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Research Article

Fatal Cardiovascular Collapse Following Acute Colchicine Ingestion

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Pages 51-54 | Published online: 23 Feb 2000

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Read on this site (10)

Wiem Barbaria, Ichrak Khamassi & Mohamed Fkili. (2023) Pediatric colchicine poisoning with survival after a “lethal” overdose: a case report. Toxicology Communications 7:1.
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Abderahmane Linani, Talia Serseg, Khedidja Benarous, Leila Bou-salah, Mohamed Yousfi, Mohammed Nabil Alama & Ghulam Md Ashraf. (2023) Cupressus sempervirens L. flavonoids as potent inhibitors to xanthine oxidase: in vitro, molecular docking, ADMET and PASS studies. Journal of Biomolecular Structure and Dynamics 41:15, pages 7055-7068.
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D. H. Schaffer, D. L. Overbeek, T. B. Erickson, E. W. Boyer, C. Goldfine, S. A. Muhsin & P. R. Chai. (2022) Severe colchicine poisoning treated successfully with kidney replacement therapy and plasmapheresis: a case report. Toxicology Communications 6:1, pages 46-50.
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Kashyap Kumar Dubey, Punit Kumar, Nikolaos E. Labrou & Pratyoosh Shukla. (2017) Biotherapeutic potential and mechanisms of action of colchicine. Critical Reviews in Biotechnology 37:8, pages 1038-1047.
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Julie Boisramé-Helms, Hassène Rahmani, Laure Stiel, Christine Tournoud & Philippe Sauder. (2015) Extracorporeal life support in the treatment of colchicine poisoning. Clinical Toxicology 53:8, pages 827-829.
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Abdulsamet Erden, Hatice Karagoz, Hasan Hüseyin Gümüscü, Samet Karahan, Mustafa Basak, Fatma Aykas, Kadir Bulut, Ali Cetinkaya, Deniz Avci & Orhan Kürsat Poyrazoglu. (2013) Colchicine intoxication: a report of two suicide cases. Therapeutics and Clinical Risk Management 9, pages 505-509.
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Huiqin Wu, Xiaoting Xiong, Xiaolan Huang, Zhixin Zhu, Fang Huang & Xiaoshan Lin. (2013) SIMULTANEOUS DETERMINATION OF 17 TOXIC ALKALOIDS IN HUMAN FLUIDS BY LIQUID CHROMATOGRAPHY COUPLED WITH ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY. Journal of Liquid Chromatography & Related Technologies 36:9, pages 1149-1162.
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Ramazan Ozdemir, Benan Bayrakci & Ozlem Teksam. (2011) Fatal poisoning in children: Acute Colchicine intoxication and new treatment approaches. Clinical Toxicology 49:8, pages 739-743.
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S. Zahra Bathaie & S. Zeinab Mousavi. (2010) New Applications and Mechanisms of Action of Saffron and its Important Ingredients. Critical Reviews in Food Science and Nutrition 50:8, pages 761-786.
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Naomi Schlesinger. (2007) Reassessing the safety of intravenous and compounded injectable colchicine in acute gout treatment. Expert Opinion on Drug Safety 6:6, pages 625-629.
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Articles from other publishers (32)

Ryota Tochinai, Yoshiyasu Nagashima, Shin‐ichi Sekizawa & Masayoshi Kuwahara. (2023) Anti‐tumor and cardiotoxic effects of microtubule polymerization inhibitors: The mechanisms and management strategies. Journal of Applied Toxicology 44:1, pages 96-106.
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齐 孙. (2023) Acute Colchicine Poisoning Resulting in Cardiac Arrest and Death: A Case Report and Literature Review. Advances in Clinical Medicine 13:11, pages 18038-18044.
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Daniel J. McCabe, Bryan Z. Wilson, Joshua B. Radke & Edward M. Bottei. (2022) A Fatal Colchicine Ingestion With Antemortem Blood Concentration. American Journal of Forensic Medicine & Pathology 43:3, pages 253-255.
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Abderahmane Linani, Khedidja Benarous, Leila Bou-Salah & Mohamed Yousfi. (2022) The inhibitory kinetics of vitamins B9, C, E, and D3 on bovine xanthine oxidase: Gout treatment. Chemico-Biological Interactions 359, pages 109922.
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Maria Pérez Marín, Sylvain Prod'hom, Suzanne Francesca de Villiers, Thomas Ferry, Vivianne Amiet, Julia Natterer, Maria-Helena Perez, Thierry Buclin, Haithem Chtioui & David Longchamp. (2021) Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support. Frontiers in Pediatrics 9.
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Maxim  Eliseev, Maria Chikina & Evgeny Nasonov. 2020. Recent Advances in Gout. Recent Advances in Gout.
近松 惣太郎 (Sotaro Chikamatsu)下川 雄三 (Yuzo Shimokawa). (2019) イヌサフランの球根を自殺目的に大量摂取したコルヒチン中毒の1救命例(A surviving case of colchicine poisoning by consuming Colchicum autumnale bulbs for attempting suicide: a case report) . Nihon Kyukyu Igakukai Zasshi: Journal of Japanese Association for Acute Medicine 30:12, pages 989-995.
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Arianna Giorgetti, Alessandro Nalesso, Giovanni Cecchetto, Marco Pizzi, Alberto Bellan, Guido Viel & Massimo Montisci. (2019) Two fatal intoxications by colchicine taken for saffron. Clinical, medico-legal and forensic toxicological implications. Legal Medicine 38, pages 64-68.
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M. N. Chikina. (2019) Prevention of arthritis attacks in the use of urate-lowering therapy in patients with gout. Rheumatology Science and Practice 56:6, pages 760-766.
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Jerry W. Snow, Louise W. Kao & R. Brent Furbee. 2017. Critical Care Toxicology. Critical Care Toxicology 1387 1409 .
Jerry W. Snow, Louise W. Kao & R. Brent Furbee. 2016. Critical Care Toxicology. Critical Care Toxicology 1 23 .
Anastasia Slobodnick, Binita Shah, Michael H. Pillinger & Svetlana Krasnokutsky. (2015) Colchicine: Old and New. The American Journal of Medicine 128:5, pages 461-470.
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Demet Demirkol, Burcin N Karacabey & Fatih Aygun. (2015) Plasma Exchange Treatment in a Case of Colchicine Intoxication. Therapeutic Apheresis and Dialysis 19:1, pages 95-97.
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Nicola Dalbeth, Thomas J. Lauterio & Henry R. Wolfe. (2014) Mechanism of Action of Colchicine in the Treatment of Gout. Clinical Therapeutics 36:10, pages 1465-1479.
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Sara Fernández, Pedro Castro, Santiago Nogué & Josep María Nicolás. (2014) Shock refractario y leucopenia grave con fracaso multiorgánico secundarios a una intoxicación por colchicina. Medicina Clínica 143:3, pages 140.
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Ryota Tochinai, Katsuya Suzuki, Yuriko Nagata, Minoru Ando, Chie Hata, Kayoko Komatsu, Tomo Suzuki, Kazumi Uchida, Shoichi Kado, Kimiyuki Kaneko & Masayoshi Kuwahara. (2014) Cardiotoxic Changes of Colchicine Intoxication in Rats: Electrocardiographic, Histopathological and Blood Chemical Analysis. Journal of Toxicologic Pathology 27:3+4, pages 223-230.
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Mohammad Amrollahi-Sharifabadi, Ahmad Seghatoleslami, Maryam Amrollahi-Sharifabadi, Farajali Bayani & Mahdi Mirjalili. (2013) Fatal Colchicine Poisoning by Accidental Ingestion of Colchicum persicum. American Journal of Forensic Medicine & Pathology 34:4, pages 295-298.
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Ryota Tochinai, Minoru Ando, Tomo Suzuki, Katsuya Suzuki, Yuriko Nagata, Chie Hata, Kazumi Uchida, Toshihide Kobayashi, Shoichi Kado & Kimiyuki Kaneko. (2013) Histopathological studies of microtubule disassembling agent-induced myocardial lesions in rats. Experimental and Toxicologic Pathology 65:6, pages 737-743.
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OF Wong, CK Koo, KS Tang, KC Chow & CL Lau. (2017) Bronchiolitis Obliterans Organising Pneumonia in a Case of Colchicine Overdose. Hong Kong Journal of Emergency Medicine 18:4, pages 249-253.
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Heike Wollersen, Freidoon Erdmann, Manfred Risse & Reinhard Dettmeyer. (2009) Accidental fatal ingestion of colchicine-containing leaves – toxicological and histological findings. Legal Medicine 11, pages S498-S499.
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Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances 693 702 .
Marc E. Levsky, Michael A. Miller, David A. Masneri & Doug Borys. (2008) Colchicine Exposures: The Texas Experience. Southern Medical Journal 101:5, pages 480-483.
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Suat Bi??er, Demet D. Soysal, Agop ??tak, Raif ????sel, Metin Karab??c??o??lu & Nedret Uzel. (2007) Acute Colchicine Intoxication in a Child. Pediatric Emergency Care 23:5, pages 314-317.
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M. Hermanns-Clausen, H. Schumacher, L. Jahn & U. Stedtler. (2007) Letale Vergiftung nach Verwechslung von Krokus (Crocus species) mit Herbstzeitloser (Colchicum autumnale)Fatal colchicine poisoning after a mix up of crocus species and colchicum autumnale. Intensivmedizin und Notfallmedizin 44:2, pages 104-109.
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Michael A. Miller, Yao-Min Hung, Christine Haller, Mark Galbo & Marc E. Levsky. (2005) Colchicine-related death presenting as an unknown case of multiple organ failure. The Journal of Emergency Medicine 28:4, pages 445-448.
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Zeljko Sundov, Zeljko Nincevic, Marija Definis-Gojanovic, Merica Glavina-Durdov, Ivana Jukic, Nada Hulina & Ante Tonkic. (2005) Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. Forensic Science International 149:2-3, pages 253-256.
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Manuel López Jiméneza & Juan García Puigb. (2004) Cartas al Editor. Medicina Clínica 123:20, pages 799.
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Miran Brvar, Tom Ploj, Gordana Kozelj, Martin Mozina, Marko Noc & Matjaz Bunc. (2004) Case report: fatal poisoning with Colchicum autumnale. Critical Care 8:1.
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. 2001. Dreisbach's Handbook of Poisoning. Dreisbach's Handbook of Poisoning 556 584 .
Barbara Weakley-Jones, John E. Gerber & Gary Biggs. (2001) Colchicine Poisoning. The American Journal of Forensic Medicine and Pathology 22:2, pages 203-206.
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Naomi Schlesinger & H. Ralph SchumacherJr.Jr.. (2001) Gout: can management be improved?. Current Opinion in Rheumatology 13:3, pages 240-244.
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Ranjit N Ratnaike, Austin G Milton & Olimpia Nigro. (2000) Drug‐Associated Diarrhoea and Constipation in Older People; 2. Constipation. The Australian Journal of Hospital Pharmacy 30:5, pages 210-213.
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