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Research Article

A New Predictor of Toxicity Following Acetaminophen Overdose Based on Pretreatment Exposure

, M.Sc. , M.D., , M.D., , M.D., , Ph.D. , M.D. & , M.D.
Pages 229-234 | Received 24 Sep 2004, Accepted 31 Jan 2005, Published online: 07 Oct 2008

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Read on this site (7)

Anselm Wong & Andis Graudins. (2017) Risk prediction of hepatotoxicity in paracetamol poisoning. Clinical Toxicology 55:8, pages 879-892.
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S. Gosselin, D. N. Juurlink, J. T. Kielstein, M. Ghannoum, V. Lavergne, T. D. Nolin & R. S. Hoffman. (2014) Extracorporeal treatment for acetaminophen poisoning: Recommendations from the EXTRIP workgroup. Clinical Toxicology 52:8, pages 856-867.
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M. J. Hodgman. (2014) Seeking a role, Psi and APAP×AT as acetaminophen risk assessment tools. Clinical Toxicology 52:5, pages 451-453.
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Summon Chomchai, Chulithida Chomchai & Taweepong Anusornsuwan. (2011) Acetaminophen psi parameter: A useful tool to quantify hepatotoxicity risk in acute acetaminophen overdose. Clinical Toxicology 49:7, pages 664-667.
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Marco L.A. Sivilotti, Thomas J. Green, Caillin Langmann, Mark Yarema, David Juurlink & David Johnson. (2010) Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose. Clinical Toxicology 48:8, pages 793-799.
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Thomas J. Green, Marco L.A. Sivilotti, Caillin Langmann, Mark Yarema, David Juurlink, Michael J. Burns & David W. Johnson. (2010) When do the aminotransferases rise after acute acetaminophen overdose?. Clinical Toxicology 48:8, pages 787-792.
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Articles from other publishers (17)

Mitchell R. McGill & Steven C. Curry. (2023) The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review. Livers 3:4, pages 569-596.
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Angela L. Chiew & Nicholas A. Buckley. (2021) Acetaminophen Poisoning. Critical Care Clinics 37:3, pages 543-561.
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D. Nicholas Bateman & James W. Dear. (2019) Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use. Toxicology Research 8:4, pages 489-498.
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Summon Chomchai & Chulathida Chomchai. (2018) Being overweight or obese as a risk factor for acute liver injury secondary to acute acetaminophen overdose. Pharmacoepidemiology and Drug Safety 27:1, pages 19-24.
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D. Nicholas Bateman & James W. Dear. (2017) Should we treat very large paracetamol overdose differently?. British Journal of Clinical Pharmacology 83:6, pages 1163-1165.
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D. Nicholas Bateman. 2017. Critical Care Toxicology. Critical Care Toxicology 1145 1169 .
Scott N. Lucyk, Mark C. Yarema, Marco L.A. Sivilotti, David W. Johnson, Alberto Nettel-Aguirre, Charlemaigne Victorino, Benoit Bailey, Richard C. Dart, Kennon Heard, Daniel A. Spyker & Barry H. Rumack. (2016) Outcomes of Patients With Premature Discontinuation of the 21-h Intravenous N-Acetylcysteine Protocol After Acute Acetaminophen Overdose. The Journal of Emergency Medicine 50:4, pages 629-637.
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D. Nicholas Bateman. (2015) Paracetamol poisoning: beyond the nomogram. British Journal of Clinical Pharmacology 80:1, pages 45-50.
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D. Nicholas Bateman. 2016. Critical Care Toxicology. Critical Care Toxicology 1 25 .
R. Amathieu, E. Levesque, J.-C. Merle, M. Chemit, C. Costentin, P. Compagnon & G. Dhonneur. (2013) Insuffisances hépatiques aiguës sévères d’origine toxique : prise en charge étiologique et symptomatique. Annales Françaises d'Anesthésie et de Réanimation 32:6, pages 416-421.
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Jeffrey L. Woodhead, Brett A. Howell, Yuching Yang, Alison H. Harrill, Harvey J. ClewellIIIIII, Melvin E. Andersen, Scott Q. Siler & Paul B. Watkins. (2012) An Analysis of N -Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury . Journal of Pharmacology and Experimental Therapeutics 342:2, pages 529-540.
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Christopher H. Remien, Frederick R. Adler, Lindsey Waddoups, Terry D. Box & Norman L. Sussman. (2012) Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: Early discrimination between survival and death. Hepatology 56:2, pages 727-734.
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Ayyasamy Manimaran, Souvendra Nath Sarkar & Palanisamy Sankar. (2010) Toxicodynamics of subacute co-exposure to groundwater contaminant arsenic and analgesic–antipyretic drug acetaminophen in rats. Ecotoxicology and Environmental Safety 73:1, pages 94-100.
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Mark C. Yarema, David W. Johnson, Marco L.A. Sivilotti, Daniel A. Spyker & Barry H. Rumack. (2009) In reply. Annals of Emergency Medicine 54:6, pages 858-859.
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Fahad M. Ali, Edward W. Boyer & Steven B. Bird. (2008) Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics. Alcohol 42:3, pages 213-218.
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Darren M Roberts & Nick A Buckley. (2007) Pharmacokinetic Considerations in Clinical Toxicology. Clinical Pharmacokinetics 46:11, pages 897-939.
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Marco L.A. Sivilotti, Mark C. Yarema, David N. Juurlink, Angela M. Good & David W. Johnson. (2005) A Risk Quantification Instrument for Acute Acetaminophen Overdose Patients Treated With N-Acetylcysteine. Annals of Emergency Medicine 46:3, pages 263-271.
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