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Research Article

Monitoring of Clozapine and Norclozapine Plasma Concentration-Time Curves in Acute Overdose

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Pages 325-328 | Published online: 14 Jun 2000

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Daniel J. Cobaugh, Andrew R. Erdman, Lisa L. Booze, Elizabeth J. Scharman, Gwenn Christianson, Anthony S. Manoguerra, E. Martin Caravati, Peter A. Chyka, Alan D. Woolf, Lewis S. Nelson & William G. Troutman. (2007) Atypical antipsychotic medication poisoning: An evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 45:8, pages 918-942.
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Mohammad Masud Iqbal, Atiq Rahman, Zahid Husain, Syed Zaber Mahmud, William G. Ryan & Jacqueline M. Feldman. (2003) Clozapine: A Clinical Review of Adverse Effects and Management. Annals of Clinical Psychiatry 15:1, pages 33-48.
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Michael J. Burns. (2001) The Pharmacology and Toxicology of Atypical Antipsychotic Agents. Journal of Toxicology: Clinical Toxicology 39:1, pages 1-14.
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Articles from other publishers (25)

Andreas Hartjes, Matthaeus Machnik, Christa Kubasta & Karl Schrattbauer. (2023) Severe Clozapine Poisoning Treated by Extracorporeal Blood Purification Therapy. Case Reports in Nephrology and Dialysis, pages 84-89.
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Can-Jun Ruan, Ismael Olmos, Carina Ricciardi, Georgios Schoretsanitis, Philippe D. Vincent, A. Elif Anıl Yağcıoğlu, Chin B. Eap, Trino Baptista, Scott R. Clark, Emilio Fernandez-Egea, Se Hyun Kim, Hsien-Yuan Lane, Jonathan Leung, Olalla Maroñas Amigo, Mariano Motuca, Susanna Every-Palmer, Ric M. Procyshyn, Christopher Rohde, Satish Suhas, Peter F.J. Schulte, Edoardo Spina, Hiroyoshi Takeuchi, Hélène Verdoux, Christoph U. Correll, Espen Molden, Carlos De Las Cuevas & Jose de Leon. (2023) Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients. Schizophrenia Research.
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Jonathan M. Meyer & Stephen M. Stahl. 2021. The Clinical Use of Antipsychotic Plasma Levels. The Clinical Use of Antipsychotic Plasma Levels 249 266 .
Madeleine S. A. Tan, Faraz Honarparvar, James R. Falconer, Harendra S. Parekh, Preeti Pandey & Dan J. Siskind. (2021) A systematic review and meta-analysis of the association between clozapine and norclozapine serum levels and peripheral adverse drug reactions. Psychopharmacology 238:3, pages 615-637.
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Hikari Fuchigami, Mandeep K. Bal, Dale A. C. Brownson, Craig E. Banks & Alan M. Jones. (2020) Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities. Scientia Pharmaceutica 88:4, pages 46.
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Marloes van Helvoort, Philip van Eijndhoven, Arnt Schellekens, Monica Pop-Purceleanu, Cornelis Kramers & Albert Batalla. (2019) Delayed complications after severe clozapine intoxication. International Clinical Psychopharmacology 34:5, pages 269-272.
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Jonathan M. Meyer & Stephen M. Stahl. 2021. The Clozapine Handbook. The Clozapine Handbook 276 306 .
Emma Tay, Andreas Sotiriou, Garry G. Graham, Kay Wilhelm, Leone Snowden & Richard O. Day. (2019) Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance. Therapeutic Advances in Psychopharmacology 9, pages 204512531983688.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 443 477 .
N. Toepfner, A. Wohlfarth, J. Naue, V. Auwärter, R. Berner & M. Hermanns-Clausen. (2013) Accidental clozapine intoxication in a toddler: clinical and pharmacokinetic lessons learnt. Journal of Clinical Pharmacy and Therapeutics 38:2, pages 165-168.
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Peter Manu, Christoph U. Correll, Martien Wampers, Ruud van Winkel, Weiping Yu, Daphna Shiffeldrim, John M. Kane & Marc De Hert. (2013) Insulin secretion in patients receiving clozapine, olanzapine, quetiapine and risperidone. Schizophrenia Research 143:2-3, pages 358-362.
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Ariane Wohlfarth, Nicole Toepfner, Maren Hermanns-Clausen & Volker Auwärter. (2011) Sensitive quantification of clozapine and its main metabolites norclozapine and clozapine-N-oxide in serum and urine using LC-MS/MS after simple liquid–liquid extraction work-up. Analytical and Bioanalytical Chemistry 400:3, pages 737-746.
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Mary A. Wittler & Eric J. Lavonas. 2010. Rosen's Emergency Medicine – Concepts and Clinical Practice. Rosen's Emergency Medicine – Concepts and Clinical Practice 2042 2046 .
Kuan-Chiao Tseng & Tzung-Jeng Hwang. (2009) Rhabdomyolysis Following Dose Increase of Clozapine and Combination Therapy With Lithium. Journal of Clinical Psychopharmacology 29:4, pages 398-399.
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Erik Sparve, Per Nordberg, Sune Forsberg & Anders Helld?n. (2009) Acute Clozapine Intoxication. Journal of Clinical Psychopharmacology 29:3, pages 302-304.
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. 2009. Meyler's Side Effects of Psychiatric Drugs. Meyler's Side Effects of Psychiatric Drugs 185 373 .
. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 823 841 .
R.J. Flanagan, E.P. Spencer, P.E. Morgan, T.R.E. Barnes & L. Dunk. (2005) Suspected clozapine poisoning in the UK/Eire, 1992–2003. Forensic Science International 155:2-3, pages 91-99.
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P. Timothy Pollak & Steven L. Shafer. (2013) Teaching Application of Clinical Pharmacology Skills Using Unusual Observations from Clozapine Overdoses. The Journal of Clinical Pharmacology 44:2, pages 141-149.
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Philip B. Mitchell. 2004. Drug Monitoring and Clinical Chemistry. Drug Monitoring and Clinical Chemistry 255 271 .
Lyle Thomas & P.Timothy Pollak. (2003) Delayed recovery associated with persistent serum concentrations after clozapine overdose. The Journal of Emergency Medicine 25:1, pages 61-66.
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R.J Flanagan, A Amin & W Seinen. (2003) Effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozapine concentrations in the domestic pig (Sus scrofa). Forensic Science International 132:1, pages 9-17.
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Alfonso Carvajal & Luis H. Mart?n Arias. 2002. 53 77 .
. 2001. Dreisbach's Handbook of Poisoning. Dreisbach's Handbook of Poisoning 390 421 .
Tae-Ju Park, Seong-Il Bae, Se-Young Choi, Byung-Jo Kang & Kyong-Tai Kim. (2001) Inhibition of nicotinic acetylcholine receptors and calcium channels by clozapine in bovine adrenal chromaffin cells. Biochemical Pharmacology 61:8, pages 1011-1019.
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