381
Views
71
CrossRef citations to date
0
Altmetric
Research Article

Preparation and In Vitro Evaluation of Self-Microemulsifying Drug Delivery Systems Containing Idebenone

, , , &
Pages 523-529 | Published online: 04 Oct 2000

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (16)

Pollyanna Álvaro Spósito, Ana Lia Mazzeti, Caroline de Oliveira Faria, Julio A Urbina, Gwenaelle Pound-Lana, Maria Terezinha Bahia & Vanessa Furtado Mosqueira. (2017) Ravuconazole self-emulsifying delivery system: in vitro activity against Trypanosoma cruzi amastigotes and in vivo toxicity. International Journal of Nanomedicine 12, pages 3785-3799.
Read now
Fahim Tamzeedul Karim, Azad Kalam, Rafi Anwar, Muhammad Masum Miah, Md Shamim Rahman & S. M. Ashraful Islam. (2015) Preparation and evaluation of SEDDS of simvastatin by in vivo, in vitro and ex vivo technique. Drug Development and Industrial Pharmacy 41:8, pages 1338-1342.
Read now
Jerry Nesamony, Ishan S. Shah, Ashish Kalra & Rose Jung. (2014) Nebulized oil-in-water nanoemulsion mists for pulmonary delivery: development, physico-chemical characterization and in vitro evaluation. Drug Development and Industrial Pharmacy 40:9, pages 1253-1263.
Read now
Kwan Yeol Yang, Du Hyeong Hwang, Abid Mehmood Yousaf, Dong Wuk Kim, Young-Jun Shin, Ok-Nam Bae, Yong-II Kim, Jong Oh Kim, Chul Soon Yong & Han-Gon Choi. (2013) Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation. International Journal of Nanomedicine 8, pages 3333-3343.
Read now
André B. da Fonseca Antunes, Bruno G. De Geest, Chris Vervaet & Jean Paul Remon. (2013) Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs. Drug Development and Industrial Pharmacy 39:5, pages 791-798.
Read now
Md. Akhlaquer Rahman, Arshad Hussain, Md. Sarfaraj Hussain, Mohd. Aamir Mirza & Zeenat Iqbal. (2013) Role of excipients in successful development of self-emulsifying/microemulsifying drug delivery system (SEDDS/SMEDDS). Drug Development and Industrial Pharmacy 39:1, pages 1-19.
Read now
Jae Kuk Ryu & Sun Dong Yoo. (2012) Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability. Drug Development and Industrial Pharmacy 38:11, pages 1313-1318.
Read now
Claudia Carbone, Rosario Pignatello, Teresa Musumeci & Giovanni Puglisi. (2012) Chemical and technological delivery systems for idebenone: a review of literature production. Expert Opinion on Drug Delivery 9:11, pages 1377-1392.
Read now
Minghui Sun, Luqin Si, Xuezhen Zhai, Zhaoze Fan, Yiming Ma, Rui Zhang & Xiangliang Yang. (2011) The influence of co-solvents on the stability and bioavailability of rapamycin formulated in self-microemulsifying drug delivery systems. Drug Development and Industrial Pharmacy 37:8, pages 986-994.
Read now
ShereenM. Assaf, NawzatD. Al-Jbour, Ala'aF. Eftaiha, AmaniM. Elsayed, MayyasM. Al-Remawi, NidalA. Qinna, Babur Chowdhry, Stephen Leharne & AdnanA. Badwan. (2011) Factors Involved in Formulation of Oily Delivery System for Proteins Based on PEG-8 Caprylic/Capric Glycerides and Polyglyceryl-6 Dioleate in a Mixture of Oleic Acid with Chitosan. Journal of Dispersion Science and Technology 32:5, pages 623-633.
Read now
Zhongbin Wu, Dan Guo, Li Deng, Yue Zhang, Qiuxia Yang & Jianming Chen. (2011) Preparation and evaluation of a self-emulsifying drug delivery system of etoposide–phospholipid complex. Drug Development and Industrial Pharmacy 37:1, pages 103-112.
Read now
Fuzheng Ren, Qiufang Jing, Jingbin Cui, Jianming Chen & Yongjia Shen. (2009) Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Anethole Trithione by Combined Use of Surfactants. Journal of Dispersion Science and Technology 30:5, pages 664-670.
Read now
Lanlan Wei, Jie Li, Liangran Guo, Shufang Nie, Weisan Pan, Peinan Sun & Hui Liu. (2007) Investigations of a Novel Self-Emulsifying Osmotic Pump Tablet Containing Carvedilol. Drug Development and Industrial Pharmacy 33:9, pages 990-998.
Read now
Shengmiao Cui, Chunshun Zhao, Dawei Chen & Zhonggui He. (2005) Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Improving In Vitro Dissolution and Oral Absorption of Pueraria Lobata Isoflavone. Drug Development and Industrial Pharmacy 31:4-5, pages 349-356.
Read now
Lanlan Wei, Peinan Sun, Shufang Nie & Weisan Pan. (2005) Preparation and Evaluation of SEDDS and SMEDDS Containing Carvedilol. Drug Development and Industrial Pharmacy 31:8, pages 785-794.
Read now
Gilberte Marti-Mestres & Françoise Nielloud. (2002) Emulsions in Health Care Applications—An Overview. Journal of Dispersion Science and Technology 23:1-3, pages 419-439.
Read now

Articles from other publishers (55)

Ravinder Verma, Vineet Mittal, Parijat Pandey, Saurabh Bhatia, Meenakshi Bhatia, Christina Karavasili, Tapan Behl, Ahmed Al-Harrasi, Priti Tagde, Manish Kumar & Deepak Kaushik. (2023) Exploring the Role of Self-Nanoemulsifying Systems in Drug Delivery: Challenges, Issues, Applications and Recent Advances. Current Drug Delivery 20:9, pages 1241-1261.
Crossref
Hani A. Alhadrami, Ahmed S.G. Srag El-Din, Hossam M. Hassan, Ahmed M. Sayed, Albaraa H. Alhadrami, Mostafa E. Rateb & Demiana M. Naguib. (2023) Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with Improved Antiviral Efficacy against SARS-CoV-2. Pharmaceutics 15:11, pages 2531.
Crossref
Umang Varia, Azad Patel, Hitesh Katariya & Krunal Detholia. (2022) Formulation and optimization of polymeric agglomerates of Bosentan monohydrate by crystallo-co-agglomeration technique. Bulletin of the National Research Centre 46:1.
Crossref
Xindi Qian, Guanru Wang, Jie Li, Xinyue Zhang, Minghui Zhang, Qingmin Yang, Zhiwen Zhang & Yaping Li. (2022) Improving oral bioavailability of water-insoluble idebenone with bioadhesive liposomes. Journal of Drug Delivery Science and Technology 75, pages 103640.
Crossref
Gyubin Noh, Taekwang Keum, Santosh Bashyal, Jo-Eun Seo, Lamichhane Shrawani, Jeong Hwan Kim & Sangkil Lee. (2021) Recent progress in hydrophobic ion-pairing and lipid-based drug delivery systems for enhanced oral delivery of biopharmaceuticals. Journal of Pharmaceutical Investigation 52:1, pages 75-93.
Crossref
Akihiro MatsumotoSatoshi MuraoChie WatanabeMasahiro Murakami. (2020) Preparation and <i>in vitro</i> tumor growth inhibitory effect of oligo (L-lactate) nanoparticles. Drug Discoveries & Therapeutics 14:6, pages 296-303.
Crossref
Navdeep Gahlawat, Ravinder Verma & Deepak Kaushik. (2020) Application of D-optimal Mixture Design for Development and Optimization of Olmesartan Medoxomil Loaded SMEDDS. Current Drug Therapy 15:5, pages 548-560.
Crossref
Kuldeep Rajpoot, Muktika Tekade, Vikas Pandey, SreeHarsha Nagaraja, Susanne R. Youngren-Ortiz & Rakesh K. Tekade. 2020. Drug Delivery Systems. Drug Delivery Systems 393 454 .
Pan Guo, Nan Li, Lili Fan, Jun Lu, Boying Liu, Bing Zhang, Yumei Wu, Zhidong Liu, Jiawei Li, Jiaxin Pi & Dongli Qi. (2019) Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry. Asian Journal of Pharmaceutical Sciences 14:3, pages 329-339.
Crossref
Lu Xiao, Ying Liu & Tao Yi. (2019) Development of a New Ex Vivo Lipolysis-Absorption Model for Nanoemulsions. Pharmaceutics 11:4, pages 164.
Crossref
Muthanna Abdulkarim, Peeyush Kumar Sharma & Mark Gumbleton. (2019) Self-emulsifying drug delivery system: Mucus permeation and innovative quantification technologies. Advanced Drug Delivery Reviews 142, pages 62-74.
Crossref
Jong-Hwa Lee, Hak Kim, Young Cho, Tae-Sung Koo & Gye Lee. (2018) Development and Evaluation of Raloxifene-Hydrochloride-Loaded Supersaturatable SMEDDS Containing an Acidifier. Pharmaceutics 10:3, pages 78.
Crossref
Ghoneim Amira M.. (2018) Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl: Pharmacokinetic study in healthy volunteers. International Journal of Pharmaceutical Sciences and Developmental Research, pages 009-019.
Crossref
Lucia Montenegro, Rita Turnaturi, Carmela Parenti & Lorella Pasquinucci. (2018) Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy. Nanomaterials 8:2, pages 87.
Crossref
Chen Ye & Hong Chi. (2018) A review of recent progress in drug and protein encapsulation: Approaches, applications and challenges. Materials Science and Engineering: C 83, pages 233-246.
Crossref
Hemal Tandel, Dhaval Shah, Jigar Vanza & Ambikanandan Misra. (2017) Lipid based formulation approach for BCS class-II drug: Modafinil in the treatment of ADHD. Journal of Drug Delivery Science and Technology 37, pages 166-183.
Crossref
Vivek P. Chavda & Dhaval Shah. 2017. Nanostructures for Cancer Therapy. Nanostructures for Cancer Therapy 653 718 .
Ravindra N. Kamble, Piyush P. Mehta & Ajay Kumar. (2015) Efavirenz Self-Nano-Emulsifying Drug Delivery System: In Vitro and In Vivo Evaluation. AAPS PharmSciTech 17:5, pages 1240-1247.
Crossref
Chukwuebuka Umeyor, Anthony Attama, Emmanuel Uronnachi, Franklin Kenechukwu, Calistus Nwakile, Ifeanyi Nzekwe, Eric Okoye & Charles Esimone. (2016) Formulation design and in vitro physicochemical characterization of surface modified self-nanoemulsifying formulations (SNEFs) of gentamicin. International Journal of Pharmaceutics 497:1-2, pages 161-198.
Crossref
Yao Li. 2015. Functional Food Ingredients and Nutraceuticals. Functional Food Ingredients and Nutraceuticals 319 372 .
Balakumar Krishnamoorthy, S. M. Habibur Rahman, N. Tamil selvan, R. Hari prasad, M. Rajkumar, M. Siva selvakumar, K. Vamshikrishna, Marslin Gregory & Chellan Vijayaraghavan. (2015) Design, formulation, in vitro, in vivo, and pharmacokinetic evaluation of nisoldipine-loaded self-nanoemulsifying drug delivery system. Journal of Nanoparticle Research 17:1.
Crossref
Samatha Akula, Aravind Kumar Gurram & Srinivas Reddy Devireddy. (2014) Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile. International Scholarly Research Notices 2014, pages 1-11.
Crossref
Tanzina Sharmin Nipun & S.M. Ashraful Islam. (2014) SEDDS of gliclazide: Preparation and characterization by in-vitro, ex-vivo and in-vivo techniques. Saudi Pharmaceutical Journal 22:4, pages 343-348.
Crossref
Young-Dae Cho & Young-Joon Park. (2013) In vitro and in vivo evaluation of a self-microemulsifying drug delivery system for the poorly soluble drug fenofibrate. Archives of Pharmacal Research 37:2, pages 193-203.
Crossref
Hongxing Ma, Mingjuan Chu, Kiyoshi Itagaki, Ping Xin, Xuegang Zhou, Dawei Zhang, Youzhi Wang, Jia Fu & Shiqin Sun. (2014) Formulation and <i>in Vitro</i> Characterization of a Novel Solid Lipid-Based Drug Delivery System. Chemical and Pharmaceutical Bulletin 62:12, pages 1173-1179.
Crossref
Shailesh T. Prajapati, Harsh A. Joshi & Chhaganbhai N. Patel. (2013) Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement. Journal of Pharmaceutics 2013, pages 1-9.
Crossref
Venkata Raman Kallakunta, Basanth Babu Eedara, Raju Jukanti, Ram Kishan Ajmeera & Suresh Bandari. (2013) A Gelucire 44/14 and labrasol based solid self emulsifying drug delivery system: formulation and evaluation. Journal of Pharmaceutical Investigation 43:3, pages 185-196.
Crossref
Bijay Kumar Poudel, Nirmal Marasini, Tuan Hiep Tran, Han-Gon Choi, Chul Soon Yong & Jong Oh Kim. (2012) Formulation, Characterization and Optimization of Valsartan Self-Microemulsifying Drug Delivery System Using Statistical Design of Experiment. Chemical and Pharmaceutical Bulletin 60:11, pages 1409-1418.
Crossref
Shweta Gupta, Sandip Chavhan & Krutika K. Sawant. (2011) Self-nanoemulsifying drug delivery system for adefovir dipivoxil: Design, characterization, in vitro and ex vivo evaluation. Colloids and Surfaces A: Physicochemical and Engineering Aspects 392:1, pages 145-155.
Crossref
M. Hamoudi, E. Fattal, C. Gueutin, V. Nicolas & A. Bochot. (2011) Beads made of cyclodextrin and oil for the oral delivery of lipophilic drugs: In vitro studies in simulated gastro-intestinal fluids. International Journal of Pharmaceutics 416:2, pages 507-514.
Crossref
A. A. Rathi, D. L. Dhamecha, M. H. G. Dehghan, M. Saifee, P. S. Wakte, S. D. Shelke & S. H. Dongre. (2011) Development and validation of a stability-indicating HPTLC assay method for idebenone. Acta Chromatographica 23:2, pages 281-294.
Crossref
Yi-Dong Yan, Jung Ae Kim, Mi Kyung Kwak, Bong Kyu Yoo, Chul Soon Yong & Han-Gon Choi. (2011) Enhanced Oral Bioavailability of Curcumin via a Solid Lipid-Based Self-Emulsifying Drug Delivery System Using a Spray-Drying Technique. Biological & Pharmaceutical Bulletin 34:8, pages 1179-1186.
Crossref
. (2010) Preparation and Evaluation of Novel Fenofibrate-loaded Self-Microemulsifying Drug Delivery System (SMEDDS). Journal of Pharmaceutical Investigation 40:6, pages 339-345.
Crossref
Xinru Li, Quan Yuan, Yanqing Huang, Yanxia Zhou & Yan Liu. (2010) Development of Silymarin Self-Microemulsifying Drug Delivery System with Enhanced Oral Bioavailability. AAPS PharmSciTech 11:2, pages 672-678.
Crossref
Qi Shen, Xi Li, Dan Yuan & Wei Jia. (2010) Enhanced Oral Bioavailability of Daidzein by Self-Microemulsifying Drug Delivery System. CHEMICAL & PHARMACEUTICAL BULLETIN 58:5, pages 639-643.
Crossref
Anne Larsen, René Holm, Mette Lund Pedersen & Anette Müllertz. (2008) Lipid-based Formulations for Danazol Containing a Digestible Surfactant, Labrafil M2125CS: In Vivo Bioavailability and Dynamic In Vitro Lipolysis. Pharmaceutical Research 25:12, pages 2769-2777.
Crossref
Ping Zhang, Ying Liu, Nianping Feng & Jie Xu. (2008) Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. International Journal of Pharmaceutics 355:1-2, pages 269-276.
Crossref
Amit A. Kale & Vandana B. Patravale. (2008) Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS) of Nimodipine. AAPS PharmSciTech 9:1, pages 191-196.
Crossref
Christopher J.H. Porter, Colin W. Pouton, Jean F. Cuine & William N. Charman. (2008) Enhancing intestinal drug solubilisation using lipid-based delivery systems. Advanced Drug Delivery Reviews 60:6, pages 673-691.
Crossref
Ying Chen, Gao Li, Xianggen Wu, Zhiyu Chen, Jiangeng Hang, Bei Qin, Song Chen & Ruihua Wang. (2008) Self-Microemulsifying Drug Delivery System (SMEDDS) of Vinpocetine: Formulation Development and in Vivo Assessment. Biological and Pharmaceutical Bulletin 31:1, pages 118-125.
Crossref
Ashok R. Patel & Pradeep R. Vavia. (2007) Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. The AAPS Journal 9:3, pages E344-E352.
Crossref
Jean F. Cuiné, William N. Charman, Colin W. Pouton, Glenn A. Edwards & Christopher J. H. Porter. (2007) Increasing the Proportional Content of Surfactant (Cremophor EL) Relative to Lipid in Self-emulsifying Lipid-based Formulations of Danazol Reduces Oral Bioavailability in Beagle Dogs. Pharmaceutical Research 24:4, pages 748-757.
Crossref
Adi Issam Arida, Moawia Mohammed Al-Tabakha & Hantash Abdel Jalil Hamoury. (2007) Improving the High Variable Bioavailability of Griseofulvin by SEDDS. CHEMICAL & PHARMACEUTICAL BULLETIN 55:12, pages 1713-1719.
Crossref
Jong Soo Woo, Tae-Seo Kim, Jae-Hyun Park & Sang-Cheol Chi. (2007) Formulation and biopharmaceutical evaluation of silymarin using SMEDDS. Archives of Pharmacal Research 30:1, pages 82-89.
Crossref
Y.G. Bachhav, A.A. Date & V.B. Patravale. (2006) Exploring the potential of N-methyl pyrrolidone as a cosurfactant in the microemulsion systems. International Journal of Pharmaceutics 326:1-2, pages 186-189.
Crossref
Andrzej Bugaj, Asta Juzeniene, Petras Juzenas, Vladimir Iani, Li Wei Ma & Johan Moan. (2006) The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid. Journal of Photochemistry and Photobiology B: Biology 83:2, pages 94-97.
Crossref
Andrzej Bugaj, Vladimir Iani, Asta Juzeniene, Petras Juzenas, Li-Wei Ma & Johan Moan. (2006) The effect of dimethylsulfoxide, 1-[2-(decylthio)ethyl]azacyclopentan-2-one and Labrafac®CC on porphyrin formation in normal mouse skin during topical application of methyl 5-aminolevulinate: A fluorescence and extraction study. Photodiagnosis and Photodynamic Therapy 3:1, pages 27-33.
Crossref
Shengmiao Cui, Chunshun Zhao, Xing Tang, Dawei Chen & Zhonggui He. (2004) Study on the bioavailability of puerarin from Pueraria lobata isoflavone self‐microemulsifying drug‐delivery systems and tablets in rabbits by liquid chromatography–mass spectrometry . Biomedical Chromatography 19:5, pages 375-378.
Crossref
Pradeep R. Patil, S. Praveen, R. H. Shobha Rani & Anant R. Paradkar. (2005) Bioavailability assessment of ketoprofen incorporated in gelled self-emulsifying formulation: A technical note. AAPS PharmSciTech 6:1, pages E9-E13.
Crossref
. 2005. Surface Activity in Drug Action. Surface Activity in Drug Action 233 293 .
Pradeep Patil, Prasad Joshi & Anant Paradkar. (2004) Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of ketoprofen. AAPS PharmSciTech 5:3, pages 43-50.
Crossref
R Neslihan Gursoy & Simon Benita. (2004) Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomedicine & Pharmacotherapy 58:3, pages 173-182.
Crossref
Chong-Kook Kim & Jeong-Sook Park. (2004) Solubility Enhancers for Oral Drug Delivery. American Journal of Drug Delivery 2:2, pages 113-130.
Crossref
Y.V.Rama Prasad, S.P Puthli, Sudarat Eaimtrakarn, Makoto Ishida, Yukako Yoshikawa, Nobuhito Shibata & Kanji Takada. (2003) Enhanced intestinal absorption of vancomycin with Labrasol and d-α-tocopheryl PEG 1000 succinate in rats. International Journal of Pharmaceutics 250:1, pages 181-190.
Crossref
. (2002) Formulation of Liquid Oral Preparations Containing Itraconazole. Journal of Korean Pharmaceutical Sciences 32:4, pages 299-303.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.