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New Drugs

Bryostatin-1: A Novel PKC Inhibitor in Clinical Development

Jeremy Kortmansky Department of Medicine, Division of Solid Tumor Oncology, Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
, M.D. &
Gary K. Schwartz Department of Medicine, Division of Solid Tumor Oncology, Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
, M.D.
Pages 924-936 | Published online: 12 Oct 2003

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M Elizabeth Sobhia, Baljinder K Grewal, Stanly Paul ML, Jigneshkumar Patel, Amandeep Kaur, Thongtinlal Haokip & Alekhya Kokkula. (2013) Protein kinase C inhibitors: a patent review (2008 – 2009). Expert Opinion on Therapeutic Patents 23:10, pages 1297-1315.
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Conxita Avila & Carlos Angulo-Preckler. (2020) Bioactive Compounds from Marine Heterobranchs. Marine Drugs 18:12, pages 657.
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Paul A. Wender, Jack L. Sloane, Quang H. Luu-Nguyen, Yasuyuki Ogawa, Akira J. Shimizu, Steven M. Ryckbosch, Jefferson H. Tyler & Clayton Hardman. (2020) Function-Oriented Synthesis: Design, Synthesis, and Evaluation of Highly Simplified Bryostatin Analogues. The Journal of Organic Chemistry 85:23, pages 15116-15128.
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Renata Tisi, Vadim Gaponenko, Marco Vanoni & Elena Sacco. (2020) Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives. Biomolecules 10:11, pages 1535.
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Rinky Raghuvanshi & Sandip B. Bharate. (2020) Preclinical and Clinical Studies on Bryostatins, A Class of Marine-Derived Protein Kinase C Modulators: A Mini-Review. Current Topics in Medicinal Chemistry 20:12, pages 1124-1135.
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Anand Thirupathi, Chandra M. Shanmugavadivelu & Sampathkumar Natarajan. (2020) Fastidious Anatomization of Biota Procured Compounds on Cancer Drug Discovery. Current Pharmaceutical Biotechnology 21:5, pages 354-363.
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Clayton Hardman, Stephen Ho, Akira Shimizu, Quang Luu-Nguyen, Jack L. Sloane, Mohamed S. A. Soliman, Matthew D. Marsden, Jerome A. Zack & Paul A. Wender. (2020) Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy. Nature Communications 11:1.
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J. Matthew Rhett, Imran Khan & John P. O’Bryan. 2020. 69 146 .
Yuwei Wang, Chunping Tang, Sheng Yao, Huanling Lai, Runze Li, Jiahui Xu, Qianqian Wang, Xing Xing Fan, Qi Biao Wu, Elaine Lai-Han Leung, Yang Ye & Xiaojun Yao. (2019) Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer. Phytomedicine 65, pages 153100.
Crossref
Hiroaki Itoh & Masayuki Inoue. (2019) Comprehensive Structure–Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses. Chemical Reviews 119:17, pages 10002-10031.
Crossref
Shaden A. M. Khalifa, Nizar Elias, Mohamed A. Farag, Lei Chen, Aamer Saeed, Mohamed-Elamir F. Hegazy, Moustafa S. Moustafa, Aida Abd El-Wahed, Saleh M. Al-Mousawi, Syed G. Musharraf, Fang-Rong Chang, Arihiro Iwasaki, Kiyotake Suenaga, Muaaz Alajlani, Ulf Göransson & Hesham R. El-Seedi. (2019) Marine Natural Products: A Source of Novel Anticancer Drugs. Marine Drugs 17:9, pages 491.
Crossref
Figuerola & Avila. (2019) The Phylum Bryozoa as a Promising Source of Anticancer Drugs. Marine Drugs 17:8, pages 477.
Crossref
Francisco A. Blanco, Agnes Czikora, Noemi Kedei, Youngki You, Gary A. Mitchell, Satyabrata Pany, Anamitra Ghosh, Peter M. Blumberg & Joydip Das. (2019) Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry 58:27, pages 3016-3030.
Crossref
Hyun-Jung Kim. (2019) Regulation of Neural Stem Cell Fate by Natural Products. Biomolecules & Therapeutics 27:1, pages 15-24.
Crossref
Fahimeh Safaeinejad, Soheyl Bahrami, Heinz Redl & Hassan Niknejad. (2018) Inhibition of Inflammation, Suppression of Matrix Metalloproteinases, Induction of Neurogenesis, and Antioxidant Property Make Bryostatin-1 a Therapeutic Choice for Multiple Sclerosis. Frontiers in Pharmacology 9.
Crossref
Yuebao Zhang, Qianyou Guo, Xianwei Sun, Ji Lu, Yanjun Cao, Qiang Pu, Zhiwen Chu, Lu Gao & Zhenlei Song. (2018) Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy. Angewandte Chemie International Edition 57:4, pages 942-946.
Crossref
Yuebao Zhang, Qianyou Guo, Xianwei Sun, Ji Lu, Yanjun Cao, Qiang Pu, Zhiwen Chu, Lu Gao & Zhenlei Song. (2018) Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy. Angewandte Chemie 130:4, pages 954-958.
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Yusuke Hanaki, Yuki Shikata, Masayuki Kikumori, Natsuki Hotta, Masaya Imoto & Kazuhiro Irie. (2018) Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochemical and Biophysical Research Communications 495:1, pages 438-445.
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Ji Lu, Yuebao Zhang, WenYu Yang, Qianyou Guo, Lu Gao & Zhenlei Song. (2017) Transformation of the B Ring to the C Ring of Bryostatins by Csp 3 –H Amination and Z to E Isomerization . Organic Letters 19:19, pages 5232-5235.
Crossref
Verónica Ruiz-Torres, Jose Encinar, María Herranz-López, Almudena Pérez-Sánchez, Vicente Galiano, Enrique Barrajón-Catalán & Vicente Micol. (2017) An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs. Molecules 22:7, pages 1037.
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Marta Rui, Rita Nasti, Emanuele Bignardi, Serena Della Volpe, Giacomo Rossino, Daniela Rossi & Simona Collina. (2017) PKC in Regenerative Therapy: New Insights for Old Targets. Pharmaceuticals 10:4, pages 46.
Crossref
Kapil Dev & Rakesh Maurya. 2017. Neuroprotective Natural Products. Neuroprotective Natural Products 153 184 .
Nicolas Jonckheere, Romain Vasseur & Isabelle Van Seuningen. (2017) The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting. Critical Reviews in Oncology/Hematology 111, pages 7-19.
Crossref
Vipin Mohan Dan & Rahul Sanawar. 2017. Bioresources and Bioprocess in Biotechnology. Bioresources and Bioprocess in Biotechnology 171 184 .
Bassel El-Rayes. 2017. Encyclopedia of Cancer. Encyclopedia of Cancer 704 706 .
Daria Firsova, Nipun Mahajan, Hiren Solanki, Christine Morrow & Olivier P. Thomas. 2017. Bioprospecting. Bioprospecting 29 50 .
Raúl García Salcedo, Carlos Olano, Cristina Gómez, Rogelio Fernández, Alfredo F. Braña, Carmen Méndez, Fernando de la Calle & José A. Salas. (2016) Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative. Microbial Cell Factories 15:1.
Crossref
Jessica S. Kelsey, Christophe Cataisson, Jinqiu Chen, Michelle A. Herrmann, Mark E. Petersen, David O. Baumann, Kevin M. McGowan, Stuart H. Yuspa, Gary E. Keck & Peter M. Blumberg. (2016) Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin. Molecular Carcinogenesis 55:12, pages 2183-2195.
Crossref
John M. Ketcham, Ivan Volchkov, Te-Yu Chen, Peter M. Blumberg, Noemi Kedei, Nancy E. Lewin & Michael J. Krische. (2016) Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C–C Bond Formation: Potency Does Not Confer Bryostatin-like Biology. Journal of the American Chemical Society 138:40, pages 13415-13423.
Crossref
Abhik Sen, Jarin Hongpaisan, Desheng Wang, Thomas J. Nelson & Daniel L. Alkon. (2016) Protein Kinase Cϵ (PKCϵ) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95. Journal of Biological Chemistry 291:32, pages 16462-16476.
Crossref
Sydney Plummer, Thomas Manning, Tess Baker, Tysheon McGreggor, Mehulkumar Patel, Greg Wylie & Dennis Phillips. (2016) Isolation, analytical measurements, and cell line studies of the iron–bryostatin-1 complex. Bioorganic & Medicinal Chemistry Letters 26:10, pages 2489-2497.
Crossref
Daryl Staveness, Rana Abdelnabi, Adam J. Schrier, Brian A. Loy, Vishal A. Verma, Brian A. DeChristopher, Katherine E. Near, Johan Neyts, Leen Delang, Pieter Leyssen & Paul A. Wender. (2016) Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death. Journal of Natural Products 79:4, pages 675-679.
Crossref
Erika A. Crane & Karl Gademann. (2016) Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis. Angewandte Chemie International Edition 55:12, pages 3882-3902.
Crossref
Erika A. Crane & Karl Gademann. (2016) Synthetisch gewonnene Naturstofffragmente in der Wirkstoffentwicklung. Angewandte Chemie 128:12, pages 3948-3970.
Crossref
Prajit Limsirichai, Thomas Gaj & David V Schaffer. (2016) CRISPR-mediated Activation of Latent HIV-1 Expression. Molecular Therapy 24:3, pages 499-507.
Crossref
. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 1063 .
Jacqueline von Salm, Christopher Witowski, Danielle Demers, Ryan Young, Laurent Calcul & Bill Baker. 2015. Marine Biomedicine. Marine Biomedicine 105 134 .
Brian A. Loy, Adam B. Lesser, Daryl Staveness, Kelvin L. Billingsley, Lynette Cegelski & Paul A. Wender. (2015) Toward a Biorelevant Structure of Protein Kinase C Bound Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogues for Analysis with Rotational Echo Double Resonance NMR Spectroscopy. Journal of the American Chemical Society 137:10, pages 3678-3685.
Crossref
Erik M. Larsen, Matthew R. Wilson & Richard E. Taylor. (2015) Conformation–activity relationships of polyketide natural products. Natural Product Reports 32:8, pages 1183-1206.
Crossref
Rituparna Borah, Narsimha Mamidi, Subhankar Panda, Sukhamoy Gorai, Suraj Kumar Pathak & Debasis Manna. (2015) Elucidating the interaction of γ-hydroxymethyl-γ-butyrolactone substituents with model membranes and protein kinase C–C1 domains. Molecular BioSystems 11:5, pages 1389-1399.
Crossref
Bassel El-Rayes. 2016. Encyclopedia of Cancer. Encyclopedia of Cancer 1 2 .
Masayuki Kikumori, Ryo C. Yanagita & Kazuhiro Irie. (2014) Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug. Tetrahedron 70:52, pages 9776-9782.
Crossref
Swaroop Makam N, Kotamballi N. Chidambara Murthy, Chandrashekhar M. Sultanpur & Raghavendra M. Rao. (2014) Natural molecules as tumour inhibitors: Promises and prospects. Journal of Herbal Medicine 4:4, pages 175-187.
Crossref
Jabeena Khazir, Darren L. Riley, Lynne A. Pilcher, Pieter De-Maayer & Bilal Ahmad Mir. (2014) Anticancer Agents from Diverse Natural Sources. Natural Product Communications 9:11, pages 1934578X1400901.
Crossref
Paul A. Wender & Daryl Staveness. (2014) Improved Protein Kinase C Affinity through Final Step Diversification of a Simplified Salicylate-Derived Bryostatin Analog Scaffold. Organic Letters 16:19, pages 5140-5143.
Crossref
Paul A. Wender, Yu Nakagawa, Katherine E. Near & Daryl Staveness. (2014) Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs. Organic Letters 16:19, pages 5136-5139.
Crossref
Rima Beesoo, Vidushi Neergheen-Bhujun, Ranjeet Bhagooli & Theeshan Bahorun. (2014) Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 768, pages 84-97.
Crossref
Ian P. Andrews, John M. Ketcham, Peter M. Blumberg, Noemi Kedei, Nancy E. Lewin, Megan L. Peach & Michael J. Krische. (2014) Synthesis of seco -B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13-Acetate-like Properties . Journal of the American Chemical Society 136:38, pages 13209-13216.
Crossref
Amedeo Amedei & Elena Niccolai. 2014. Natural Products Analysis. Natural Products Analysis 43 113 .
Dipjyoti Talukdar, Subhankar Panda, Rituparna Borah & Debasis Manna. (2014) Membrane Interaction and Protein Kinase C-C1 Domain Binding Properties of 4-Hydroxy-3-(hydroxymethyl) Phenyl Ester Analogues. The Journal of Physical Chemistry B 118:27, pages 7541-7553.
Crossref
Noemi Kedei, Jin-Qiu Chen, Michelle A. Herrmann, Andrea Telek, Paul K. Goldsmith, Mark E. Petersen, Gary E. Keck & Peter M. Blumberg. (2014) Molecular Systems Pharmacology: Isoelectric Focusing Signature of Protein Kinase Cδ Provides an Integrated Measure of Its Modulation in Response to Ligands. Journal of Medicinal Chemistry 57:12, pages 5356-5369.
Crossref
Paul A. Wender, Alison C. Donnelly, Brian A. Loy, Katherine E. Near & Daryl Staveness. 2014. Natural Products in Medicinal Chemistry. Natural Products in Medicinal Chemistry 473 544 .
Danielle Skropeta & Liangqian Wei. (2014) Recent advances in deep-sea natural products. Nat. Prod. Rep. 31:8, pages 999-1025.
Crossref
Thomas J. Nelson, Abhik Sen, Daniel L. Alkon & Miao-Kun Sun. (2014) Adduct formation in liquid chromatography-triple quadrupole mass spectrometric measurement of bryostatin 1. Journal of Chromatography B 944, pages 55-62.
Crossref
Adriana Lorente, Janire Lamariano-Merketegi, Fernando Albericio & Mercedes Álvarez. (2013) Tetrahydrofuran-Containing Macrolides: A Fascinating Gift from the Deep Sea. Chemical Reviews 113:7, pages 4567-4610.
Crossref
Alyssa X. Wu-zhangAlexandra C. Newton. (2013) Protein kinase C pharmacology: refining the toolbox. Biochemical Journal 452:2, pages 195-209.
Crossref
Karin von Schwarzenberg & Angelika M. Vollmar. (2013) Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy. Cancer Letters 332:2, pages 295-303.
Crossref
N. Kedei, A. Telek, A.M. Michalowski, M.B. Kraft, W. Li, Y.B. Poudel, A. Rudra, M.E. Petersen, G.E. Keck & P.M. Blumberg. (2013) Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochemical Pharmacology 85:3, pages 313-324.
Crossref
Yasuyuki Ogawa, Phillip P. Painter, Dean J. Tantillo & Paul A. Wender. (2012) Mechanistic and Computational Studies of Exocyclic Stereocontrol in the Synthesis of Bryostatin-like Cis- 2,6-Disubstituted 4-Alkylidenetetrahydropyrans by Prins Cyclization . The Journal of Organic Chemistry 78:1, pages 104-115.
Crossref
Guilherme F. Perini & Luis E. Fayad. 2013. Non-Hodgkin Lymphoma. Non-Hodgkin Lymphoma 173 189 .
Se-Kwon KimSe-Kwon Kim & Ira Bhatnagar. 2012. Marine Pharmacognosy. Marine Pharmacognosy 281 302 .
Brian A. DeChristopher, Brian A. Loy, Matthew D. Marsden, Adam J. Schrier, Jerome A. Zack & Paul A. Wender. (2012) Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nature Chemistry 4:9, pages 705-710.
Crossref
Ana Lopez-Campistrous, Xiaohua Song, Adam J. Schrier, Paul A. Wender, Nancy A. Dower & James C. Stone. (2012) Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines. Experimental Hematology 40:8, pages 646-656.e2.
Crossref
Ji Lu, Zhenlei Song, Yuebao Zhang, Zubao Gan & Hongze Li. (2012) Prins Cyclization of Bis(silyl) Homoallylic Alcohols to Form 2,6- cis -Tetrahydropyrans Containing a Geometrically Defined Exocyclic Vinylsilane: Efficient Synthesis of Ring B of the Bryostatins . Angewandte Chemie International Edition 51:22, pages 5367-5370.
Crossref
Ji Lu, Zhenlei Song, Yuebao Zhang, Zubao Gan & Hongze Li. (2012) Prins Cyclization of Bis(silyl) Homoallylic Alcohols to Form 2,6‐ cis ‐Tetrahydropyrans Containing a Geometrically Defined Exocyclic Vinylsilane: Efficient Synthesis of Ring B of the Bryostatins . Angewandte Chemie 124:22, pages 5463-5466.
Crossref
Brian A. DeChristopher, Alice C. Fan, Dean W. Felsher & Paul A. Wender. (2012) “Picolog,” a Synthetically-Available Bryostatin Analog, Inhibits Growth of MYC-Induced Lymphoma In Vivo . Oncotarget 3:1, pages 58-66.
Crossref
Yoichi Nakao & Nobuhiro Fusetani. 2012. Handbook of Marine Natural Products. Handbook of Marine Natural Products 1145 1229 .
Yu Lu & Michael J. Krische. 2012. Total Synthesis of Natural Products. Total Synthesis of Natural Products 103 130 .
Danielle Skropeta, Natalie Pastro & Ana Zivanovic. (2011) Kinase Inhibitors from Marine Sponges. Marine Drugs 9:10, pages 2131-2154.
Crossref
David Cragg, Gordon Kingston & David NewmanDavid Newman. 2011. Anticancer Agents from Natural Products, Second Edition. Anticancer Agents from Natural Products, Second Edition 199 218 .
Yu Lu, Sang Kook Woo & Michael J. Krische. (2011) Total Synthesis of Bryostatin 7 via C–C Bond-Forming Hydrogenation . Journal of the American Chemical Society 133:35, pages 13876-13879.
Crossref
Barry M. Trost, Alison J. Frontier, Oliver R. Thiel, Hanbiao Yang & Guangbin Dong. (2011) Total Synthesis of Bryostatins: The Development of Methodology for the Atom‐Economic and Stereoselective Synthesis of the Ring C Subunit. Chemistry – A European Journal 17:35, pages 9762-9776.
Crossref
Paul A. Wender & Adam J. Schrier. (2011) Total Synthesis of Bryostatin 9. Journal of the American Chemical Society 133:24, pages 9228-9231.
Crossref
Virpi Talman, Raimo K. Tuominen, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma & Elina Ekokoski. (2011) C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells. PLoS ONE 6:5, pages e20053.
Crossref
Noemi Kedei, Emanuel Lubart, Nancy E. Lewin, Andrea Telek, Langston Lim, Poonam Mannan, Susan H. Garfield, Matthew B. Kraft, Gary E. Keck, Sofiya Kolusheva, Raz Jelinek & Peter M. Blumberg. (2011) Some Phorbol Esters Might Partially Resemble Bryostatin 1 in their Actions on LNCaP Prostate Cancer Cells and U937 Leukemia Cells. ChemBioChem 12:8, pages 1242-1251.
Crossref
Travis J. Maures, Hsiao-Wen Su, Lawrence S. Argetsinger, Sergio Grinstein & Christin Carter-Su. (2011) Phosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distribution. Journal of Cell Science 124:9, pages 1542-1552.
Crossref
Paul A. Wender, Brian A. Loy & Adam J. Schrier. (2011) Translating Nature’s Library: The Bryostatins and Function-Oriented Synthesis. Israel Journal of Chemistry 51:3-4, pages 453-472.
Crossref
Yunkun Qi & Shutao Ma. (2011) The Medicinal Potential of Promising Marine Macrolides with Anticancer Activity. ChemMedChem 6:3, pages 399-409.
Crossref
Preeti Vaishnav & Arnold L. Demain. (2011) Unexpected applications of secondary metabolites. Biotechnology Advances 29:2, pages 223-229.
Crossref
Ofer Zohar, Rotem Lavy, Xiaomei Zi, Thomas J. Nelson, Jarin Hongpaisan, Chaim G. Pick & D.L. Alkon. (2011) PKC activator therapeutic for mild traumatic brain injury in mice. Neurobiology of Disease 41:2, pages 329-337.
Crossref
Chen Zhong, Xiangdong Zhou, Minghui Zhang & Yide Hu. (2011) Anti-angiogenesis effect of Demethyl bryoanthrathiophene (DBT) in vitro. The Chinese-German Journal of Clinical Oncology 10:2, pages 63-69.
Crossref
Maria Eugenia Ariza, Rupal Ramakrishnan, Narendra P. Singh, Ashok Chauhan, Prakash S. Nagarkatti & Mitzi Nagarkatti. (2011) Bryostatin-1, a Naturally Occurring Antineoplastic Agent, Acts as a Toll-like Receptor 4 (TLR-4) Ligand and Induces Unique Cytokines and Chemokines in Dendritic Cells. Journal of Biological Chemistry 286:1, pages 24-34.
Crossref
Bassel El-Rayes. 2011. Encyclopedia of Cancer. Encyclopedia of Cancer 572 574 .
Ira Bhatnagar & Se-Kwon Kim. (2010) Marine Antitumor Drugs: Status, Shortfalls and Strategies. Marine Drugs 8:10, pages 2702-2720.
Crossref
Anthony P. Lam, Joseph A. Sparano, Vincent Vinciguerra, Allyson J. Ocean, Paul Christos, Howard Hochster, Fernando Camacho, Sanjay Goel, Sridhar Mani & Andreas Kaubisch. (2010) Phase II Study of Paclitaxel Plus the Protein Kinase C Inhibitor Bryostatin-1 in Advanced Pancreatic Carcinoma. American Journal of Clinical Oncology 33:2, pages 121-124.
Crossref
Karl J. Hale & Soraya Manaviazar. (2010) New Approaches to the Total Synthesis of the Bryostatin Antitumor Macrolides. Chemistry – An Asian Journal 5:4, pages 704-754.
Crossref
Ji-Hye Kang, Yerim Kim, Shin-Hye Won, Song-Kyu Park, Chang Woo Lee, Hwan-Mook Kim, Nancy E. Lewin, Nicholas A. Perry, Larry V. Pearce, Daniel J. Lundberg, Robert J. Surawski, Peter M. Blumberg & Jeewoo Lee. (2010) Polar 3-alkylidene-5-pivaloyloxymethyl-5′-hydroxymethyl-γ-lactones as protein kinase C ligands and antitumor agents. Bioorganic & Medicinal Chemistry Letters 20:3, pages 1008-1012.
Crossref
James J. La Clair. (2010) Natural product mode of action (MOA) studies: a link between natural and synthetic worlds. Natural Product Reports 27:7, pages 969.
Crossref
. 2010. Meyler's Side Effects of Drugs in Cancer and Immunology. Meyler's Side Effects of Drugs in Cancer and Immunology 491 598 .
Yu Lu & Michael J. Krische. (2009) Concise Synthesis of the Bryostatin A-Ring via Consecutive C−C Bond Forming Transfer Hydrogenations. Organic Letters 11:14, pages 3108-3111.
Crossref
Jon Roffey, Carine Rosse, Mark Linch, Andrew Hibbert, Neil Q McDonald & Peter J Parker. (2009) Protein kinase C intervention—the state of play. Current Opinion in Cell Biology 21:2, pages 268-279.
Crossref
Sandrine Gerber-Lemaire & Pierre Vogel. (2008) Spongistatins: Biological activity and synthetic studies. Comptes Rendus Chimie 11:11-12, pages 1382-1418.
Crossref
Derek C. Cole, Magda Asselin, Agnes Brennan, Robert Czerwinski, John W. Ellingboe, Lori Fitz, Rita Greco, Xinyi Huang, Diane Joseph-McCarthy, Michael F. Kelly, Matthew Kirisits, Julie Lee, Yuanhong Li, Paul Morgan, Joseph R. Stock, Désirée H. H. Tsao, Allan Wissner, Xiaoke Yang & Divya Chaudhary. (2008) Identification, Characterization and Initial Hit-to-Lead Optimization of a Series of 4-Arylamino-3-Pyridinecarbonitrile as Protein Kinase C theta (PKCθ) Inhibitors. Journal of Medicinal Chemistry 51:19, pages 5958-5963.
Crossref
Meena Jaggi, Subhash C. Chauhan, Cheng Du & K.C. Balaji. (2008) Bryostatin 1 modulates β-catenin subcellular localization and transcription activity through protein kinase D1 activation. Molecular Cancer Therapeutics 7:9, pages 2703-2712.
Crossref
Paul A. Wender & Vishal A. Verma. (2008) The Design, Synthesis, and Evaluation of C7 Diversified Bryostatin Analogs Reveals a Hot Spot for PKC Affinity. Organic Letters 10:15, pages 3331-3334.
Crossref
Eric W Schmidt. (2008) Trading molecules and tracking targets in symbiotic interactions. Nature Chemical Biology 4:8, pages 466-473.
Crossref
Tadhg P. BegleyDaniel Flachshaar & J��rn Piel. 2007. Wiley Encyclopedia of Chemical Biology. Wiley Encyclopedia of Chemical Biology.
Bassel F. El-Rayes, Shadan Ali, Philip A. Philip & Fazlul H. Sarkar. (2008) Protein Kinase C. Pancreas 36:4, pages 346-352.
Crossref
Paul A. Wender, Brian A. DeChristopher & Adam J. Schrier. (2008) Efficient Synthetic Access to a New Family of Highly Potent Bryostatin Analogues via a Prins-Driven Macrocyclization Strategy. Journal of the American Chemical Society 130:21, pages 6658-6659.
Crossref
Danielle Skropeta. (2008) Deep-sea natural products. Natural Product Reports 25:6, pages 1131.
Crossref
Cameron McIlwain. 2008. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 4 .
Yun Oh, Michael Lahn, Asavari Wagle & Roy Herbst. 2007. Targeted Therapies in Oncology. Targeted Therapies in Oncology 103 121 .
Yoichi Nakao & Nobuhiro Fusetani. (2007) Enzyme Inhibitors from Marine Invertebrates. Journal of Natural Products 70:4, pages 689-710.
Crossref
Katie M. Ruocco, Ekaterina I. Goncharova, Matthew R. Young, Nancy H. Colburn, James B. McMahon & Curtis J. Henrich. (2007) A High-Throughput Cell-Based Assay to Identify Specific Inhibitors of Transcription Factor AP-1. SLAS Discovery 12:1, pages 133-139.
Crossref
Basil F. El-Rayes, Shirish Gadgeel, Anthony F. Shields, Stephanie Manza, Patricia Lorusso & Philip A. Philip. (2006) Phase I Study of Bryostatin 1 and Gemcitabine. Clinical Cancer Research 12:23, pages 7059-7062.
Crossref
Paul A. Wender, Joshua C. Horan & Vishal A. Verma. (2006) Total Synthesis and Initial Biological Evaluation of New B-Ring-Modified Bryostatin Analogs. Organic Letters 8:23, pages 5299-5302.
Crossref
John D. Roberts, Mitchell R. Smith, Eric J. Feldman, Louise Cragg, Michael M. Millenson, Gail J. Roboz, Connie Honeycutt, Rose Thune, Kristin Padavic-Shaller, W. Hans Carter, Viswanathan Ramakrishnan, Anthony J. Murgo & Steven Grant. (2006) Phase I Study of Bryostatin 1 and Fludarabine in Patients with Chronic Lymphocytic Leukemia and Indolent (Non-Hodgkin's) Lymphoma. Clinical Cancer Research 12:19, pages 5809-5816.
Crossref
Paul A. Wender & Joshua C. Horan. (2006) Synthesis and PKC Binding of a New Class of A-Ring Diversifiable Bryostatin Analogues Utilizing a Double Asymmetric Hydrogenation and Cross-Coupling Strategy. Organic Letters 8:20, pages 4581-4584.
Crossref
A. M. Kuzirian, H. T. Epstein, C. J. Gagliardi, T. J. Nelson, M. Sakakibara, C. Taylor, A. B. Scioletti & D. L. Alkon. (2006) Bryostatin Enhancement of Memory in Hermissenda . The Biological Bulletin 210:3, pages 201-214.
Crossref
L.H. Schwartz, J.A.C. Colville, M.S. Ginsberg, L. Wang, M. Mazumdar, J. Kalaigian, H. Hricak, D. Ilson & G.K. Schwartz. (2006) Measuring tumor response and shape change on CT: esophageal cancer as a paradigm. Annals of Oncology 17:6, pages 1018-1023.
Crossref
C. Thomas Powell & Lihong Yin. (2006) Overexpression of PKCε sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin 1. International Journal of Cancer 118:6, pages 1572-1576.
Crossref
Trever G. Bivona, Steven E. Quatela, Brian O. Bodemann, Ian M. Ahearn, Michael J. Soskis, Adam Mor, John Miura, Heidi H. Wiener, Latasha Wright, Shahryar G. Saba, Duke Yim, Adam Fein, Ignacio Pérez de Castro, Chi Li, Craig B. Thompson, Adrienne D. Cox & Mark R. Philips. (2006) PKC Regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-Xl on Mitochondria and Induces Apoptosis. Molecular Cell 21:4, pages 481-493.
Crossref
Theresa Mikalsen, Nancy Gerits & Ugo Moens. 2006. 153 223 .
. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 563 .
Sanghamitra Mohanty, Jie Huang & Alakananda Basu. (2005) Enhancement of Cisplatin Sensitivity of Cisplatin-Resistant Human Cervical Carcinoma Cells by Bryostatin 1. Clinical Cancer Research 11:18, pages 6730-6737.
Crossref
Alessia PascaleMarialaura AmadioGiovanni ScapagniniCristina LanniMarco RacchiAlessandro ProvenzaniStefano GovoniDaniel L. AlkonAlessandro Quattrone. (2005) Neuronal ELAV proteins enhance mRNA stability by a PKCα-dependent pathway. Proceedings of the National Academy of Sciences 102:34, pages 12065-12070.
Crossref
Paul A. Wender, Michael O. Clarke & Joshua C. Horan. (2005) Role of the A-Ring of Bryostatin Analogues in PKC Binding:  Synthesis and Initial Biological Evaluation of New A-Ring-Modified Bryologs. Organic Letters 7:10, pages 1995-1998.
Crossref
Ted S Gross, Katy A King, Natalia A Rabaia, Pranali Pathare & Sundar Srinivasan. (2004) Upregulation of Osteopontin by Osteocytes Deprived of Mechanical Loading or Oxygen. Journal of Bone and Mineral Research 20:2, pages 250-256.
Crossref
Caitlin Hammond, Yonghong Shi, Jenny Mena, Jelena Tomic, David Cervi, Liwei He, Amanda E. Millar, Mark DeBenedette, Andre C. Schuh, Jeremy L. Baryza, Paul A. Wender, Laszlo Radvanyi & David E. Spaner. (2005) Effect of Serum and Antioxidants on the Immunogenicity of Protein Kinase C-Activated Chronic Lymphocytic Leukemia Cells. Journal of Immunotherapy 28:1, pages 28-39.
Crossref
Gerd Liebezeit. 2005. Marine Biotechnology II. Marine Biotechnology II 1 28 .

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