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Journal of Toxicology: Clinical Toxicology Volume 40, 2002 - Issue 5
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Research Article

Intrathecal Vincristine: Fatal Myeloencephalopathy Despite Cerebrospinal Fluid Perfusion

Andrés Alcaraz Pediatric Intensive Care Unit, Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain, University of Oviedo, Oviedo, Spain
,
Corsino Rey Hospital Central de Asturias, Corsino Rey, Unidad de Cuidados Intensivos Pediátricos, C/Celestino Villamil s.n. 33006, Oviedo, Spain
,
Andrés Concha Pediatric Intensive Care Unit, Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain, University of Oviedo, Oviedo, Spain
&
Alberto Medina Pediatric Intensive Care Unit, Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain, University of Oviedo, Oviedo, Spain
Pages 557-561 | Published online: 08 Jan 2002

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M. Scalzone, P. Coccia, G. Cerchiara, P. Maurizi, S. Mastrangelo, A. Ruggiero & R. Riccardi. (2010) Errors Involving Patients Receiving Intrathecal Chemotherapy. Journal of Chemotherapy 22:2, pages 83-87.
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Articles from other publishers (37)

Mark V. Koning, Rene van der Zwan & Markus Klimek. (2023) Drainage or lavage as a salvage manoeuvre after intrathecal drug errors: A systematic review with therapeutic recommendations. Journal of Clinical Anesthesia 89, pages 111184.
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Wolfgang Grisold & Valentina Carozzi. (2021) Toxicity in Peripheral Nerves: An Overview. Toxics 9:9, pages 218.
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Eugene R Viscusi, Vincent Hugo, Klaus Hoerauf & Frederick S Southwick. (2021) Neuraxial and peripheral misconnection events leading to wrong-route medication errors: a comprehensive literature review. Regional Anesthesia & Pain Medicine 46:2, pages 176-181.
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Peter J Gilbar. (2019) Inadvertent intrathecal administration of vincristine: Time to finally abolish the syringe. Journal of Oncology Pharmacy Practice 26:2, pages 263-266.
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H. Liu, R. Tariq, G. L. Liu, H. Yan & A. D. Kaye. (2017) Inadvertent intrathecal injections and best practice management. Acta Anaesthesiologica Scandinavica 61:1, pages 11-22.
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Delyan P. Ivanov, Abdal-jabbar Al-Rubai, Anna M. Grabowska & Margaret K. Pratten. (2016) Separating chemotherapy-related developmental neurotoxicity from cytotoxicity in monolayer and neurosphere cultures of human fetal brain cells. Toxicology in Vitro 37, pages 88-96.
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Delyan P. Ivanov, Beth Coyle, David A. Walker & Anna M. Grabowska. (2016) In vitro models of medulloblastoma: Choosing the right tool for the job. Journal of Biotechnology 236, pages 10-25.
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Agni Sekhar Saha, Md. Fekarul Islam, Sukanta Bhattacharya & Prabhas Prasun Giri. (2016) Clinical Presentation of Inadvertent Intrathecal Vincristine Masquerading Guillain–Barre Syndrome. Indian Journal of Hematology and Blood Transfusion 32:S1, pages 59-61.
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Peter Gilbar, Carole R Chambers & Maria Larizza. (2014) Medication safety and the administration of intravenous vincristine: International survey of oncology pharmacists. Journal of Oncology Pharmacy Practice 21:1, pages 10-18.
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Peter J. Gilbar. (2014) Intrathecal Chemotherapy. Cancer Nursing 37:4, pages 299-309.
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Peter Gilbar. (2011) Inadvertent intrathecal administration of vincristine: Has anything changed?. Journal of Oncology Pharmacy Practice 18:1, pages 155-157.
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Guang ZengHuilai MaXiangbo WangHuifang YanXinhua WanBin JiangRobert E. FontaineZhenglai WuShaobin LinFeng RuanHuihui Liu. (2011) Paraplegia and Paraparesis From Intrathecal Methotrexate and Cytarabine Contaminated With Trace Amounts of Vincristine in China During 2007. Journal of Clinical Oncology 29:13, pages 1765-1770.
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Douglas J Noble & Liam J Donaldson. (2011) Republished paper: The quest to eliminate intrathecal vincristine errors: a 40-year journey. Postgraduate Medical Journal 87:1023, pages 71-74.
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Adriana D'Addario, Juan Galuppo, Carlos Navari, Marcelo Schultz, Nélida Cuello, Juan C. Troncoso & Miguel Angel Riudavets. (2010) Accidental Intrathecal Administration of Vincristine. American Journal of Forensic Medicine & Pathology 31:1, pages 83-84.
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Kate Scatchard & Siow Ming Lee. 2010. Neuro-Oncology. Neuro-Oncology 352 371 .
Bernadette Hennipman, Esther de Vries, Jos P. M. Bökkerink, Lynn M. Ball & Anjo J. P. Veerman. (2009) Intrathecal Vincristine. Journal of Pediatric Hematology/Oncology 31:11, pages 816-819.
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Jeffrey S. Wefel, Robert Collins & Anne E. Kayl. 2009. Cognition and Cancer. Cognition and Cancer 97 114 .
Jeffrey S. Wefel, Mariana E. Witgert & Christina A. Meyers. (2008) Neuropsychological Sequelae of Non-Central Nervous System Cancer and Cancer Therapy. Neuropsychology Review 18:2, pages 121-131.
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Patrick Nisse, Julien Charpentier, François Dubois, Sylvie Deheul & Monique Mathieu-Nolf. (2007) Administration accidentelle intrathécale de vindésine : à propos de 2 cas mortels. Therapies 62:4, pages 360-361.
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Peter J GILBAR & Michael J DOOLEY. (2007) Review of case reports of inadvertent intrathecal administration of vincristine: Recommendations to reduce occurrence. Asia-Pacific Journal of Clinical Oncology 3:2, pages 59-65.
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Manfred Hauben & Jeffrey K Aronson. (2007) Gold Standards in Pharmacovigilance. Drug Safety 30:8, pages 645-655.
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Michael R. Cohen. 2007. Medication Errors, 2nd Edition. Medication Errors, 2nd Edition.
Jennifer L. Lagman, Cara C. Tigue, Steven M. Trifilio, Steven Belknap, Charlie G. Buffie & Charles L. Bennett. (2007) Inadvertent intrathecal administration of vincristine. Community Oncology 4:1, pages 45-46.
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. 2007. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose 927 941 .
Peter J Gilbar & Christine V Carrington. (2016) The incidence of extravasation of vinca alkaloids supplied in syringes or mini-bags. Journal of Oncology Pharmacy Practice 12:2, pages 113-118.
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Suzanne M. Mahon & Lisa Schulmeister. (2006) Preventing Vincristine Administration Errors: Does Evidence Support Minibag Infusions?. Clinical Journal of Oncology Nursing 10:2, pages 271-273.
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Leo Kager, Claudia Langebrake & Ulrike Kastner. 2006. Pädiatrische Hämatologie und Onkologie. Pädiatrische Hämatologie und Onkologie 560 577 .
Peter Gilbar, Michael Dooley & Jo-anne Brien. (2004) Inadvertent intrathecal administration of vincristine: are we fulfilling our roles as oncology pharmacists?. Journal of Oncology Pharmacy Practice 10:4, pages 187-189.
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Peter J GilbarChristine V Carrington. (2004) Preventing intrathecal administration of vincristine. Medical Journal of Australia 181:8, pages 464-464.
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Angela Stefanou & Michael Dooley. (2003) Simple Method to Eliminate the Risk of Inadvertent Intrathecal Vincristine Administration. Journal of Clinical Oncology 21:10, pages 2044-2044.
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