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Yuan-yuan Xu, Cheng-zhu Xu, You-feng Liang, Dan-qun Jin, Jie Ding, Yao Sheng, Le Zhang & Fang Deng. (2022) Ascorbic acid and hydrocortisone synergistically inhibit septic organ injury via improving oxidative stress and inhibiting inflammation. Immunopharmacology and Immunotoxicology 44:5, pages 786-794.
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Richard R. Watkins, Robert A. Bonomo & Jordi Rello. (2022) Managing sepsis in the era of precision medicine: challenges and opportunities. Expert Review of Anti-infective Therapy 20:6, pages 871-880.
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Articles from other publishers (51)
Yali Sun, Yongfang Yang, Zhuoyi Ye & Tongwen Sun. (2023) HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status. Journal of Intensive Medicine 3:4, pages 320-325.
Crossref
Crossref
Egle Belousoviene, Zivile Pranskuniene, Egle Vaitkaitiene, Vidas Pilvinis & Andrius Pranskunas. (2023) Effect of high-dose intravenous ascorbic acid on microcirculation and endothelial glycocalyx during sepsis and septic shock: a double-blind, randomized, placebo-controlled study. BMC Anesthesiology 23:1.
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Crossref
Huoyan Liang, Qingqing Mu, Wenju Sun, Liming Liu, Simin Qiu, Zili Xu, Yuqing Cui, Yan Yan & Tongwen Sun. (2023) Effect of intravenous vitamin C on adult septic patients: a systematic review and meta-analysis. Frontiers in Nutrition 10.
Crossref
Crossref
Kunkun Wang, Ling Yin, Yang Song, Mengqi Zhang, Yun Lu & Shan Wang. (2022) The Use of Hydrocortisone, Ascorbic Acid and Thiamine in Patients with Sepsis and Septic Shock – A Systematic Review. Journal of Pharmacy Practice 36:4, pages 933-940.
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Crossref
Jinlong Wang, Qianwen Song, Shuhe Yang, Haofei Wang, Shanshan Meng, Lili Huang, Qing Li, Jingyuan Xu, Jianfeng Xie & Yingzi Huang. (2023) Effects of hydrocortisone combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients: A pilot study. Clinical Hemorheology and Microcirculation 84:2, pages 111-123.
Crossref
Crossref
Paul A. Blakeslee & Kristiina Hyrkäs. (2023) Impact of supplemental thiamin on lactate levels in adults with septic shock. Nutrition in Clinical Practice 38:3, pages 580-601.
Crossref
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Juan Novoa, Gil Hardy & William Manzanares. (2023) Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy. Nutrition 109, pages 112000.
Crossref
Crossref
Baofang Liang, Jianwei Su, Hanquan Shao, Huiying Chen & Baocheng Xie. (2023) The outcome of IV vitamin C therapy in patients with sepsis or septic shock: a meta-analysis of randomized controlled trials. Critical Care 27:1.
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Crossref
Chengli Wen, Yuan Li, Qinxue Hu, Hui Liu, Xinxin Xu & Muhan Lü. (2023) IV Vitamin C in Sepsis: A Latest Systematic Review and Meta-Analysis. International Journal of Clinical Practice 2023, pages 1-15.
Crossref
Crossref
Sudaryadi Sudaryadi, Eddy Harijanto & Indro Mulyono. (2023) Comparison of Hydrocortisone with Combined Hydrocortisone, Ascorbic Acid, and Thiamine as an Adjuvant Therapy on Septic Shock Patients on Mortality: A Systematic Review and Meta-analysis. Open Access Macedonian Journal of Medical Sciences 11:F, pages 171-179.
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Crossref
Zhuangli Li, Xiaoli Zhang, Yongliang Wu, Chao Xie, Chengjiang Liu, Xiuyu He, Zehua Wu, Guofang Hua & Yuedong Li. (2023) Hydrocortisone, vitamin C, and thiamine may not improve the outcome of patients with sepsis or septic shock: a systematic review and meta-analysis. Emergency and Critical Care Medicine Publish Ahead of Print.
Crossref
Crossref
Katherine Kozarek & Diane Head. 2023. Evidence-Based Practice of Anesthesiology. Evidence-Based Practice of Anesthesiology
217
225
.
Jonathan Brown, Cassie Robertson, Luis Sevilla, Jorge Garza, Hytham Rashid, Ana C Benitez, Mikhail Shipotko & Zuhair Ali. (2022) A Systematic Review and Meta-Analysis on Possible Role of Vitamin C in Sepsis. Cureus.
Crossref
Crossref
Nafiseh Shokri-mashhadi, Ali Aliyari, Zahra Hajhashemy, Saeed Saadat & Mohammad Hossein Rouhani. (2022) Is it time to reconsider the administration of thiamine alone or in combination with vitamin C in critically ill patients? A meta-analysis of clinical trial studies. Journal of Intensive Care 10:1.
Crossref
Crossref
Patrice Rosengrave, Emma Spencer, Jonathan Williman, Jan Mehrtens, Stacey Morgan, Tara Doyle, Kymbalee Van Der Heyden, Anna Morris, Geoff Shaw & Anitra C. Carr. (2022) Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial. Critical Care 26:1.
Crossref
Crossref
Deven Juneja, Prashant Nasa & Ravi Jain. (2022) Current role of high dose vitamin C in sepsis management: A concise review. World Journal of Critical Care Medicine 11:6, pages 349-363.
Crossref
Crossref
Ching-Yi Chen, Chien-Tung Chiu, Ho-Sheng Lee & Chih-Cheng Lai. (2022) The impact of vitamin C-containing treatment on the mortality of patients with sepsis: a systematic review and meta-analysis of randomized controlled trials. Journal of Infection and Public Health.
Crossref
Crossref
Ana Luiza Cabrera Martimbianco, Rafael Leite Pacheco, Ângela Maria Bagattini, Roberta de Fátima Carreira Moreira Padovez, Luciano Cesar Pontes Azevedo & Rachel Riera. (2022) Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials.. Journal of Critical Care 71, pages 154099.
Crossref
Crossref
Qing-Quan Lyu, Rui-Qiang Zheng, Qi-Hong Chen, Jiang-Quan Yu, Jun Shao & Xiao-Hua Gu. (2022) Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial. Critical Care 26:1.
Crossref
Crossref
Qing Zhao, Jianguo Xiao & Hui Liu. (2022) No benefit of hydrocortisone, ascorbic acid, and thiamine in reducing mortality in adult sepsis patients: a systematic review and meta-analysis. Emergency and Critical Care Medicine 2:3, pages 167-174.
Crossref
Crossref
Xiaolu Li, Yanyan Yang, Bei Zhang, Xiaotong Lin, Xiuxiu Fu, Yi An, Yulin Zou, Jian-Xun Wang, Zhibin Wang & Tao Yu. (2022) Lactate metabolism in human health and disease. Signal Transduction and Targeted Therapy 7:1.
Crossref
Crossref
Arnav Agarwal, John Basmaji, Shannon M. Fernando, Fang Zhou Ge, Yingqi Xiao, Haseeb Faisal, Kimia Honarmand, Mathieu Hylands, Vincent Lau, Kimberley Lewis, Rachel Couban, François Lamontagne & Neill K. J. Adhikari. (2022) Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review. NEJM Evidence 1:9.
Crossref
Crossref
Jihad Mallat, Nadeem Rahman, Fadi Hamed, Glenn Hernandez & Marc-Olivier Fischer. (2022) Pathophysiology, mechanisms, and managements of tissue hypoxia. Anaesthesia Critical Care & Pain Medicine 41:4, pages 101087.
Crossref
Crossref
Marwah Muhammad, Ahmad Jahangir, Ali Kassem, Saud Bin Abdul Sattar, Abdullah Jahangir, Syeda Sahra, Muhammad Rafay Khan Niazi, Ahmad Mustafa, Zeeshan Zia, Fasih Sami Siddiqui, Waleed Sadiq, Danil Mishiyev, Aleena Sammar, Loai Dahabra, Aazib Irshad, Dany Elsayegh & Michel Chalhoub. (2022) The Role and Efficacy of Vitamin C in Sepsis: A Systematic Review and Meta-Analysis. Advances in Respiratory Medicine 90:4, pages 281-299.
Crossref
Crossref
Stuart Feichtinger, Angélique de Man, Adam A. Dalia, Molly K. Groose & Micah T. Long. (2022) Sepsis and Resuscitation: The Importance of Time. Critical Care Medicine 50:6, pages e615-e616.
Crossref
Crossref
David A. WackerSusan L. BurtonJohn P. BergerA. J. HeggJamie HeisdorfferQi WangEmily J. MedcraftRonald A. Reilkoff. (2022) Evaluating Vitamin C in Septic Shock: A Randomized Controlled Trial of Vitamin C Monotherapy*. Critical Care Medicine 50:5, pages e458-e467.
Crossref
Crossref
Dagan Coppock, Pierre-Christian Violet, Gustavo Vasquez, Katherine Belden, Michael Foster, Bret Mullin, Devon Magee, Isabelle Mikell, Lokesh Shah, Victoria Powers, Brian Curcio, Daniel Monti & Mark Levine. (2022) Pharmacologic Ascorbic Acid as Early Therapy for Hospitalized Patients with COVID-19: A Randomized Clinical Trial. Life 12:3, pages 453.
Crossref
Crossref
Jayshil J. Patel, Alfonso Ortiz-Reyes, Rupinder Dhaliwal, John Clarke, Aileen Hill, Christian Stoppe, Zheng-Yii Lee & Daren K. Heyland. (2021) IV Vitamin C in Critically Ill Patients: A Systematic Review and Meta-Analysis. Critical Care Medicine 50:3, pages e304-e312.
Crossref
Crossref
Nara Aline Costa, Amanda Gomes Pereira, Clara Sandra Araujo Sugizaki, Nayane Maria Vieira, Leonardo Rufino Garcia, Sérgio Alberto Rupp de Paiva, Leonardo Antonio Mamede Zornoff, Paula Schmidt Azevedo, Bertha Furlan Polegato & Marcos Ferreira Minicucci. (2022) Insights Into Thiamine Supplementation in Patients With Septic Shock. Frontiers in Medicine 8.
Crossref
Crossref
Tomoko Fujii, Georgia Salanti, Alessandro Belletti, Rinaldo Bellomo, Anitra Carr, Toshi A. Furukawa, Nora Luethi, Yan Luo, Alessandro Putzu, Chiara Sartini, Yasushi Tsujimoto, Andrew A. Udy, Fumitaka Yanase & Paul J. Young. (2021) Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis. Intensive Care Medicine 48:1, pages 16-24.
Crossref
Crossref
Sander Rozemeijer, Bob Smit, Paul W. G. Elbers, Armand R. J. Girbes, Heleen M. Oudemans-van Straaten & Angelique M. E. de Man. (2021) Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation–reduction potential measurement. Intensive Care Medicine Experimental 9:1.
Crossref
Crossref
Weilan Na, Huili Shen, Yichu Li & Dong Qu. (2021) Hydrocortisone, ascorbic acid, and thiamine (HAT) for sepsis and septic shock: a meta-analysis with sequential trial analysis. Journal of Intensive Care 9:1.
Crossref
Crossref
Sander Rozemeijer, Harm-Jan de Grooth, Paul W. G. Elbers, Armand R. J. Girbes, Corstiaan A. den Uil, Eric A. Dubois, Evert-Jan Wils, Thijs C. D. Rettig, Arthur R. H. van Zanten, Roel Vink, Bas van den Bogaard, Rob J. Bosman, Heleen M. Oudemans-van Straaten & Angélique M. E. de Man. (2021) Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial. Trials 22:1.
Crossref
Crossref
Sander Rozemeijer, Frans A. L. van der Horst & Angélique M. E. de Man. (2021) Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker?. Critical Care 25:1.
Crossref
Crossref
Sean S. Scholz, Rainer Borgstedt, Nicole Ebeling, Leoni C. Menzel, Gerrit Jansen & Sebastian Rehberg. (2021) Mortality in septic patients treated with vitamin C: a systematic meta-analysis. Critical Care 25:1.
Crossref
Crossref
Tong Wu, Chang Hu, Weipeng Huang, Qiancheng Xu, Bo Hu & Jianguo Li. (2021) Effect of Combined Hydrocortisone, Ascorbic Acid and Thiamine for Patients with Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. Shock 56:6, pages 880-889.
Crossref
Crossref
Benjamin AssoulineAnna FaivreThomas VerissimoFrédéric SanglaLena BerchtoldRaphaël GiraudKarim BendjelidSebastian SgardelloNadia EliaJérôme PuginSophie de Seigneux & David Legouis. (2021) Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis*. Critical Care Medicine 49:12, pages 2112-2120.
Crossref
Crossref
Ting Li, Jun Zeng, Di-huan Li, Guang-yu Yang, Kai Wang, Hong-fei Deng & Hua Jiang. (2021) Efficacy of intravenous vitamin C intervention for septic patients: A systematic review and meta-analysis based on randomized controlled trials. The American Journal of Emergency Medicine 50, pages 242-250.
Crossref
Crossref
Dhan Bahadur Shrestha, Pravash Budhathoki, Yub Raj Sedhai, Sujit Kumar Mandal, Shreeja Shikhrakar, Saurab Karki, Ram Kaji Baniya, Markos G. Kashiouris, Xian Qiao & Alpha A. Fowler. (2021) Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis. Nutrients 13:10, pages 3564.
Crossref
Crossref
Yatin Mehta, Subhal B Dixit, Kapil Zirpe, Randhir Sud, Palepu B Gopal, Parvaiz A Koul, Vijay K Mishra, Abdul S Ansari & Vijay S Chamle. (2021) Therapeutic Approaches in Modulating the Inflammatory and Immunological Response in Patients With Sepsis, Acute Respiratory Distress Syndrome, and Pancreatitis: An Expert Opinion Review. Cureus.
Crossref
Crossref
Ryota Sato, Daisuke Hasegawa, Narut Prasitlumkum, Miki Ueoka, Kazuki Nishida, Kunihiko Takahashi, Michitaka Nasu & Siddharth Dugar. (2021) Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis. Critical Care Medicine Publish Ahead of Print.
Crossref
Crossref
Francesco Gavelli, Luigi Mario Castello & Gian Carlo Avanzi. (2021) Management of sepsis and septic shock in the emergency department. Internal and Emergency Medicine 16:6, pages 1649-1661.
Crossref
Crossref
Ka Man Fong, Shek Yin Au & George Wing Yiu Ng. (2021) Steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock: a systematic review and component network meta-analysis. Scientific Reports 11:1.
Crossref
Crossref
Anna Kanjo, Zsolt Molnar, Noémi Zádori, Noémi Gede, Bálint Erőss, Lajos Szakó, Tamás Kiss, Zsolt Márton, Manu L N G Malbrain, Konstanty Szuldrzynski, Jakub Szrama, Krzysztof Kusza, Klaus Kogelmann & Péter Hegyi. (2021) Dosing of Extracorporeal Cytokine Removal In Septic Shock (DECRISS):
protocol of a prospective, randomised, adaptive, multicentre clinical
trial. BMJ Open 11:8, pages e050464.
Crossref
Crossref
Christos Michailides & Dimitrios Velissaris. (2021) Common anti-oxidant vitamin C as an anti-infective agent with remedial role on SARS-CoV-2 infection. An update. Monaldi Archives for Chest Disease.
Crossref
Crossref
Christian Kressin, Komal Pandya, Barbara Magnuson Woodward, Chris Donaldson & Alexander H. Flannery. (2021) Ascorbic Acid in the Acute Care Setting. Journal of Parenteral and Enteral Nutrition 45:5, pages 874-881.
Crossref
Crossref
Zengzheng Ge, Jiewu Huang, Yawei Liu, Jun Xiang, Yanxia Gao, Joseph Harold Walline, Xin Lu, Shiyuan Yu, Lina Zhao & Yi Li. (2021) Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis. European Journal of Emergency Medicine 28:3, pages 189-195.
Crossref
Crossref
Claudia Patricia Cardona Ocampo, José Fernando Gómez González, Germán Alberto Moreno Gómez, Andrés Mauricio García Cuevas, Carlos Mario Sánchez Cadavid & Edgardo Quiñones Quiñones. (2021) Vitamina C, tiamina e hidrocortisona en choque séptico (protocolo VITHA): estudio de cohortes. Acta Colombiana de Cuidado Intensivo 21:2, pages 111-119.
Crossref
Crossref
Renqi Yao, Yibing Zhu, Yue Yu, Zhixuan Li, Lixue Wang, Liyu Zheng, Jingyan Li, Huibin Huang, Guosheng Wu, Feng Zhu, Zhaofan Xia, Chao Ren & Yongming Yao. (2021) Combination therapy of thiamine, vitamin C and hydrocortisone in treating patients with sepsis and septic shock: a meta-analysis and trial sequential analysis. Burns & Trauma 9.
Crossref
Crossref
S. Rozemeijer, F. A. L. van der Horst & A. M. E. de Man. 2021. Annual Update in Intensive Care and Emergency Medicine 2021. Annual Update in Intensive Care and Emergency Medicine 2021
25
34
.
Vidya Menon, Zubair U Mohamed, Pratibha Prasannan, Merlin Moni, Fabia Edathadathil, Preetha Prasanna, Anup Menon, Sabarish Nair, CR Greeshma, Dipu T Sathyapalan & Veena Menon. (2020) Vitamin C Therapy for Routine Care in Septic Shock (ViCTOR) Trial: Effect of Intravenous Vitamin C, Thiamine, and Hydrocortisone Administration on Inpatient Mortality among Patients with Septic Shock. Indian Journal of Critical Care Medicine 24:8, pages 653-661.
Crossref
Crossref