HSP70 promotes MLKL polymerization and necroptosis

Andrea N. Johnstona Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA;b Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA

https://orcid.org/0000-0003-1082-1155 View further author information

Zhigao Wangb Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USACorrespondence[email protected]

https://orcid.org/0000-0002-6544-4302 View further author information

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Yingbo Zhou, Zhangtao Cai, Yijia Zhai, Jintao Yu, Qiujing He, Yuan He, Siriporn Jitkaew & Zhenyu Cai. (2023) Necroptosis inhibitors: mechanisms of action and therapeutic potential. Apoptosis.
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Subhajit Roy, Punnag Saha, Dipro Bose, Ayushi Trivedi, Madhura More, Shuo Xiao, Anna Mae Diehl & Saurabh Chatterjee. (2023) Hepatic NLRP3-Derived Hsp70 Binding to TLR4 Mediates MASLD to MASH Progression upon Inhibition of PP2A by Harmful Algal Bloom Toxin Microcystin, a Second Hit. International Journal of Molecular Sciences 24:22, pages 16354.
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Erpeng Wu, Wenyan He, Chenlu Wu, Zhangcheng Chen, Shijie Zhou, Xialian Wu, Zhiheng Hu, Kelong Jia, Jiasong Pan, Limin Wang, Jie Qin, Dan Liu, Junxia Lu, Huayi Wang, Jixi Li, Sheng Wang & Liming Sun. (2023) HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation. Cell Research 33:11, pages 851-866.
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Tao Chen, Yun-Na Tao, Yan Wu, Xu Ren, Yun-Fei Li & Yu-Hai Wang. (2023) HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma. Molecular Biology Reports.
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Lili Liu, Liangyou Zhao, Yuan Liu, Xiaoli Yu & Xinyuan Qiao. (2021) Rutin Ameliorates Cadmium-Induced Necroptosis in the Chicken Liver via Inhibiting Oxidative Stress and MAPK/NF-κB Pathway. Biological Trace Element Research 200:4, pages 1799-1810.
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Xuan Li, You Cai, Jiao Luo, Jingyun Ding, Guojun Yao, Xiaohua Xiao, Yizhe Tang & Zhen Liang. (2021) Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice. Cell Death Discovery 7:1.
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Wei-Tao Yan, Shuang Lu, Yan-Di Yang, Wen-Ya Ning, Yan Cai, Xi-Min Hu, Qi Zhang & Kun Xiong. (2021) Research trends, hot spots and prospects for necroptosis in the field of neuroscience. Neural Regeneration Research 16:8, pages 1628.
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HSP70 promotes MLKL polymerization and necroptosis

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HSP70 promotes MLKL polymerization and necroptosis

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