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Cogent Chemistry Volume 4, 2018 - Issue 1
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Research Article

Intact NIST monoclonal antibody characterization—Proteoforms, glycoforms—Using CE-MS and CE-LIF

Chien-Hsun ChenThermo Fisher Scientific, Chromatography and Mass Spectrometry, 355 River Oaks Parkway, San Jose, CA95134, USA;Thermo Fisher Scientific, Life Science Solutions, 180 Oyster Point Parkway, South San Francisco, CA94080, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2620-5066View further author information
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Huatao FengDepartment of Chemistry, National University of Singapore, Science Drive 3, SingaporeS117543, SingaporeCorrespondence[email protected]
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Rui GuoDepartment of Chemistry, National University of Singapore, Science Drive 3, SingaporeS117543, SingaporeCorrespondence[email protected]
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Pingjing LiDepartment of Chemistry, National University of Singapore, Science Drive 3, SingaporeS117543, SingaporeCorrespondence[email protected]
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Anna Karen C. LasernaDepartment of Chemistry, National University of Singapore, Science Drive 3, SingaporeS117543, SingaporeCorrespondence[email protected]
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Ya JiDepartment of Chemistry, National University of Singapore, Science Drive 3, SingaporeS117543, SingaporeCorrespondence[email protected]
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Bao Hui NgDepartment of Chemistry, National University of Singapore, Science Drive 3, SingaporeS117543, SingaporeCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4946-3623View further author information
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Sam Fong Yau LiDepartment of Chemistry, National University of Singapore, Science Drive 3, SingaporeS117543, SingaporeCorrespondence[email protected]
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Shaheer H. KhanThermo Fisher Scientific, Life Science Solutions, 180 Oyster Point Parkway, South San Francisco, CA94080, USACorrespondence[email protected]
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Aran PaulusThermo Fisher Scientific, Chromatography and Mass Spectrometry, 355 River Oaks Parkway, San Jose, CA95134, USACorrespondence[email protected]
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Shiaw-Min ChenThermo Fisher Scientific, Life Science Solutions, 180 Oyster Point Parkway, South San Francisco, CA94080, USACorrespondence[email protected]
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Achim E. KargerThermo Fisher Scientific, Life Science Solutions, 180 Oyster Point Parkway, South San Francisco, CA94080, USACorrespondence[email protected]
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Michael WenzThermo Fisher Scientific, Life Science Solutions, 180 Oyster Point Parkway, South San Francisco, CA94080, USACorrespondence[email protected]
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Daniel Lopez FerrerThermo Fisher Scientific, Chromatography and Mass Spectrometry, 355 River Oaks Parkway, San Jose, CA95134, USACorrespondence[email protected]
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Andreas F. HuhmerThermo Fisher Scientific, Chromatography and Mass Spectrometry, 355 River Oaks Parkway, San Jose, CA95134, USACorrespondence[email protected]
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Andreas KrupkeThermo Fisher Scientific, Life Science Solutions, 180 Oyster Point Parkway, South San Francisco, CA94080, USACorrespondence[email protected]
[email protected] [email protected]
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Kishore CholkarCustopharm Inc, USAView further author information
(Reviewing editor) show all
Article: 1480455 | Received 27 Mar 2018, Accepted 21 May 2018, Published online: 17 Jun 2018

Citations (25)

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Rafael D. Melani, Kristina Srzentić, Vincent R. Gerbasi, John P. McGee, Romain Huguet, Luca Fornelli & Neil L. Kelleher. (2019) Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry. mAbs 11:8, pages 1351-1357.
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Xiaoyue Song, Huairu Tian & Guolin Zhang. Application of capillary electrophoresis-sodium dodecyl sulfate in assessing the purity of monoclonal antibody biopharmaceuticals. Journal of Liquid Chromatography & Related Technologies 0:0, pages 1-11.
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Articles from other publishers (23)

Katarína Maráková, Martina Opetová & Radovan Tomašovský. (2023) Capillary electrophoresis‐mass spectrometry for intact protein analysis: Pharmaceutical and biomedical applications (2018–March 2023). Journal of Separation Science 46:15.
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Hassan A. Alhazmi & Mohammed Albratty. (2023) Analytical Techniques for the Characterization and Quantification of Monoclonal Antibodies. Pharmaceuticals 16:2, pages 291.
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Wei Wang, Wenjun Wang & Guinevere S.M. Lageveen‐Kammeijer. 2022. Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics. Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics 335 375 .
Tessa Reinert, Alain Beck, Pascal Houzé, Rabah Gahoual & Yannis Francois. 2022. Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics. Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics 281 312 .
Cynthia Nagy, Melinda Andrási, Narmin Hamidli, Gyöngyi Gyémánt & Attila Gáspár. (2022) Top-down proteomic analysis of monoclonal antibodies by capillary zone electrophoresis-mass spectrometry. Journal of Chromatography Open 2, pages 100024.
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Deenesh K Babi, Jan Griesbach, Stephen Hunt, Francis Insaidoo, David Roush, Robert Todd, Arne Staby, John Welsh & Felix Wittkopp. (2022) Opportunities and challenges for model utilization in the biopharmaceutical industry: current versus future state. Current Opinion in Chemical Engineering 36, pages 100813.
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Zachary D. Kelley, Mark A. Lovell & Bert C. Lynn. (2021) Pharmacokinetic and metabolic analysis of an Alzheimer's disease therapeutic in rat serum via microfluidic CZE–MS. Biomedical Chromatography 36:1.
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Christoph Gstöttner, Michaela Hook, Tony Christopeit, Alexander Knaupp, Tilman Schlothauer, Dietmar Reusch, Markus Haberger, Manfred Wuhrer & Elena Domínguez-Vega. (2021) Affinity Capillary Electrophoresis–Mass Spectrometry as a Tool to Unravel Proteoform-Specific Antibody–Receptor Interactions. Analytical Chemistry 93:45, pages 15133-15141.
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Norberto A. Guzman & Daniel E. Guzman. (2021) Immunoaffinity Capillary Electrophoresis in the Era of Proteoforms, Liquid Biopsy and Preventive Medicine: A Potential Impact in the Diagnosis and Monitoring of Disease Progression. Biomolecules 11:10, pages 1443.
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Elli Makrydaki, Pavlos Kotidis, Karen M Polizzi & Cleo Kontoravdi. (2021) Hitting the sweet spot with capillary electrophoresis: advances in N-glycomics and glycoproteomics. Current Opinion in Biotechnology 71, pages 182-190.
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Zhe Zhang, Christian Hug, Yuanqi Tao, Francis Bitsch & Yang Yang. (2021) Solving Complex Biologics Truncation Problems by Top-Down Mass Spectrometry. Journal of the American Society for Mass Spectrometry 32:8, pages 1928-1935.
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Tao Chen, Shijia Tang, Elizabeth S. Hecht, Chun-Wan Yen, Nisana Andersen, Steven Chin, Lance Cadang, Brian Roper, Alberto Estevez, Alexis Rohou, Debby Chang, Lu Dai, Peter Liu, Mohammad Al-Sayah, Karthik Nagapudi, Fiona Lin, Amin Famili, Chloe Hu, Robert Kuhn, Cinzia Stella, Christopher M. Crittenden, Jason A. Gruenhagen, Cadapakam Venkatramani, Rami N. Hannoush, Dennis Leung, Richard Vandlen & Peter Yehl. (2021) Discovery of a dual pathway aggregation mechanism for a therapeutic constrained peptide. Journal of Pharmaceutical Sciences 110:6, pages 2362-2371.
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Claire I. Butré & Arnaud Delobel. 2021. Carbohydrate Analysis by Modern Liquid Phase Separation Techniques. Carbohydrate Analysis by Modern Liquid Phase Separation Techniques 761 814 .
Angel Puerta, Laura Gomez-Ruiz, Jose C. Diez-Masa & Mercedes de Frutos. 2021. Carbohydrate Analysis by Modern Liquid Phase Separation Techniques. Carbohydrate Analysis by Modern Liquid Phase Separation Techniques 645 727 .
Christoph Gstöttner, Simone Nicolardi, Markus Haberger, Dietmar Reusch, Manfred Wuhrer & Elena Domínguez-Vega. (2020) Intact and subunit-specific analysis of bispecific antibodies by sheathless CE-MS. Analytica Chimica Acta 1134, pages 18-27.
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Zachary D. Kelley, D. Trent Rogers, John M. Littleton & Bert C. Lynn. (2019) Microfluidic capillary zone electrophoresis mass spectrometry analysis of alkaloids in Lobelia cardinalis transgenic and mutant plant cell cultures. ELECTROPHORESIS 40:22, pages 2921-2928.
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Antony Lechner, Jérémie Giorgetti, Rabah Gahoual, Alain Beck, Emmanuelle Leize-Wagner & Yannis-Nicolas François. (2019) Insights from capillary electrophoresis approaches for characterization of monoclonal antibodies and antibody drug conjugates in the period 2016–2018. Journal of Chromatography B 1122-1123, pages 1-17.
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Rabah Gahoual, Emmanuelle Leize‐Wagner, Pascal Houzé & Yannis‐Nicolas François. (2018) Revealing the potential of capillary electrophoresis/mass spectrometry: the tipping point. Rapid Communications in Mass Spectrometry 33:S1, pages 11-19.
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