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Expert Review of Precision Medicine and Drug Development
Personalized medicine in drug development and clinical practice
Volume 1, 2016 - Issue 5
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Review

The pharmacogenetic road to avoid adverse drug reactions and therapeutic failures in revolving door patients with psychiatric illnesses: focus on the CYP2D6 isoenzymes

Francesco PanzaGeriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy;Unit of Neurodegenerative Disease, Department of Basic Medicine Sciences, Neuroscience, and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy;Unit of Neurodegenerative Disease, Department of Clinical Research in Neurology, University of Bari ‘Aldo Moro’ at ‘Pia Fondazione Card. G. Panico’, Tricase, ItalyCorrespondence[email protected]
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Madia LozuponeUnit of Neurodegenerative Disease, Department of Basic Medicine Sciences, Neuroscience, and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy;Psychiatric Unit, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyView further author information
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Eleonora StellaPsychiatric Unit, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyView further author information
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Giuseppe MiscioLaboratory of Clinical Chemistry, Department of Clinical Pathology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, ItalyView further author information
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Maddalena La MontagnaPsychiatric Unit, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyView further author information
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Antonio DanieleInstitute of Neurology, Catholic University of Sacred Heart, Rome, ItalyView further author information
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Lazzaro di MauroLaboratory of Clinical Chemistry, Department of Clinical Pathology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, ItalyView further author information
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Antonello BellomoPsychiatric Unit, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyView further author information
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Giancarlo LogroscinoUnit of Neurodegenerative Disease, Department of Basic Medicine Sciences, Neuroscience, and Sense Organs, University of Bari ‘Aldo Moro’, Bari, Italy;Unit of Neurodegenerative Disease, Department of Clinical Research in Neurology, University of Bari ‘Aldo Moro’ at ‘Pia Fondazione Card. G. Panico’, Tricase, ItalyView further author information
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Antonio GrecoGeriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, ItalyView further author information
&
Davide SeripaGeriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, ItalyCorrespondence[email protected]
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Pages 431-442 | Received 23 Mar 2016, Accepted 24 Aug 2016, Published online: 14 Sep 2016

Citations (6)

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Madia Lozupone, Davide Seripa, Eleonora Stella, Maddalena La Montagna, Vincenzo Solfrizzi, Nicola Quaranta, Federica Veneziani, Alberto Cester, Rodolfo Sardone, Caterina Bonfiglio, Gianluigi Giannelli, Paola Bisceglia, Roberto Bringiotti, Antonio Daniele, Antonio Greco, Antonello Bellomo, Giancarlo Logroscino & Francesco Panza. (2017) Innovative biomarkers in psychiatric disorders: a major clinical challenge in psychiatry. Expert Review of Proteomics 14:9, pages 809-824.
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Articles from other publishers (5)

Rustin D. Crutchley & Nicole Keuler. (2022) Sub-Analysis of CYP-GUIDES Data: Assessing the Prevalence and Impact of Drug-Gene Interactions in an Ethnically Diverse Cohort of Depressed Individuals. Frontiers in Pharmacology 13.
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Gualberto Ruaño, Joseph Tortora, Saskia Robinson, Seth Baker, Theodore Holford, Andrew Winokur & John W. Goethe. (2021) Subanalysis of the CYP-GUIDES Trial: CYP2D6 Functional Stratification and Operational Timeline Selection. Psychiatry Research 297, pages 113571.
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Gualberto Ruaño, Saskia Robinson, Theodore Holford, Raveen Mehendru, Seth Baker, Joseph Tortora & John W. Goethe. (2020) Results of the CYP-GUIDES randomized controlled trial: Total cohort and primary endpoints. Contemporary Clinical Trials 89, pages 105910.
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Gualberto Ruaño, Theodore Holford, Richard L. Seip, John W. Goethe & Raveen Mehendru. (2019) Pharmacogenetic clinical decision support for psychiatric hospitalization: Design of the CYP-GUIDES randomized controlled trial. Contemporary Clinical Trials 83, pages 27-36.
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Madia Lozupone, Maddalena La Montagna, Francesca D’Urso, Antonio Daniele, Antonio Greco, Davide Seripa, Giancarlo Logroscino, Antonello Bellomo & Francesco Panza. 2019. Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders. Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders 135 162 .

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