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Cancer Investigation Volume 23, 2005 - Issue 1
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Clinical Science Review

Pathology of the Future: Molecular Profiling for Targeted Therapy

Virginia Espina National Cancer Institute, Labotatory of Pathology, Bethesda, Maryland, USA; , 9000 Rockville Pike, Bldg. 10, Room BIB53, Bethesda, MD, 20892, USA
,
David Geho National Cancer Institute, Labotatory of Pathology, Bethesda, Maryland, USA
,
Arpita I. Mehta National Cancer Institute, Labotatory of Pathology, Bethesda, Maryland, USA; NIH-Howard Hughes Research Scholar, Howard Hughes Medical Institute, Bethesda, Maryland, USA
,
Emanuel F. Petricoin III Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Cellular and Gene Therapy, Bethesda, Maryland, USA
,
Lance A. Liotta National Cancer Institute, Labotatory of Pathology, Bethesda, Maryland, USA
&
Kevin P. Rosenblatt National Cancer Institute, Labotatory of Pathology, Bethesda, Maryland, USA; Laboratory of Pathology, University of Texas Southwestern, Dallas, Texas, USA
Pages 36-46 | Published online: 11 Jun 2009

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Vincent P. Klink & Giselle Thibaudeau. (2014) Laser microdissection of semi-thin sections from plastic-embedded tissue for studying plant–organism developmental processes at single-cell resolution. Journal of Plant Interactions 9:1, pages 610-617.
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Articles from other publishers (46)

Xianhua Shi, Linxi Chen, Siyi Chen & Duanping Sun. (2021) Electrochemical aptasensors for the detection of hepatocellular carcinoma-related biomarkers. New Journal of Chemistry 45:34, pages 15158-15169.
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Houman Kholafazad Kordasht & Mohammad Hasanzadeh. (2020) Aptamer based recognition of cancer cells: Recent progress and challenges in bioanalysis. Talanta 220, pages 121436.
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Joelle C. Boulos, Muhammad Rahama Yousof Idres & Thomas Efferth. (2020) Investigation of cancer drug resistance mechanisms by phosphoproteomics. Pharmacological Research 160, pages 105091.
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Reynolds K. Brobey, Dwight German, Patricia K. Sonsalla, Prem Gurnani, Johanne Pastor, C-C Hsieh, John Papaconstantinou, Philip P. Foster, Makoto Kuro-o & Kevin P. Rosenblatt. (2015) Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways. PLOS ONE 10:10, pages e0139914.
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Jianfei Xia, Daimin Song, Zonghua Wang, Feifei Zhang, Min Yang, Rijun Gui, Lin Xia, Sai Bi, Yanzhi Xia, Yanhui Li & Linhua Xia. (2015) Single electrode biosensor for simultaneous determination of interferon gamma and lysozyme. Biosensors and Bioelectronics 68, pages 55-61.
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H. Liu, T. L. McDowell, N. E. Hanson, X. Tang, J. Fujimoto & J. Rodriguez-Canales. (2013) Laser Capture Microdissection for the Investigative Pathologist. Veterinary Pathology 51:1, pages 257-269.
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Brian T. Luke, Jack R. Collins, Jens K. Habermann, DaRue A. Prieto, Timothy D. Veenstra & Thomas Ried. (2013) Comparing biomarkers and proteomic fingerprints for classification studies. Journal of Biomedical Science and Engineering 06:04, pages 453-465.
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Liang Cheng, Shaobo Zhang, Gregory T. MacLennan, Sean R. Williamson, Darrell D. Davidson, Mingsheng Wang, Timothy D. Jones, Antonio Lopez-Beltran & Rodolfo Montironi. (2013) Laser-assisted Microdissection in Translational Research. Applied Immunohistochemistry & Molecular Morphology 21:1, pages 31-47.
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Phulwinder K. Grover, Adrian G. Cummins, Timothy J. Price, Ian C. Roberts-Thomson & Jennifer E. Hardingham. (2012) A simple, cost-effective and flexible method for processing of snap-frozen tissue to prepare large amounts of intact RNA using laser microdissection. Biochimie 94:12, pages 2491-2497.
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Kevin P. Rosenblatt, Michael L. Huebschman & Harold R. Garner. 2012. Molecular Profiling. Molecular Profiling 311 324 .
Robert D. Cardiff. 2012. Genetically Engineered Mice for Cancer Research. Genetically Engineered Mice for Cancer Research 133 180 .
Yuan Zhang & Leaf Huang. 2011. Drug Delivery in Oncology. Drug Delivery in Oncology 1359 1390 .
Peter Szodoray & Philip Alex. (2012) Protein Array Diagnostics for Guiding Therapy in Rheumatoid Arthritis. Molecular Diagnosis & Therapy 15:5, pages 247-254.
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Xu Hun, Huaicheng Chen & Wei Wang. (2011) A electrogenerated chemiluminescence biosensor for Ramos cancer cell using DNA encapsulated Ru(bpy)3Cl2 as signal probe. Biosensors and Bioelectronics 26:9, pages 3887-3893.
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Xiaoli Zhu, Ya Cao, Zhiqiang Liang & Genxi Li. (2010) Aptamer-based and DNAzyme-linked colorimetric detection of cancer cells. Protein & Cell 1:9, pages 842-846.
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Mina Kalantari, Alejandro Garcia-Carranca, Claudia Dalia Morales-Vazquez, Rosemary Zuna, Delia Perez Montiel, Itzel E. Calleja-Macias, Bo Johansson, Sonia Andersson & Hans-Ulrich Bernard. (2009) Laser capture microdissection of cervical human papillomavirus infections: Copy number of the virus in cancerous and normal tissue and heterogeneous DNA methylation. Virology 390:2, pages 261-267.
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Eunkyung Kim, Pooja Dua & Soyoun Kim. (2009) Cell-based aptamer selection for diagnosing cancer and predicting cancer progression. Toxicology and Environmental Health Sciences 1:2, pages 140-143.
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Ji-Young Ahn, Eunkyung Kim, Jae-Chun Ryu & Soyoun Kim. (2009) Selection of aptamers in SELEX process. Toxicology and Environmental Health Sciences 1:1, pages 1-7.
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Yong Qian, Xianglin Shi, Vincent Castranova & Nancy L. Guo. 2009. Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response. Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response 287 298 .
Bharat N. Nathwani, Sebastian J. Sasu, Arshad N. Ahsanuddin, Antonio M. Hernandez & Milton R. Drachenberg. (2007) The Critical Role of Histology in an Era of Genomics and Proteomics: A Commentary and Reflection. Advances in Anatomic Pathology 14:6, pages 375-400.
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Antonella Naldini, Camilla Ardinghi, Daniela Massi, Marco Santucci, Alessandro Franchi, Francesca Tarantini, Pierangelo Geppetti, Giuseppe Cirino & Fabio Carraro. (2007) A Ribonuclease Protection Assay-based Approach for Analysis of Angiogenic Gene Expression in Archival Tissues. Diagnostic Molecular Pathology 16:3, pages 147-152.
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Ricardo V. Lloyd. (2007) In situ techniques in diagnostic pathology. Human Pathology 38:8, pages 1103-1104.
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Dali Huang, George P. Casale, Jun Tian, Nizar K. Wehbi, Neil A. Abrahams, Zahid Kaleem, Lynette M. Smith, Sonny L. Johansson, Johny E. Elkahwaji & George P. HemstreetIIIIII. (2007) Quantitative Fluorescence Imaging Analysis for Cancer Biomarker Discovery: Application to β-Catenin in Archived Prostate Specimens. Cancer Epidemiology, Biomarkers & Prevention 16:7, pages 1371-1381.
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Dihua Shangguan, Zehui Charles Cao, Ying Li & Weihong Tan. (2007) Aptamers Evolved from Cultured Cancer Cells Reveal Molecular Differences of Cancer Cells in Patient Samples. Clinical Chemistry 53:6, pages 1153-1155.
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Nyam‐Osor Chimge, Frank Ruddle & Dashzeveg Bayarsaihan. (2006) Laser‐assisted microdissection (LAM) in developmental biology. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 308B:2, pages 113-118.
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K-F Becker, C Schott, S Hipp, V Metzger, P Porschewski, R Beck, J Nährig, I Becker & H Höfler. (2007) Quantitative protein analysis from formalin-fixed tissues: implications for translational clinical research and nanoscale molecular diagnosis. The Journal of Pathology 211:3, pages 370-378.
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M.A. Reymond & W. Schlegel. 2007. 103 142 .
H. Voshol, S. Hoving & J. van Oostrum. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 27 50 .
Ziping Yang, Lyndsay E Harris, Darryl E Palmer-Toy & William S Hancock. (2006) Multilectin Affinity Chromatography for Characterization of Multiple Glycoprotein Biomarker Candidates in Serum from Breast Cancer Patients. Clinical Chemistry 52:10, pages 1897-1905.
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Dihua Shangguan, Ying Li, Zhiwen Tang, Zehui Charles Cao, Hui William Chen, Prabodhika Mallikaratchy, Kwame Sefah, Chaoyong James Yang & Weihong Tan. (2006) Aptamers evolved from live cells as effective molecular probes for cancer study. Proceedings of the National Academy of Sciences 103:32, pages 11838-11843.
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Doris Porombka, Sibylle Herzog, Wolfgang Baumg?rtner & Christiane Herden. (2006) Preservation of RNA and destruction of infectivity in microdissected brain tissues of Lewis rats infected with the Borna disease virus. Journal of Virological Methods 135:2, pages 247-253.
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Gerhard S. Mundinger, Virginia Espina, Lance A. Liotta, Emanuel F. PetricoinIIIIII & Katherine R. Calvo. (2006) Clinical phosphoproteomic profiling for personalized targeted medicine using reverse phase protein microarray. Targeted Oncology 1:3.
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Robert C Millikan. (2006) Commentary: The Human Genome: philosopher's stone or magic wand?. International Journal of Epidemiology 35:3, pages 578-581.
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C Gulmann, KM Sheehan, EW Kay, LA Liotta & EF Petricoin. (2006) Array-based proteomics: mapping of protein circuitries for diagnostics, prognostics, and therapy guidance in cancer. The Journal of Pathology 208:5, pages 595-606.
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Crossref
U J Roblick & G Auer. (2005) Proteomics and clinical surgery. British Journal of Surgery 92:12, pages 1464-1465.
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Nana E TchaboElizabeth A Guancial, Josephine A CzechowiczElise C Kohn. (2016) The Role of Proteomics in the Diagnosis and Treatment of Ovarian Cancer. Women's Health 1:3, pages 365-374.
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Virginia Espina. (2005) Entwicklung der Protein-Microarray-Technik und Nutzung im Rahmen einer individualisierten molekularen Tumortherapie. Onkologie 28:4, pages 40-42.
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György Marko-Varga. 2005. Proteomics and Peptidomics: New Technology Platforms Elucidating Biology. Proteomics and Peptidomics: New Technology Platforms Elucidating Biology 1 67 .
Richard M. Schultz. 2005. Advances in Targeted Cancer Therapy. Advances in Targeted Cancer Therapy 1 17 .

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