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Original Article

The Neuropharmacology of L-Theanine(N-Ethyl-L-Glutamine)

A Possible Neuroprotective and Cognitive Enhancing Agent

(Associate Professor) , , &
Pages 21-30 | Published online: 20 Aug 2009

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Read on this site (10)

Umut Yilmaz, Yusuf Buzdagli, Muhammed Lütfü Polat, Yusuf Bakir, Burak Ozhanci, Sena Alkazan & Halil Ucar. (2023) Effect of single or combined caffeine and L-Theanine supplementation on shooting and cognitive performance in elite curling athletes: a double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition 20:1.
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Neil Bernard Boyle, Jac Billington, Clare Lawton, Frits Quadt & Louise Dye. (2022) A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers. Nutritional Neuroscience 25:9, pages 1845-1859.
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Tharaka L. Dassanayake, Chanaka N. Kahathuduwa & Vajira S. Weerasinghe. (2022) L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study. Nutritional Neuroscience 25:4, pages 698-708.
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Yang Wei, Jia Xu, Siwei Miao, Kang Wei, Lanlan Peng, Yuanfeng Wang & Xinlin Wei. (2022) Recent advances in the utilization of tea active ingredients to regulate sleep through neuroendocrine pathway, immune system and intestinal microbiota. Critical Reviews in Food Science and Nutrition 0:0, pages 1-29.
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Suhyeon Kim, Kyungae Jo, Ki-Bae Hong, Sung Hee Han & Hyung Joo Suh. (2019) GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharmaceutical Biology 57:1, pages 64-72.
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Chanaka N. Kahathuduwa, Tharaka L. Dassanayake, A. M. Tissa Amarakoon & Vajira S. Weerasinghe. (2017) Acute effects of theanine, caffeine and theanine–caffeine combination on attention. Nutritional Neuroscience 20:6, pages 369-377.
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Xi-Chong Yu, Bo-La Wu, Jin-Chao Gao & Wei Yang. (2016) Theanine enhanced both the toxicity of strychnine and anticonvulsion of pentobarbital sodium. Drug and Chemical Toxicology 39:2, pages 217-223.
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Sumathi Thangarajan, Asha Deivasigamani, Suganya Sarumani Natarajan, Prasanna Krishnan & Sandhya Koombankallil Mohanan. (2014) Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum. International Journal of Neuroscience 124:9, pages 673-684.
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Articles from other publishers (22)

Gisèle Pickering, Lionel Noah, Bruno Pereira, Jonathan Goubayon, Vincent Leray, Ambre Touron, Nicolas Macian, Lise Bernard, Christian Dualé, Veronique Roux & Carine Chassain. (2023) Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Frontiers in Nutrition 10.
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Kenneth M. Martin. 2023. Canine and Feline Behavior for Veterinary Technicians and Nurses. Canine and Feline Behavior for Veterinary Technicians and Nurses 364 390 .
Daisuke FURUSHIMA, Ibuki SUGIYAMA, Yuzuki NOMURA, Keiko UNNO & Hiroshi YAMADA. (2022) Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study. Journal of Nutritional Science and Vitaminology 68:6, pages 540-546.
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Muhammed Furkan Dasdelen, Sezgin Er, Berkan Kaplan, Suleyman Celik, Mustafa Caglar Beker, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Havakhanum Mamedova, Sarah Sylla, James Komorowski, Sara Perez Ojalvo, Kazim Sahin & Ertugrul Kilic. (2022) A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality via Regulating Brain Electrochemical Activity. Frontiers in Nutrition 9.
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Monika Szot, Ewa Karpęcka-Gałka, Remigiusz Dróżdż & Barbara Frączek. (2022) Can Nutrients and Dietary Supplements Potentially Improve Cognitive Performance Also in Esports?. Healthcare 10:2, pages 186.
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Benjamin S. Weeks, Samuel D. Weeks, Amanda Kim, Landon Kessler & Pedro P. Perez. 2021. Functional Foods - Phytochemicals and Health Promoting Potential. Functional Foods - Phytochemicals and Health Promoting Potential.
Heather Way, Grant Williams, Sharon Hausman-Cohen & Jordan Reeder. (2021) Genomics as a Clinical Decision Support Tool: Successful Proof of Concept for Improved ASD Outcomes. Journal of Personalized Medicine 11:7, pages 596.
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Sarah Kölling, Fabian Loch & Michael Kellmann. 2021. Sport in Kultur und Gesellschaft. Sport in Kultur und Gesellschaft 467 479 .
Xiangbing Mao, Xiangjun Xiao, Daiwen Chen, Bing Yu & Jun He. (2019) Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism. International Journal of Molecular Sciences 20:21, pages 5249.
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Hidese, Ogawa, Ota, Ishida, Yasukawa, Ozeki & Kunugi. (2019) Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients 11:10, pages 2362.
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Sarah Kölling, Fabian Loch & Michael Kellmann. 2019. Sport in Kultur und Gesellschaft. Sport in Kultur und Gesellschaft 1 13 .
Jiwon Kim & Jihye Kim. (2018) Green Tea, Coffee, and Caffeine Consumption Are Inversely Associated with Self-Report Lifetime Depression in the Korean Population. Nutrients 10:9, pages 1201.
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Penelope Hannant, Teresa Tavassoli & Sarah Cassidy. (2016) The Role of Sensorimotor Difficulties in Autism Spectrum Conditions. Frontiers in Neurology 7.
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Young-Seok Kim, Sang Mi Kwak & Seung-Kwon Myung. (2015) Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies. Neuroepidemiology 44:1, pages 51-63.
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Lei Feng, Tze-Pin Ng, Ee-Heok Kua & Victor R. Preedy. 2013. Tea in Health and Disease Prevention. Tea in Health and Disease Prevention 1325 1336 .
Liang Zhang, Zheng-Zhu Zhang, Ya-Ning Lu, Jing-Song Zhang & Victor R. Preedy. 2013. Tea in Health and Disease Prevention. Tea in Health and Disease Prevention 425 435 .
Lisa Radosta. (2012) Anxiolytic Supplements. Advances in Small Animal Medicine and Surgery 25:2, pages 1-3.
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Janet Bryan, Michelle Tuckey, Suzanne J.L. Einöther, Ursula Garczarek, Adam Garrick & Eveline A. De Bruin. (2012) Relationships between tea and other beverage consumption to work performance and mood. Appetite 58:1, pages 339-346.
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Wilfried Dimpfel, Klaus Koch & Gabriele Weiss. (2012) Single Dose Effects of Pascoflair<sup>&#174;</sup> on Current Source Density (CSD) of Human EEG. Neuroscience and Medicine 03:02, pages 130-140.
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Joseph A. Araujo, Christina de Rivera, Jennifer L. Ethier, Gary M. Landsberg, Sagi Denenberg, Stephanie Arnold & Norton W. Milgram. (2010) ANXITANE® tablets reduce fear of human beings in a laboratory model of anxiety-related behavior. Journal of Veterinary Behavior: Clinical Applications and Research 5:5, pages 268-275.
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X. Di, J. Yan, Y. Zhao, J. Zhang, Z. Shi, Y. Chang & B. Zhao. (2010) l-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. Neuroscience 168:3, pages 778-786.
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Tae Il Kim, Yong Kyung Lee, Sang Gi Park, Im Seop Choi, Jung Ok Ban, Hyoung Kook Park, Sang-Yoon Nam, Young Won Yun, Sang Bae Han, Ki Wan Oh & Jin Tae Hong. (2009) l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways. Free Radical Biology and Medicine 47:11, pages 1601-1610.
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