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Journal of Biopharmaceutical Statistics Volume 14, 2004 - Issue 4
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Original Articles

An Evaluation of a Bayesian Method of Dose Escalation Based on Bivariate Binary Responses

John Whitehead Medical and Pharmaceutical Statistics Research Unit, The University of Reading, UK; Medical and Pharmaceutical Statistics Research Unit, P.O. Box 240 Earley Gate, Reading, RG6 6FN, UKCorrespondence[email protected]
,
Yinghui Zhou Medical and Pharmaceutical Statistics Research Unit, The University of Reading, UK
,
John Stevens AstraZeneca R&D Charnwood, Loughborough, UK
&
Graham Blakey AstraZeneca R&D Charnwood, Loughborough, UK
Pages 969-983 | Received 01 Mar 2004, Accepted 01 Mar 2004, Published online: 02 Feb 2007

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P. Colin, M. Delattre, P. Minini & S. Micallef. (2017) An Escalation for Bivariate Binary Endpoints Controlling the Risk of Overtoxicity (EBE-CRO): Managing Efficacy and Toxicity in Early Oncology Clinical Trials. Journal of Biopharmaceutical Statistics 27:6, pages 1054-1072.
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Vladimir Dragalin. (2010) Sequential Methods in Multi-Arm Clinical Trials. Sequential Analysis 29:4, pages 444-462.
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ValeriiV. Fedorov & Yuehui Wu. (2007) Dose Finding Designs for Continuous Responses and Binary Utility. Journal of Biopharmaceutical Statistics 17:6, pages 1085-1096.
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Articles from other publishers (19)

Takashi Daimon, Akihiro Hirakawa & Shigeyuki MatsuiTakashi Daimon, Akihiro Hirakawa & Shigeyuki Matsui. 2019. Dose-Finding Designs for Early-Phase Cancer Clinical Trials. Dose-Finding Designs for Early-Phase Cancer Clinical Trials 95 120 .
Sarah Zohar. 2014. Wiley StatsRef: Statistics Reference Online. Wiley StatsRef: Statistics Reference Online.
Oleksandr Sverdlov & Weng Kee Wong. (2014) Novel Statistical Designs for Phase I/II and Phase II Clinical Trials With Dose-Finding Objectives. Therapeutic Innovation & Regulatory Science 48:5, pages 601-612.
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Sarah Zohar. 2014. Methods and Applications of Statistics in Clinical Trials. Methods and Applications of Statistics in Clinical Trials 658 666 .
Atanu Biswas & Jesús López-Fidalgo. (2013) Compound designs for dose-finding in the presence of nondesignable covariates. Pharmaceutical Statistics 12:2, pages 92-101.
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Takashi Daimon. (2012) The Continual Reassessment Method (CRM) and Related Topics^|^mdash;A Review. Part II: Modified/Extended CRMs and Related Designs.. Japanese Journal of Biometrics 33:1, pages 31-76.
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Richard Chin. 2011. Adaptive and Flexible Clinical Trials. Adaptive and Flexible Clinical Trials 129 141 .
V. Seegers, S. Chevret & M. Resche-Rigon. (2011) Dose-finding design driven by efficacy in onco-hematology phase I/II trials. Statistics in Medicine 30:13, pages 1574-1583.
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Yinghui Zhou. (2010) Adaptive designs for Phase I dose‐finding studies. Fundamental & Clinical Pharmacology 24:2, pages 129-138.
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Shayne Cox GadJerry Nedelman, Frank Bretz, Roland Fisch, Anna Georgieva, Chyi-Hung Hsu, Joseph Kahn, Ryosei Kawai, Phil Lowe, Jeff Maca, José Pinheiro, Anthony Rossini, Heinz Schmidli, Jean-Louis Steimer & Jing Yu. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Fabián S. Tibaldi, Benoit H. L. Beck & Alun Bedding. (2008) Implementation of a Phase 1 Adaptive Clinical Trial in a Treatment of Type 2 Diabetes. Drug Information Journal 42:5, pages 455-465.
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Vladimir Dragalin, Valerii Fedorov & Yuehui Wu. (2008) Adaptive designs for selecting drug combinations based on efficacy–toxicity response. Journal of Statistical Planning and Inference 138:2, pages 352-373.
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Sarah Zohar & Vincent Levy. (2012) Dose Estimation. Pharmaceutical Medicine 22:1, pages 35-40.
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Sarah Zohar. 2007. Wiley Encyclopedia of Clinical Trials. Wiley Encyclopedia of Clinical Trials.
Brenda Gaydos, Michael Krams, Inna Perevozskaya, Frank Bretz, Qing Liu, Paul Gallo, Don Berry, Christy Chuang-Steln, José Pinheiro & Alun Bedding. (2006) Adaptive Dose-Response Studies. Drug Information Journal 40:4, pages 451-461.
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Vladimir Dragalin. (2006) Adaptive Designs: Terminology and Classification. Drug Information Journal 40:4, pages 425-435.
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Vladimir Dragalin & Valerii Fedorov. (2006) Adaptive designs for dose-finding based on efficacy–toxicity response. Journal of Statistical Planning and Inference 136:6, pages 1800-1823.
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Yinghui Zhou, John Whitehead, Elisa Bonvini & John W. Stevens. (2006) Bayesian decision procedures for binary and continuous bivariate dose-escalation studies. Pharmaceutical Statistics 5:2, pages 125-133.
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John Whitehead, Yinghui Zhou, John Stevens, Graham Blakey, Jim Price & Joanna Leadbetter. (2005) Bayesian decision procedures for dose‐escalation based on evidence of undesirable events and therapeutic benefit. Statistics in Medicine 25:1, pages 37-53.
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