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Review Article

The physiological role of the brain GLP-1 system in stress

Marie K. HoltCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, WC1E 6BTLondon, UKView further author information

Stefan TrappCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, WC1E 6BTLondon, UKCorrespondence[email protected]

https://orcid.org/0000-0003-0665-4948 View further author information

William WisdenImperial College London, UKView further author information

(Reviewing Editor)

Article: 1229086 | Received 01 Aug 2016, Accepted 23 Aug 2016, Published online: 14 Sep 2016

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https://doi.org/10.1080/23312025.2016.1229086
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Samantha M. Fortin, Jack C. Chen, Marisa C. Petticord, Forrest J. RagozzinoJames H. Peters & Matthew R. Hayes. (2023) The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1. Science Advances 9:38.
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Dawood Khan, Ananyaa Sridhar, Peter R. Flatt & R.Charlotte Moffett. (2023) Disturbed ovarian morphology, oestrous cycling and fertility of high fat fed rats are linked to alterations of incretin receptor expression. Reproductive Biology 23:3, pages 100784.
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T. AndrainiJ. MardatillahN.T. KartinahN. ParamitaD.I.S. SantosoS. YolandaB.C. PuspasariH. Rusli. (2023) Physical exercise promotes memory function in diabetes mellitus rats: a look at glucagon like peptide-1 and glucagon like peptide-1 receptor. Comparative Exercise Physiology 19:1, pages 71-79.
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Mehdi Farokhnia, Samantha J. Fede, Erica N. Grodin, Brittney D. Browning, Madeline E. Crozier, Melanie L. Schwandt, Colin A. Hodgkinson, Reza Momenan & Lorenzo Leggio. (2022) Differential association between the GLP1R gene variants and brain functional connectivity according to the severity of alcohol use. Scientific Reports 12:1.
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Meenakshi Bose, Gabriela Farias Quipildor, Michelle E. Ehrlich & Stephen R. Salton. (2022) Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development. Cells 11:22, pages 3629.
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Mehdi Farokhnia, Brittney D. Browning, Madeline E. Crozier, Hui Sun, Fatemeh Akhlaghi & Lorenzo Leggio. (2022) The glucagon‐like peptide‐1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post‐mortem brain study. Addiction Biology 27:5.
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Ashmita Mukherjee, Adrianne M. DiBrog & Elizabeth G. Mietlicki-Baase. (2022) The impact of binge-like palatable food intake on the endogenous glucagon-like peptide-1 system in female rats. Behavioural Brain Research 428, pages 113869.
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Wenyu Dai, Jieyu Liu, Yan Qiu, Ziwei Teng, Sujuan Li, Hui Yuan, Jing Huang, Hui Xiang, Hui Tang, Bolun Wang, Jindong Chen & Haishan Wu. (2022) Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence. Frontiers in Pharmacology 13.
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Marie K. Holt & Linda Rinaman. (2021) The role of nucleus of the solitary tract glucagon‐like peptide‐1 and prolactin‐releasing peptide neurons in stress: anatomy, physiology and cellular interactions. British Journal of Pharmacology 179:4, pages 642-658.
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Pablo Ricardo Bertelli, Ricieri Mocelin, Matheus Marcon, Adrieli Sachett, Rosane Gomez, Adriane Ribeiro Rosa, Ana Paula Herrmann & Angelo Piato. (2021) Anti-stress effects of the glucagon-like peptide-1 receptor agonist liraglutide in zebrafish. Progress in Neuro-Psychopharmacology and Biological Psychiatry 111, pages 110388.
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Nadya Povysheva, Huiyuan Zheng & Linda Rinaman. (2021) Glucagon-like peptide 1 receptor-mediated stimulation of a GABAergic projection from the bed nucleus of the stria terminalis to the hypothalamic paraventricular nucleus. Neurobiology of Stress 15, pages 100363.
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Ehraz Mehmood Siddiqui, Sidharth Mehan, Shubham Upadhayay, Andleeb Khan, Maryam Halawi, Azhar Ahmed Halawi & Rana M. Alsaffar. (2021) Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage. Saudi Journal of Biological Sciences 28:11, pages 6417-6431.
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Marie K. Holt. (2021) Mind affects matter: Hindbrain GLP1 neurons link stress, physiology and behaviour. Experimental Physiology 106:9, pages 1853-1862.
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Ayoze González-Santana, Judith Estévez-Herrera, Elizabeth P. Seward, Ricardo Borges & José David Machado. (2021) Glucagon-like peptide-1 receptor controls exocytosis in chromaffin cells by increasing full-fusion events. Cell Reports 36:8, pages 109609.
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Jan Detka & Katarzyna Głombik. (2021) Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression. Pharmacological Reports 73:4, pages 1020-1032.
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Sean J. O’Sullivan & James S. Schwaber. (2021) Similarities in alcohol and opioid withdrawal syndromes suggest common negative reinforcement mechanisms involving the interoceptive antireward pathway. Neuroscience & Biobehavioral Reviews 125, pages 355-364.
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Jesper Vestlund, Filip Bergquist, Valentina Licheri, Louise Adermark & Elisabet Jerlhag. (2020) Activation of glucagon‐like peptide‐1 receptors and skilled reach foraging. Addiction Biology 26:3.
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Rosa M. Leon, Tito Borner, Lauren M. Stein, Norma A. Urrutia, Bart C. De Jonghe, Heath D. Schmidt & Matthew R. Hayes. (2021) Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology 187, pages 108477.
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Yolanda Diz-Chaves, Salvador Herrera-Pérez, Lucas C. González-Matías, José Antonio Lamas & Federico Mallo. (2020) Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress. Nutrients 12:11, pages 3304.
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Marie K. Holt, Daniel R. Cook, Daniel I. Brierley, James E. Richards, Frank Reimann, Alexander V. Gourine, Nephtali Marina & Stefan Trapp. (2020) PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice. Molecular Metabolism 39, pages 101024.
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Marie K. Holt, Lisa E. Pomeranz, Kevin T. Beier, Frank Reimann, Fiona M. Gribble & Linda Rinaman. (2019) Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons. The Journal of Neuroscience 39:49, pages 9767-9781.
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Rosa M. Leon, Tito Borner, David J. Reiner, Lauren M. Stein, Rinzin Lhamo, Bart C. De Jonghe & Matthew R. Hayes. (2019) Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology 44:10, pages 1742-1751.
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Sarah J. Terrill, Marie K. Holt, Calyn B. Maske, Nataly Abrams, Frank Reimann, Stefan Trapp & Diana L. Williams. (2019) Endogenous GLP-1 in lateral septum promotes satiety and suppresses motivation for food in mice. Physiology & Behavior 206, pages 191-199.
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Michał Wiciński, Maciej Socha, Bartosz Malinowski, Eryk Wódkiewicz, Maciej Walczak, Karol Górski, Maciej Słupski & Katarzyna Pawlak-Osińska. (2019) Liraglutide and its Neuroprotective Properties—Focus on Possible Biochemical Mechanisms in Alzheimer’s Disease and Cerebral Ischemic Events. International Journal of Molecular Sciences 20:5, pages 1050.
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Marie K. HoltJames E. RichardsDaniel R. CookDaniel I. BrierleyDiana L. Williams, Frank ReimannFiona M. Gribble & Stefan Trapp. (2019) Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabetes 68:1, pages 21-33.
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Jordan Rowlands, Julian Heng, Philip Newsholme & Rodrigo Carlessi. (2018) Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function. Frontiers in Endocrinology 9.
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J. Patrick Card, Aaron L. Johnson, Ida J. Llewellyn-Smith, Huiyuan Zheng, Rishi Anand, Daniel I. Brierley, Stefan Trapp & Linda Rinaman. (2018) GLP-1 neurons form a local synaptic circuit within the rodent nucleus of the solitary tract. Journal of Comparative Neurology 526:14, pages 2149-2164.
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Diana L. Williams, Nicole A. Lilly, Ian J. Edwards, Pallas Yao, James E. Richards & Stefan Trapp. (2018) GLP-1 action in the mouse bed nucleus of the stria terminalis. Neuropharmacology 131, pages 83-95.
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Lihua Duan, Xiaoquan Rao, Zachary Braunstein, Amelia C. Toomey & Jixin Zhong. (2017) Role of Incretin Axis in Inflammatory Bowel Disease. Frontiers in Immunology 8.
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Marie K. Holt, Ida J. Llewellyn-Smith, Frank Reimann, Fiona M. Gribble & Stefan Trapp. (2017) Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse. Molecular Metabolism 6:8, pages 909-921.
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Melissa A. Burmeister, Jennifer E. Ayala, Hannah Smouse, Adriana Landivar-Rocha, Jacob D. Brown, Daniel J. Drucker, Doris A. Stoffers, Darleen A. Sandoval, Randy J. Seeley & Julio E. Ayala. (2017) The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice. Diabetes 66:2, pages 372-384.
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