Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 19, 2002 - Issue 6
226
Views
67
CrossRef citations to date
0
Altmetric
Original

AGING AND THE CIRCADIAN RHYTHM OF MELATONIN: A CROSS-SECTIONAL STUDY OF CHINESE SUBJECTS 30–110 YR OF AGE

, , , &
Pages 1171-1182 | Received 10 Jun 2002, Accepted 10 Jul 2002, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Yanshan Li, Xiaomeng Cui, Zunzhong Li, Qian Jia, Li Jiang, Zhenchun Zhang, Qing Lu, Jibo Wang & Lindi Jiang. (2020) High melatonin levels are related to spinal ossification in patients with ankylosing spondylitis. Modern Rheumatology 30:2, pages 373-378.
Read now
Natalya V. Semenova, Irina M. Madaeva, Tatiana A. Bairova, Radzhana M. Zhambalova, Leonid F. Sholokhov & Luybov I. Kolesnikova. (2018) Association of the melatonin circadian rhythms with clock 3111T/C gene polymorphism in Caucasian and Asian menopausal women with insomnia. Chronobiology International 35:8, pages 1066-1076.
Read now
Mariana Batista Ribeiro, Daniele Manfredini, Cláudia Tavares-Silva, Leandro Costa, Ronir Raggio Luiz, Saul Paiva, Júnia Maria Serra-Negra, Andréa Fonseca-Gonçalves & Lucianne Cople Maia. (2018) Association of possible sleep bruxism in children with different chronotype profiles and sleep characteristics. Chronobiology International 35:5, pages 633-642.
Read now
Katja Linda Waller, Erik Lykke Mortensen, Kirsten Avlund, Merete Osler, Birgitte Fagerlund, Martin Lauritzen, Steen Gammeltoft & Poul Jennum. (2016) Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition. Nature and Science of Sleep 8, pages 47-53.
Read now
Yong Seo Koo, Jin-Young Song, Eun-Yeon Joo, Heon-Jeong Lee, Eunil Lee, Sang-kun Lee & Ki-Young Jung. (2016) Outdoor artificial light at night, obesity, and sleep health: Cross-sectional analysis in the KoGES study. Chronobiology International 33:3, pages 301-314.
Read now
Ching-Ching Su, Pei-Yuan Su, Shu-Yi Wang & Chia-Chin Lin. (2015) Circadian rhythm mediates the relationship between physical activity and quality of life in younger and older cancer survivors. Chronobiology International 32:10, pages 1417-1426.
Read now
Michael H. Smolensky, Linda L. Sackett-Lundeen & Francesco Portaluppi. (2015) Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases. Chronobiology International 32:8, pages 1029-1048.
Read now
Yuval Weigl, IsraelE. Ashkenazi, Aviva Dotan & Leah Peleg. (2010) Shapes and structures of biological rhythms: variability of phenotypes in two strains of mice and their progeny. Biological Rhythm Research 41:1, pages 27-39.
Read now
P. Prahalathan, D. Arul, M. Jayakumar & P. Subramanian. (2010) Effect of melatonin on temporal patterns of redox status in young and aged rats. Biological Rhythm Research 41:1, pages 7-16.
Read now
Torsten Paul & Björn Lemmer. (2007) Disturbance of Circadian Rhythms in Analgosedated Intensive Care Unit Patients with and without Craniocerebral Injury. Chronobiology International 24:1, pages 45-61.
Read now
J. F. Walters, S. M. Hampton, G. A. A. Ferns & D. J. Skene. (2005) Effect of Menopause on Melatonin and Alertness Rhythms Investigated in Constant Routine Conditions. Chronobiology International 22:5, pages 859-872.
Read now
Olivier Coste, Maurice Beaumont, Denise Batéjat, Pascal Van Beers & Yvan Touitou. (2004) Prolonged Mild Hypoxia Modifies Human Circadian Core Body Temperature and may be Associated with Sleep Disturbances. Chronobiology International 21:3, pages 419-433.
Read now

Articles from other publishers (55)

Avnish Kumar Verma, Mohammad Idreesh KhanFauzia AshfaqSyed Ibrahim Rizvi. (2023) Crosstalk Between Aging, Circadian Rhythm, and Melatonin. Rejuvenation Research.
Crossref
Ahmadreza Keihani, Ahmad Mayeli & Fabio Ferrarelli. (2022) Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment. Advanced Biology 7:11.
Crossref
Yidan Pang, Siyuan Zhu, Jun Xu, Cuimin Su, Bo Wu, Changqing Zhang & Junjie Gao. (2023) Myeloid Cells As a Promising Target for Brain–Bone Degenerative Diseases from a Metabolic Point of View. Advanced Biology 7:10.
Crossref
Dimitar Terziev & Dora Terzieva. (2023) Experimental Data on the Role of Melatonin in the Pathogenesis of Nonalcoholic Fatty Liver Disease. Biomedicines 11:6, pages 1722.
Crossref
Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen, Xiao Chen, Yanhao Chen, Yu Chen, Yutian Chen, Zhiyang Chen, Jagadish K. Chhetri, Yingjie Ding, Junlin Feng, Jun Guo, Mengmeng Guo, Chuting He, Yujuan Jia, Haiping Jiang, Ying Jing, Dingfeng Li, Jiaming Li, Jingyi Li, Qinhao Liang, Rui Liang, Feng Liu, Xiaoqian Liu, Zuojun Liu, Oscar Junhong Luo, Jianwei Lv, Jingyi Ma, Kehang Mao, Jiawei Nie, Xinhua Qiao, Xinpei Sun, Xiaoqiang Tang, Jianfang Wang, Qiaoran Wang, Siyuan Wang, Xuan Wang, Yaning Wang, Yuhan Wang, Rimo Wu, Kai Xia, Fu-Hui Xiao, Lingyan Xu, Yingying Xu, Haoteng Yan, Liang Yang, Ruici Yang, Yuanxin Yang, Yilin Ying, Le Zhang, Weiwei Zhang, Wenwan Zhang, Xing Zhang, Zhuo Zhang, Min Zhou, Rui Zhou, Qingchen Zhu, Zhengmao Zhu, Feng Cao, Zhongwei Cao, Piu Chan, Chang Chen, Guobing Chen, Hou-Zao Chen, Jun Chen, Weimin Ci, Bi-Sen Ding, Qiurong Ding, Feng Gao, Jing-Dong J. Han, Kai Huang, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jian Li, Xin Li, Baohua Liu, Feng Liu, Lin Liu, Qiang Liu, Qiang Liu, Xingguo Liu, Yong Liu, Xianghang Luo, Shuai Ma, Xinran Ma, Zhiyong Mao, Jing Nie, Yaojin Peng, Jing Qu, Jie Ren, Ruibao Ren, Moshi Song, Zhou Songyang, Yi Eve Sun, Yu Sun, Mei Tian, Shusen Wang, Si Wang, Xia Wang, Xiaoning Wang, Yan-Jiang Wang, Yunfang Wang, Catherine C. L. Wong, Andy Peng Xiang, Yichuan Xiao, Zhengwei Xie, Daichao Xu, Jing Ye, Rui Yue, Cuntai Zhang, Hongbo Zhang, Liang Zhang, Weiqi Zhang, Yong Zhang, Yun-Wu Zhang, Zhuohua Zhang, Tongbiao Zhao, Yuzheng Zhao, Dahai Zhu, Weiguo Zou, Gang Pei & Guang-Hui Liu. (2023) Biomarkers of aging. Science China Life Sciences 66:5, pages 893-1066.
Crossref
Wei-Zhen Zhu, Qi-Ying He, De-Chao Feng, Qiang Wei & Lu Yang. (2023) Circadian rhythm in prostate cancer: time to take notice of the clock. Asian Journal of Andrology 25:2, pages 184.
Crossref
Mauro Giovanni Carta, Elisa Pintus, Rosanna Zaccheddu, Omar Callia, Giuliana Conti, Cesar Ivan Aviles Gonzalez, Luigi Minerba, Roberto Demontis, Massimiliano Pau, Eleonora Cocco, Maria Petronilla Penna, Goce Kalcev, Stefano Lorrai, Fernanda Velluzzi, Andrea Lovoselli, Marco Monticone, Maria Valeria Massidda, Maria Rita Pinna, Laura Atzori, Alberto Cauli, Alessandra Scano, Germano Orrù, Antonio Crisafulli, Sofia Cosentino, Sergio Machado, Dario Fortin, Gian Mario Migliaccio, Gabriele Finco, Mario Musu & Giulia Cossu. (2022) Social and Behavioral Rhythms is Related to the Perception of Quality of Life in Old Adults. The Open Psychology Journal 15:1.
Crossref
Leda Pistiolis, Djino Khaki, Anikó Kovács & Roger Olofsson Bagge. (2022) The Effect of Melatonin Intake on Survival of Patients with Breast Cancer—A Population-Based Registry Study. Cancers 14:23, pages 5884.
Crossref
Kejia Hu, Wanlu Li, Yunquan Zhang, Huashuai Chen, Chen Bai, Zhenchun Yang, Thiess Lorenz, Keyang Liu, Kokoro Shirai, Jinglu Song, Qi Zhao, Yali Zhao, Junfeng (Jim) Zhang, Jing Wei, Jiahao Pan, Jin Qi, Tingting Ye, Yi Zeng & Yao Yao. (2022) Association between outdoor artificial light at night and sleep duration among older adults in China: A cross-sectional study. Environmental Research 212, pages 113343.
Crossref
Russel J. Reiter, Ramaswamy Sharma, Sergio Rosales-Corral, Jasmine de Mange, William T. Phillips, Dun Xian Tan & Ryan D. Bitar. (2022) Melatonin in ventricular and subarachnoid cerebrospinal fluid: Its function in the neural glymphatic network and biological significance for neurocognitive health. Biochemical and Biophysical Research Communications 605, pages 70-81.
Crossref
Thodur Madapusi Balaji, Saranya Varadarajan, Raghunathan Jagannathan, Archana A. Gupta, A. Thirumal Raj, Shankargouda Patil, Hammam Ibrahim Fageeh & Hytham N. Fageeh. (2020) Melatonin levels in periodontitis vs. the healthy state: A systematic review and meta‐analysis. Oral Diseases 28:2, pages 284-306.
Crossref
Saeed Mehrzadi, Mohammad Yahya Karimi, Alireza Fatemi, Russel J. Reiter & Azam Hosseinzadeh. (2021) SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin. Pharmacology & Therapeutics 224, pages 107825.
Crossref
Lindsay M. Melhuish Beaupre, Gregory M. Brown, Vanessa F. Gonçalves & James L. Kennedy. (2021) Melatonin’s neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders. Translational Psychiatry 11:1.
Crossref
Francesco Dernie & Daniel Adeyoju. (2021) A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy. Experimental Gerontology 143, pages 111163.
Crossref
Yvan Touitou & Sébastien Point. (2020) Effects and mechanisms of action of light-emitting diodes on the human retina and internal clock. Environmental Research 190, pages 109942.
Crossref
Tuya Nanzadsuren, Tuul Myatav, Amgalanbaatar Dorjkhuu & Khandsuren Byamba. (2019) Association between serum melatonin and skin aging in an urban population of Mongolia. Journal of Cosmetic Dermatology 19:6, pages 1501-1507.
Crossref
Brian V. Lananna & Erik S. Musiek. (2020) The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration. Neurobiology of Disease 139, pages 104832.
Crossref
Linyi Li, Zhenxiang Zhao, Jianjun Ma, Jinhua Zheng, Shen Huang, Shiyu Hu, Qi Gu & Siyuan Chen. (2020) Elevated Plasma Melatonin Levels Are Correlated With the Non-motor Symptoms in Parkinson’s Disease: A Cross-Sectional Study. Frontiers in Neuroscience 14.
Crossref
James M. Olcese. (2020) Melatonin and Female Reproduction: An Expanding Universe. Frontiers in Endocrinology 11.
Crossref
Sergio A. Rosales-Corral, Russel J. Reiter & Xiaoyan Liu. 2020. Aging. Aging 243 257 .
Irina Odinokova, Yulia Baburina, Alexey Kruglov, Irina Fadeeva, Alena Zvyagina, Linda Sotnikova, Vladimir Akatov & Olga Krestinina. (2018) Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats. International Journal of Molecular Sciences 19:6, pages 1555.
Crossref
Rikie M. Scholtens, Barbara C. van Munster, Martijn van Faassen, Marijn F. van Kempen, Ido P. Kema & Sophia E. de Rooij. (2017) Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. Mechanisms of Ageing and Development 167, pages 1-4.
Crossref
Suzanne Hood & Shimon Amir. (2017) The aging clock: circadian rhythms and later life. Journal of Clinical Investigation 127:2, pages 437-446.
Crossref
Gaia Favero, Lorenzo Franceschetti, Francesca Bonomini, Luigi Fabrizio Rodella & Rita Rezzani. (2017) Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation. International Journal of Endocrinology 2017, pages 1-13.
Crossref
Rikie M. Scholtens, Sophia E. J. A. de Rooij, Annelies E. Vellekoop, Bart C. Vrouenraets & Barbara C. van Munster. (2016) Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. PLOS ONE 11:12, pages e0167621.
Crossref
Yvan Touitou, David Touitou & Alain Reinberg. (2016) Disruption of adolescents’ circadian clock: The vicious circle of media use, exposure to light at night, sleep loss and risk behaviors. Journal of Physiology-Paris 110:4, pages 467-479.
Crossref
Rikie M. Scholtens, Barbara C. van Munster, Marijn F. van Kempen & Sophia E.J.A. de Rooij. (2016) Physiological melatonin levels in healthy older people: A systematic review. Journal of Psychosomatic Research 86, pages 20-27.
Crossref
J. M. Bumb & Ingo S. Nölte. 2016. Melatonin, Neuroprotective Agents and Antidepressant Therapy. Melatonin, Neuroprotective Agents and Antidepressant Therapy 43 53 .
Kenji Obayashi, Keigo Saeki, Nobuhiro Tone, Junko Iwamoto, Kimie Miyata, Yoshito Ikada & Norio Kurumatani. (2015) Lower Melatonin Secretion in Older Females: Gender Differences Independent of Light Exposure Profiles. Journal of Epidemiology 25:1, pages 38-43.
Crossref
Sergio A. Rosales-Corral, Russel J. Reiter, Dun-Xian Tan, Lucien C. Manchester & Xiaoyan Liu. 2014. Aging. Aging 177 193 .
Rahimah Zakaria, Amnon Brzezinski & Venkataramanujam Srinivasan. 2014. Melatonin and Melatonergic Drugs in Clinical Practice. Melatonin and Melatonergic Drugs in Clinical Practice 193 203 .
Keiko Wada, Kozue Nakamura, Yuya Tamai, Michiko Tsuji, Takako Masue, Kaori Watanabe, Kyoko Ando & Chisato Nagata. (2013) Associations of urinary 6-sulfatoxymelatonin with demographics, body mass, sex steroids, and lifestyle factors in preschool Japanese children. Annals of Epidemiology 23:2, pages 60-65.
Crossref
Susan Hurley, David O Nelson, Erika Garcia, Robert Gunier, Andrew Hertz & Peggy Reynolds. (2013) A cross-sectional analysis of light at night, neighborhood sociodemographics and urinary 6-sulfatoxymelatonin concentrations: implications for the conduct of health studies. International Journal of Health Geographics 12:1, pages 39.
Crossref
Stephanie J. Crowley, Christine Acebo & Mary A. Carskadon. (2012) Human puberty: Salivary melatonin profiles in constant conditions. Developmental Psychobiology 54:4, pages 468-473.
Crossref
Wei-Chung Mao, Hsin-Chien Lee & Hsi-Chung Chen. 2012. Introduction to Modern Sleep Technology. Introduction to Modern Sleep Technology 137 164 .
Yvan Touitou. (2011) Désynchronisation de l'horloge interne, lumière et mélatonine. Bulletin de l'Académie Nationale de Médecine 195:7, pages 1527-1549.
Crossref
Jörg H. Stehle, Anastasia Saade, Oliver Rawashdeh, Katrin Ackermann, Antje Jilg, Tamás Sebestény & Erik Maronde. (2011) A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. Journal of Pineal Research 51:1, pages 17-43.
Crossref
Regina P. Markus, Claudia L.M. Silva, Daiane Gil Franco, Eduardo Mortani BarbosaJr.Jr. & Zulma S. Ferreira. (2010) Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?. Pharmacology & Therapeutics 126:3, pages 251-262.
Crossref
Susana Esteban, Celia Garau, Sara Aparicio, David Moranta, Pere Barceló, Maria Antonia Fiol & Rubén Rial. (2010) Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain. Journal of Pineal Research 48:2, pages 170-177.
Crossref
Ingo Nölte, Ann-Theres Lütkhoff, Boris A. Stuck, Björn Lemmer, Michael Schredl, Peter Findeisen & Christoph Groden. (2009) Pineal volume and circadian melatonin profile in healthy volunteers: An interdisciplinary approach. Journal of Magnetic Resonance Imaging 30:3, pages 499-505.
Crossref
Jolanta B. Zawilska, Debra J. Skene & Josephine Arendt. (2009) Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacological Reports 61:3, pages 383-410.
Crossref
Ettore Ferrari & Flavia Magri. (2008) Role of neuroendocrine pathways in cognitive decline during aging. Ageing Research Reviews 7:3, pages 225-233.
Crossref
Sophia L. Markantonis, Eleftheria Tsakalozou, Anteia Paraskeva, Chryssoula Staikou & Argyro Fassoulaki. (2008) Melatonin Pharmacokinetics in Premenopausal and Postmenopausal Healthy Female Volunteers. The Journal of Clinical Pharmacology 48:2, pages 240-245.
Crossref
E. Ferrari, L. Cravello, F. Falvo, L. Barili, S.B. Solerte, M. Fioravanti & F. Magri. (2008) Neuroendocrine features in extreme longevity. Experimental Gerontology 43:2, pages 88-94.
Crossref
Ivanna Antoniuk-Shcheglova & Valeriy Shatilo. (2008) Effect of long-term use of various melatonin doses in elderly peopleWpływ długoterminowego stosowania różnych dawek melatoniny u osób w wieku podeszłym. Annales UMCS, Pharmacia 21:1, pages 265-268.
Crossref
Stephen Y. W. Shiu. (2007) Towards rational and evidence-based use of melatonin in prostate cancer prevention and treatment. Journal of Pineal Research 43:1, pages 1-9.
Crossref
Leonid Kayumov, Alan Lowe, Shadab A. Rahman, Robert F. Casper & Colin M. Shapiro. (2007) Prevention of melatonin suppression by nocturnal lighting: relevance to cancer. European Journal of Cancer Prevention 16:4, pages 357-362.
Crossref
Chun W. Tam, Chi W. Mo, Kwok-Ming Yao & Stephen Y. W. Shiu. (2007) Signaling mechanisms of melatonin in antiproliferation of hormone-refractory 22Rv1 human prostate cancer cells: implications for prostate cancer chemoprevention. Journal of Pineal Research 42:2, pages 191-202.
Crossref
Ying-Hui Wu & Dick F. Swaab. (2005) The human pineal gland and melatonin in aging and Alzheimer's disease. Journal of Pineal Research 38:3, pages 145-152.
Crossref
André Bogdan, Belal Bouchareb & Yvan Touitou. (2007) Response of circulating leptin to Ramadan daytime fasting: a circadian study. British Journal of Nutrition 93:4, pages 515-518.
Crossref
Y Weigl, L Peleg, A Dotan & I.E Ashkenazi. (2004) Gender-dependent differences in biological rhythms of mice. Life Sciences 75:7, pages 857-868.
Crossref
Yasmina Djeridane & Yvan Touitou. (2004) Ex vivo studies on the acute and chronic effects of DHEA and DHEA-sulfate on melatonin synthesis in young- and old-rat pineal glands. Steroids 69:5, pages 343-349.
Crossref
Yvan Touitou & Erhard Haus. 2004. The Neuroendocrine Immune Network in Ageing. The Neuroendocrine Immune Network in Ageing 165 193 .
Brahim Selmaoui & Yvan Touitou. (2003) Reproducibility of the circadian rhythms of serum cortisol and melatonin in healthy subjects: a study of three different 24-h cycles over six weeks. Life Sciences 73:26, pages 3339-3349.
Crossref
Zi-Yan Zhao, Fang-Hong Lu, Yi Xie, Yue-Rong Fu, André Bogdan & Yvan Touitou. (2003) Cortisol secretion in the elderly. Influence of age, sex and cardiovascular disease in a Chinese population. Steroids 68:6, pages 551-555.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.