Advanced search
Publication Cover
Particulate Science and Technology
An International Journal
Volume 21, 2003 - Issue 4
Submit an article Journal homepage
168
Views
41
CrossRef citations to date
0
Altmetric
Original Articles

Investigating Density Distributions for Tablets of Different Geometry During the Compaction of Pharmaceuticals

BRUNEL EILIAZADEH Department of Chemical Engineering and Chemical Technology, Imperial College, London, U.K.
,
BRIAN J. BRISCOE Department of Chemical Engineering and Chemical Technology, Imperial College, London, U.K.
,
YONG SHENG Department of Chemical Engineering and Chemical Technology, Imperial College, London, U.K.
&
KENDAL PITT Merck, Sharp & Dohme Ltd. Hoddesdon, Hertfordshire, U.K.
Pages 303-316 | Published online: 02 Feb 2011

Citations (41)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Jason Franck, Admassu Abebe, Rekha Keluskar, Kyle Martin, Antara Majumdar, Niranjan Kottala & Howard Stamato. (2015) Axial strength test for round flat faced versus capsule shaped bilayer tablets. Pharmaceutical Development and Technology 20:2, pages 139-145.
Read now
Sameh Abdel-Hamid & Gabriele Betz. (2013) Investigating the effect of punch geometry on high speed tableting through radial die-wall pressure monitoring. Pharmaceutical Development and Technology 18:1, pages 46-54.
Read now

Articles from other publishers (39)

Shumaiya Ferdoush, Sarah Bu Kzam, Pedro H.C. Martins, Jan Dewanckele & Marcial Gonzalez. (2023) Fast time-resolved micro-CT imaging of pharmaceutical tablets: Insights into water uptake and disintegration. International Journal of Pharmaceutics 648, pages 123565.
Crossref
Hetvi Triboandas, Kendal Pitt, Mariana Bezerra, Delphine Ach-Hubert & Walkiria Schlindwein. (2022) Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools. Pharmaceutics 14:11, pages 2398.
Crossref
Prakash Chandra Pradhan, Arkadeb Mukhopadhyay, Randeep Kumar, Aditi Kundu, Neeraj Patanjali, Anirban Dutta, Deeba Kamil, Tusar Kanti Bag, Rashmi Aggarwal, Chellapilla Bharadwaj, P. K. Singh & Anupama Singh. (2022) Performance appraisal of Trichoderma viride based novel tablet and powder formulations for management of Fusarium wilt disease in chickpea. Frontiers in Plant Science 13.
Crossref
Luz Nadiezda Naranjo Gómez, Thomas De Beer & Ashish Kumar. (2022) Finite Element Modeling of Powder Compaction: Mini-Tablets in Comparison with Conventionally Sized Tablets. Pharmaceutical Research 39:9, pages 2109-2118.
Crossref
Ka̅rlis Be̅rziņš, Peter III J. G. Remoto, Sara J. Fraser-Miller & Keith C. Gordon. (2022) Nondestructive Spatial Dehydration Analysis of Crystalline Hydrates in Pharmaceutical Solid Dosage Forms Using Spatially Offset Low-Frequency Raman Spectroscopy. Crystal Growth & Design 22:5, pages 2946-2953.
Crossref
Işık Sena Akgün, Enis Demir, Murat Işık, Nadin Ekmekçiyan, Erkan Şenses & Can Erkey. (2022) Protective coating of highly porous alginate aerogel particles in a Wurster fluidized bed. Powder Technology 402, pages 117331.
Crossref
G. Alonso Aruffo, M. Michrafy, D. Oulahna & A. Michrafy. (2022) Modelling powder compaction with consideration of a deep grooved punch. Powder Technology 395, pages 681-694.
Crossref
Barbara V. Schönfeld, Ulrich Westedt & Karl G. Wagner. (2021) Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying. International Journal of Pharmaceutics: X 3, pages 100102.
Crossref
Işık Sena Akgün & Can Erkey. (2021) Fluidization regimes for alginate aerogel particles in a laboratory scale Wurster fluidized bed. Powder Technology 387, pages 295-312.
Crossref
F. Rahimi Mehr, M. Salavati, A. Morgenthal, S. Kamrani & C. Fleck. (2021) Computational analysis and experimental calibration of cold isostatic compaction of Mg-SiC nanocomposite powders. Materials Today Communications 27, pages 102321.
Crossref
Marco Bellini, Mathias Walther & Roland Bodmeier. (2019) Evaluation of manufacturing process parameters causing multilayer tablets delamination. International Journal of Pharmaceutics 570, pages 118607.
Crossref
Justin Yong Soon Tay, Berlinda Wen Ting Kok, Celine Valeria Liew & Paul Wan Sia Heng. (2019) Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose. Journal of Pharmaceutical Sciences 108:9, pages 3011-3019.
Crossref
Vincent Mazel, Harona Diarra, Jérôme Malvestio & Pierre Tchoreloff. (2018) Lamination of biconvex tablets: Numerical and experimental study. International Journal of Pharmaceutics 542:1-2, pages 66-71.
Crossref
Daniel Markl, Prince Bawuah, Cathy Ridgway, Sander van den Ban, Daniel J. Goodwin, Jarkko Ketolainen, Patrick Gane, Kai-Erik Peiponen & J. Axel Zeitler. (2018) Fast and non-destructive pore structure analysis using terahertz time-domain spectroscopy. International Journal of Pharmaceutics 537:1-2, pages 102-110.
Crossref
Jing Tao, Sophia Robertson-Lavalle, Preetanshu Pandey & Sherif Badawy. (2017) Understanding the Delamination Risk of a Trilayer Tablet Using Minipiloting Tools. Journal of Pharmaceutical Sciences 106:11, pages 3346-3352.
Crossref
Henrietta Tsosie, James Thomas, John Strong & Antonios Zavaliangos. (2017) Scanning Electron Microscope Observations of Powder Sticking on Punches during a Limited Number (N < 5) of Compactions of Acetylsalicylic Acid. Pharmaceutical Research 34:10, pages 2012-2024.
Crossref
Yusuke Hattori, Ryota Aoki & Makoto Otsuka. (2016) Use of partial least-squares analysis and fractionated X-ray computed tomography images in the investigation of density distribution of round tablets. Powder Technology 302, pages 261-264.
Crossref
Marten Klukkert, Jian X. Wu, Jukka Rantanen, Jens M. Carstensen, Thomas Rades & Claudia S. Leopold. (2016) Multispectral UV imaging for fast and non-destructive quality control of chemical and physical tablet attributes. European Journal of Pharmaceutical Sciences 90, pages 85-95.
Crossref
Xian-Zhen Yin, Li Wu, Ying Li, Tao Guo, Hai-Yan Li, Ti-Qiao Xiao, Peter York, Ashwini Nangia, Shuang-Ying Gui & Ji-Wen Zhang. (2016) Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting. Scientific Reports 6:1.
Crossref
Biplob Mitra, Jon Hilden & James D. Litster. (2015) Novel use of monodisperse granules to deconvolute impacts of granule size versus granule solid fraction on tablet tensile strength. Advanced Powder Technology 26:2, pages 553-562.
Crossref
Saori Otoguro, Yoshihiro Hayashi, Takahiro Miura, Naoto Uehara, Shunichi Utsumi, Yoshinori Onuki, Yasuko Obata & Kozo Takayama. (2015) Numerical Investigation of the Residual Stress Distribution of Flat-Faced and Convexly Curved Tablets Using the Finite Element Method. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 63:11, pages 890-900.
Crossref
Yoshihiro Hayashi, Saori Otoguro, Takahiro MiuraYoshinori Onuki, Yasuko Obata & Kozo Takayama. (2014) Effect of Process Variables on the Drucker–Prager Cap Model and Residual Stress Distribution of Tablets Estimated by the Finite Element Method. Chemical and Pharmaceutical Bulletin 62:11, pages 1062-1072.
Crossref
Admassu Abebe, Ilgaz Akseli, Omar Sprockel, Niranjan Kottala & Alberto M. Cuitiño. (2014) Review of bilayer tablet technology. International Journal of Pharmaceutics 461:1-2, pages 549-558.
Crossref
Yoshihiro Hayashi, Takahiro Miura, Takuya Shimada, Yoshinori Onuki, Yasuko Obata & Kozo Takayama. (2013) Prediction of Tablet Characteristics from Residual Stress Distribution Estimated by the Finite Element Method. Journal of Pharmaceutical Sciences 102:10, pages 3678-3686.
Crossref
N. Heigl, A. Hodzic, M. Llusa, W. Tritthart, F. Reiter, S. D. Fraser, P. Laggner & J. G. Khinast. (2012) Potential of Raman Spectroscopy for Evaluating Crushing Strength of Tablets. Journal of Pharmaceutical Innovation 7:2, pages 76-86.
Crossref
A. Hodzic, M. Llusa, N. Heigl, W. Tritthart, S.D. Fraser, P. Laggner & J.G. Khinast. (2012) Effect of process variables on the Small and Wide Angle X-ray Scattering (SWAXS) patterns of powders, granules and pharmaceutical tablets. Powder Technology 221, pages 447-452.
Crossref
Mikael Sjödahl, Clive R. Siviour & Fredrik Forsberg. (2012) Digital Volume Correlation Applied to Compaction of Granular Materials. Procedia IUTAM 4, pages 179-195.
Crossref
Vishal Koradia, Mikko Tenho, Heidi Lopez de Diego, Michiel Ringkjøbing-Elema, Jørn Møller-Sonnergaard, Jarno Salonen, Vesa-Pekka Lehto & Jukka Rantanen. (2011) Investigation of Solid Phase Composition on Tablet Surfaces by Grazing Incidence X-ray Diffraction. Pharmaceutical Research 29:1, pages 134-144.
Crossref
Carson J. Smith, James D. Stephens, Bruno C. Hancock, Armin Saeedi Vahdat & Cetin Cetinkaya. (2011) Acoustic assessment of mean grain size in pharmaceutical compacts. International Journal of Pharmaceutics 419:1-2, pages 137-146.
Crossref
Simo Matti Siiriä, Osmo Antikainen, Jyrki Heinämäki & Jouko Yliruusi. (2011) 3D Simulation of Internal Tablet Strength During Tableting. AAPS PharmSciTech 12:2, pages 593-603.
Crossref
Hideaki SATOTakahiro MIURAHiroya FURUICHI. (2011) FEM Analysis of Tablet Hardness and Punch Strength Using ANSYS Software. Journal of Computational Science and Technology 5:3, pages 120-133.
Crossref
P.R. Laity & R.E. Cameron. (2010) Synchrotron X-ray microtomographic study of tablet swelling. European Journal of Pharmaceutics and Biopharmaceutics 75:2, pages 263-276.
Crossref
I. Akseli, B.C. Hancock & C. Cetinkaya. (2009) Non-destructive determination of anisotropic mechanical properties of pharmaceutical solid dosage forms. International Journal of Pharmaceutics 377:1-2, pages 35-44.
Crossref
Peter R. Laity & Ruth E. Cameron. (2009) A small-angle X-ray scattering study of local variations within powder compacts. Powder Technology 192:3, pages 287-297.
Crossref
L.H. Han, J.A. Elliott, A.C. Bentham, A. Mills, G.E. Amidon & B.C. Hancock. (2008) A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders. International Journal of Solids and Structures 45:10, pages 3088-3106.
Crossref
Ai Ling Ching, Celine Valeria Liew, Lai Wah Chan & Paul Wan Sia Heng. (2008) Modifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices. European Journal of Pharmaceutical Sciences 33:4-5, pages 361-370.
Crossref
Kendal Pitt & Csaba Sinka. 2007. Granulation. Granulation 735 778 .
Matthew P. Mullarney & Bruno C. Hancock. (2006) Mechanical property anisotropy of pharmaceutical excipient compacts. International Journal of Pharmaceutics 314:1, pages 9-14.
Crossref
Brunel Eiliazadeh, Kendal Pitt & Brian Briscoe. (2004) Effects of punch geometry on powder movement during pharmaceutical tabletting processes. International Journal of Solids and Structures 41:21, pages 5967-5977.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.