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Research Article

Cadmium Hepatotoxicity and Alterations of the Mitochondrial Function

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Pages 407-413 | Published online: 24 Jul 2000

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Jae Hyeon Park, Byung Mu Lee & Hyung Sik Kim. (2021) Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress. Journal of Toxicology and Environmental Health, Part B 24:3, pages 95-118.
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Claus U Niemann & Natalie J Serkova. (2007) Biochemical mechanisms of nephrotoxicity: application for metabolomics. Expert Opinion on Drug Metabolism & Toxicology 3:4, pages 527-544.
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Yuichi OISHI, Motoko OHNISHI, Kazuo KOBAYASHI-HATTORI, Toshichika TAKITA & Tadashi NOGUCHI. (2007) Cadmium Cation Increases the Production and mRNA Levels of Insulin-Like Growth Factor-Binding Protein-1 in HepG2. Bioscience, Biotechnology, and Biochemistry 71:5, pages 1334-1337.
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Wing-Kee Lee, Ulrich Bork & Frank Thévenod. (2004) Mitochondria as a Target of Cadmium Nephrotoxicity: Induction of Swelling and Cytochrome c Release. Toxicology Mechanisms and Methods 14:1-2, pages 67-71.
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Articles from other publishers (35)

Moonjung Hyun, Hyejin Kim, Jehein Kim, Juhong Lee, Ho Jeong Lee, Laxmi Rathor, Jeremy Meier, Andrew Larner, Seon Min Lee, Yeongyu Moon, Jungil Choi, Sung Min Han & Jeong-Doo Heo. (2023) Melatonin protects against cadmium-induced oxidative stress via mitochondrial STAT3 signaling in human prostate stromal cells. Communications Biology 6:1.
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Aalekhya Reddam, Sarah McLarnan & Allison Kupsco. (2022) Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature. Current Environmental Health Reports 9:4, pages 631-649.
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Xing Qin, Peng Wu, Ting Wen, Rui Jia, Ronghua Zhang, Jiaoting Jin, Fangfang Hu, Qiao Yi Chen & Jingxia Dang. (2022) Comparative assessment of blood Metal/metalloid levels, clinical heterogeneity, and disease severity in amyotrophic lateral sclerosis patients. NeuroToxicology 89, pages 12-19.
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Riccardo Oggiano, Andrea Pisano, Angela Sabalic, Cristiano Farace, Grazia Fenu, Simone Lintas, Giovanni Forte, Beatrice Bocca & Roberto Madeddu. (2020) An overview on amyotrophic lateral sclerosis and cadmium. Neurological Sciences 42:2, pages 531-537.
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Małgorzata Dżugan, Wojciech Trybus, Marcin Lis, Monika Wesołowska, Ewa Trybus, Anna Kopacz-Bednarska & Teodora Król. (2018) Cadmium-induced ultrastructural changes in primary target organs of developing chicken embryos (Gallus domesticus). Journal of Trace Elements in Medicine and Biology 50, pages 167-174.
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Fan Yang, Jianzhao Liao, Ruonan Pei, Wenlan Yu, Qingyue Han, Ying Li, Jianying Guo, Lianmei Hu, Jiaqiang Pan & Zhaoxin Tang. (2018) Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes. Chemosphere 204, pages 36-43.
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Mohammad Mohajeri, Mehdi Rezaee & Amirhossein Sahebkar. (2017) Cadmium-induced toxicity is rescued by curcumin: A review. BioFactors 43:5, pages 645-661.
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Fan Yang, Huabin Cao, Rongsheng Su, Jianying Guo, Chengmei Li, Jiaqiang Pan & Zhaoxin Tang. (2017) Liver mitochondrial dysfunction and electron transport chain defect induced by high dietary copper in broilers. Poultry Science 96:9, pages 3298-3304.
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K. Reyes-Gordillo, R. Shah, M.R. Lakshman, R.E. Flores-Beltrán & P. Muriel. 2017. Liver Pathophysiology. Liver Pathophysiology 687 704 .
Karima F. Mahrous, Aziza M. Hassan, Hasnaa A. Radwan & M.A. Mahmoud. (2015) Inhibition of cadmium- induced genotoxicity and histopathological changes in Nile tilapia fish by Egyptian and Tunisian montmorillonite clay. Ecotoxicology and Environmental Safety 119, pages 140-147.
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Rongsheng Su, Huabin Cao, Jiaqiang Pan, Chengmei Li, Yizhou Chen & Zhaoxin Tang. (2015) The Protective Roles of Selenium on Hepatic Tissue Ultrastructure and Mitochondrial Antioxidant Capacity in Copper-Overloaded Rats. Biological Trace Element Research 167:1, pages 110-114.
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Wylly Ramsés García-Niño & José Pedraza-Chaverrí. (2014) Protective effect of curcumin against heavy metals-induced liver damage. Food and Chemical Toxicology 69, pages 182-201.
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Ying-Yong Zhao & Rui-Chao Lin. 2014. 69 89 .
S Xu, H Pi, Y Chen, N Zhang, P Guo, Y Lu, M He, J Xie, M Zhong, Y Zhang, Z Yu & Z Zhou. (2013) Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity. Cell Death & Disease 4:3, pages e540-e540.
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E. V. Kravenskaya & N. V. Fedirko. (2012) Molecular Mechanisms of Cadmium-Induced Nonspecific Mitochondrial Permeability. Neurophysiology 43:6, pages 494-497.
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Rongsheng Su, Rongmei Wang, Shining Guo, Huabin Cao, Jiaqiang Pan, Chengmei Li, Dayou Shi & Zhaoxin Tang. (2011) In Vitro Effect of Copper Chloride Exposure on Reactive Oxygen Species Generation and Respiratory Chain Complex Activities of Mitochondria Isolated from Broiler Liver. Biological Trace Element Research 144:1-3, pages 668-677.
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WP MaoNN Zhang, FY Zhou, WX Li, HY Liu, J. Feng, L. Zhou, CJ Wei, YB Pan & ZJ He. (2010) Cadmium directly induced mitochondrial dysfunction of human embryonic kidney cells. Human & Experimental Toxicology 30:8, pages 920-929.
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Yue Zhang, Jia-Han Li, Xiao-Rong Liu, Feng-Lei Jiang, Fang-Fang Tian & Yi Liu. (2011) Spectroscopic and Microscopic Studies on the Mechanisms of Mitochondrial Toxicity Induced by Different Concentrations of Cadmium. The Journal of Membrane Biology 241:1, pages 39-49.
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Ilya O. KurochkinMarkus Etzkorn, David Buchwalter, Larry LeamyInna M. Sokolova. (2011) Top-down control analysis of the cadmium effects on molluscan mitochondria and the mechanisms of cadmium-induced mitochondrial dysfunction. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300:1, pages R21-R31.
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Ann Cuypers, Michelle Plusquin, Tony Remans, Marijke Jozefczak, Els Keunen, Heidi Gielen, Kelly Opdenakker, Ambily Ravindran Nair, Elke Munters, Tom J. Artois, Tim Nawrot, Jaco Vangronsveld & Karen Smeets. (2010) Cadmium stress: an oxidative challenge. BioMetals 23:5, pages 927-940.
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Giuseppe Cannino, Elisa Ferruggia, Claudio Luparello & Anna Maria Rinaldi. (2009) Cadmium and mitochondria. Mitochondrion 9:6, pages 377-384.
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Wing-Kee Lee & Frank Thévenod. (2008) Novel roles for ceramides, calpains and caspases in kidney proximal tubule cell apoptosis: Lessons from in vitro cadmium toxicity studies. Biochemical Pharmacology 76:11, pages 1323-1332.
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M.S. Yang, D. Li, T. Lin, J.J. Zheng, W. Zheng & J.Y. Qu. (2008) Increase in intracellular free/bound NAD[P]H as a cause of Cd-induced oxidative stress in the HepG2 cells. Toxicology 247:1, pages 6-10.
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Wing-Kee Lee & Frank Thévenod. (2006) A role for mitochondrial aquaporins in cellular life-and-death decisions?. American Journal of Physiology-Cell Physiology 291:2, pages C195-C202.
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Gerhard Krumschnabel, Claudia Manzl, Christian Berger & Bettina Hofer. (2005) Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes. Toxicology and Applied Pharmacology 209:1, pages 62-73.
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Wing-Kee Lee, Malte Spielmann, Ulrich Bork & Frank Thévenod. (2005) Cd 2+ -induced swelling-contraction dynamics in isolated kidney cortex mitochondria: role of Ca 2+ uniporter, K + cycling, and protonmotive force . American Journal of Physiology-Cell Physiology 289:3, pages C656-C664.
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Wing-Kee Lee, Ulrich Bork, Fatemeh Gholamrezaei & Frank Thévenod. (2005) Cd 2+ -induced cytochrome c release in apoptotic proximal tubule cells: role of mitochondrial permeability transition pore and Ca 2+ uniporter . American Journal of Physiology-Renal Physiology 288:1, pages F27-F39.
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I. M. Sokolova, S. Evans & F. M. Hughes. (2004) Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition. Journal of Experimental Biology 207:19, pages 3369-3380.
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I. M. Sokolova. (2004) Cadmium effects on mitochondrial function are enhanced by elevated temperatures in a marine poikilotherm, Crassostrea virginica Gmelin (Bivalvia: Ostreidae). Journal of Experimental Biology 207:15, pages 2639-2648.
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Claudia Manzl, Gerhard Krumschnabel, Pablo J Schwarzbaum & Reinhard Dallinger. (2004) Acute toxicity of cadmium and copper in hepatopancreas cells from the Roman snail (Helix pomatia). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 138:1, pages 45-52.
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Peter Jacobs & Lucille Wood. (2004) Macronutrients. Disease-a-Month 50:2, pages 46-50.
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P. F. DEHN, C. M. WHITE, D. E. CONNERS, G. SHIPKEY & T. A. CUMBO. (2004) CHARACTERIZATION OF THE HUMAN HEPATOCELLULAR CARCINOMA (HEPG2) CELL LINE AS AN IN VITRO MODEL FOR CADMIUM TOXICITY STUDIES. In Vitro Cellular & Developmental Biology - Animal 40:5, pages 172.
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Daniel J. Dorta, Samara Leite, K?tia C. DeMarco, Ieda M.R. Prado, Tiago Rodrigues, F?bio E. Mingatto, S?rgio A. Uyemura, Antonio C. Santos & Carlos Curti. (2003) A proposed sequence of events for cadmium-induced mitochondrial impairment. Journal of Inorganic Biochemistry 97:3, pages 251-257.
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Nada Žnidaršič, Jasna Štrus & Damjana Drobne. (2003) Ultrastructural alterations of the hepatopancreas in Porcellio scaber under stress. Environmental Toxicology and Pharmacology 13:3, pages 161-174.
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Elena A. Belyaeva, Vadim V. Glazunov & Sergey M. Korotkov. (2002) Cyclosporin A-sensitive permeability transition pore is involved in Cd2+-induced dysfunction of isolated rat liver mitochondria: doubts no more. Archives of Biochemistry and Biophysics 405:2, pages 252-264.
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