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Research Article

Biocides: Characterization of the Allergenic Hazard of Methylisothiazolinone

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Pages 187-199 | Published online: 18 Nov 2003

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Min Kook Kim, Kyu-Bong Kim, Hyung Sik Kim & Byung-Mu Lee. (2019) Alternative skin sensitization prediction and risk assessment using proinflammatory biomarkers, interleukin-1 beta (IL-1β) and inducible nitric oxide synthase (iNOS). Journal of Toxicology and Environmental Health, Part A 82:5, pages 361-378.
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Min Kook Kim, Kyu-Bong Kim, Kyungsil Yoon, Sam Kacew, Hyung Sik Kim & Byung-Mu Lee. (2018) IL-1α and IL-1β as alternative biomarkers for risk assessment and the prediction of skin sensitization potency. Journal of Toxicology and Environmental Health, Part A 81:17, pages 830-843.
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David A. Basketter. (2010) Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment. Cutaneous and Ocular Toxicology 29:1, pages 4-9.
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Judy Strickland, David G. AllenDori GermolecNicole KleinstreuerVictor J. JohnsonTravis GulledgeJim TruaxAnna LowitTimothy DoleTimothy McMahonMelissa PangerJudy FaceyStephen Savage. (2022) Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds. Applied In Vitro Toxicology 8:4, pages 117-128.
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Carola Lidén, Niklas Andersson & Ian R. White. (2022) Preservatives in non‐cosmetic products: Increasing human exposure requires action for protection of health. Contact Dermatitis 87:5, pages 389-405.
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Dafne Musino, Aurélie Rosset, Cécile Lelong, Sylvie Luche, Virginie Bergé, Grégory Brochard, Manon Plumail, Benedicte Trouiller, Aurélien Auger, Arnaud Guiot, Julien Patouillard, Stephanie Desrousseaux, Sébastien Artous, Thierry Rabilloud, Delphine Boutry & Isabelle Capron. (2021) CNC/AgNP hybrids as safer-by-design biocides in paints. Environmental Science: Nano 8:12, pages 3673-3684.
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Jakob Ferløv Schwensen & Jeanne Duus Johansen. 2020. Kanerva’s Occupational Dermatology. Kanerva’s Occupational Dermatology 507 520 .
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Min Kook Kim, Kyu-Bong Kim, Joo Young Lee, Seung Jun Kwack, Yong Chan Kwon, Ji Soo Kang, Hyung Sik Kim & Byung-Mu Lee. (2019) Risk Assessment of 5-Chloro-2-Methylisothiazol-3(2H)-One/2-Methylisothiazol-3(2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics. Toxicological Research 35:2, pages 103-117.
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J. Ezendam, B.G.H. Bokkers, W. Bil & J.E. Delmaar. (2018) Skin sensitisation quantitative risk assessment (QRA) based on aggregate dermal exposure to methylisothiazolinone in personal care and household cleaning products. Food and Chemical Toxicology 112, pages 242-250.
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Jakob Ferløv Schwensen & Jeanne Duus Johansen. 2018. Kanerva’s Occupational Dermatology. Kanerva’s Occupational Dermatology 1 14 .
W. Bil, A.G. Schuur, J. Ezendam & B.G.H. Bokkers. (2017) Probabilistic derivation of the interspecies assessment factor for skin sensitization. Regulatory Toxicology and Pharmacology 88, pages 34-44.
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J.F. Schwensen, C. Menné Bonefeld, C. Zachariae, C. Agerbeck, T.H. Petersen, C. Geisler, U.E. Bollmann, K. Bester & J.D. Johansen. (2016) Cross‐reactivity between methylisothiazolinone, octylisothiazolinone and benzisothiazolinone using a modified local lymph node assay. British Journal of Dermatology 176:1, pages 176-183.
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Carola Lidén, Kerem Yazar, Jeanne D. Johansen, Ann-Therese Karlberg, Wolfgang Uter & Ian R. White. (2016) Comparative sensitizing potencies of fragrances, preservatives, and hair dyes. Contact Dermatitis 75:5, pages 265-275.
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Mark Wilkinson & David Orton. 2016. Rook's Textbook of Dermatology, Ninth Edition. Rook's Textbook of Dermatology, Ninth Edition 1 105 .
Jakob Schwensen & Jacob Thyssen. (2016) Contact Allergy to Preservatives—Is the European Commission a Commendable Risk Manager?. Cosmetics 3:3, pages 29.
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Camille Debeuckelaere, François-Marie Moussallieh, Karim Elbayed, Izzie-Jacques Namer, Valérie Berl, Elena Giménez-Arnau & Jean-Pierre Lepoittevin. (2016) In situ chemical behaviour of methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) in reconstructed human epidermis: a new approach to the cross-reactivity issue . Contact Dermatitis 74:3, pages 159-167.
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. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 58 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 26 .
Jakob F. Schwensen, Ian R. White, Jacob P. Thyssen, Torkil Menné & Jeanne D. Johansen. (2015) Failures in risk assessment and risk management for cosmetic preservatives in Europe and the impact on public health. Contact Dermatitis 73:3, pages 133-141.
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K. Yazar, M.D. Lundov, A. Faurschou, M. Matura, A. Boman, J.D. Johansen & C. Lid?n. (2015) Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study. British Journal of Dermatology 173:1, pages 115-122.
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Jakob F. Schwensen, Michael D. Lundov, Rossana Bossi, Piu Banerjee, Elena Gimenez-Arnau, Jean-Pierre Lepoittevin, Carola Lidén, Wolfgang Uter, Kerem Yazar, Ian R. White & Jeanne D. Johansen. (2015) Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries. Contact Dermatitis 72:3, pages 127-138.
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Olivier Aerts, Marie Baeck, Lieve Constandt, Bita Dezfoulian, Marie-Claude Jacobs, Stefan Kerre, Hilde Lapeere, Lauranne Pierret, Kristien Wouters & An Goossens. (2014) The dramatic increase in the rate of methylisothiazolinone contact allergy in Belgium: a multicentre study. Contact Dermatitis 71:1, pages 41-48.
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Graham A Johnston. (2014) The rise in prevalence of contact allergy to methylisothiazolinone in the British Isles. Contact Dermatitis 70:4, pages 238-240.
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David W. Roberts. (2013) Methylisothiazolinone is categorised as a strong sensitiser in the Murine Local Lymph Node Assay. Contact Dermatitis 69:5, pages 261-262.
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Magnus Bruze, Malin Engfeldt, Margarida Gonçalo & An Goossens. (2013) Recommendation to include methylisothiazolinone in the European baseline patch test series - on behalf of the European Society of Contact Dermatitis and the European Environmental and Contact Dermatitis Research Group. Contact Dermatitis 69:5, pages 263-270.
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John P. McFadden, Jack Mann, Jonathan M. L. White, Piu Banerjee & Ian R. White. (2013) Outbreak of methylisothiazolinone allergy targeting those aged ≥40 years. Contact Dermatitis 69:1, pages 53-55.
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. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 29 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 25 .
Margarida Gonçalo & An Goossens. (2013) Whilst Rome Burns: The Epidemic of Contact Allergy to Methylisothiazolinone. Contact Dermatitis 68:5, pages 257-258.
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Mari Paz Castanedo-Tardana & Kathryn A. Zug. (2013) Methylisothiazolinone. Dermatitis 24:1, pages 2-6.
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M.D. Lundov, T. Krongaard, T.L. Menné & J.D. Johansen. (2011) Methylisothiazolinone contact allergy: a review. British Journal of Dermatology 165:6, pages 1178-1182.
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Michael D. Lundov, Claus Zachariae & Jeanne D. Johansen. (2011) Methylisothiazolinone contact allergy and dose-response relationships. Contact Dermatitis 64:6, pages 330-336.
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Michael D. Lundov, Jacob P. Thyssen, Claus Zachariae & Jeanne D. Johansen. (2010) Prevalence and cause of methylisothiazolinone contact allergy. Contact Dermatitis 63:3, pages 164-167.
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Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. (2019) Final Report of the Safety Assessment of Methylisothiazolinone. International Journal of Toxicology 29:4_suppl, pages 187S-213S.
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David A. Basketter, Catherine J. Clapp, Bob J. Safford, Ian R. Jowsey, Pauline McNamee, Cindy A. Ryan & Frank G. Gerberick. (2008) Preservatives and Skin Sensitization Quantitative Risk Assessment. Dermatitis 19:1, pages 20-27.
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