazquez, Juan Carlos García López, Anayeli Vazquez-Valladolid, José Alejandro Roque-Jimenez, German D. Mendoza-Martinez, Pedro A. Hernandez-Garcia, Monika Palacios-Martinez, Alfonso J. Chay-Canul & Héctor A. Lee-Rangel. (2022) Herbal Vitamin C Prevents DNA Oxidation and Modifies the Metabolomic Water Profile of Tilapia (Oreochromis spp.). Life 12:8, pages 1243.
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Aracely Zúñiga-Serrano, Hugo B. Barrios-García, Robin C. Anderson, Michael E. Hume, Miguel Ruiz-Albarrán, Yuridia Bautista-Martínez, Nadia A. Sánchez-Guerra, José Vázquez-Villanueva, Fidel Infante-Rodríguez & Jaime Salinas-Chavira. (2022) Antimicrobial and Digestive Effects of Yucca schidigera Extracts Related to Production and Environment Implications of Ruminant and Non-Ruminant Animals: A Review. Agriculture 12:8, pages 1198.
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Kannan Mohan, Durairaj Karthick Rajan, Thirunavukkarasu Muralisankar, Abirami Ramu Ganesan, Kasi Marimuthu & Palanivel Sathishkumar. (2022) The potential role of medicinal mushrooms as prebiotics in aquaculture: A review. Reviews in Aquaculture 14:3, pages 1300-1332.
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Hamed Ghafarifarsani, Morteza Yousefi, Seyed Hossein Hoseinifar, Marina Paolucci, Chompunut Lumsangkul, Sanchai Jaturasitha & Hien Van Doan. (2022) Beneficial effects of Persian shallot (Allium hirtifolium) extract on growth performance, biochemical, immunological and antioxidant responses of rainbow trout Oncorhynchus mykiss fingerlings. Aquaculture 555, pages 738162.
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Omid Rezaei, Mehdi Shamsaie Mehrgan & Hamed Paknejad. (2022) Dietary garlic (Allium sativum) powder improved zootechnical performance, digestive enzymes activity, and innate immunity in narrow-clawed crayfish (Postantacus leptodactylus). Aquaculture Reports 24, pages 101129.
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Muhammad Safwan Ahamad Bustamam, Hamza Ahmed Pantami, Amalina Ahmad Azam, Khozirah Shaari, Chong Chou Min & Intan Safinar Ismail. (2022) The Immunostimulant Effects of Isochrysis galbana Supplemented Diet on the Spleen of Red Hybrid Tilapia (Oreochromis spp.) Evaluated by Nuclear Magnetic Resonance Metabolomics. Aquaculture Nutrition 2022, pages 1-22.
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Sarmad Ghazi Al-Shawi, Asraa Yacoob Yousif, Zena Kadhim Al-Younis, Rustem Adamovich Shichiyakh, Angelina Olegovna Zekiy & Saeid Shahbazi Naserabad. (2022) Dietary silymarin, Silybum marianum extract ameliorates cadmium chloride toxicity in common carp, Cyprinus carpio . Annals of Animal Science 22:2, pages 741-750.
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Nada M. A. Hashem, Mai A. M. El‐Son, Ahmed I. Ateya & Rasha M. Saleh. (2022) Impact of lactoferrin supplementation on oxidative stress, gene expression and immunity dysfunction induced by  Aeromonas veronii in Nile tilapia ( Oreochromis niloticus ) . Aquaculture Research 53:6, pages 2392-2407.
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Zixue Guo, Ling Li, Yue Wang, Tianyu Liu, Yu Xie, Dongsheng Jia, Zhencai Yang, Peiyu Zhang & Haiyan Liu. (2022) Dietary Chinese herbal extract mixture improves reproductive performance and external quality of fertilized eggs in Chinese soft-shelled turtle (Pelodiscus sinensis) broodstock. Aquaculture Reports 23, pages 101072.
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Jeyaraj Jeyavani, Ashokkumar Sibiya, Jeyachandran Sivakamavalli, Mani Divya, Elumalai Preetham, Baskaralingam Vaseeharan & Caterina Faggio. (2022) Phytotherapy and combined nanoformulations as a promising disease management in aquaculture: a review. Aquaculture International 30:2, pages 1071-1086.
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Mahmoud A. O. Dawood, Mohammed F. El Basuini, Sevdan Yilmaz, Hany M. R. Abdel-Latif, Mahmoud Alagawany, Zulhisyam Abdul Kari, Mohammad Khairul Azhar Abdul Razab, Noor Khalidah Abdul Hamid, Tossapol Moonmanee & Hien Van Doan. (2022) Exploring the Roles of Dietary Herbal Essential Oils in Aquaculture: A Review. Animals 12:7, pages 823.
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Hany M.R. Abdel-Latif, Mahmoud A.O. Dawood, Mahmoud Alagawany, Caterina Faggio, Joanna Nowosad & Dariusz Kucharczyk. (2022) Health benefits and potential applications of fucoidan (FCD) extracted from brown seaweeds in aquaculture: An updated review. Fish & Shellfish Immunology 122, pages 115-130.
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Ghasem Rashidian, Khalid Shahin, Gehad E. Elshopakey, Heba H. Mahboub, Azin Fahim, Hiam Elabd, Marko D. Prokić & Caterina Faggio. (2022) The Dietary Effects of Nutmeg (Myristica fragrans) Extract on Growth, Hematological Parameters, Immunity, Antioxidant Status, and Disease Resistance of Common Carp (Cyprinus carpio) against Aeromonas hydrophila. Journal of Marine Science and Engineering 10:3, pages 325.
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Hwa Yong Oh, Tae Hoon Lee, Da-Yeon Lee, Chang-Hwan Lee, Min-Soo Joo, Hee Sung Kim & Kyoung-Duck Kim. (2022) Dietary Supplementation with Ginger (Zingiber officinale) Residue from Juice Extraction Improves Juvenile Black Rockfish (Sebastes schlegelii) Growth Performance, Antioxidant Enzyme Activity and Resistance to Streptococcus iniae Infection. Animals 12:5, pages 546.
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